公开(公告)号：US11470827B2

公开(公告)日：2022-10-18

申请号：US16218299

申请日：2018-12-12

Applicant: Alector LLC

Inventor： Ilaria Tassi ,  Asa Abeliovich ,  Seung-Joo Lee ,  Arnon Rosenthal ,  Tina Schwabe

IPC: A01K67/027 ,  C07H21/04 ,  C07K14/705 ,  A61K49/00

Abstract: Provided herein are transgenic non-human animals whose genomes comprise two or more human genes selected from TREM1, TREML1, TREM2, TREML2, and TREML4, to methods of screening candidate agents that bind to and/or modulate the function and/or activity of at least one of the human genes in the transgenic non-human animals, and to methods of screening candidate agents to determine their effect on one or more activities and/or functions associated with expression of at least one of the human genes in the transgenic non-human animals. Further provided herein are methods of recapitulating a human TREM immune system in a non-human animal, and methods of generating a non-human animal disease model comprising a human TREM repertoire.

公开(公告)号：US11440957B2

公开(公告)日：2022-09-13

申请号：US16959081

申请日：2018-12-21

Applicant: ALECTOR LLC

Inventor： Arnon Rosenthal ,  Eric Brown ,  Tina Schwabe ,  Angie Yee ,  Herve Rhinn

IPC: C07K16/18 ,  C07K16/28

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal antibodies, antibody fragments, etc., that specifically bind a TMEM106B polypeptide, e.g., a mammalian TMEM106B or human TMEM106B, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US11254743B2

公开(公告)日：2022-02-22

申请号：US16869315

申请日：2020-05-07

Applicant: ALECTOR LLC

Inventor： Patricia Culp ,  Helen Lam ,  Arnon Rosenthal ,  Seung-Joo Lee ,  Nels P. Nielson ,  Robert Pejchal

IPC: C07K16/28 ,  A61K39/00 ,  C07K16/46

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind one or more epitopes within a CD33 protein, e.g., human CD33 or a mammalian CD33, and have improved and/or enhanced functional characteristics, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US11174313B2

公开(公告)日：2021-11-16

申请号：US15735946

申请日：2016-06-11

Applicant: ALECTOR LLC

Inventor： Arnon Rosenthal ,  Kate Monroe ,  Francesca Avogadri-Connors

IPC: C07K16/28 ,  A61K47/68 ,  C12N15/62 ,  C12N15/85 ,  A61K39/00 ,  A61P35/00

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind one or more epitopes within a CD33 protein, e.g., human CD33 or a mammalian CD33, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US11136390B2

公开(公告)日：2021-10-05

申请号：US15735947

申请日：2016-06-11

Applicant: ALECTOR LLC

Inventor： Kate Monroe ,  Helen Lam ,  Francesca Avogadri-Connors ,  Seung-Joo Lee ,  William Monteith ,  Herve Rhinn ,  Arnon Rosenthal

IPC: C07K16/28 ,  A61K39/395 ,  A61K39/00 ,  A61K45/06 ,  A61P35/00 ,  C12N15/85

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind one or more epitopes within a CD33 protein, e.g., human CD33 or a mammalian CD33, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US10308718B2

公开(公告)日：2019-06-04

申请号：US15867609

申请日：2018-01-10

Applicant: ALECTOR LLC

Inventor： Arnon Rosenthal ,  Tina Schwabe ,  Michael Kurnellas ,  Robert Pejchal ,  Anthony B. Cooper

IPC: C07K16/28 ,  A61K31/7088

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind on or more epitopes within a Sortilin protein, e.g., human Sortilin or a mammalian Sortilin, and use of such compostions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20190040131A1

公开(公告)日：2019-02-07

申请号：US16054840

申请日：2018-08-03

Applicant: ALECTOR LLC

Inventor： Patricia Culp ,  Helen Lam ,  Arnon Rosenthal ,  Seung-Joo Lee ,  Nels P. Nielson ,  Robert Pejchal

IPC: C07K16/28 ,  C07K16/46

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind one or more epitopes within a CD33 protein, e.g., human CD33 or a mammalian CD33, and have improved and/or enhanced functional characteristics, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20240270866A1

公开(公告)日：2024-08-15

申请号：US18423604

申请日：2024-01-26

Applicant: Alector LLC

Inventor： Andrew Pincetic ,  Arnon Rosenthal

IPC: C07K16/28 ,  A61K39/00 ,  A61P25/28 ,  G01N33/68

CPC classification number: C07K16/2896 ,  A61P25/28 ,  G01N33/6854 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/56 ,  C07K2317/92

Abstract: The present disclosure provides antibodies and antibody fragments that bind to human SIRPA. In some embodiments, the antibodies are SIRPA agonists. The antibodies and antibody fragments disclosed herein may be used for the treatment and/or diagnosis of diseases, disorders, and conditions associated with reduced SIRPA activity.

公开(公告)号：US12004494B2

公开(公告)日：2024-06-11

申请号：US17475116

申请日：2021-09-14

Applicant: Alector LLC

Inventor： Arnon Rosenthal ,  Seung-Joo Lee

IPC: A01K67/027 ,  A01K67/0275 ,  A01K67/0276 ,  C07K14/705 ,  C12N15/85

CPC classification number: A01K67/0276 ,  A01K67/0275 ,  C07K14/7056 ,  C07K14/70596 ,  C12N15/8509 ,  A01K2207/15 ,  A01K2217/05 ,  A01K2217/052 ,  A01K2217/07 ,  A01K2217/15 ,  A01K2227/105 ,  A01K2267/01 ,  A01K2267/03

Abstract: Provided herein are transgenic non-human animals whose genomes comprise two or more human genes selected from CD33, Siglec-5, Siglec-7, Siglec-9, Siglec-11, Siglec-14, and Siglec-16, to methods of screening candidate agents that bind to and/or modulate the function and/or activity of at least one of the human genes in the transgenic non-human animals, and to methods of screening candidate agents to determine their effect on one or more activities and/or functions associated with expression of at least one of the human genes in the transgenic non-human animals. Further provided herein are methods of recapitulating a human Siglec immune system in a non-human animal, and methods of generating a non-human animal disease model comprising a human Siglec repertoire.

公开(公告)号：US11976119B2

公开(公告)日：2024-05-07

申请号：US17707637

申请日：2022-03-29

Applicant: Alector LLC

Inventor： Andrew Pincetic ,  Wei-Hsien Ho ,  Patricia Culp ,  Arnon Rosenthal

IPC: C07K16/28 ,  C07K16/24 ,  C07K16/40 ,  C07K16/42 ,  C12N15/85

CPC classification number: C07K16/283 ,  C07K16/246 ,  C07K16/2818 ,  C07K16/2827 ,  C07K16/40 ,  C07K16/4283 ,  C12N15/85 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/32 ,  C07K2317/55 ,  C07K2317/567 ,  C07K2317/622 ,  C07K2317/732 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, antibodies, antibody fragments, etc., that specifically bind a SIRPA polypeptide, e.g., a mammalian SIRPA or human SIRPA, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.