公开(公告)号：USD965139S1

公开(公告)日：2022-09-27

申请号：US29710574

申请日：2019-10-24

Applicant: AMGEN INC.

Designer： Scott R. Gibson ,  Mehran Mojarrad ,  Paul Daniel Faucher

公开(公告)号：USD963158S1

公开(公告)日：2022-09-06

申请号：US29710577

申请日：2019-10-24

Applicant: AMGEN INC.

Designer： Scott R. Gibson ,  Mehran Mojarrad ,  Paul Daniel Faucher

公开(公告)号：US20210228797A1

公开(公告)日：2021-07-29

申请号：US17256240

申请日：2019-07-12

Applicant: AMGEN INC.

Inventor： Matthew Wayne Janke ,  Sudeshna Dutta Ray ,  Scott R. Gibson ,  Daniel Eduardo Groszmann ,  Wael Mismar ,  Mehran Mojarrad ,  Robert Allen Dees ,  Paul Daniel Faucher

IPC: A61M5/145 ,  A61M39/22 ,  A61M5/162

Abstract: Fluid path assemblies for drug delivery devices and methods of establishing a fluid flow path for drug delivery devices are described that include a needle shield valve member that couples to a reservoir having a needle mounted thereto. The needle shield valve member includes an internal barrier that protects the needle and/or contains a drug within the reservoir until activation of the drug delivery device. Upon activation, there is relative movement between the reservoir and needle shield valve member until the needle pierces the barrier to establish a fluid flow path from the reservoir through the needle shield valve member.

公开(公告)号：US12109389B2

公开(公告)日：2024-10-08

申请号：US17256240

申请日：2019-07-12

Applicant: AMGEN INC.

Inventor： Matthew Wayne Janke ,  Sudeshna Dutta Ray ,  Scott R. Gibson ,  Daniel Eduardo Groszmann ,  Wael Mismar ,  Mehran Mojarrad ,  Robert Allen Dees ,  Paul Daniel Faucher

IPC: A61M5/14 ,  A61M5/145 ,  A61M5/162 ,  A61M39/22 ,  A61M5/158

CPC classification number: A61M5/1452 ,  A61M5/1626 ,  A61M39/221 ,  A61M2005/1585 ,  A61M2205/52

Abstract: Fluid path assemblies for drug delivery devices and methods of establishing a fluid flow path for drug delivery devices are described that include a needle shield valve member that couples to a reservoir having a needle mounted thereto. The needle shield valve member includes an internal barrier that protects the needle and/or contains a drug within the reservoir until activation of the drug delivery device. Upon activation, there is relative movement between the reservoir and needle shield valve member until the needle pierces the barrier to establish a fluid flow path from the reservoir through the needle shield valve member.

公开(公告)号：US20230347075A1

公开(公告)日：2023-11-02

申请号：US17780596

申请日：2020-11-17

Applicant: AMGEN INC.

Inventor： Ali Nekouzadeh ,  Mehran Mojarrad ,  Joshua Tamsky ,  Paul Daniel Faucher ,  Scott R. Gibson ,  Kimberly Sepulveda ,  Sheldon B. Moberg

IPC: A61M5/48 ,  A61M5/158 ,  A61M5/315

CPC classification number: A61M5/482 ,  A61M5/158 ,  A61M5/31576

Abstract: A drug delivery device includes a housing, a container disposed in the housing, a drive mechanism, a needle assembly, a fluid flow path, and a vortex flow adapter. The container contains a medicament which is urged out of the container by the drive mechanism. The needle assembly has a needle and/or a cannula to deliver the medicament from the container. The fluid flow path fluidically connects the container and the needle assembly. The vortex flow adapter is disposed within or defines at least a portion of the fluid flow path, and is adapted to urge the medicament to flow in a vortex pattern.

公开(公告)号：US20220265975A1

公开(公告)日：2022-08-25

申请号：US17642345

申请日：2020-10-05

Applicant: AMGEN INC.

Inventor： Mehran Mojarrad ,  Scott R. Gibson ,  Heejin Lee

IPC: A61M31/00 ,  A61M5/20 ,  A61M5/142 ,  A61M5/14

Abstract: The devices, assemblies, and methods described herein utilize photoacoustic principals to create a jet of fluid using a ultrasonic resonance member and a pulsed laser light beam. The ultrasonic resonance member is a treated substrate having an liquid interface surface in contact with a fluid. When a pulsed laser light beam is applied to the treated substrate, pressure is generated via induced ultrasonic waves to urge the fluid into a jet stream.

公开(公告)号：US20210346601A1

公开(公告)日：2021-11-11

申请号：US17264139

申请日：2019-09-23

Applicant: AMGEN INC.

Inventor： Heejin Lee ,  Scott Robert Gibson ,  Mehran Mojarrad ,  Jeffrey Schacherl

IPC: A61M5/172 ,  A61M5/14 ,  A61M5/168

Abstract: Systems and methods for interventional dosing based on sensed feedback are disclosed. A system may include one or more reservoirs filled or fillable with, respectively, one or more drug products, an administration member, a fluid delivery system, one or more sensors, and optionally a controller. The administration member may be insertable into a patient and connected or connectable in fluid communication with the one or more reservoirs. The fluid delivery system may be operable to deliver the one or more drug products from the one or more reservoirs to the patient via the administration member. The one or more sensors may be operable to sense one or more biological conditions of the patient, including, but not limited to, a cytokine level and/or a biomarker indicative of cytokine release syndrome. The controller may be configured to control operation of the fluid delivery system based on output from the one or more sensors.

公开(公告)号：US11083840B2

公开(公告)日：2021-08-10

申请号：US15995442

申请日：2018-06-01

Applicant: AMGEN INC.

Inventor： Scott Robert Gibson ,  Sudeshna Dutta Ray ,  Daniel Eduardo Groszmann ,  Mehran Mojarrad ,  Nathan Thomas Balcom ,  Alejandro Campillo-Agusti ,  Alan D. Payne ,  Lawrence Scott Ring

IPC: A61M5/162 ,  A61M39/14 ,  A61M5/145 ,  A61M5/32 ,  A61M5/158

Abstract: Modular fluid path assemblies are provided that include conduit, coupling, and needle portions of a fluid path fluidly coupled to an outlet of a container. The modular fluid path assemblies further include a needle shield having a tip of the needle embedded therein. So configured, in embodiments, the modular fluid path assemblies can be sterilized, a medicament can be filled in the container, and a stopper inserted in the container so that the pre-sterilized and pre-filled modular fluid path assemblies can have a closed container integrity (CCI) seal.

公开(公告)号：US20210060259A1

公开(公告)日：2021-03-04

申请号：US16961762

申请日：2019-01-17

Applicant: AMGEN INC.

Inventor： Sudeshna Dutta Ray ,  Scott R. Gibson ,  Daniel Eduardo Groszmann ,  Mehran Mojarrad ,  Robert Allen Dees ,  Jonathan Dean Johnson ,  Antonio S. Murcia

IPC: A61M5/315 ,  A61M5/20

Abstract: A flexible plunger rod, drug delivery mechanism, drug delivery device, and methods are described that utilize the flexible plunger rod perform drug delivery operations. In embodiments, the flexible plunger rod can be stored in a curved configuration to thereby reduce a footprint of the drug delivery mechanism and device.