公开(公告)号：US11446327B2

公开(公告)日：2022-09-20

申请号：US15329664

申请日：2015-07-30

Applicant: AMORPHICAL LTD.

Inventor： Ali Abo Riziq ,  Sharon Hershkovitz ,  Yosef Ben ,  Yigal Blum

IPC: A61K33/10 ,  C01F11/18 ,  A23C9/13 ,  A23C9/152 ,  A23C19/09 ,  A23C19/068 ,  A23C19/076 ,  A23L33/16 ,  A61K9/00 ,  A61K9/10 ,  A61K47/10 ,  A61K47/14 ,  A61K47/26 ,  A61K47/34 ,  A61K47/40 ,  A23C13/12 ,  A23C11/00

Abstract: The present invention provides stable amorphous calcium carbonate (ACC) compositions, and food articles comprising said compositions.

公开(公告)号：US20220152094A1

公开(公告)日：2022-05-19

申请号：US17456693

申请日：2021-11-29

Applicant: AMORPHICAL LTD.

Inventor： Yosef Ben ,  Abraham Shahar ,  Amir Arav

IPC: A61K33/10 ,  A61K9/00 ,  A61K9/06 ,  A61K9/10 ,  A61P21/00 ,  A61P15/08 ,  A61K47/02 ,  A61K47/12 ,  A61K47/24 ,  A61K47/26 ,  C12N5/073 ,  C12N5/076 ,  C12N5/071

Abstract: Stabilized amorphous calcium carbonate (ACC) for treatment of several neurological, muscular and infertility diseases and conditions is provided. In particular, the stabilized ACC may be used in the treatment of axonal defects and muscular dystrophy. In addition, provided are improved methods used in assistant reproductive technology. Examples of such methods are in vitro fertilization and improvement of sperm quality. The improved IVF method, for example, comprises addition of the stabilized ACC to the cell culture medium in which the stages of fertilization and embryo development occurs.

公开(公告)号：US11052107B2

公开(公告)日：2021-07-06

申请号：US15579010

申请日：2016-06-02

Applicant: AMORPHICAL LTD.

Inventor： Yosef Ben ,  Yigal Dov Blum ,  Hagay Moshe ,  Ben Ashkenazi

IPC: A61K9/10 ,  A61K9/14 ,  A61K33/10 ,  A61K47/24 ,  A61K9/00 ,  A61P31/00 ,  A61P35/00

Abstract: The present invention provides solid compositions of amorphous calcium carbonate (ACC) and a polyphosphate, bisphosphonate or pharmaceutical salts thereof as a stabilizer. Said stabilizers stabilizes the ACC and prevent crystallization to crystalline calcium carbonate ((′( (″) for a long period of time, even in an aqueous suspension. The invention further provides pharmaceutical composition comprising the solid ACC compositions as well their use in treating of certain diseases and conditions.

公开(公告)号：US10758565B2

公开(公告)日：2020-09-01

申请号：US15578829

申请日：2016-06-02

Applicant: AMORPHICAL LTD.

Inventor： Yosef Ben ,  Yigal Dov Blum

IPC: A61K31/00 ,  A61K33/10 ,  A61K9/00 ,  A61K9/14 ,  A61P35/00 ,  A61K47/24 ,  A61K9/10 ,  A61P31/00

Abstract: The present invention provides compositions comprising amorphous calcium carbonate (ACC), suitable to being administered by inhalation, and methods for their use in treating ACC-responsive diseases and conditions. Further provided are ACC compositions suitable for buccal or sublingual administration.

公开(公告)号：US20190262391A1

公开(公告)日：2019-08-29

申请号：US16343463

申请日：2017-10-23

Applicant: AMORPHICAL LTD.

Inventor： Yosef Ben

IPC: A61K33/10 ,  A61K31/66 ,  A61P35/02 ,  A61K9/00 ,  A23L29/00

Abstract: The present invention provides compositions and methods of treating a leukemia, including chronic lymphocytic leukemia, wherein the method comprises administering a stabilized amorphous calcium carbonate to a person in need thereof.

公开(公告)号：US20190030068A1

公开(公告)日：2019-01-31

申请号：US16069762

申请日：2017-01-17

Applicant: AMORPHICAL LTD.

Inventor： Yosef Ben ,  Abraham Shahar ,  Amir Arav

IPC: A61K33/10 ,  A61P21/00 ,  A61K9/00 ,  C12N5/073 ,  C12N5/076 ,  C12N5/071 ,  A61P15/08 ,  A61K47/24 ,  A61K47/02 ,  A61K47/26 ,  A61K47/12

Abstract: Stabilized amorphous calcium carbonate (ACC) for treatment of several neurological, muscular and infertility diseases and conditions is provided. In particular, the stabilized ACC may be used in the treatment of axonal defects and muscular dystrophy. In addition, provided are improved methods used in assistant reproductive technology. Examples of such methods are in vitro fertilization and improvement of sperm quality. The improved IVF method, for example, comprises addition of the stabilized ACC to the cell culture medium in which the stages of fertilization and embryo development occurs.

公开(公告)号：US20180140631A1

公开(公告)日：2018-05-24

申请号：US15579010

申请日：2016-06-02

Applicant: AMORPHICAL LTD.

Inventor： Yosef Ben ,  Yigal Dov Blum ,  Hagay Moshe ,  Ben Ashkenazi

IPC: A61K33/10 ,  A61K47/24 ,  A61K9/14

CPC classification number: A61K33/10 ,  A61K9/0019 ,  A61K9/0056 ,  A61K9/0073 ,  A61K9/10 ,  A61K9/143 ,  A61K47/24 ,  A61P31/00 ,  A61P35/00

Abstract: The present invention provides solid compositions of amorphous calcium carbonate (ACC) and a polyphosphate, bisphosphonate or pharmaceutical salts thereof as a stabilizer. Said stabilizers stabilizes the ACC and prevent crystallization to crystalline calcium carbonate ((′((″) for a long period of time, even in an aqueous suspension. The invention further provides pharmaceutical composition comprising the solid ACC compositions as well their use in treating of certain diseases and conditions.

公开(公告)号：US20170216349A1

公开(公告)日：2017-08-03

申请号：US15329677

申请日：2015-07-30

Applicant: AMORPHICAL LTD.

Inventor： Yigal Blum ,  Yosef Ben ,  Sharon Hershkovitz

IPC: A61K33/10 ,  A61K9/10 ,  A61K9/00 ,  A61K47/14 ,  A61K47/40 ,  A61K47/34 ,  A61K47/26 ,  C01F11/18 ,  A61K47/10

CPC classification number: A61K33/10 ,  A23C9/1322 ,  A23C9/1522 ,  A23C11/00 ,  A23C13/12 ,  A23C19/0684 ,  A23C19/0765 ,  A23C19/0921 ,  A23L33/16 ,  A23V2002/00 ,  A23V2250/032 ,  A23V2250/1578 ,  A23V2250/1886 ,  A23V2250/192 ,  A23V2250/5482 ,  A61K9/0014 ,  A61K9/10 ,  A61K47/10 ,  A61K47/14 ,  A61K47/26 ,  A61K47/34 ,  A61K47/40 ,  C01F11/18 ,  C01F11/185 ,  C01P2002/02 ,  C01P2002/72

Abstract: The present invention provides stabilized amorphous calcium carbonate (ACC) formulations, comprising ACC and a non-aqueous liquid carrier in which the ACC is dispersed. The present invention further provides cosmetic and pharmaceutical compositions comprising ACC.