公开(公告)号：US20070213588A1

公开(公告)日：2007-09-13

申请号：US11710808

申请日：2007-02-26

申请人： Koki Morishita ,  Akira Hasegawa

发明人： Koki Morishita ,  Akira Hasegawa

IPC分类号： A61B1/12 ,  A61B1/06 ,  A61B6/00

CPC分类号： A61B5/0071 ,  A61B1/043 ,  A61B1/0638 ,  A61B5/0084

摘要： A fluorescent dye/probe that can rapidly identify the presence of disease is efficiently applied in a living organism and optically detected to obtain clear fluorescent images. There is provided an endoscope system and an observation method using the same, comprising agent dispensing means for dispensing towards an acquisition object a fluorescent agent that binds with a specific substance inside the acquisition object or that accumulates inside the acquisition object; control means for controlling the agent-dispensing means; a light source portion for emitting excitation light for exciting the fluorescent agent and irradiation light having different spectral characteristics from the excitation light; an optical system for transmitting the excitation light and the irradiation light towards the acquisition object; and image-acquisition means, disposed at a portion that is inserted inside a body cavity and capable of acquiring fluorescence excited from the acquisition object by the excitation light, and light in a different wavelength band, which is excited from the acquisition object by the irradiation light; wherein the control means controls the agent-dispensing means so that the acquisition object is irradiated with the irradiation light before the fluorescent agent is spouted out towards the acquisition object.

摘要翻译： 可以快速鉴定疾病存在的荧光染料/探针在活体中有效地应用，并被光学检测以获得清晰的荧光图像。 提供了一种内窥镜系统及使用该内窥镜系统的观察方法，其特征在于，具备向所述取得对象物分配与所述取得对象物内的特定物质结合或者积聚在所述取得对象物内的荧光剂的药剂分配单元; 用于控制药剂分配装置的控制装置; 用于发射用于激发荧光剂的激发光的光源部分和具有与激发光不同的光谱特性的照射光; 用于将激发光和照射光朝向采集对象传输的光学系统; 以及图像获取装置，设置在插入体腔内部并且能够通过激发光获取从所述获取对象激发的荧光的部分以及通过所述照射从所述获取对象激发的不同波长带的光 光; 其中所述控制装置控制所述药剂分配装置，使得在所述荧光剂向所述获取对象喷出之前，使所述照射光照射所述获取对象。

公开(公告)号：US07072498B1

公开(公告)日：2006-07-04

申请号：US10079327

申请日：2002-02-19

申请人： Jimmy Roehrig ,  Sussan Pourjavid ,  Xiaolan Zhang ,  Haili Chui ,  Akira Hasegawa

发明人： Jimmy Roehrig ,  Sussan Pourjavid ,  Xiaolan Zhang ,  Haili Chui ,  Akira Hasegawa

IPC分类号： G06K9/00

CPC分类号： G06T7/0012 ,  G06T2207/20081 ,  G06T2207/30068

摘要： A method and apparatus for analyzing a medical image obtained from one of a plurality of digital modalities, the method comprising transforming or mapping the initial medical image to create a uniform contrast response and appearance regardless of the original modality of the image.

公开(公告)号：US20050237416A1

公开(公告)日：2005-10-27

申请号：US11113123

申请日：2005-04-25

申请人： Akira Hasegawa

发明人： Akira Hasegawa

IPC分类号： G01N21/64 ,  A61B1/00 ,  A61B1/04 ,  A61B19/00 ,  G02B23/26 ,  G02B26/02 ,  H04N5/225 ,  H04N9/083

CPC分类号： H04N9/083 ,  H04N5/2254 ,  H04N2005/2255

摘要： An image pickup apparatus includes an objective optical system, an image pickup element having a surface at an image formed by the objective optical system, and an etalon positioned between the objective optical system and the surface of the image pickup element. The etalon includes a gap, an optical path length of which is controllable for scanning the wavelengths transmitted by the etalon to thereby select the wavelengths that reach the surface. An optical filter is positioned between the objective optical system and the surface and has a first wavelength range over which incident light is reflected, a second wavelength range over which incident light is transmitted, and a boundary wavelength range that is bounded by the first and second wavelength ranges. The boundary wavelength range lies entirely within the wavelength range the peak transmission of the etalon can be scanned. A method of calibrating the etalon is also disclosed.

摘要翻译： 图像拾取装置包括物镜光学系统，具有由物镜光学系统形成的图像的表面的图像拾取元件以及位于物镜光学系统和图像拾取元件的表面之间的标准具。 标准具包括间隙，其光程长度可被控制用于扫描由标准具传输的波长，从而选择到达表面的波长。 光学滤光器位于物镜光学系统和表面之间，具有入射光被反射的第一波长范围，透射入射光的第二波长范围和由第一和第二边界限定的边界波长范围 波长范围 边界波长范围完全在可以扫描标准具的峰值传输的波长范围内。 还公开了校准标准具的方法。

公开(公告)号：US06500225B2

公开(公告)日：2002-12-31

申请号：US09447583

申请日：1999-11-23

申请人： Akira Hasegawa ,  Shinji Fujiwara ,  Kunio Saegusa

发明人： Akira Hasegawa ,  Shinji Fujiwara ,  Kunio Saegusa

IPC分类号： B22F312

CPC分类号： C23C14/3414 ,  C04B35/453

摘要： A method for producing an indium-tin-oxide sintered body comprising the steps of; molding a powder comprising indium, tin and oxygen, and sintering the molded article in oxygen gas-containing atmosphere, wherein the halogen content of the powder comprising indium, tin and oxygen is 0.02% by weight or less, the concentration of oxygen in the oxygen gas-containing atmosphere is 90% or more during the sintering, the partial pressure of moisture contained in the oxygen gas-containing atmosphere is 800 Pa or less during the sintering, and the molded article is maintained at a temperature in the range from 1500 to 1650° C. for 1 hour or more for the sintering.

摘要翻译： 一种铟锡氧化物烧结体的制造方法，其特征在于，包括以下工序：将含有铟，锡和氧的粉末成型，在含氧气氛中烧结成型品，其中，含有铟，锡， 氧为0.02重量％以下时，含氧气体的气氛中的氧浓度在烧结时为90％以上，所以含氧气体气氛中含有的水分分压在烧结时为800Pa以下 ，并将成形体在1500〜1650℃的温度范围内保持1小时以上进行烧结。

公开(公告)号：US06339675B1

公开(公告)日：2002-01-15

申请号：US09037304

申请日：1998-03-09

申请人： Yoshinori Shimizu ,  Akira Hasegawa ,  Masayoshi Mizuno ,  Takayuki Ishida

发明人： Yoshinori Shimizu ,  Akira Hasegawa ,  Masayoshi Mizuno ,  Takayuki Ishida

IPC分类号： H04N5928

CPC分类号： H04N9/8063 ,  H04N5/85 ,  H04N9/8227

摘要： Conventionally, a particular countermeasure has been taken for each of the error factors. That is, each error requires a circuit and the like for carrying out the countermeasure, which leads to an increase size of the entire circuit. The present invention includes a controller 14 which resets a system time clock STC serving as the system reference time with a time management information PTM in a video decoder 7. This reset time is compared to a time management information PTM or DTM of the video decoder 7 or an audio decoder 11. According to a result of the comparison, the synchronization lag between the video signal and the audio signal is controlled.

摘要翻译： 通常，对于每个错误因素已经采取了特定的对策。 也就是说，每个错误都需要用于执行对策的电路等，这导致整个电路的尺寸增加。本发明包括一个控制器14，其将用作系统参考时间的系统时钟STC复位为 视频解码器7中的时间管理信息PTM。该复位时间与视频解码器7或音频解码器11的时间管理信息PTM或DTM进行比较。根据该比较的结果，视频信号与 音频信号被控制。

公开(公告)号：US06322965B1

公开(公告)日：2001-11-27

申请号：US09020846

申请日：1998-02-09

申请人： Kenjiro Yamaguchi ,  Tomiko Kashiwakuma ,  Yukie Chiba ,  Shintaro Yagi ,  Akira Hasegawa

发明人： Kenjiro Yamaguchi ,  Tomiko Kashiwakuma ,  Yukie Chiba ,  Shintaro Yagi ,  Akira Hasegawa

IPC分类号： C12Q168

CPC分类号： C07K14/005 ,  A61K38/00 ,  C07K2319/00 ,  C12N2770/24222 ,  Y10S436/811 ,  Y10S436/82 ,  Y10S530/806 ,  Y10S530/826

摘要： A chimera antigen peptide containing the epitope regions in the core region, the NS3 region, and the NS4 region of the HCV polypeptide. A sensitive detection of a wide range of infection by hepatitis C virus (HCV) can be carried out.

摘要翻译： 含有HCV多核苷酸核心区域，NS3区域和NS4区域中的表位区域的嵌合抗原肽。 可以进行丙型肝炎病毒（HCV）的广泛感染的敏感检测。

公开(公告)号：US5871904A

公开(公告)日：1999-02-16

申请号：US501195

申请日：1995-07-11

申请人： Tomiko Kashiwakuma ,  Shintaro Yagi ,  Akira Hasegawa ,  Tadahiro Kajita ,  Yohsuke Ohta ,  Hiroyuki Mori

发明人： Tomiko Kashiwakuma ,  Shintaro Yagi ,  Akira Hasegawa ,  Tadahiro Kajita ,  Yohsuke Ohta ,  Hiroyuki Mori

IPC分类号： G01N33/53 ,  C07K14/18 ,  C07K16/10 ,  C12N5/10 ,  C12N5/20 ,  C12P21/08 ,  G01N33/576 ,  G01N33/577 ,  C12Q1/70 ,  C07K16/08 ,  C12N5/12

CPC分类号： C07K14/005 ,  C07K16/10 ,  C12N2770/24222

摘要： This invention concerns a monoclonal antibody having binding specificity for an antigenic determinant site on core structural protein from Non-A,Non-B hepatitis virus (NANBV); a hybridoma cell line capable of producing the monoclonal antibody; a process for the preparation of the monoclonal antibody; an immunoassay of NANBV-related antigens by use of the monoclonal antibody; and a test kit for use in the immunoassay. The preferred monoclonal antibody is 5E3, 5F11, 515S or 1080S. The monoclonal antibody can specifically recognize the NANBV core structural protein in sera from patients with Non-A,Non-B hepatitis thereby being served extensively as an antibody in various immunological reagents for definitive diagnosis of Non-A, Non-B hepatitis.

摘要翻译： 本发明涉及对来自非A非乙型肝炎病毒（NANBV）的核心结构蛋白上的抗原决定簇位点具有结合特异性的单克隆抗体; 能够产生单克隆抗体的杂交瘤细胞系; 一种制备单克隆抗体的方法; 通过使用单克隆抗体对NANBV相关抗原的免疫测定; 和用于免疫测定的测试试剂盒。 优选的单克隆抗体是5E3,5F11,515S或1080S。 单克隆抗体可以特异性识别来自非A型非乙型肝炎患者的血清中的NANBV核心结构蛋白，从而作为用于非A型非乙型肝炎确定诊断的各种免疫试剂中的抗体作为抗体。

公开(公告)号：US5567684A

公开(公告)日：1996-10-22

申请号：US305832

申请日：1994-09-14

申请人： Stephan Ladisch ,  Akira Hasegawa

发明人： Stephan Ladisch ,  Akira Hasegawa

IPC分类号： A61K31/70 ,  A61K31/7028 ,  A61P37/06 ,  C07H3/06 ,  C07H15/10 ,  C08B37/00

CPC分类号： C07H15/10 ,  C07H3/06

摘要： Synthetic compounds which are useful for suppressing an immune response are disclosed. The synthetic compounds have the formula ##STR1## wherein A is a carbohydrate moiety which corresponds to the carbohydrate moiety of a naturally occurring ganglioside, n is 5 to 20 and m is to 20. Also presented are methods for suppressing an immune response in an animal and compositions of matter employing the compounds as shown above.

摘要翻译： 公开了可用于抑制免疫应答的合成化合物。 合成化合物具有式“IMAGE”，其中A是对应于天然存在的神经节苷脂的碳水化合物部分的碳水化合物部分，n为5至20，m为20.还提供了抑制动物免疫应答的方法 和使用上述化合物的物质组成。

公开(公告)号：US5371202A

公开(公告)日：1994-12-06

申请号：US833794

申请日：1992-02-12

申请人： Akira Hasegawa

发明人： Akira Hasegawa

IPC分类号： C07H1/00 ,  C07H3/06 ,  C07H5/10 ,  C07H13/04 ,  C07H13/08 ,  C07H15/18 ,  C07H23/00

CPC分类号： C07H13/04 ,  C07H13/08 ,  C07H15/18 ,  C07H23/00 ,  C07H3/06

摘要： An improved process for the preparation of O-glycosyl compounds of sialic acid, which are useful as intermediates in the synthesis of sialoconjugated glycosides. This process comprises effecting condensation reaction between thioglycosides of sialic acid and sugar derivatives in the presence of N-iodosuccinimide and trifluoromethanesulfonic acid. O-glycosyl compounds of sialic acid are prepared in high resio- and stereo-selectivity and in high yields.

摘要翻译： 一种用于制备唾液酸O-糖基化合物的改进方法，其可用作合成唾液酸糖苷的中间体。 该方法包括在N-碘代琥珀酰亚胺和三氟甲磺酸的存在下进行唾液酸的硫代糖苷与糖衍生物之间的缩合反应。 唾液酸的O-糖基化合物以高回收率和立体选择性和高产率制备。

公开(公告)号：US5280151A

公开(公告)日：1994-01-18

申请号：US666379

申请日：1991-03-08

申请人： Tetsuo Matsunaga ,  Shunji Miyamoto ,  Tadahiro Takamatsu ,  Akira Hasegawa

发明人： Tetsuo Matsunaga ,  Shunji Miyamoto ,  Tadahiro Takamatsu ,  Akira Hasegawa

IPC分类号： F26B13/08 ,  F26B3/347 ,  F26B13/00 ,  F26B13/18 ,  F26B23/08 ,  H05B6/14 ,  H05B6/64

CPC分类号： F26B13/004 ,  F26B13/183 ,  F26B3/347

摘要： In drying a beltlike article such as a slide fastener tape by high-frequency induction heating, the tape is wound on the outer circumferential surface of a rotary drum heated from inside while rotating. An induction heating coil is mounted on the outer circumferential surface of a stationary drum, as an inner drum, with a gap with the inner circumferential surface of the rotary drum. The rotary drum is supported at one end by a rotary shaft via an adiabatic material. The stationary inner drum is made of a metal plate having a high heat conductivity for facilitating heat radiation of the heating coil, while the rotary drum is made of a cladding plate including iron and copper plates in combination.

摘要翻译： 在通过高频感应加热干燥诸如拉链带的带状制品时，将带卷绕在从内部加热旋转的滚筒的外周表面上，同时旋转。 感应加热线圈安装在作为内滚筒的固定滚筒的外圆周表面上，与旋转滚筒的内圆周表面间隙。 旋转鼓通过绝热材料由旋转轴在一端支撑。 固定内筒由具有高导热性的金属板制成，用于促进加热线圈的热辐射，同时旋转鼓由包括铁和铜板的包层板组合而成。