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公开(公告)号：US11149254B2
公开(公告)日：2021-10-19
申请号：US13506369
申请日：2012-04-13
申请人： Aladar A. Szalay , Nanhai G. Chen , Yong A. Yu , Qian Zhang
发明人： Aladar A. Szalay , Nanhai G. Chen , Yong A. Yu , Qian Zhang
IPC分类号： C12N7/00 , A61K35/768 , C07K16/22
摘要： Clonal strains of vaccinia viruses are provided. Also provided are methods of identifying and isolating attenuated and oncolytic clonal strains from virus preparations. Modified recombinant forms of the clonal strains also are provided. The clonal strains and virus preparations can be used for diagnostic and therapeutic methods, in particular for therapy and diagnosis or monitoring treatment of proliferative disorders, including neoplastic diseases, such as, but are not limited to, solid tumors and blood cancers.
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22.发明申请公开(公告)号：US20120308484A1
公开(公告)日：2012-12-06
申请号：US13506369
申请日：2012-04-13
申请人： Aladar A. Szalay , Nanhai G. Chen , Yong A. Yu , Qian Zhang
发明人： Aladar A. Szalay , Nanhai G. Chen , Yong A. Yu , Qian Zhang
IPC分类号： C12N7/04 , G01N21/64 , G01N21/76 , G01N24/00 , A61K49/04 , G01N23/00 , A61K35/76 , A61P35/00 , A61K39/395 , A61K49/06 , C12Q1/70 , G01N23/22
CPC分类号： C12N7/00 , A61K35/768 , C07K16/22 , C07K2317/622 , C12N2710/24121 , C12N2710/24132 , C12N2710/24143
摘要： Clonal strains of vaccinia viruses are provided. Also provided are methods of identifying and isolating attenuated and oncolytic clonal strains from virus preparations. Modified recombinant forms of the clonal strains also are provided. The clonal strains and virus preparations can be used for diagnostic and therapeutic methods, in particular for therapy and diagnosis or monitoring treatment of proliferative disorders, including neoplastic diseases, such as, but are not limited to, solid tumors and blood cancers.
摘要翻译： 提供了痘苗病毒的克隆菌株。 还提供鉴定和分离来自病毒制剂的减毒和溶瘤克隆菌株的方法。 还提供了克隆株的修饰重组形式。 克隆菌株和病毒制剂可用于诊断和治疗方法，特别是用于治疗和诊断或监测治疗增殖性疾病，包括肿瘤性疾病，例如但不限于实体瘤和血液癌。
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23.发明申请公开(公告)号：US20090155287A1
公开(公告)日：2009-06-18
申请号：US12080766
申请日：2008-04-04
申请人： Nanhai Chen , Alexa Frentzen , Aladar A. Szalay , Yong A. Yu , Qian Zhang
发明人： Nanhai Chen , Alexa Frentzen , Aladar A. Szalay , Yong A. Yu , Qian Zhang
IPC分类号： C12N7/00 , A61K35/76 , A61K39/395 , A61K39/00 , A61P35/04
CPC分类号： C12N7/00 , A61K9/0019 , A61K31/282 , A61K31/4745 , A61K31/7068 , A61K33/24 , A61K35/76 , A61K38/1709 , A61K38/1793 , A61K38/20 , A61K38/204 , A61K38/36 , A61K38/484 , A61K39/12 , A61K39/285 , A61K39/3955 , A61K45/06 , A61K48/00 , A61K48/0058 , A61K49/0008 , A61K49/0045 , A61K49/0047 , A61K49/0097 , A61K49/14 , A61K49/1896 , A61K2039/523 , A61K2039/5254 , A61K2039/5256 , C07K14/005 , C07K14/47 , C07K14/54 , C07K14/5412 , C07K14/7155 , C07K16/22 , C07K2317/622 , C07K2317/73 , C07K2319/00 , C07K2319/20 , C07K2319/60 , C07K2319/61 , C07K2319/74 , C12N15/86 , C12N2710/14171 , C12N2710/24121 , C12N2710/24122 , C12N2710/24132 , C12N2710/24141 , C12N2710/24143 , C12N2710/24162 , C12Q1/04 , G01N33/574 , G01N33/585
摘要： Modified viruses and methods for preparing the modified viruses are provided. Vaccines that contain the viruses are provided. The viruses can be used in methods of treatment of diseases, such as proliferative and inflammatory disorders, including cancer, and as anti-tumor and/or antiangiogenic agents. The viruses also can be used in diagnostic methods.
摘要翻译： 提供了修饰的病毒和用于制备修饰的病毒的方法。 提供含有病毒的疫苗。 病毒可以用于治疗诸如增殖性和炎性疾病（包括癌症）的疾病的方法，以及作为抗肿瘤和/或抗血管生成剂。 病毒也可用于诊断方法。
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公开(公告)号：US20130129614A9
公开(公告)日：2013-05-23
申请号：US13506738
申请日：2012-05-10
申请人： Aladar A. Szalay , Nanhai Chen , Yong A. Yu , Qian Zhang , Yuman Fong
发明人： Aladar A. Szalay , Nanhai Chen , Yong A. Yu , Qian Zhang , Yuman Fong
CPC分类号： C07K14/705 , A61K35/76 , A61K35/768 , A61K38/00 , C12N7/00 , C12N2710/24132 , C12N2710/24143 , G01N33/574 , Y02A50/471 , Y02A50/473
摘要： Modified viruses encoding transporter proteins and methods for preparing the modified viruses are provided. Vaccines that contain the viruses are provided. The viruses also can be used in diagnostic methods, such detection and imaging of tumors. The viruses also can be used in methods of treatment of diseases, such as proliferative and inflammatory disorders, including as anti-tumor agents.
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公开(公告)号：US20090117034A1
公开(公告)日：2009-05-07
申请号：US12157960
申请日：2008-06-13
申请人： Nanhai Chen , Aladar A. Szalay , Yong A. Yu , Qian Zhang , Yuman Fong
发明人： Nanhai Chen , Aladar A. Szalay , Yong A. Yu , Qian Zhang , Yuman Fong
IPC分类号： A61K51/02 , C12N7/01 , A61K35/76 , A61K49/04 , A61K39/395 , A61P35/00 , A61P35/04 , A61P35/02 , A61B10/00 , A61K49/00 , A61K49/06 , A61K39/285
CPC分类号： C07K14/705 , A61K35/76 , A61K35/768 , A61K38/00 , C12N7/00 , C12N2710/24132 , C12N2710/24143 , G01N33/574 , Y02A50/471 , Y02A50/473
摘要： Modified viruses encoding transporter proteins and methods for preparing the modified viruses are provided. Vaccines that contain the viruses are provided. The viruses also can be used in diagnostic methods, such detection and imaging of tumors. The viruses also can be used in methods of treatment of diseases, such as proliferative and inflammatory disorders, including as anti-tumor agents.
摘要翻译： 提供了编码转运蛋白的修饰病毒和用于制备修饰病毒的方法。 提供含有病毒的疫苗。 病毒也可用于诊断方法，如肿瘤的检测和成像。 病毒也可用于治疗诸如增殖性和炎症性疾病的疾病的方法，包括作为抗肿瘤剂。
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公开(公告)号：US08865153B2
公开(公告)日：2014-10-21
申请号：US13506738
申请日：2012-05-10
申请人： Aladar A. Szalay , Nanhai Chen , Yong A. Yu , Qian Zhang
发明人： Aladar A. Szalay , Nanhai Chen , Yong A. Yu , Qian Zhang
IPC分类号： C12N7/00 , C07K14/705 , G01N33/574 , A61K35/76 , C12N15/39 , A61K38/00
CPC分类号： C07K14/705 , A61K35/76 , A61K35/768 , A61K38/00 , C12N7/00 , C12N2710/24132 , C12N2710/24143 , G01N33/574 , Y02A50/471 , Y02A50/473
摘要： Modified viruses encoding transporter proteins and methods for preparing the modified viruses are provided. Vaccines that contain the viruses are provided. The viruses also can be used in diagnostic methods, such detection and imaging of tumors. The viruses also can be used in methods of treatment of diseases, such as proliferative and inflammatory disorders, including as anti-tumor agents.
摘要翻译： 提供了编码转运蛋白的修饰病毒和用于制备修饰病毒的方法。 提供含有病毒的疫苗。 病毒也可用于诊断方法，如肿瘤的检测和成像。 病毒也可用于治疗诸如增殖性和炎症性疾病的疾病的方法，包括作为抗肿瘤剂。
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公开(公告)号：US08852927B2
公开(公告)日：2014-10-07
申请号：US12660314
申请日：2010-02-23
申请人： Aladar A. Szalay , Nanhai Chen , Yong A. Yu , Qian Zhang
发明人： Aladar A. Szalay , Nanhai Chen , Yong A. Yu , Qian Zhang
IPC分类号： C12N15/39 , G01N33/574 , C12N7/00 , A61K35/76 , C07K14/705 , A61K38/00
CPC分类号： C07K14/705 , A61K35/76 , A61K35/768 , A61K38/00 , C12N7/00 , C12N2710/24132 , C12N2710/24143 , G01N33/574 , Y02A50/471 , Y02A50/473
摘要： Modified viruses encoding transporter proteins and methods for preparing the modified viruses are provided. Vaccines that contain the viruses are provided. The viruses also can be used in diagnostic methods, such detection and imaging of tumors. The viruses also can be used in methods of treatment of diseases, such as proliferative and inflammatory disorders, including as anti-tumor agents.
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28.发明申请公开(公告)号：US20130273007A1
公开(公告)日：2013-10-17
申请号：US13986866
申请日：2013-06-12
申请人： Aladar A. Szalay , Yong A. Yu , Nanhai Chen , Qian Zhang
发明人： Aladar A. Szalay , Yong A. Yu , Nanhai Chen , Qian Zhang
IPC分类号： A61K35/76
CPC分类号： C12N7/00 , A61K9/0019 , A61K31/282 , A61K31/4745 , A61K31/7068 , A61K33/24 , A61K35/76 , A61K38/1709 , A61K38/1793 , A61K38/20 , A61K38/204 , A61K38/36 , A61K38/484 , A61K39/12 , A61K39/285 , A61K39/3955 , A61K45/06 , A61K48/00 , A61K48/0058 , A61K49/0008 , A61K49/0045 , A61K49/0047 , A61K49/0097 , A61K49/14 , A61K49/1896 , A61K2039/523 , A61K2039/5254 , A61K2039/5256 , C07K14/005 , C07K14/47 , C07K14/54 , C07K14/5412 , C07K14/7155 , C07K16/22 , C07K2317/622 , C07K2317/73 , C07K2319/00 , C07K2319/20 , C07K2319/60 , C07K2319/61 , C07K2319/74 , C12N15/86 , C12N2710/14171 , C12N2710/24121 , C12N2710/24122 , C12N2710/24132 , C12N2710/24141 , C12N2710/24143 , C12N2710/24162 , C12Q1/04 , G01N33/574 , G01N33/585
摘要： Lister strain vaccinia viruses that are encode a modified A34R gene resulting in increased extracellular enveloped virus (EEV) form of the virus and/or increased resistance of the virus to neutralizing antibodies. The viruses can be used in methods of treatment of diseases, such as proliferative and inflammatory disorders, including as anti-tumor agents.
摘要翻译： 编码修饰的A34R基因的Lister菌株痘苗病毒导致增加的细胞外包膜病毒（EEV）形式的病毒和/或增加的病毒抗中和抗体。 病毒可以用于治疗诸如增殖性和炎症性疾病的疾病的方法，包括作为抗肿瘤剂。
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公开(公告)号：US20110293527A1
公开(公告)日：2011-12-01
申请号：US13136519
申请日：2011-08-02
申请人： Nanhai Chen , Alexa Frentzen , Aladar A. Szalay , Yong A. Yu , Qian Zhang
发明人： Nanhai Chen , Alexa Frentzen , Aladar A. Szalay , Yong A. Yu , Qian Zhang
CPC分类号： C12N7/00 , A61K9/0019 , A61K31/282 , A61K31/4745 , A61K31/7068 , A61K33/24 , A61K35/76 , A61K38/1709 , A61K38/1793 , A61K38/20 , A61K38/204 , A61K38/36 , A61K38/484 , A61K39/12 , A61K39/285 , A61K39/3955 , A61K45/06 , A61K48/00 , A61K48/0058 , A61K49/0008 , A61K49/0045 , A61K49/0047 , A61K49/0097 , A61K49/14 , A61K49/1896 , A61K2039/523 , A61K2039/5254 , A61K2039/5256 , C07K14/005 , C07K14/47 , C07K14/54 , C07K14/5412 , C07K14/7155 , C07K16/22 , C07K2317/622 , C07K2317/73 , C07K2319/00 , C07K2319/20 , C07K2319/60 , C07K2319/61 , C07K2319/74 , C12N15/86 , C12N2710/14171 , C12N2710/24121 , C12N2710/24122 , C12N2710/24132 , C12N2710/24141 , C12N2710/24143 , C12N2710/24162 , C12Q1/04 , G01N33/574 , G01N33/585
摘要： Modified viruses and methods for preparing the modified viruses are provided. Vaccines that contain the viruses are provided. The viruses can be used in methods of treatment of diseases, such as proliferative and inflammatory disorders, including cancer, and as anti-tumor and/or antiangiogenic agents. The viruses also can be used in diagnostic methods.
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公开(公告)号：US20100233078A1
公开(公告)日：2010-09-16
申请号：US12660314
申请日：2010-02-23
申请人： Aladar A. Szalay , Nanhai Chen , Yong A. Yu , Qian Zhang
发明人： Aladar A. Szalay , Nanhai Chen , Yong A. Yu , Qian Zhang
CPC分类号： C07K14/705 , A61K35/76 , A61K35/768 , A61K38/00 , C12N7/00 , C12N2710/24132 , C12N2710/24143 , G01N33/574 , Y02A50/471 , Y02A50/473
摘要： Modified viruses encoding transporter proteins and methods for preparing the modified viruses are provided. Vaccines that contain the viruses are provided. The viruses also can be used in diagnostic methods, such detection and imaging of tumors. The viruses also can be used in methods of treatment of diseases, such as proliferative and inflammatory disorders, including as anti-tumor agents.
摘要翻译： 提供了编码转运蛋白的修饰病毒和用于制备修饰病毒的方法。 提供含有病毒的疫苗。 病毒也可用于诊断方法，如肿瘤的检测和成像。 病毒也可用于治疗诸如增殖性和炎症性疾病的疾病的方法，包括作为抗肿瘤剂。
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