利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

57 条记录 (耗时 0.085 秒)

    Nucleic acids encoding human transporter proteins
    25.
    发明授权
    Nucleic acids encoding human transporter proteins 失效
    编码人类转运蛋白的核酸

    公开(公告)号：US06548271B1

    公开(公告)日：2003-04-15

    申请号：US09556916

    申请日：2000-04-21

    申请人： Alex Turner ,  Brian Zambrowicz ,  Michael Nehls ,  Glenn A. Friedrich ,  Arthur T. Sands

    发明人： Alex Turner ,  Brian Zambrowicz ,  Michael Nehls ,  Glenn A. Friedrich ,  Arthur T. Sands

    IPC分类号： C07H2102

    CPC分类号： C07K14/705 ,  A01K2217/05

    摘要： The present invention provides two novel families of novel human transporter proteins (NTPs). The invention additionally provides for agonists, antagonists, antibodies, antisense molecules that are specific for the NTPs, and further provides genetically engineered expression vectors for the NTPs and host comprising the same. The invention further provides for processes for identifying/producing molecules that effect NTP activity which comprise the use of the disclosed NTPs or genes encoding the same.

    摘要翻译： 本发明提供两种新型人类转运蛋白（NTPs）的新家族。 本发明另外提供对NTP有特异性的激动剂，拮抗剂，抗体，反义分子，并进一步提供用于NTP和包含其的宿主的基因工程表达载体。 本发明进一步提供鉴定/产生影响NTP活性的分子的方法，其包括使用所公开的NTP或编码其的基因。

    Indexed library of cells containing genomic modifications and methods of making and utilizing the same
    29.
    发明申请
    Indexed library of cells containing genomic modifications and methods of making and utilizing the same 审中-公开
    指定的含有基因组修饰的细胞库，以及制备和利用它们的方法

    公开(公告)号：US20090149336A1

    公开(公告)日：2009-06-11

    申请号：US11978961

    申请日：2007-10-29

    申请人： Brian Zambrowicz ,  Glenn A. Friedrich ,  Allan Bradley ,  Arthur T. Sands

    发明人： Brian Zambrowicz ,  Glenn A. Friedrich ,  Allan Bradley ,  Arthur T. Sands

    IPC分类号： C40B30/04

    CPC分类号： C12N15/1082 ,  A01K2217/075 ,  C12N15/102 ,  C12N15/1034 ,  C12N15/1051 ,  C12N15/85 ,  C12N15/86 ,  C12N2740/10043 ,  C12N2800/60 ,  C12N2840/203 ,  C12N2840/44

    摘要： Methods and vectors (both DNA and retroviral) are provided for the construction of a Library of mutated cells. The Library will preferably contain mutations in essentially all genes present in the genome of the cells. The nature of the Library and the vectors allow for methods of screening for mutations in specific genes, and for gathering nucleotide sequence data from each mutated gene to provide a database of tagged gene sequences. Such a database provides a means to access the individual mutant cell clones contained in the Library. The invention includes the described Library, methods of making the same, and vectors used to construct the Library. Methods are also provided for accessing individual parts of the Library either by sequence or by pooling and screening. The invention also provides for the generation of non-human transgenic animals which are mutant for specific genes as isolated and generated from the cells of the Library.

    摘要翻译： 提供方法和载体（DNA和逆转录病毒）用于构建突变细胞库。 该文库优选地在基因组中存在基因组中所有基因的突变。 图书馆和载体的性质允许筛选特定基因突变的方法，并收集每个突变基因的核苷酸序列数据，以提供标记基因序列的数据库。 这样的数据库提供了访问图书馆中包含的各个突变细胞克隆的方法。 本发明包括描述的库，制作方法和用于构建库的向量。 还提供了通过序列或汇总和筛选来访问图书馆的各个部分的方法。 本发明还提供了从文库细胞中分离并产生的特异性基因突变的非人转基因动物的产生。