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21.
公开(公告)号:US08604032B2
公开(公告)日:2013-12-10
申请号:US13112611
申请日:2011-05-20
申请人: Pingda Ren , Yi Liu , Liansheng Li , Katrina Chan , Alfredo C. Castro , Catherine A. Evans
发明人: Pingda Ren , Yi Liu , Liansheng Li , Katrina Chan , Alfredo C. Castro , Catherine A. Evans
IPC分类号: A01N43/64 , A01N43/90 , A01N43/54 , A61K31/53 , A61K31/52 , A61K31/519 , A61K31/505 , C07D487/00 , C07D239/00 , C07D239/70 , C07D471/00 , C07D473/00 , C07D401/00 , C07D403/00 , C07D405/00 , C07D409/00 , C07D411/00 , C07D413/00 , C07D417/00 , C07D419/00 , C07D215/00
CPC分类号: C07D473/34 , A61K31/47 , A61K31/52 , C07D401/14 , C07D473/16 , C07D473/32 , C07D487/04 , Y02A50/414 , Y02A50/463
摘要: Provided herein are compounds of formula (I), pharmaceutical compositions comprising the compounds, and methods of use thereof The compounds provided herein modulate kinase activity, including PI3 kinase activity, and are useful for treating diseases and conditions associated with kinase activity, including diseases and conditions associated with PI3 kinase activity.
摘要翻译: 本文提供了式(I)化合物,包含该化合物的药物组合物及其使用方法本文提供的化合物调节激酶活性,包括PI3激酶活性,并且可用于治疗与激酶活性相关的疾病和病症,包括疾病和 与PI3激酶活性相关的病症。
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公开(公告)号:US09056877B2
公开(公告)日:2015-06-16
申请号:US13552473
申请日:2012-07-18
申请人: Alfredo C. Castro , Catherine A. Evans , Andre Lescarbeau , Tao Liu , Daniel A. Snyder , Martin R. Tremblay , Pingda Ren , Yi Liu , Liansheng Li , Katrina Chan
发明人: Alfredo C. Castro , Catherine A. Evans , Andre Lescarbeau , Tao Liu , Daniel A. Snyder , Martin R. Tremblay , Pingda Ren , Yi Liu , Liansheng Li , Katrina Chan
IPC分类号: C07D277/20 , C07D513/04
CPC分类号: C07D513/04 , A61K31/519 , C07D519/00
摘要: Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.
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公开(公告)号:US20130029984A1
公开(公告)日:2013-01-31
申请号:US13552473
申请日:2012-07-18
申请人: Alfredo C. Castro , Catherine A. Evans , Andre Lescarbeau , Tao Liu , Daniel A. Snyder , Martin R. Tremblay , Pingda Ren , Yi Liu , Liansheng Li , Katrina Chan
发明人: Alfredo C. Castro , Catherine A. Evans , Andre Lescarbeau , Tao Liu , Daniel A. Snyder , Martin R. Tremblay , Pingda Ren , Yi Liu , Liansheng Li , Katrina Chan
IPC分类号: A61K31/519 , A61K31/5377 , A61K31/4725 , A61P37/06 , C07D495/04 , A61P35/00 , A61P29/00 , C07D513/04 , A61K31/506
CPC分类号: C07D513/04 , A61K31/519 , C07D519/00
摘要: Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.
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公开(公告)号:US20130029982A1
公开(公告)日:2013-01-31
申请号:US13552460
申请日:2012-07-18
申请人: Alfredo C. Castro , Catherine A. Evans , Somarajannair Janardanannair , Andre Lescarbeau , Tao Liu , Daniel A. Snyder , Martin R. Tremblay , Pingda Ren , Yi Liu , Liansheng Li , Katrina Chan
发明人: Alfredo C. Castro , Catherine A. Evans , Somarajannair Janardanannair , Andre Lescarbeau , Tao Liu , Daniel A. Snyder , Martin R. Tremblay , Pingda Ren , Yi Liu , Liansheng Li , Katrina Chan
IPC分类号: A61K31/519 , C07D513/04 , C07D495/04 , A61K31/4375 , C07D487/04 , A61P37/00 , A61K31/53 , C07D473/34 , A61K31/52 , A61K31/5377 , A61P35/00 , A61P29/00 , C07D471/04 , A61K31/5025
CPC分类号: C07D471/04 , C07D473/34 , C07D487/04 , C07D495/04 , C07D513/04
摘要: Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.
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公开(公告)号:US20120122838A1
公开(公告)日:2012-05-17
申请号:US13293828
申请日:2011-11-10
申请人: Pingda Ren , Yi Liu , Liansheng Li , Katrina Chan , Troy Edward Wilson , Alfredo C. Castro , Catherine A. Evans , Daniel A. Snyder
发明人: Pingda Ren , Yi Liu , Liansheng Li , Katrina Chan , Troy Edward Wilson , Alfredo C. Castro , Catherine A. Evans , Daniel A. Snyder
IPC分类号: A61K31/52 , C07D473/34 , A61K31/5377 , C07D498/08 , A61K31/5386 , C07D513/04 , C07D413/14 , C07D471/04 , A61K31/519 , C07D487/04 , A61K31/5025 , A61P29/00 , A61P37/06 , A61K31/553 , C12N9/99
CPC分类号: C07D473/34 , C07D401/12 , C07D413/14 , C07D471/04 , C07D487/04 , C07D513/04 , C07D519/00
摘要: Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.
摘要翻译: 本文描述了调节激酶活性(包括PI3激酶活性)的化合物和药物组合物,以及化合物,药物组合物和治疗与激酶活性(包括PI3激酶活性)相关的疾病和病症的方法。
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公开(公告)号:US08669365B2
公开(公告)日:2014-03-11
申请号:US12199722
申请日:2008-08-27
申请人: Brian Austad , Mark L. Behnke , Alfredo C. Castro , André B. Charette , Michael J. Grogan , Somarajannair Janardanannair , Andre Lescarbeau , Stephane Peluso , Martin Tremblay
发明人: Brian Austad , Mark L. Behnke , Alfredo C. Castro , André B. Charette , Michael J. Grogan , Somarajannair Janardanannair , Andre Lescarbeau , Stephane Peluso , Martin Tremblay
IPC分类号: C07D211/00 , C07D471/00 , C07D311/96
CPC分类号: A61K31/4355 , A61K9/0014 , A61K31/17 , A61K31/196 , A61K31/198 , A61K31/454 , A61K31/4745 , A61K31/519 , A61K31/56 , A61K31/573 , A61K31/58 , A61K31/664 , A61K31/69 , A61K31/704 , A61K31/7068 , A61K31/7076 , A61K38/21 , A61K45/06 , A61N5/10 , C07D307/94 , C07D471/04 , C07D471/10 , C07D491/04 , C07D491/048 , C07D491/10 , C07D491/107 , C07J69/00
摘要: The invention provides novel derivatives of cyclopamine having the following formula:
摘要翻译: 本发明提供具有下式的环巴胺的新型衍生物:
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公开(公告)号:US20130108583A1
公开(公告)日:2013-05-02
申请号:US13475510
申请日:2012-05-18
申请人: Alfredo C. Castro , Michael J. Grogan , William Matsui , Karen J. McGovern , Martin R. Tremblay
发明人: Alfredo C. Castro , Michael J. Grogan , William Matsui , Karen J. McGovern , Martin R. Tremblay
IPC分类号: C07D491/107 , A61K31/4355 , A61K45/06
CPC分类号: A61K31/4355 , A61K9/0014 , A61K31/17 , A61K31/196 , A61K31/198 , A61K31/454 , A61K31/4745 , A61K31/519 , A61K31/56 , A61K31/573 , A61K31/58 , A61K31/664 , A61K31/69 , A61K31/704 , A61K31/7068 , A61K31/7076 , A61K38/21 , A61K45/06 , A61N5/10 , C07D307/94 , C07D471/04 , C07D471/10 , C07D491/04 , C07D491/048 , C07D491/10 , C07D491/107 , C07J69/00
摘要: The invention provides methods for treating various conditions using derivatives of cyclopamine having the following formula:
摘要翻译: 本发明提供使用具有下式的环巴胺衍生物治疗各种病症的方法:
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公开(公告)号:US07994191B2
公开(公告)日:2011-08-09
申请号:US12629382
申请日:2009-12-02
IPC分类号: A61K31/4355 , A61K31/438
CPC分类号: C07D491/14 , C07D513/14
摘要: The present invention relates to steroidal alkaloids that can be used in the treatment of hedgehog pathway related disorders, particularly cancer.
摘要翻译: 本发明涉及可用于治疗刺猬蛋白通路相关疾病,特别是癌症的类固醇生物碱。
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29.Compounds and methods for inhibiting the interaction of BCL proteins with binding partners 有权
标题翻译: 抑制BCL蛋白与结合配偶体相互作用的化合物和方法公开(公告)号:US07928244B2
公开(公告)日:2011-04-19
申请号:US11842581
申请日:2007-08-21
申请人: Alfredo C. Castro , Kristopher M. Depew , Michael J. Grogan , Charles W. Johannes , Edward B. Holson , Brian T. Hopkins , Gregg F. Keaney , Nii O. Koney , Tao Liu , David A. Mann , Marta Nevalainen , Stephane Peluso , Lawrence B. Perez , Daniel A. Snyder , Thomas T. Tibbitts
发明人: Alfredo C. Castro , Kristopher M. Depew , Michael J. Grogan , Charles W. Johannes , Edward B. Holson , Brian T. Hopkins , Gregg F. Keaney , Nii O. Koney , Tao Liu , David A. Mann , Marta Nevalainen , Stephane Peluso , Lawrence B. Perez , Daniel A. Snyder , Thomas T. Tibbitts
IPC分类号: C07D261/02 , A61K31/42
CPC分类号: C07D261/02 , A61K31/42 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D413/10 , C07D413/12 , C07D417/12
摘要: The invention relates to isoxazolidine containing compounds that bind to bcl proteins and inhibit Bcl function. The compounds may be used for treating and modulating disorders associated with hyperproliferation, such as cancer.
摘要翻译: 本发明涉及与bcl蛋白结合并抑制Bcl功能的含异唑烷的化合物。 该化合物可用于治疗和调节与过度增生相关的疾病,例如癌症。
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30.
公开(公告)号:US07842815B2
公开(公告)日:2010-11-30
申请号:US11600332
申请日:2006-11-15
申请人: Alfredo C. Castro , Edward B. Holson , Brian T. Hopkins , Nii O. Koney , Daniel A. Snyder , Thomas T. Tibbitts
发明人: Alfredo C. Castro , Edward B. Holson , Brian T. Hopkins , Nii O. Koney , Daniel A. Snyder , Thomas T. Tibbitts
IPC分类号: C07D261/02
CPC分类号: C07D261/02 , C07D261/18 , C07D413/10 , C07D413/12 , C07D417/12 , C07D498/04
摘要: One aspect of the present invention relates to heterocyclic compounds that bind to bcl proteins and inhibit Bcl function. Another aspect of the present invention relates to compositions comprising a heterocyclic compound of the invention. The present invention provides methods for treating and modulating disorders associated with hyperproliferation, such as cancer.
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