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公开(公告)号：US5607475A
公开(公告)日：1997-03-04
申请号：US518129
申请日：1995-08-22
CPC分类号： A61L33/0047 , A61L27/28 , A61L27/34 , A61L31/10 , A61L33/0029 , Y10S623/924
摘要： A medical article having a metal or glass surface with the surface having an adherent coating of improved biocompatibility. The coating is made by first applying to the surface an silane compound having a pendant vinyl functionality such that the silane adheres to the surface and then, in a separate step, forming a graft polymer on the surface with applied vinylsilane such that the pendant vinyl functionality of the vinylsilane is incorporated into the graft polymer by covalent bonding with the polymer. Biomolecules may then be covalently attached to the base layer.
摘要翻译： 具有金属或玻璃表面的医疗制品，其表面具有改进的生物相容性的粘附涂层。 通过首先向表面施加具有侧链乙烯基官能团的硅烷化合物，使得硅烷粘附到表面，然后在单独的步骤中，用所施加的乙烯基硅烷在表面上形成接枝聚合物，使得侧链乙烯基官能度 的乙烯基硅烷通过与聚合物共价键结合到接枝聚合物中。 然后可以将生物分子共价连接到基层。
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公开(公告)号：US5415938A
公开(公告)日：1995-05-16
申请号：US193964
申请日：1994-02-09
CPC分类号： A61L33/0041 , A61L33/0005 , A61L33/0029 , Y10T428/31 , Y10T428/31504 , Y10T428/31562 , Y10T428/31721 , Y10T428/31946
摘要： An improved spacer material for improving the biocompatibility of a biomaterial and a method for making it in which a polyalkylimine is covalently attached to an aminated substrate and combined with a crosslinking agent which is at least difunctional in aldehyde groups. The polyalkylimine can be, for example, polyethyleneimine and the crosslinking agent can be, for example, glutaraldehyde. Preferably, the crosslinking agent is applied in dilute solution and at a pH suitable to accomplish light crosslinking of the polyalkyaimine and also provide aldehyde linkages at the interface between the biomolecule and the spacer.
摘要翻译： 用于改善生物材料的生物相容性的改进的间隔物材料及其制备方法，其中聚烷基亚胺共价连接到胺化底物上并与醛基中至少具有双官能团的交联剂组合。 聚烷基亚胺可以是例如聚乙烯亚胺，交联剂可以是例如戊二醛。 优选地，交联剂以稀溶液和适于实现聚烷基亚胺的轻交联的pH施加，并且还在生物分子和间隔物之间的界面处提供醛键。
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公开(公告)号：US5308641A
公开(公告)日：1994-05-03
申请号：US6218
申请日：1993-01-19
CPC分类号： A61L33/0041 , A61L33/0005 , A61L33/0029 , Y10T428/31 , Y10T428/31504 , Y10T428/31562 , Y10T428/31721 , Y10T428/31946
摘要： An improved spacer material for improving the biocompatibility of a biomaterial and a method for making it in which a polyalkylimine is covalently attached to an aminated substrate and combined with a crosslinking agent which is at least difunctional in aldehyde groups. The polyalkylizine can be, for example, polyethyleneimine and the crosslinking agent can be, for example, glutaraldehyde. Preferably, the crosslinking agent is applied in dilute solution and at a pH suitable to accomplish light crosslinking of the polyalkylimine and also provide aldehyde linkages at the interface between the biomolecule and the spacer.
摘要翻译： 用于改善生物材料的生物相容性的改进的间隔物材料及其制备方法，其中聚烷基亚胺共价连接到胺化底物上并与醛基中至少具有双官能团的交联剂组合。 聚烷基胺可以是例如聚乙烯亚胺，交联剂可以是例如戊二醛。 优选地，交联剂以稀溶液和适于实现聚烷基亚胺的轻交联的pH施加，并且还在生物分子和间隔物之间的界面处提供醛键。
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公开(公告)号：US5866113A
公开(公告)日：1999-02-02
申请号：US813470
申请日：1997-03-07
IPC分类号： A61L31/00 , A61L27/22 , A61L27/34 , A61L27/54 , A61L29/04 , A61L29/08 , A61L29/16 , A61L31/04 , A61L31/10 , A61L31/16 , A61L33/00 , A61L33/12 , C08J7/00 , A61K31/765 , A61K31/78 , A61L27/00 , C08L33/02
CPC分类号： A61L33/128 , A61L27/22 , A61L27/34 , A61L27/54 , A61L29/044 , A61L29/085 , A61L29/16 , A61L31/043 , A61L31/10 , A61L31/16 , A61L33/0029 , A61L33/0041 , A61L33/0076 , A61L33/0088 , A61L2300/00 , Y10S530/815 , Y10S530/816
摘要： A medical device having a surface graft matrix comprising carboxyl-functional groups located on the device, the surface graft matrix comprising an outer portion; and one or more biomolecules covalently coupled to the surface graft matrix, wherein a majority of the biomolecules are located in the outer portion of the surface graft matrix. The surface graft matrix can also be loaded with a pharmaceutical agent.
摘要翻译： 一种具有包含位于所述装置上的羧基官能团的表面接枝基质的医疗装置，所述表面移植物基质包含外部部分; 共价偶联到表面接枝基质上的一种或多种生物分子，其中大部分生物分子位于表面移植物基质的外部。 表面接枝基质也可以加载药剂。
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公开(公告)号：US5834051A
公开(公告)日：1998-11-10
申请号：US801986
申请日：1997-02-19
申请人： Jean A. Woloszko , Marc Hendriks , Patrick T. Cahalan , Michel L. P. M. Verhoeven , Linda L. Cahalan , Antoine N. J. Camps
发明人： Jean A. Woloszko , Marc Hendriks , Patrick T. Cahalan , Michel L. P. M. Verhoeven , Linda L. Cahalan , Antoine N. J. Camps
CPC分类号： A61N1/05
摘要： To minimize the incidence and consequences of device related infection that occur after prosthetics implants of neuro-muscular stimulating devices, an infection resistant intra-muscular lead has been developed and is disclosed herein. Infection incidence has been decreased by using biomaterials able to release antibacterial drugs (gentamicin) at a controlled rate for the first 3-6 weeks after implant.
摘要翻译： 为了最小化在神经 - 肌肉刺激装置的假体植入物之后发生的装置相关感染的发生率和后果，已经开发了抗感染的肌肉内的铅，并且在本文中公开。 通过使用生物材料能够以植入后的前3-6周以受控的速率释放抗菌药物（庆大霉素），使感染发生率降低。
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公开(公告)号：US4486290A
公开(公告)日：1984-12-04
申请号：US519938
申请日：1983-08-03
IPC分类号： G01N27/403 , G01N27/46
CPC分类号： G01N27/4035
摘要： A combination ion sensing and reference electrode and a method for producing it. The electrode is formed of bi-lumen plastic tubing using one lumen as sensing chamber and the other as a reference chamber. A portion of the sensing chamber extends distally relative to the reference chamber, and is permeated with an ion selective material by soaking that portion in a solution containing the ion selective material. The method of manufacture is thereby simplified and sealing of the chambers is improved.
摘要翻译： 一种组合离子感测和参比电极及其制造方法。 电极由使用一个腔作为感测室并且另一个作为参考室的双腔塑料管形成。 感测室的一部分相对于参考室向远侧延伸，并且通过将该部分浸泡在含有离子选择性材料的溶液中而被离子选择性材料渗透。 由此简化了制造方法，改善了室的密封性。
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