公开(公告)号：US11873500B2

公开(公告)日：2024-01-16

申请号：US17683227

申请日：2022-02-28

Applicant: ALTRIA CLIENT SERVICES LLC

Inventor： Chengalrayan Kudithipudi ,  Alec J. Hayes ,  Robert Frank Hart ,  Yanxin Shen ,  Jesse Frederick ,  Dongmei Xu

IPC: A01H6/82 ,  A01H5/12 ,  A01H1/06 ,  A24B13/00 ,  C12N15/82 ,  A01H1/04 ,  C12Q1/6895

CPC classification number: C12N15/8261 ,  A01H1/045 ,  A01H1/06 ,  A01H5/12 ,  A01H6/823 ,  A24B13/00 ,  C12N15/8218 ,  C12N15/8243 ,  C12Q1/6895 ,  C12Q2600/13 ,  C12Q2600/156

Abstract: Provided herein are genetic markers and a coding sequence associated with a low- or ultra-low anatabine trait in tobacco.

公开(公告)号：US11849695B2

公开(公告)日：2023-12-26

申请号：US17954654

申请日：2022-09-28

Applicant: Altria Client Services LLC

Inventor： Chengalrayan Kudithipudi ,  Rutger Van Der Hoeven ,  Ndjido Ardo Kane

IPC: A01H6/82 ,  A01H5/12 ,  A24B13/00 ,  A24D1/00 ,  A01H1/06

CPC classification number: A01H6/823 ,  A01H1/06 ,  A01H5/12 ,  A24B13/00 ,  A24D1/00

Abstract: A process for producing a reduced tobacco-specific nitrosamine (TSNA) tobacco plant comprising reducing and/or eliminating anatabine biosynthesis in wild-type tobacco plant. In addition, use of such plants for discovery of molecular markers that are closely linked with genes required for anatabine biosynthesis and for discovery of genes required for anatabine biosynthesis. In addition, a smoking composition, a smoking article and a smokeless tobacco oral delivery product contain the tobacco material.

公开(公告)号：US11492633B2

公开(公告)日：2022-11-08

申请号：US17096213

申请日：2020-11-12

Applicant: Altria Client Services LLC

Inventor： Chengalrayan Kudithipudi ,  Alec J. Hayes

IPC: C12N15/82 ,  A01H1/06 ,  A24B13/00

Abstract: This disclosure provides tobacco plants having a mutation in PR50 and transgenic tobacco plants containing a PR50 RNAi, and methods of making and using such plants.

公开(公告)号：US20220192250A1

公开(公告)日：2022-06-23

申请号：US17690364

申请日：2022-03-09

Applicant: ALTRIA CLIENT SERVICES LLC

Inventor： Chengalrayan Kudithipudi ,  Alec J. Hayes ,  Marcos Fernando de Godoy Lusso ,  Jerry Whit Morris

IPC: A24D1/00 ,  C12N15/82 ,  A24D3/04 ,  A24B13/00

Abstract: This disclosure provides tobacco plants containing a PMT RNAi and tobacco plants having a mutation in PMT, and methods of making and using such plants.

公开(公告)号：US11034969B2

公开(公告)日：2021-06-15

申请号：US16228035

申请日：2018-12-20

Applicant: Altria Client Services LLC

Inventor： Chengalrayan Kudithipudi ,  Raja Payyavula ,  Dong Qi ,  Yanxin Shen

IPC: C12N15/82 ,  C07K14/415

Abstract: The present specification provides for, and includes recombinant polynucleotides that encode plant-native, callus-preferred promoters operably linked to a coding region for a visual marker gene. The present specification also provides for, and includes plants comprising the recombinant nucleotides, methods to select callus comprising the disclosed recombinant nucleotides, and methods to create plants comprising the recombinant nucleotides.

公开(公告)号：US20210100213A1

公开(公告)日：2021-04-08

申请号：US17116816

申请日：2020-12-09

Applicant: Altria Client Services LLC

Inventor： Jesse Frederick ,  Chengalrayan Kudithipudi ,  Dongmei Xu

IPC: A01H6/82 ,  C12N9/90 ,  C07K14/415 ,  C12N15/82 ,  A01H5/12 ,  C12N9/10 ,  C12N9/88 ,  A01H5/10

Abstract: The present disclosure provides metabolic signatures and genetic markers for tracking enhanced nitrogen utilization efficiency phenotypes in tobacco plants and for introgressing enhanced nitrogen utilization efficiency phenotypes into tobacco plants. The disclosure also provides tobacco plants comprising enhanced nitrogen utilization efficiency and methods to the creation of tobacco plants comprising enhanced nitrogen utilization efficiency. The disclosure also provides recombinant polynucleotides and polypeptides for enhancing nitrogen utilization efficiency in modified tobacco plants and tobacco plants comprising the provided recombinant polynucleotides and polypeptides.

公开(公告)号：US10113174B2

公开(公告)日：2018-10-30

申请号：US14789177

申请日：2015-07-01

Applicant: Altria Client Services LLC

Inventor： Chengalrayan Kudithipudi ,  Alec J. Hayes

IPC: C12N15/82 ,  A01H5/06 ,  A01H1/02 ,  A24B13/00 ,  A01H1/06 ,  A01H5/12

Abstract: This disclosure provides tobacco plants having a mutation in PR50 and transgenic tobacco plants containing a PR50 RNAi, and methods of making and using such plants.

公开(公告)号：US20180098564A1

公开(公告)日：2018-04-12

申请号：US15727418

申请日：2017-10-06

Applicant: Altria Client Services LLC

Inventor： Jesse Frederick ,  Chengalrayan Kudithipudi ,  Dongmei Xu

IPC: A24B15/20 ,  C12N15/10 ,  C12N15/66 ,  C12N15/82

CPC classification number: A24B15/20 ,  A61K38/00 ,  C12N9/88 ,  C12N15/102 ,  C12N15/66 ,  C12N15/8243 ,  C12N15/825 ,  C12N15/8261 ,  C12N15/8269 ,  C12Y401/01015 ,  Y02A40/146

Abstract: This disclosure provides a number of sequences involved in nitrogen utilization, methods of using such sequences, tobacco plants carrying modifications to such sequences, tobacco plants transgenic for such sequences, and tobacco products made from such plants.

公开(公告)号：US20250101447A1

公开(公告)日：2025-03-27

申请号：US18974011

申请日：2024-12-09

Applicant: Altria Client Services LLC

Inventor： Chengalrayan Kudithipudi ,  Yanxin Shen ,  Dongmei Xu ,  Jesse Frederick ,  Jaemo Yang

IPC: C12N15/82 ,  C07K14/415

Abstract: This disclosure provides a number of sequences involved in axillary bud growth in tobacco, methods of using such sequences, tobacco plants carrying modifications to such sequences or transgenes of such sequences, and tobacco products made from tobacco leaf harvested from such plants.

公开(公告)号：US12163139B2

公开(公告)日：2024-12-10

申请号：US17587441

申请日：2022-01-28

Applicant: ALTRIA CLIENT SERVICES LLC

Inventor： Jesse Frederick ,  Chengalrayan Kudithipudi ,  Dongmei Xu

IPC: C12N15/82 ,  A24B3/12 ,  A24B15/20 ,  C12N9/88 ,  C12N15/10 ,  C12N15/66 ,  A61K38/00

Abstract: This disclosure provides a number of sequences involved in nitrogen utilization, methods of using such sequences, tobacco plants carrying modifications to such sequences, tobacco plants transgenic for such sequences, and tobacco products made from such plants.