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    Method of making an auto-calibrating test sensor
    21.
    发明申请
    Method of making an auto-calibrating test sensor 审中-公开
    制作自动校准测试传感器的方法

    公开(公告)号：US20080105024A1

    公开(公告)日：2008-05-08

    申请号：US11982819

    申请日：2007-11-05

    Applicant: John P. Creaven ,  Andrew J. Dosmann ,  Allen J. Brenneman ,  Steven C. Charlton

    Inventor： John P. Creaven ,  Andrew J. Dosmann ,  Allen J. Brenneman ,  Steven C. Charlton

    IPC: G01N21/00 ,  G01N27/00

    CPC classification number: G01N33/48771 ,  G01N21/274 ,  G01N21/278 ,  G01N21/8483 ,  Y10T29/49004

    Abstract: A test sensor is made that is adapted to assist in determining the concentration of an analyte in a fluid sample. The method includes providing a lid and providing a base. The lid is attached to the base to form an attached lid-base structure. The lid-base structure has a first end adapted to receive the fluid sample and a second opposing end adapted to be placed into a meter. Auto-calibration information is assigned to the lid-base structure. The second opposing end is formed such that the shape of the second opposing end corresponds to the auto-calibration information.

    Abstract translation: 制造测试传感器，其适于帮助确定流体样品中分析物的浓度。 该方法包括提供盖子并提供底座。 盖子附接到基座以形成附接的盖子结构。 盖基结构具有适于容纳流体样品的第一端和适于放置在仪表中的第二相对端。 自动校准信息被分配给盖子结构。 第二相对端形成为使得第二相对端的形状对应于自动校准信息。

    Photometric readhead with light-shaping plate
    22.
    发明授权
    Photometric readhead with light-shaping plate 失效
    光度读数头与光成型板

    公开(公告)号：US06181417B2

    公开(公告)日：2001-01-30

    申请号：US09062987

    申请日：1998-04-20

    Applicant: Andrew J. Dosmann

    Inventor： Andrew J. Dosmann

    IPC: G01J328

    CPC classification number: G01N21/255 ,  G01J3/0262 ,  G01N2201/0631 ,  G01N2201/0634 ,  G01N2201/0642

    Abstract: A readhead for a spectrometer for illuminating a target area and receiving light from said target area is provided with a housing adapted to be incorporated in a spectrometer, a light source mounted in a fixed position relative to the housing, a support mechanism adapted to support a biological sample to be illuminated by the light source, a light-shaping mechanism disposed between the light source and the support for increasing the diameter, intensity, and uniformity of the light beam, and a photodetector mounted in fixed position relative to the housing, the photodetector being adapted to detect light from a biological sample disposed in the target area illuminated light sources. The light sources may be in the form of a light-emitting diode that emits substantially monochromatic light having a first wavelength, and the readhead may also include a second light-emitting diode that is adapted to emit substantially monochromatic light of a second wavelength towards the target area.

    Abstract translation: 用于照射目标区域并接收来自所述目标区域的光的光谱仪的读取头设置有适于结合在光谱仪中的壳体，安装在相对于壳体的固定位置的光源，适于支撑 由光源照射的生物样品，设置在光源和支撑体之间的光成形机构，用于增加光束的直径，强度和均匀性;以及光电检测器，其安装在相对于壳体的固定位置， 光电检测器适于检测设置在目标区域照明光源中的生物样品的光。 光源可以是发射基本上具有第一波长的单色光的发光二极管的形式，并且读取头还可以包括第二发光二极管，其适于将基本上第二波长的单色光朝向 目标区域。

    METHOD FOR DETERMINING THE CONCENTRATION OF AN ANALYTE IN A FLUID
    24.
    发明申请
    METHOD FOR DETERMINING THE CONCENTRATION OF AN ANALYTE IN A FLUID 有权
    用于确定流体中分析物浓度的方法

    公开(公告)号：US20100279326A1

    公开(公告)日：2010-11-04

    申请号：US12834639

    申请日：2010-07-12

    Applicant: Andrew J. Dosmann ,  Christine D. Nelson ,  Mary Ellen Warchal-Windham

    Inventor： Andrew J. Dosmann ,  Christine D. Nelson ,  Mary Ellen Warchal-Windham

    IPC: C12Q1/54 ,  C12M1/34

    CPC classification number: G01N21/31 ,  G01N21/255 ,  G01N21/274 ,  G01N21/314 ,  G01N21/3151 ,  G01N21/3577 ,  G01N21/39 ,  G01N21/78

    Abstract: A total transmission spectroscopy system for use in determining the analyte concentration in a fluid sample comprises a sample cell receiving area, a light source, a collimating lens, a first lens, a second lens, and a detector. The sample cell receiving area is adapted to receive a sample to be analyzed. The sample cell receiving area is constructed of a substantially optically clear material. The collimating lens is adapted to receive light from the light source and adapted to illuminate the sample cell receiving area with a substantially collimated beam of light. The first lens is adapted to receive regular and scattered light transmitted through the sample at a first angle of divergence. The first lens receives light having a first angle of acceptance. The first lens outputs light having a second angle of divergence. The second angle of divergence is less than the first angle of divergence. The second lens is adapted to receive light from the first lens and adapted to output a substantially collimated beam of light. The detector is adapted to measure the light output by the second lens.

    Abstract translation: 用于确定流体样品中分析物浓度的总透射光谱系统包括样品池接收区域，光源，准直透镜，第一透镜，第二透镜和检测器。 样品池接收区域适于接收待分析的样品。 样品池接收区域由基本上光学透明的材料构成。 准直透镜适于接收来自光源的光，并且适于以基本上准直的光束照亮样品池接收区域。 第一透镜适于以第一发散角接收透过样品的规则和散射光。 第一透镜接收具有第一接受角的光。 第一透镜输出具有第二发散角的光。 第二发散角小于第一发散角。 第二透镜适于接收来自第一透镜的光并适于输出基本上准直的光束。 检测器适于测量第二透镜的光输出。

    Transmission spectroscopy system for use in the determination of analytes in body fluid
    25.
    发明授权
    Transmission spectroscopy system for use in the determination of analytes in body fluid 有权
    用于测定体液中分析物的透射光谱系统

    公开(公告)号：US07787109B2

    公开(公告)日：2010-08-31

    申请号：US11791556

    申请日：2005-12-12

    Applicant: Andrew J. Dosmann ,  Christine D. Nelson ,  Mary Ellen Warchal-Windham

    Inventor： Andrew J. Dosmann ,  Christine D. Nelson ,  Mary Ellen Warchal-Windham

    IPC: G01N33/48

    CPC classification number: G01N21/31 ,  G01N21/255 ,  G01N21/274 ,  G01N21/314 ,  G01N21/3151 ,  G01N21/3577 ,  G01N21/39 ,  G01N21/78

    Abstract: A total transmission spectroscopy system for use in determining the analyte concentration in a fluid sample comprises a sample cell receiving area, a light source, a collimating lens, a first lens, a second lens, and a detector. The sample cell receiving area is adapted to receive a sample to be analyzed. The sample cell receiving area is constructed of a substantially optically clear material. The collimating lens is adapted to receive light from the light source and adapted to illuminate the sample cell receiving area with a substantially collimated beam of light. The first lens is adapted to receive regular and scattered light transmitted through the sample at a first angle of divergence. The first lens receives light having a first angle of acceptance. The first lens outputs light having a second angle of divergence. The second angle of divergence is less than the first angle of divergence. The second lens is adapted to receive light from the first lens and adapted to output a substantially collimated beam of light. The detector is adapted to measure the light output by the second lens.

    Abstract translation: 用于确定流体样品中分析物浓度的总透射光谱系统包括样品池接收区域，光源，准直透镜，第一透镜，第二透镜和检测器。 样品池接收区域适于接收待分析的样品。 样品池接收区域由基本上光学透明的材料构成。 准直透镜适于接收来自光源的光，并适于以基本准直的光束照亮样品池接收区域。 第一透镜适于以第一发散角接收透过样品的规则和散射光。 第一透镜接收具有第一接受角的光。 第一透镜输出具有第二发散角的光。 第二发散角小于第一发散角。 第二透镜适于接收来自第一透镜的光并适于输出基本上准直的光束。 检测器适于测量第二透镜的光输出。

    SINGLE-SENSOR METER SYSTEM WITH NO SENSOR HANDLING AND METHOD OF USING THE SAME
    26.
    发明申请
    SINGLE-SENSOR METER SYSTEM WITH NO SENSOR HANDLING AND METHOD OF USING THE SAME 审中-公开
    无传感器处理的单传感器仪表系统及其使用方法

    公开(公告)号：US20100178703A1

    公开(公告)日：2010-07-15

    申请号：US12530803

    申请日：2007-03-12

    Applicant: John P. Creaven ,  Andrew J. Dosmann ,  Jason R. Diehl ,  William W. McCloud

    Inventor： John P. Creaven ,  Andrew J. Dosmann ,  Jason R. Diehl ,  William W. McCloud

    IPC: G01N35/00 ,  G01N33/48 ,  G01N27/00 ,  G01N21/00 ,  G01N21/75

    CPC classification number: G01N33/48757 ,  G01N2035/00089 ,  Y10T436/11

    Abstract: A single-sensor meter system for dispensing sensors for testing of an analyte concentration in a fluid comprises a container assembly and a single-sensor meter. The container assembly includes inner and outer cartridges. The inner cartridge includes a plurality of test sensors and a mechanical mechanism. The container assembly forms exactly one opening for dispensing the test sensors one at a time. The opening is covered by an end cap so as to assist in preventing or inhibiting moisture from entering the interior of the container assembly. The mechanical mechanism is adapted to advance the plurality of test sensors. The single-sensor meter is adapted to align with and operatively connects to the container assembly. The single-sensor meter includes a test-sensor extraction mechanism adapted to grip a test sensor and pull the test sensor through the opening to a dispensed position.

    Abstract translation: 用于分配用于测量流体中的分析物浓度的传感器的单传感器计量系统包括容器组件和单传感器计量器。 容器组件包括内筒和外筒。 内筒包括多个测试传感器和机械机构。 容器组件恰好形成一个用于一次一个地分配测试传感器的开口。 开口由端盖覆盖，以帮助防止或阻止水分进入容器组件的内部。 机械机构适于推进多个测试传感器。 单传感器表适于与容器组件对准并可操作地连接到容器组件。 单传感器仪表包括测试传感器提取机构，其适于夹持测试传感器并将测试传感器通过开口拉到分配位置。

    Multiwavelength readhead for use in the determination of analytes in body fluids
    29.
    发明授权
    Multiwavelength readhead for use in the determination of analytes in body fluids 有权
    用于测定体液中分析物的多波长读数头

    公开(公告)号：US07154592B2

    公开(公告)日：2006-12-26

    申请号：US10770059

    申请日：2004-02-02

    Applicant: Jeffery S. Reynolds ,  Andrew J. Dosmann

    Inventor： Jeffery S. Reynolds ,  Andrew J. Dosmann

    IPC: G01N33/48

    CPC classification number: A61B5/1455 ,  A61B5/14532 ,  G01N21/255 ,  G01N21/474 ,  G01N21/49 ,  G01N21/78 ,  G01N21/8483 ,  G01N2021/3148 ,  G01N2021/3181 ,  G01N2201/0627

    Abstract: A readhead for use in the determination of the concentration of an analyte in a sample comprises a read area for receiving the sample, a light source including a plurality light emitting elements for outputting light at a plurality of wavelengths, a light guide having an input end and an output end, a lens for receiving light from the output end of the light guide and for illuminating the sample with a substantially collimated beam of light, and a detector for detecting light from the sample in response to illuminating the sample. The input end of the light guide being optically coupled to the light source for receiving light output by the plurality of light emitting elements. The input end of the light guide has a center that is offset from the center of at least one of the plurality of light elements. The light guide guides a substantial portion of the light received from the light source to the output end of the light guide.

    Abstract translation: 用于确定样品中分析物浓度的读头包括用于接收样品的读取区域，包括用于输出多个波长的光的多个发光元件的光源，具有输入端 以及输出端，用于从光导的输出端接收光并且用基本上准直的光束照射样品的透镜以及响应于照射样品来检测来自样品的光的检测器。 光导体的输入端光耦合到光源，用于接收由多个发光元件输出的光。 光导的输入端具有偏离多个光元件中的至少一个的中心的中心。 光导引导从光源接收的大部分光线到光导的输出端。

    Spectrometer normalization system
    30.
    发明授权
    Spectrometer normalization system 失效
    光谱仪归一化系统

    公开(公告)号：US5822071A

    公开(公告)日：1998-10-13

    申请号：US826297

    申请日：1997-03-27

    Applicant: Andrew J. Dosmann ,  Christine D. Nelson

    Inventor： Andrew J. Dosmann ,  Christine D. Nelson

    IPC: G01J3/28 ,  G01N21/27 ,  G01N21/00

    CPC classification number: G01N21/274

    Abstract: A system for normalizing measurements obtained from spectrometers to correct for measurement biases in individual spectrometers. The normalization system is adapted for use in spectrometers having an optical assembly for obtaining characteristic data from a test sample. A normalization factor is obtained in each spectrometer by placing a holographic dispersion filter between the light source and detector in the position normally occupied by the test sample, the filter having been encoded with a symbol representing a nominal value of light expected to pass through the filter. The spectrometer determines the value of light passing through the filter and calculates a normalization factor based on the ratio between the nominal value of the filter and the actual value obtained by the spectrometer. The normalization factor is stored in system memory and the filter removed so that the spectrometer may thereafter be used to evaluate a plurality of test samples. The measured results obtained from the test samples are normalized by multiplying them by the stored normalization factor. Where measurements are obtained from a plurality of spectrometers, the normalized results vary less than about 10% from instrument to instrument for a variety of types of characteristic data, including turbidimetric microalbumin assays.

    Abstract translation: 用于对从光谱仪获得的测量进行归一化以校正各个光谱仪中的测量偏差的系统。 归一化系统适用于具有用于从测试样品获得特征数据的光学组件的光谱仪中。 在每个光谱仪中通过在通常由测试样品占据的位置处在光源和检测器之间放置全息色散滤光器来获得归一化因子，滤光器已经用代表预期通过滤光器的光的标称值的符号编码 。 光谱仪确定通过滤光器的光的值，并根据滤光片的标称值与光谱仪获得的实际值之间的比值计算归一化因子。 归一化因子存储在系统存储器中，并且滤除器被去除，使得之后可以使用光谱仪来评估多个测试样品。 从测试样品获得的测量结果通过将它们乘以存储的归一化因子进行归一化。 在从多个光谱仪获得测量的情况下，对于各种类型的特征数据（包括比浊微量白蛋白测定），标准化结果从仪器到仪器的变化小于约10％。

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