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    Process for the enzymatic separation of the optical isomers of racemic oxazolidinonic derivatives
    27.
    发明授权
    Process for the enzymatic separation of the optical isomers of racemic oxazolidinonic derivatives 失效
    外消旋恶唑烷酮衍生物的光学异构体的酶分离方法

    公开(公告)号：US4933290A

    公开(公告)日：1990-06-12

    申请号：US137721

    申请日：1987-12-24

    申请人： Pietro Cesti ,  Daniele Bianchi ,  Franco Francalanci ,  Walter Cabri

    发明人： Pietro Cesti ,  Daniele Bianchi ,  Franco Francalanci ,  Walter Cabri

    IPC分类号： C12P17/14 ,  C12P41/00

    CPC分类号： C12P17/14 ,  C12P41/004

    摘要： There is disclosed a process for the biotechnological resolution, by enzymatic esterification of the corresponding racemic mixture of the S(+) and R(-) optical isomers of the oxazolidinonic compounds having formula (I): ##STR1## wherein R represents a, linear or branched, C.sub.1 -C.sub.8 alkyl group, which process is characterized in that, the racemic 3-alkyl-5-hydroxymethyl-oxazolidin-2-one derivative of formula (I) is reacted with an esterifying compound, selected from esters having formula (III): ##STR2## wherein R represents a, linear or branched, C.sub.1 -C.sub.10 alkyl or alkenyl group and R" represents a linear or branched, C.sub.1 -C.sub.4 alkyl, alkenyl group, a haloalkyl (chlorine, bromine) group or a diacyl glycerolic group or from acids having formula (IV):R'"--COOH (IV)wherein R'" represents a, linear or branched, C.sub.1 -C.sub.20 alkyl or alkenyl group or from anhydrides having formula (V): ##STR3## wherein R.sup.IV represents a, linear or branched, C.sub.1 -C.sub.6 alkyl group, in the presence of an enzyme, immobilized on a porous carrier, capable of giving rise selectively to the esterification reaction of the R(-) isomer, while leaving the S(+) isomer substantially unchanged, which latter is then separated according to known techniques.