公开(公告)号：US08673000B2

公开(公告)日：2014-03-18

申请号：US13112656

申请日：2011-05-20

申请人： Charles Tabor ,  Carol E. Eberhardt ,  Timothy G. Laske ,  Timothy R. Ryan ,  Joseph C. Morrow ,  Tammy Y. Tam ,  Brian A. Glynn ,  Anne L. Brody Rubin ,  J. Michael Tuchek

发明人： Charles Tabor ,  Carol E. Eberhardt ,  Timothy G. Laske ,  Timothy R. Ryan ,  Joseph C. Morrow ,  Tammy Y. Tam ,  Brian A. Glynn ,  Anne L. Brody Rubin ,  J. Michael Tuchek

IPC分类号： A61F2/24

CPC分类号： A61F2/2418 ,  A61F2/013 ,  A61F2/07 ,  A61F2/2433 ,  A61F2/2436 ,  A61F2/89 ,  A61F2/90 ,  A61F2002/016 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2220/0091 ,  A61F2230/0006 ,  A61F2230/0054 ,  A61F2230/008 ,  A61F2250/0018 ,  A61F2250/003 ,  A61F2250/0039

摘要： A stented valve including a generally tubular stent structure that has a longitudinal axis, first and second opposite ends, a plurality of commissure support structures spaced from the first and second ends and extending generally parallel to the longitudinal axis, at least one structural wire positioned between each two adjacent commissure support structures, and at least one wing portion extending from two adjacent commissure support structures and toward one of the first and second ends of the stent structure. The stented valve further includes a valve structure attached within the generally tubular stent structure to the commissure support structures.

摘要翻译： 一种支架式阀，包括大致管状的支架结构，其具有纵向轴线，第一和第二相对端部，与第一和第二端部间隔开并且大致平行于纵向轴线延伸的多个连合支撑结构，至少一个结构线定位在 每个两个相邻的连合支撑结构，以及从两个相邻的合金支撑结构延伸并且朝向支架结构的第一和第二端中的一个延伸的至少一个翼部。 支架瓣膜还包括附接在大致管状支架结构内的连接支撑结构的瓣膜结构。

公开(公告)号：US08500801B2

公开(公告)日：2013-08-06

申请号：US12714757

申请日：2010-03-01

申请人： Carol E. Eberhardt ,  Faisal Kalam

发明人： Carol E. Eberhardt ,  Faisal Kalam

IPC分类号： A61F2/24

CPC分类号： A61F2/2418 ,  A61F2/2415 ,  A61F2/82 ,  A61F2210/0014 ,  A61F2230/0023 ,  A61F2230/0054 ,  A61F2240/001 ,  B21C37/065 ,  B21C37/157 ,  B21D31/00

摘要： A single piece stent construction having a plurality of commissure posts, each of which extends upwardly from a solid ring along a bend line and generally along a central longitudinal axis of the stent.

摘要翻译： 单件支架结构具有多个连合柱，每个连合柱从固体环沿着弯曲线向上延伸，并且大体上沿支架的中心纵向轴线延伸。

公开(公告)号：US08241274B2

公开(公告)日：2012-08-14

申请号：US12570888

申请日：2009-09-30

申请人： James R. Keogh ,  Timothy R. Ryan ,  Carol E. Eberhardt ,  Mark T. Stewart ,  James R. Skarda ,  Timothy G. Laske ,  Alexander J. Hill ,  Jack D. Lemmon ,  David E. Francischelli

发明人： James R. Keogh ,  Timothy R. Ryan ,  Carol E. Eberhardt ,  Mark T. Stewart ,  James R. Skarda ,  Timothy G. Laske ,  Alexander J. Hill ,  Jack D. Lemmon ,  David E. Francischelli

IPC分类号： A61B18/04

CPC分类号： A61F2/2496 ,  A61B5/0044 ,  A61B5/1076 ,  A61B5/6853 ,  A61B8/445 ,  A61B18/1442 ,  A61B34/20 ,  A61B90/37 ,  A61B90/39 ,  A61B2017/00243 ,  A61B2018/00291 ,  A61B2018/00351 ,  A61B2018/00577 ,  A61B2034/2051 ,  A61B2034/2063 ,  A61B2090/378 ,  A61B2090/397 ,  A61F2/2433 ,  A61F2210/009 ,  A61F2250/0096 ,  A61N7/02

摘要： A device and method for valve replacement or valve repair is disclosed comprising the steps of acquiring an anatomical image of a patient, correlating the image to the patient, guiding a valve replacement delivery member or a valve repair delivery member within the patient while tracking the position of the delivery member in the patient, positioning the valve replacement member or valve repair member in a desired position to place a valve or repair valve and removing the delivery member from the patient. In one aspect of the invention, a delivery system is provided for percutaneous delivery of a heart valve to a predetermined position in the heart of a patient, where the delivery system itself includes features that allow it to be accurately positioned in the heart. In another aspect of the invention, a delivery system is provided for percutaneous repair of a heart valve in the heart of a patient, where the repair system itself includes features that allow it to be accurately positioned in the heart. In another aspect of the invention, a method and device are provided that involve imaging a native root using an interoperative technique, then introducing a device that is easily visualized in a chosen imaging modality.

摘要翻译： 公开了一种用于瓣膜置换或瓣膜修复的装置和方法，包括以下步骤：获取患者的解剖图像，将图像与患者相关联，在跟踪位置的同时引导患者内的瓣膜置换输送构件或瓣膜修复递送构件 的患者中的输送构件，将瓣膜置换构件或瓣膜修复构件定位在期望的位置以放置瓣膜或修复瓣膜并从患者移除输送构件。 在本发明的一个方面，提供一种用于将心脏瓣膜经皮递送到患者心脏中的预定位置的递送系统，其中递送系统本身包括允许其准确地定位在心脏中的特征。 在本发明的另一方面，提供一种用于经皮修复患者心脏中的心脏瓣膜的递送系统，其中所述修复系统本身包括允许其准确地定位在心脏中的特征。 在本发明的另一方面，提供了一种方法和装置，其涉及使用手术技术对本地根进行成像，然后引入在选择的成像模式中容易可视化的装置。

公开(公告)号：US5546820A

公开(公告)日：1996-08-20

申请号：US339364

申请日：1994-11-14

申请人： Carol E. Eberhardt ,  Mark J. Capps ,  Luis Salazar

发明人： Carol E. Eberhardt ,  Mark J. Capps ,  Luis Salazar

IPC分类号： A61F2/24 ,  G01M10/00 ,  F16K37/00

CPC分类号： A61F2/2412 ,  A61F2/2472

摘要： A fixture for testing a circumferentially compliant bioprosthetic valve. The fixture comprises a silicone rubber simulated aorta which approximates the geometry of a healthy human aorta and a cradle for the aorta. The compliance characteristics of the aorta can be selected by varying the proportions of ingredients in the silicone rubber, so that simulated aortas of different compliance but identical geometries can be provided. The compliant valve is disposed inside the aorta and held in place by suturing or the like. In one embodiment, the aorta and valve are supported by means of a cylindrical cradle, with the inflow and outflow ends of the aorta being folded over cylindrical rims on the respective inflow and outflow ends of the cradle. End caps are then fitted in place over the folded-over ends of the aorta, the end caps having holes therein to allow flow through the aorta and valve. The end caps are provided with O-rings on their outer surfaces, so that the assembled fixture can be inserted into a testing apparatus, with the aorta and valve held in place in the sealed flow loop of the apparatus. In another embodiment, adapter rings are provided for the inflow and outflow ends of the aorta, with the ends of the aorta being folded over cylindrical rims disposed around the inner circumference of each of the adapter rings. The adapter rings are also provided with O-rings, allowing the ends of the aorta to be received in a testing apparatus so that the aorta and valve are disposed along the sealed flow loop of the apparatus.

公开(公告)号：US5406857A

公开(公告)日：1995-04-18

申请号：US910933

申请日：1992-07-09

申请人： Carol E. Eberhardt ,  Mark J. Capps ,  Luis Salazar

发明人： Carol E. Eberhardt ,  Mark J. Capps ,  Luis Salazar

IPC分类号： A61F2/24 ,  G01M19/00

CPC分类号： A61F2/2412 ,  A61F2/2472

摘要： A fixture for testing a circumferentially compliant bioprosthetic valve. The fixture comprises a silicone rubber simulated aorta which approximates the geometry of a healthy human aorta and a cradle for the aorta. The compliance characteristics of the aorta can be selected by varying the proportions of ingredients in the silicone rubber, so that simulated aortas of different compliance but identical geometries can be provided. The compliant valve is disposed inside the aorta and held in place by suturing or the like. In one embodiment, the aorta and valve are supported by means of a cylindrical cradle, with the inflow and outflow ends of the aorta being folded over cylindrical rims on the respective inflow and outflow ends of the cradle. End caps are then fitted in place over the folded-over ends of the aorta, the end caps having holes therein to allow flow through the aorta and valve. The end caps are provided with O-rings on their outer surfaces, so that the assembled fixture can be inserted into a testing apparatus, with the aorta and valve held in place in the sealed flow loop of the apparatus. In another embodiment, adapter rings are provided for the inflow and outflow ends of the aorta, with the ends of the aorta being folded over cylindrical rims disposed around the inner circumference of each of the adapter rings. The adapter rings are also provided with O-rings, allowing the ends of the aorta to be received in a testing apparatus so that the aorta and valve are disposed along the sealed flow loop of the apparatus.

摘要翻译： 用于测试周向顺应性生物假体瓣膜的夹具。 该固定装置包括模拟主动脉的硅橡胶，其近似于健康人主动脉的几何形状和用于主动脉的支架。 可以通过改变硅橡胶中成分的比例来选择主动脉的顺应特性，从而可以提供不同顺应性但相同几何形状的模拟主动脉。 顺应性阀设置在主动脉内部并通过缝合等保持在适当的位置。 在一个实施例中，主动脉和瓣膜通过圆柱形支架支撑，主动脉的流入和流出端折叠在支架的相应流入和流出端上的圆柱形边缘上。 然后将端盖安装在主动脉的折叠端上的适当位置，端盖在其中具有孔以允许流过主动脉和瓣膜。 端盖在其外表面上设置有O形环，使得组装的夹具可以插入到测试装置中，其中主动脉和瓣膜保持在装置的密封流动回路中的适当位置。 在另一个实施例中，为主动脉的流入端和流出端设置适配环，其中主动脉的端部折叠在围绕每个适配环的内圆周设置的圆柱形轮缘上。 接头环还设置有O形环，允许主动脉的端部被接收在测试装置中，使得主动脉和瓣膜沿着装置的密封流动环路设置。

公开(公告)号：US20100274354A1

公开(公告)日：2010-10-28

申请号：US12766554

申请日：2010-04-23

申请人： Carol E. Eberhardt

发明人： Carol E. Eberhardt

IPC分类号： A61F2/24

CPC分类号： A61F2/2412 ,  A61F2/064 ,  A61F2/07 ,  A61F2/2418 ,  A61F2002/075 ,  A61F2220/0008 ,  A61F2220/0075 ,  A61F2250/0018 ,  A61F2250/0037 ,  A61F2250/0039 ,  A61F2250/0048 ,  A61L27/3625

摘要： A stented valve including a compressible and expandable stent frame having a generally tubular body portion having an interior area and a longitudinal axis, a bioprosthetic valve positioned at least partially within the interior area of the tubular body portion of the stent frame and having an inner wall from which a plurality of leaflets extend; and a tubular covering material including a first portion extending from a first end of the stent frame to a second end of the stent frame, and a second portion extending beyond the second end of the stent frame.

摘要翻译： 一种包括可压缩且可扩张的支架框架的支架瓣膜，所述支架框架具有具有内部区域和纵向轴线的大致管状主体部分，生物假体瓣膜至少部分地定位在支架框架的管状主体部分的内部区域内，并且具有内壁 多个小叶从该小叶延伸出来; 以及管状覆盖材料，其包括从支架框架的第一端延伸到支架框架的第二端的第一部分，以及延伸超过支架框架的第二端的第二部分。

公开(公告)号：US20100268324A1

公开(公告)日：2010-10-21

申请号：US12714757

申请日：2010-03-01

申请人： Carol E. Eberhardt ,  Faisal Kalam

发明人： Carol E. Eberhardt ,  Faisal Kalam

IPC分类号： A61F2/86 ,  B21D31/00

CPC分类号： A61F2/2418 ,  A61F2/2415 ,  A61F2/82 ,  A61F2210/0014 ,  A61F2230/0023 ,  A61F2230/0054 ,  A61F2240/001 ,  B21C37/065 ,  B21C37/157 ,  B21D31/00

摘要： A single piece stent construction having a plurality of commissure posts, each of which extends upwardly from a solid ring along a bend line and generally along a central longitudinal axis of the stent.

摘要翻译： 单件支架结构具有多个连合柱，每个连合柱从固体环沿弯曲线向上延伸，并且大体沿着支架的中心纵向轴线延伸。

公开(公告)号：US06350282B1

公开(公告)日：2002-02-26

申请号：US08570373

申请日：1995-12-11

申请人： Carol E. Eberhardt

发明人： Carol E. Eberhardt

IPC分类号： A61F224

CPC分类号： A61F2/2409 ,  A61F2/2412 ,  A61F2/2415 ,  A61F2220/0075

摘要： A supported bioprosthetic heart valve is provided. The valve includes a stent and a bilogical valve member. The stent has an annular frame defined by a support rail. The support rail is formed to define a triad of axially-projecting circumferentially-spaced commissure posts, each post having an inverted U-shaped configuration and a pair of legs. Each of the pair of legs has an upper end and a lower end. The lower end of each leg merges smoothly with the lower end of a leg of an adjacent commissure post. A sleeve having an inflow end and an outflow end is fitted around the annular frame. The biological valve member is defined by a tubular wall and three leaflets, the three leaflets being attached to the tubular wall and axially converging along three commissures. The biological valve member has a shape which fits the contour of the support rail and is disposed under the support rail. The biological valve member is sutured to the support rail and the outflow end of the sleeve. The bioprosthetic valve member also includes a suturing cuff which is not rigidly attached to the support rail allowing the valve to expand and contract in the lateral direction. The suturing cuff is formed by wrapping the inflow end of the sleeve around a ring-shaped cushion and suturing the sleeve to itself encapsulating thus the ring-shaped cushion. An inflow support ring may also be provided within the suturing cuff for added lateral support.

摘要翻译： 提供支持的生物假体心脏瓣膜。 该阀包括支架和生物阀构件。 支架具有由支撑轨限定的环形框架。 支撑轨道形成为限定了三角形的轴向突出的周向间隔的合缝柱，每个柱具有倒U形构造和一对腿。 一对腿中的每一个具有上端和下端。 每个腿的下端平滑地与邻近的连合柱的腿的下端融合。 具有流入端和流出端的套筒围绕环形框架安装。 生物阀构件由管状壁和三个叶片限定，三个叶片附接到管状壁并沿着三个连合部轴向收敛。 生物阀构件具有适合支撑轨的轮廓并且设置在支撑轨下方的形状。 将生物阀构件缝合到支撑轨和套筒的流出端。 生物假体阀构件还包括未刚性地附接到支撑轨道的缝合箍，其允许阀在横向方向上膨胀和收缩。 缝合箍是通过将套筒的流入端环绕在环形垫上并将套管缝合到自身封装的环形衬垫上而形成的。 还可以在缝合箍内设置流入支撑环，以增加横向支撑。

公开(公告)号：US06347632B1

公开(公告)日：2002-02-19

申请号：US07910970

申请日：1992-07-09

申请人： Carol E. Eberhardt ,  David J. Myers

发明人： Carol E. Eberhardt ,  David J. Myers

IPC分类号： A61B1900

CPC分类号： A61F2/2412

摘要： A method of creating a simulated aorta patterned from a natural aorta and having a preselected amount of compliance is disclosed. The dimensions of a simulated aortic root patterned according to the dimensions of a natural aorta are first selected and a mold provided. The amount of circumferential compliance desired in the simulated aorta is then selected, based on natural circumferential compliancies. A material such as silicone rubber formed of an elastomer and a filler is used to form the aorta, the durometer of the material being varied by varying the relative amount of the components, to provide the selected amount of circumferential compliance in a simulated aorta having the selected dimensions. The aorta is then formed curing the material in the mold for about 24 hours. Groups of simulated aortas so produced, sometimes having different sizes and/or compliancies are also disclosed. A method of testing non-stented valves using the aortas is included.

摘要翻译： 公开了一种创建从天然主动脉图案化并具有预选量的顺应性的模拟主动脉的方法。 首先选择根据天然主动脉的尺寸进行图案化的模拟主动脉根的尺寸，并提供模具。 然后根据天然圆周顺应性选择模拟主动脉期望的圆周顺应量。 使用由弹性体和填料形成的诸如硅橡胶的材料以形成主动脉，通过改变组件的相对量来改变材料的硬度，以在具有所述主动脉的模拟主动脉中提供选定量的圆周顺应性 所选尺寸。 然后使主动脉固化模具中的材料约24小时。 如此生产的模拟主动脉组，有时具有不同的尺寸和/或顺应性。 包括使用主动脉测试非支架瓣膜的方法。

公开(公告)号：US5824060A

公开(公告)日：1998-10-20

申请号：US129636

申请日：1993-09-29

申请人： Grant W. Christie ,  Carol E. Eberhardt

发明人： Grant W. Christie ,  Carol E. Eberhardt

IPC分类号： A01N1/02 ,  A61F2/24

CPC分类号： A01N1/0263 ,  A01N1/02 ,  A01N1/0247 ,  A01N1/0289 ,  A61F2/2415

摘要： A natural tissue heart valve includes a tubular wall having an outflow section and valve leaflets which allow flow into the outflow section. A heart valve of this type is subjected to a fixative fluid to provide a first differential fluid pressure across the tubular wall of the outflow section and a second differential fluid pressure across the valve leaflets. The first differential fluid pressure acts outwardly on the tubular wall, and the differential pressures are unequal.

摘要翻译： 天然组织心脏瓣膜包括具有流出部分和允许流入流出部分的瓣叶的管状壁。 这种类型的心脏瓣膜经受固定液体，以跨过流出部分的管状壁提供第一差分流体压力，并且在瓣膜单张上提供第二差分流体压力。 第一差分流体压力在管状壁上向外作用，并且差压是不相等的。