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公开(公告)号：US20240165619A1
公开(公告)日：2024-05-23
申请号：US17772647
申请日：2021-05-31
Inventor： Zhukai LIU , Ding DING
IPC: B01L3/00
CPC classification number: B01L3/502753 , B01L2300/0874 , B01L2300/1883
Abstract: The present disclosure provide a detection chip having at least one functional region, the functional region including: a reaction region and a non-reaction region surrounding the reaction region. The detection chip includes: a first substrate and a second substrate opposite to each other. In the reaction region, a side of the first substrate facing the second substrate is provided with reaction grooves arranged in an array along a first direction and a second direction; first communication grooves each between two reaction grooves adjacent in the first direction, and connected with the two reaction grooves; and second communication grooves each between two first communication grooves adjacent in the second direction, and connected with the two adjacent first communication grooves, and the first direction intersects the second direction. The embodiments of the present disclosure further provide a fabrication method and a sample introduction method of the detection chip.
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22.发明公开公开(公告)号：US20240359174A1
公开(公告)日：2024-10-31
申请号：US18029792
申请日：2022-05-19
Applicant: BOE TECHNOLOGY GROUP CO., LTD.
Inventor： Yunqing MU , Haonan LIU , Zhukai LIU , Ding DING
IPC: B01L3/00
CPC classification number: B01L3/502707 , B01L2200/025 , B01L2200/12 , B01L2200/16 , B01L2300/12 , B01L2300/161
Abstract: A gene detection substrate is provided, including: a substrate; a gene detection channel in the substrate, an opening of the gene detection channel is on one side of the substrate; the gene detection channel includes a sample injection groove, a sample outgoing groove and a flow channel groove sequentially connected and communicated with each other; the flow channel groove includes reaction holes and flow channel structures; the reaction holes are distributed at intervals, and any two adjacent reaction holes are communicated with each other through the flow channel structure; the flow channel structure includes a first, second, and third sub-grooves sequentially connected and communicated with each other; a width of each of the first and third sub-grooves in a first direction is smaller than that of the second sub-groove in the first direction; and the first direction is perpendicular to an arrangement direction of two adjacent reaction holes.
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公开(公告)号：US20240299933A1
公开(公告)日：2024-09-12
申请号：US18024892
申请日：2022-03-15
Inventor： Kang PENG , Ding DING , Zhukai LIU
CPC classification number: B01L3/502715 , B01L2200/0647 , B01L2200/12 , B01L2300/04 , B01L2300/0645 , B01L2300/161 , B01L2400/06 , H01L27/1214
Abstract: Provided are a microfluidic chip and a usage method thereof, and a microfluidic system. The microfluidic chip includes a substrate layer, the substrate layer includes a substrate and a drive electrode layer; and a cover plate layer arranged opposite the substrate layer, a space between the cover plate layer and the substrate layer form a solution accommodating space; the cover plate layer includes a solution inlet hole, a solution outlet hole, and limiting recesses arranged on a side of the cover plate layer facing the substrate layer, the solution inlet hole, the solution outlet hole and each limiting recess are in communication with the solution accommodating space, and an end surface of the solution inlet hole adjacent to the substrate layer, an end surface of the solution outlet hole adjacent to the substrate layer, and opening surfaces of the plurality of limiting recesses are arranged substantially flush with one another.
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公开(公告)号：US20240226879A1
公开(公告)日：2024-07-11
申请号：US17928342
申请日：2021-10-29
Inventor： Zijian ZHAO , Houqian GAO , Hairong JING , Ding DING , Shinying LAU
IPC: B01L3/00
CPC classification number: B01L3/502715 , B01L3/502707 , B01L2200/027 , B01L2200/12 , B01L2300/041 , B01L2300/12 , B01L2300/161
Abstract: A detection chip and a preparation method thereof, the detection chip may include a base substrate and a detection layer, the detection layer is provided on the base substrate and include a plurality of detection holes, each of at least a portion of the plurality of detection holes has a hole wall provided with a hydrophilic layer, and a contact angle of the hydrophilic layer is within 20 degrees. The detection chip can implement high-throughput, crosstalk does not easily occur between adjacent detection holes, which, thus, may improve detection accuracy.
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公开(公告)号：US20240181443A1
公开(公告)日：2024-06-06
申请号：US17789263
申请日：2021-08-27
Inventor： Ruijun DENG , Zhukai LIU , Ding DING
IPC: B01L3/00 , B01L7/00 , C12Q1/6851
CPC classification number: B01L3/5023 , B01L3/502753 , B01L7/52 , C12Q1/6851 , B01L2200/16 , B01L2300/069 , B01L2300/0816 , B01L2300/161 , B01L2300/18
Abstract: A high-throughput test chip includes: a backplane, a cover plate and a connector. The backplane and the cover plate are aligned to form a plurality of accommodation chambers. Test chip units are disposed on one side of the backplane facing the cover plate, and each of the test chip units is located in the corresponding accommodation chamber. Each of the accommodation chambers is provided with a liquid inlet and a liquid outlet. The connector includes pipelines; each of the pipelines is provided with a valve structure configured to control connection or disconnection of the pipeline. In each pair of a pipeline and an accommodation chamber, an inlet of the pipeline communicates with the liquid outlet of the accommodation chamber; the pipelines form at least one pipeline group, each pipeline group at least includes two pipelines, and the pipelines in each pipeline group share the same sample liquid outlet.
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Patent Agency Ranking
26.发明公开公开(公告)号：US20240175521A1
公开(公告)日：2024-05-30
申请号：US17790332
申请日：2021-08-17
Inventor： Beiyuan FAN , Weifeng XU , Ding DING
IPC: F16K99/00
CPC classification number: F16K99/0015 , F16K99/0046 , F16K2099/0084
Abstract: A control valve structure, a using method thereof, a microfluidic chip, and a nucleic acid extraction device. The control valve structure includes: a cover plate layer, a first channel layer, a first adhesive layer, a second channel layer, at least one valve core, and at least one elastic film. When the valve core is embedded in the first limiting hole, the elastic film seals the first limiting hole, and the second limiting hole, the first through hole and the liquid outlet channel form a sample liquid flow channel; and when the valve core is embedded in the second limiting hole, the elastic film seals the second limiting hole so as to block the sample liquid flow channel.
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公开(公告)号：US20240165615A1
公开(公告)日：2024-05-23
申请号：US17772639
申请日：2021-05-27
Inventor： Kang PENG , Beiyuan FAN , Ding DING
IPC: B01L3/00
CPC classification number: B01L3/502723 , B01L3/502707 , B01L2200/0642 , B01L2200/0684 , B01L2300/0645 , B01L2300/0816 , B01L2300/161 , B01L2300/1827
Abstract: The present disclosure provides a detection chip, including: a micro-cavity-defining layer having a plurality of micro-pores extending through the micro-cavity-defining layer are arranged; and a ventilative liquid-resistant layer on a side of the micro-cavity-defining layer and completely covering openings on a side of the plurality of micro-pores. The ventilative liquid-resistant layer is configured to allow gas to pass therethrough and to block liquid from passing therethrough. The present disclosure also provides a method for manufacturing a detection chip and a sample introduction method for the detection chip.
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公开(公告)号：US20230116464A1
公开(公告)日：2023-04-13
申请号：US17605348
申请日：2021-01-29
Applicant: BOE TECHNOLOGY GROUP CO., LTD.
Inventor： Weifeng XU , Beiyuan FAN , Da LI , Ding DING
Abstract: A device and a driving method for driving a microfluidic chip are disclosed. The device for driving a microfluidic chip includes a carrying member configured to carry the microfluidic chip; a releasing member configured to electrically connected to the microfluidic chip, and control the release of the reagent of the microfluidic chip a valve control member configured to control the opening and closing of the flow channel in the valve control area of the microfluidic chip when the valve control area is within the valve control range of the valve control member a fluid driving member configured to drive the flow of fluid in the microfluidic chip, and a controller configured to control the driving process of the microfluidic chip.
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公开(公告)号：US20220339630A1
公开(公告)日：2022-10-27
申请号：US17731746
申请日：2022-04-28
Inventor： Lin DENG , Fan YANG , Da LI , Xiangguo MA , Ding DING
Abstract: The present disclosure provides a chip, a microfluidic device including the chip, and a method for sorting target droplets. The chip includes a first container for accommodating a first fluid, a second container for accommodating a second fluid, a delivery channel including a first flow channel communicating with the first container and a second flow channel communicating with the second container, the first flow channel and the second flow channel intersecting and communicating with each other at a junction, and at least one collector. A portion of the first flow channel includes the junction and is divided into two sections by the junction, in each section, the section thickens gradually along a first direction away from the junction. The second flow channel includes the junction and is divided into two sections by the junction, in each section, the section thickens gradually along a second direction away from the junction.
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公开(公告)号：US20250019687A1
公开(公告)日：2025-01-16
申请号：US18274203
申请日：2022-05-31
Inventor： Beiyuan FAN , Ding DING
IPC: C12N15/10
Abstract: The present disclosure provides a microfluidic chip configured to extract a nucleic acid, the microfluidic chip including: a first substrate having at least two buffer areas configured to cooperate with a magnet, and being provided with a microfluidic channel, wherein the microfluidic channel includes a primary flow channel and a plurality of buffer flow channels connected in series to the primary flow channel, the buffer flow channels are in the buffer areas, different buffer flow channels are in different buffer areas, respectively, and each of the buffer flow channels has a double-spiral shape; and a second substrate opposite to the first substrate. The microfluidic chip has a plurality of openings in communication with the primary flow channel. The present disclosure further provides a nucleic acid extraction apparatus and a nucleic acid extraction method.
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