公开(公告)号：US20170056172A1

公开(公告)日：2017-03-02

申请号：US15138863

申请日：2016-04-26

Applicant: BOSTON SCIENTIFIC SCIMED, INC.

Inventor： Amr Salahieh ,  Jean-Pierre Dueri ,  Hans F. Valencia ,  Brian D. Brandt ,  Dwight P. Morejohn ,  Claudio Argento ,  Tom Saul ,  Ulrich R. Haug

IPC: A61F2/24

CPC classification number: A61F2/2439 ,  A61F2/24 ,  A61F2/2409 ,  A61F2/2412 ,  A61F2/2418 ,  A61F2/243 ,  A61F2/2433 ,  A61F2/2436 ,  A61F2/90 ,  A61F2002/9528 ,  A61F2220/0016 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2230/005 ,  A61F2230/0054 ,  A61F2230/0078 ,  A61F2230/008 ,  A61F2250/006

Abstract: The invention includes methods of and apparatus for endovascularly replacing a heart valve of a patient. One aspect of the invention provides a method including the steps of endovascularly delivering a replacement valve and an expandable anchor to a vicinity of the heart valve in an unexpanded configuration; and applying an external non-hydraulically expanding or non-pneumatically expanding actuation force on the anchor to change the shape of the anchor, such as by applying proximally and/or distally directed force on the anchor using a releasable deployment tool to expand and contract the anchor or parts of the anchor. Another aspect of the invention provides an apparatus including a replacement valve; an anchor; and a deployment tool comprising a plurality of anchor actuation elements adapted to apply a non-hydraulically expanding or non-pneumatically expanding actuation force on the anchor to reshape the anchor.

Abstract translation: 本发明包括用于血管内置换患者心脏瓣膜的方法和装置。 本发明的一个方面提供了一种方法，包括以未膨胀的构造将置换瓣膜和可扩张锚固体血管内输送到心脏瓣膜附近的步骤; 以及在所述锚上施加外部非液压膨胀或非气动扩张的致动力以改变所述锚的形状，例如通过使用可释放的展开工具向所述锚上施加近端和/或远端定向的力， 锚或锚的部分。 本发明的另一方面提供了一种包括置换阀的装置; 锚点 以及展开工具，其包括适于在锚上施加非液压膨胀或非气动膨胀的致动力的多个锚致动元件，以重构锚固件。

公开(公告)号：US10925724B2

公开(公告)日：2021-02-23

申请号：US15842306

申请日：2017-12-14

Applicant: BOSTON SCIENTIFIC SCIMED, INC.

Inventor： Amr Salahieh ,  Brian D. Brandt ,  Dwight P. Morejohn ,  Ulrich R. Haug ,  Jean-Pierre Dueri ,  Hans F. Valencia ,  Robert A. Geshlider

IPC: A61F2/24

Abstract: Apparatus for endovascularly replacing a patient's heart valve, including: a replacement valve adapted to be delivered endovascularly to a vicinity of the heart valve; an expandable anchor adapted to be delivered endovascularly to the vicinity of the heart valve; and a lock mechanism configured to maintain a minimum amount of anchor expansion. The invention also includes a method for endovascularly replacing a patient's heart valve. In some embodiments the method includes the steps of: endovascularly delivering a replacement valve and an expandable anchor to a vicinity of the heart valve; expanding the anchor to a deployed configuration; and locking the anchor in the deployed configuration.

公开(公告)号：US20190152651A1

公开(公告)日：2019-05-23

申请号：US16258018

申请日：2019-01-25

Applicant: BOSTON SCIENTIFIC SCIMED INC.

Inventor： Amr Salahieh ,  Tom Saul ,  Robert Geshlider ,  Andrea Johnson ,  Dwight Morejohn ,  Daniel Hildebrand ,  Jean-Pierre Dueri

IPC: B65D25/04 ,  B65D81/22 ,  B65D41/04 ,  B65B55/16 ,  A61F2/00 ,  B65B5/04 ,  A61F2/24

Abstract: The invention provides a two-part package and method of use for a pre-attached medical implant and delivery tool system. The package includes a wet compartment and a dry compartment and allows a pre-attached implant and delivery tool system to be at least partially stored immersed in a fluid in the wet compartment and at least partially stored in the dry compartment. In one embodiment the implant comprises a replacement heart valve, and the heart valve is stored inside the wet compartment while the heart valve delivery tool remains dry in the dry compartment.

公开(公告)号：US20180110616A1

公开(公告)日：2018-04-26

申请号：US15842503

申请日：2017-12-14

Applicant: BOSTON SCIENTIFIC SCIMED, INC.

Inventor： Amr Salahieh ,  Brian D. Brandt ,  Dwight P. Morejohn ,  Ulrich R. Haug ,  Jean-Pierre Dueri ,  Hans F. Valencia ,  Robert A. Geshlider

IPC: A61F2/24

CPC classification number: A61F2/2412 ,  A61F2/2418 ,  A61F2/2439 ,  A61F2220/0016 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2230/005 ,  A61F2230/0054 ,  A61F2230/0065 ,  A61F2230/0078 ,  A61F2250/0069

Abstract: Apparatus for endovascularly replacing a patient's heart valve, including: a replacement valve adapted to be delivered endovascularly to a vicinity of the heart valve; an expandable anchor adapted to be delivered endovascularly to the vicinity of the heart valve; and a lock mechanism configured to maintain a minimum amount of anchor expansion. The invention also includes a method for endovascularly replacing a patient's heart valve. In some embodiments the method includes the steps of: endovascularly delivering a replacement valve and an expandable anchor to a vicinity of the heart valve; expanding the anchor to a deployed configuration; and locking the anchor in the deployed configuration.

公开(公告)号：US20180104051A1

公开(公告)日：2018-04-19

申请号：US15842306

申请日：2017-12-14

Applicant: BOSTON SCIENTIFIC SCIMED, INC.

Inventor： Amr Salahieh ,  Brian D. Brandt ,  Dwight P. Morejohn ,  Ulrich R. Haug ,  Jean-Pierre Dueri ,  Hans F. Valencia ,  Robert A. Geshlider

IPC: A61F2/24

CPC classification number: A61F2/2412 ,  A61F2/2418 ,  A61F2/2439 ,  A61F2220/0016 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2230/005 ,  A61F2230/0054 ,  A61F2230/0065 ,  A61F2230/0078 ,  A61F2250/0069

Abstract: Apparatus for endovascularly replacing a patient's heart valve, including: a replacement valve adapted to be delivered endovascularly to a vicinity of the heart valve; an expandable anchor adapted to be delivered endovascularly to the vicinity of the heart valve; and a lock mechanism configured to maintain a minimum amount of anchor expansion. The invention also includes a method for endovascularly replacing a patient's heart valve. In some embodiments the method includes the steps of: endovascularly delivering a replacement valve and an expandable anchor to a vicinity of the heart valve; expanding the anchor to a deployed configuration; and locking the anchor in the deployed configuration.

公开(公告)号：US20170340438A1

公开(公告)日：2017-11-30

申请号：US15675978

申请日：2017-08-14

Applicant: BOSTON SCIENTIFIC SCIMED, INC.

Inventor： Amr Salahieh ,  Brian D. Brandt ,  Dwight P. Morejohn ,  Ulrich R. Haug ,  Jean-Pierre Dueri ,  Hans F. Valencia ,  Robert A. Geshlider

IPC: A61F2/24

CPC classification number: A61F2/2412 ,  A61F2/2418 ,  A61F2/2439 ,  A61F2220/0016 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2230/005 ,  A61F2230/0054 ,  A61F2230/0065 ,  A61F2230/0078 ,  A61F2250/0069

Abstract: Apparatus for endovascularly replacing a patient's heart valve, including: a replacement valve adapted to be delivered endovascularly to a vicinity of the heart valve; an expandable anchor adapted to be delivered endovascularly to the vicinity of the heart valve; and a lock mechanism configured to maintain a minimum amount of anchor expansion. The invention also includes a method for endovascularly replacing a patient's heart valve. In some embodiments the method includes the steps of: endovascularly delivering a replacement valve and an expandable anchor to a vicinity of the heart valve; expanding the anchor to a deployed configuration; and locking the anchor in the deployed configuration.

公开(公告)号：US09585749B2

公开(公告)日：2017-03-07

申请号：US14490000

申请日：2014-09-18

Applicant: BOSTON SCIENTIFIC SCIMED, INC.

Inventor： Amr Salahieh ,  Brian D. Brandt ,  Dwight P. Morejohn ,  Ulrich R. Haug ,  Jean-Pierre Dueri ,  Hans F. Valencia ,  Robert A. Geshlider ,  Jeff A. Krolik

IPC: A61F2/24

CPC classification number: A61F2/2412 ,  A61F2/2415 ,  A61F2/2418 ,  A61F2/2436 ,  A61F2210/0014 ,  A61F2220/0016 ,  A61F2220/0083 ,  A61F2230/005 ,  A61F2230/0054 ,  A61F2230/0078 ,  A61F2250/0039

Abstract: A replacement heart valve assembly. An expandable anchor is disclosed that has a skirt region, a lip region, and a plurality of posts attached to the skirt region. A replacement heart valve is attached to the posts. The lip region has interlocking elements that are secured to the posts where the interlocking elements have eyelets. Tabs extend into the eyelets to mate with holes in the posts.

Abstract translation: 更换心脏瓣膜组件。 公开了一种可膨胀锚固件，其具有裙部区域，唇缘区域和附接到裙部区域的多个支柱。 替换心脏瓣膜连接到柱上。 唇部区域具有互锁元件，其固定到互锁元件具有孔眼的柱上。 标签延伸到孔眼中以与柱中的孔相配合。

公开(公告)号：US09532872B2

公开(公告)日：2017-01-03

申请号：US14553459

申请日：2014-11-25

Applicant: Boston Scientific Scimed, Inc.

Inventor： Amr Salahieh ,  Hans F. Valencia ,  Brian D. Brandt ,  Claudio Argento ,  Ulrich R. Haug ,  Jean-Pierre Dueri ,  Daniel K. Hildebrand ,  Dwight P. Morejohn ,  Tom Saul

IPC: A61F2/24 ,  A61B17/064 ,  A61B17/068 ,  A61F2/90 ,  A61B17/221 ,  A61B17/22 ,  A61F2/95

CPC classification number: A61F2/2427 ,  A61B17/0644 ,  A61B17/068 ,  A61B17/221 ,  A61B2017/22035 ,  A61B2017/2215 ,  A61F2/2409 ,  A61F2/2418 ,  A61F2/2433 ,  A61F2/2436 ,  A61F2/2439 ,  A61F2/90 ,  A61F2002/9534 ,  A61F2220/0008 ,  A61F2220/0016 ,  A61F2220/0025 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2230/005 ,  A61F2230/0078 ,  A61F2230/008 ,  A61F2250/001

Abstract: The present invention relates to apparatus and methods for endovascularly delivering and releasing a prosthesis, e.g., an aortic prosthesis, within and/or across a patient's native heart valve, referred to hereinafter as replacing the patient's heart valve. In some embodiments the delivery system comprises a plurality of first actuatable element adapted to engage a plurality of second elements in a first configuration to capture the implant within the delivery system, and wherein the plurality of first actuatable element are adapted to engage the plurality of second elements in a second configuration and to release the implant from the delivery system.

Abstract translation: 本发明涉及用于在患者的天然心脏瓣膜内和/或穿过患者的天然心脏瓣膜内血管内递送和释放假体（例如主动脉假体）的装置和方法，以下称为替换患者的心脏瓣膜。 在一些实施例中，递送系统包括多个第一致动元件，其适于以第一构造接合多个第二元件以在输送系统内捕获植入物，并且其中多个第一可致动元件适于接合多个第二可动元件 元件处于第二配置并且从输送系统释放植入物。

公开(公告)号：US20160376063A1

公开(公告)日：2016-12-29

申请号：US15197938

申请日：2016-06-30

Applicant: BOSTON SCIENTIFIC SCIMED INC.

Inventor： Amr Salahieh ,  Tom Saul ,  Robert Geshlider ,  Andrea Johnson ,  Dwight Morejohn ,  Daniel Hildebrand ,  Jean-Pierre Dueri

IPC: B65D25/04 ,  B65D81/22 ,  A61F2/24 ,  B65B5/04 ,  B65B55/16 ,  A61F2/00 ,  B65D41/04

CPC classification number: B65D25/04 ,  A61F2/0095 ,  A61F2/2427 ,  A61F2002/9517 ,  B65B5/04 ,  B65B55/16 ,  B65D41/04 ,  B65D81/22

Abstract: The invention provides a two-part package and method of use for a pre-attached medical implant and delivery tool system. The package includes a wet compartment and a dry compartment and allows a pre-attached implant and delivery tool system to be at least partially stored immersed in a fluid in the wet compartment and at least partially stored in the dry compartment. In one embodiment the implant comprises a replacement heart valve, and the heart valve is stored inside the wet compartment while the heart valve delivery tool remains dry in the dry compartment.

Abstract translation: 本发明提供了用于预附接的医疗植入物和递送工具系统的两部分包装和使用方法。 该包装包括湿室和干燥室，并且允许将预先附着的植入物和递送工具系统至少部分地储存在浸入湿室中的流体中并且至少部分储存在干燥室中。 在一个实施例中，植入物包括置换心脏瓣膜，并且心脏瓣膜储存在湿室内，而心脏瓣膜递送工具在干燥室中保持干燥。

公开(公告)号：US20160135951A1

公开(公告)日：2016-05-19

申请号：US15006227

申请日：2016-01-26

Applicant: BOSTON SCIENTIFIC SCIMED, INC.

Inventor： Amr Salahieh ,  Brian D. Brandt ,  Dwight P. Morejohn ,  Ulrich R. Haug ,  Jean-Pierre Dueri ,  Hans F. Valencia ,  Robert A. Geshlider ,  Jeff A. Krolik

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2/2427 ,  A61F2/2433 ,  A61F2/2436 ,  A61F2/2439 ,  A61F2002/9528 ,  A61F2220/0016 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/005 ,  A61F2230/0054 ,  A61F2230/0065 ,  A61F2230/0078 ,  A61F2250/006

Abstract: Apparatus for endovascularly replacing a patient's heart valve, including: a delivery catheter having a diameter of 21 french or less; an expandable anchor disposed within the delivery catheter; and a replacement valve disposed within the delivery catheter. The invention also includes a method for endovascularly replacing a heart valve of a patient. In some embodiments the method includes the steps of: inserting a catheter having a diameter no more than 21 french into the patient; endovascularly delivering a replacement valve and an expandable anchor to a vicinity of the heart valve through the catheter; and deploying the anchor and the replacement valve.

Abstract translation: 用于血管内替换患者心脏瓣膜的装置，包括：直径为21法郎或更小的输送导管; 布置在输送导管内的可扩张锚; 以及设置在输送导管内的置换瓣膜。 本发明还包括用于血管内置换患者心脏瓣膜的方法。 在一些实施例中，该方法包括以下步骤：将具有不超过21个法兰的直径的导管插入患者体内; 通过导管将血管内递送更换瓣膜和可扩张锚固件到心脏瓣膜附近; 并部署锚杆和更换阀。