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21.发明授权公开(公告)号：US09120794B2
公开(公告)日：2015-09-01
申请号：US14575171
申请日：2014-12-18
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Lynn Abell , Leonard Adam , Cullen L. Cavallaro , Heather Finlay , Todd J. Friends , Jon J. Hangeland , Ji Jang , R. Michael Lawrence , John Lloyd , Zulan Pi , George O. Tora , Jennifer X. Qiao , Carol Hui Hu , Tammy C. Wang
IPC: C07D471/04 , C07D403/12 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D405/06 , C07D405/12 , C07D417/04 , C07D417/06 , C07D207/28 , C07D207/38 , C07D417/12 , C07D487/04 , C07D413/06
CPC classification number: C07D471/04 , C07D207/28 , C07D207/38 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D413/06 , C07D417/04 , C07D417/06 , C07D417/12 , C07D487/04
Abstract: The present invention provides compounds of Formula (I) or Formula (III): as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.
Abstract translation: 本发明提供式（I）或式（III）的化合物：如说明书中所定义和包含任何这些新化合物的组合物。 这些化合物是可用作药物的内皮脂肪酶抑制剂。
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22.发明授权Amide, urea or sulfone amide linked benzothiazole inhibitors of endothelial lipase 有权酰胺，尿素或砜酰胺连接苯并噻唑抑制剂的内皮脂肪酶公开(公告)号：US08987314B2
公开(公告)日：2015-03-24
申请号：US13944921
申请日：2013-07-18
Applicant: Bristol-Myers Squibb Company
Inventor： Heather Finlay , Ji Jiang , Soong-Hoon Kim , Brandon Parkhurst , Jennifer X. Qiao , Tammy C. Wang , Zulan Pi , George O. Tora , John Lloyd , James A. Johnson
IPC: C07D277/64 , C07D417/04 , C07D417/10 , C07D417/12 , C07D417/14 , A61K31/428 , A61P9/10
CPC classification number: C07D277/64 , C07D417/04 , C07D417/10 , C07D417/12 , C07D417/14
Abstract: The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.
Abstract translation: 本发明提供式（I）化合物：如说明书中所定义和包含任何这些新化合物的组合物。 这些化合物是可用作药物的内皮脂肪酶抑制剂。
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23.发明申请公开(公告)号：US20140221357A1
公开(公告)日：2014-08-07
申请号：US14346745
申请日：2012-09-25
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Lynn Abell , Leonard Adam , Cullen L. Cavallaro , Heather Finlay , Todd J. Friends , Jon J. Hangeland , Ji Jiang , R. Michael Lawrence , John Lloyd , Zulan Pi , George O. Tora , Jennifer X. Qiao , Carol Hui Hu , Tammy C. Wang
IPC: C07D207/38 , C07D417/12 , C07D471/04 , C07D417/04 , C07D401/12 , C07D403/12 , C07D403/04 , C07D487/04 , C07D403/06
CPC classification number: C07D471/04 , C07D207/28 , C07D207/38 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D413/06 , C07D417/04 , C07D417/06 , C07D417/12 , C07D487/04
Abstract: The present invention provides compounds of Formula (I) or Formula (III): [INSERT CHEMICAL STRUCTURE HERE] (I) [INSERT CHEMICAL STRUCTURE HERE] (III) as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.
Abstract translation: 本发明提供式（I）或式（III）的化合物：[INSERT CHEMICAL Structure这里]（I）如本说明书中定义的[INSERT CHEMICAL STRUCTURE HERE]（III）和包含任何这些新化合物的组合物。 这些化合物是可用作药物的内皮脂肪酶抑制剂。
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公开(公告)号：US11673886B2
公开(公告)日：2023-06-13
申请号：US17349980
申请日：2021-06-17
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Peter W. Glunz , Vladimir Ladziata , Indawati De Lucca , George O. Tora , Tarun Kumar Maishal , Raghuram Tangirala , Kamalraj Thiyagarajan
IPC: C07D417/12 , C07D401/14 , C07D403/12 , C07D417/14 , C07D471/04 , C07D495/04 , C07D519/00 , C07D491/052
CPC classification number: C07D417/12 , C07D401/14 , C07D403/12 , C07D417/14 , C07D471/04 , C07D491/052 , C07D495/04 , C07D519/00
Abstract: The present invention provides compounds of Formula (I):
or stereoisomers, tautomers, or pharmaceutically-acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.-
公开(公告)号：US11078197B2
公开(公告)日：2021-08-03
申请号：US16629717
申请日：2018-07-11
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Peter W. Glunz , Vladimir Ladziata , Indawati De Lucca , George O. Tora , Tarun Kumar Maishal , Raghuram Tangirala , Kamalraj Thiyagarajan
IPC: C07D417/12 , C07D401/14 , C07D403/12 , C07D417/14 , C07D471/04 , C07D491/052 , C07D495/04 , C07D519/00
Abstract: The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically-acceptable salts thereof wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.
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Patent Agency Ranking
公开(公告)号：US10889565B2
公开(公告)日：2021-01-12
申请号：US16309168
申请日：2017-06-14
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Ji Jiang , Heather Finlay , Soong-Hoon Kim , Wei Meng , George O. Tora
IPC: C07D401/12 , C07D221/00 , C07D401/14 , C07D413/14 , C07D471/04
Abstract: The present invention provides compounds of Formula (I) wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.
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公开(公告)号：US09540323B2
公开(公告)日：2017-01-10
申请号：US14418023
申请日：2013-07-30
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Alexandre L'Heureux , Sheldon Hiebert , Carol Hu , Patrick Y. S. Lam , John Lloyd , Zulan Pi , Jennifer X. Qiao , Carl Thibeault , George O. Tora , Wu Yang , Yufeng Wang , Tammy C. Wang , Michael S. Bowsher , Ruel Rejean
IPC: C07D209/26 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/14 , C07D409/04 , C07D413/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D498/04 , C07D209/14 , C07D513/04 , C07D403/12 , C07D413/14 , C07D417/04
CPC classification number: C07D209/26 , C07D209/14 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D403/14 , C07D409/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D498/04 , C07D513/04
Abstract: The present invention provides compounds of Formula (I): Formula (I) as defined in the specification and compositions comprising any of such novel compounds. These compounds are antagonists of P2Y1 receptor which may be used medicaments.
Abstract translation: 本发明提供式（I）化合物：如说明书中所定义的式（I）和包含任何这些新化合物的组合物。 这些化合物是可以使用药物的P2Y1受体的拮抗剂。
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公开(公告)号：US09169240B2
公开(公告)日：2015-10-27
申请号：US14427105
申请日：2013-09-05
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： George O. Tora , Heather Finlay , Carol Hui Hu , Ji Jiang , James A. Johnson , Soong-Hoon Kim , John Lloyd , Brandon Parkhurst , Zulan Pi , Jennifer X. Qiao , Tammy C. Wang
IPC: C07D417/06 , C07D417/14
CPC classification number: C07D417/06 , C07D417/14
Abstract: The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicament.
Abstract translation: 本发明提供式（I）化合物：如说明书中所定义和包含任何这些新化合物的组合物。 这些化合物是可用作药物的内皮脂肪酶抑制剂。
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29.发明申请公开(公告)号：US20150105378A1
公开(公告)日：2015-04-16
申请号：US14575171
申请日：2014-12-18
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Lynn Abell , Leonard Adam , Cullen L. Cavallaro , Heather Finlay , Todd J. Friends , Jon J. Hangeland , Ji Jiang , R. Michael Lawrence , John Lloyd , Zulan Pi , George O. Tora , Jennifer X. Qiao , Carol Hui Hu , Tammy C. Wang
IPC: C07D471/04 , C07D487/04 , C07D413/06 , C07D403/06 , C07D401/12 , C07D207/38 , C07D417/12
CPC classification number: C07D471/04 , C07D207/28 , C07D207/38 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D413/06 , C07D417/04 , C07D417/06 , C07D417/12 , C07D487/04
Abstract: The present invention provides compounds of Formula (I) or Formula (III): as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.
Abstract translation: 本发明提供式（I）或式（III）的化合物：如说明书中所定义和包含任何这些新化合物的组合物。 这些化合物是可用作药物的内皮脂肪酶抑制剂。
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30.发明授权公开(公告)号：US08952180B2
公开(公告)日：2015-02-10
申请号：US14346745
申请日：2012-09-25
Applicant: Bristol-Myers Squibb Company
Inventor： Lynn Abell , Leonard Adam , Cullen L. Cavallaro , Heather Finlay , Todd J. Friends , Jon J. Hangeland , Ji Jiang , R. Michael Lawrence , John Lloyd , Zulan Pi , George O. Tora , Jennifer X. Qiao , Carol Hui Hu , Tammy C. Wang
IPC: A61K31/44 , A61K31/40 , C07D221/02 , C07D205/00 , C07D207/38 , C07D403/12 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D405/06 , C07D405/12 , C07D417/04 , C07D417/06 , C07D471/04 , C07D207/28 , C07D417/12 , C07D487/04
CPC classification number: C07D471/04 , C07D207/28 , C07D207/38 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D413/06 , C07D417/04 , C07D417/06 , C07D417/12 , C07D487/04
Abstract: The present invention provides compounds of Formula (I) or Formula (III): [INSERT CHEMICAL STRUCTURE HERE] (I) [INSERT CHEMICAL STRUCTURE HERE] (III) as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.
Abstract translation: 本发明提供式（I）或式（III）的化合物：[INSERT CHEMICAL Structure这里]（I）如本说明书中定义的[INSERT CHEMICAL STRUCTURE HERE]（III）和包含任何这些新化合物的组合物。 这些化合物是可用作药物的内皮脂肪酶抑制剂。
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