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公开(公告)号：US11161837B2
公开(公告)日：2021-11-02
申请号：US16083972
申请日：2017-03-17
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Kap-Sun Yeung , John F. Kadow , Rajesh Onkardas Bora , Prakash Anjanappa , Kumaravel Selvakumar , Samayamunthula Venkata Satya Arun Kumar Gupta
IPC: C07D405/12 , C07D307/84 , C07D413/12 , A61K31/343 , A61K31/4245 , A61K31/506 , A61P31/00 , A61P31/14
Abstract: The disclosure provides compounds of formula (I), including their salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.
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公开(公告)号：US20200291002A1
公开(公告)日：2020-09-17
申请号：US16083972
申请日：2017-03-17
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Kap-Sun Yeung , John F. Kadow , Rajesh Onkardas Bora , Prakash Anjanappa , Kumaravel Selvakumar , Samayamunthula Venkata Satya Arun Gupta
IPC: C07D405/12 , C07D307/84 , C07D413/12
Abstract: The disclosure provides compounds of formula (I), including their salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.
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公开(公告)号：US20180099953A1
公开(公告)日：2018-04-12
申请号：US15551012
申请日：2016-02-17
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Tao Wang , Zhiwei Yin , John F. Kadow
IPC: C07D405/10 , A61P31/14 , C07D405/12 , C07D307/84 , C07D413/14 , C07D405/14 , C07D417/14
CPC classification number: C07D405/10 , A61P31/14 , C07D307/84 , C07D401/10 , C07D401/14 , C07D405/12 , C07D405/14 , C07D413/14 , C07D417/14
Abstract: Compounds of Formula I, including their salts, as well as compositions and methods of using the compounds are set forth. The compounds have activity against hepatitis C virus (HCV) and areuseful in treating those infected with HCV.
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公开(公告)号：US20180030017A1
公开(公告)日：2018-02-01
申请号：US15551009
申请日：2016-02-17
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Tao Wang , Zhiwei Yin , John F. Kadow
IPC: C07D307/82 , C07D405/12
CPC classification number: C07D307/82 , C07D307/84 , C07D405/12
Abstract: Compounds of Formula (I), including their salts, as well as compositions and methods of using the compounds are set forth. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
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公开(公告)号：US20180022723A1
公开(公告)日：2018-01-25
申请号：US15551017
申请日：2016-02-19
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Kap-Sun Yeung , John F. Kadow , Rajesh Onkardas Bora , Prakash Anjanapa , Samayamunthula Venkata Satya Arun Kumar
IPC: C07D307/84 , C07D417/12 , C07D413/12 , C07B59/00 , C07D405/12
CPC classification number: C07D307/84 , C07B59/002 , C07B2200/05 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04
Abstract: The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.
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Patent Agency Ranking
26.发明授权公开(公告)号：US09840511B2
公开(公告)日：2017-12-12
申请号：US15312022
申请日：2015-05-19
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Tao Wang , Zhongxing Zhang , John F. Kadow
IPC: C07D307/78 , C07D491/048 , C07D405/10 , C07D307/84
CPC classification number: C07D491/048 , C07D307/84 , C07D405/10
Abstract: Compounds of Formula I, including their salts, as well as compositions and methods of using the compounds are set forth. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV: formula (I).
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27.发明授权Imidazopyridine macrocycles as inhibitors of human immunodeficiency virus replication 有权咪唑并吡啶大环化合物作为人体免疫缺陷病毒复制的抑制剂公开(公告)号：US09409922B2
公开(公告)日：2016-08-09
申请号：US14619213
申请日：2015-02-11
Applicant: Bristol-Myers Squibb Company
Inventor： Kevin Peese , Zhongyu Wang , John F. Kadow , Prasanna Sivaprakasam , B. Narasimhulu Naidu
IPC: C07D471/04 , C07D498/22
CPC classification number: C07D498/22 , C07D471/04
Abstract: The disclosure generally relates to compounds of formula I, including compositions and methods for treating human immunodeficiency virus (HIV) infection. The disclosure provides novel inhibitors of HIV, pharmaceutical compositions containing such compounds, and methods for using these compounds in the treatment of HIV infection.
Abstract translation: 本公开一般涉及式I化合物，包括用于治疗人类免疫缺陷病毒（HIV）感染的组合物和方法。 本公开提供了HIV的新型抑制剂，含有这些化合物的药物组合物，以及使用这些化合物治疗HIV感染的方法。
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公开(公告)号：US20160158200A1
公开(公告)日：2016-06-09
申请号：US14903024
申请日：2013-07-09
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Piyasena Hewawasam , Omar D. Lopez , Yong Tu , Alan Xiangdong Wang , Ningning Xu , John F. Kadow , Nicholas A. Meanwell , Samayamunthula Venkata Satya Arun Kumar Gupta , Indasi J. Gopi Kumar , Suresh Kumar Punugupati , Makonen Belema
IPC: A61K31/4178 , A61K31/444 , A61K31/4439 , A61K31/497 , A61K31/695 , A61K31/4545 , A61K31/5377 , A61K31/437 , A61K31/5365 , A61K31/519 , A61K45/06 , A61K31/4725
CPC classification number: A61K31/4178 , A61K31/4184 , A61K31/437 , A61K31/439 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61K31/519 , A61K31/5365 , A61K31/5377 , A61K31/695 , A61K31/7056 , A61K38/21 , A61K45/06 , A61K2300/00
Abstract: The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein.
Abstract translation: 本公开通常涉及抗病毒化合物，更具体地涉及可以抑制丙型肝炎病毒（HCV）编码的NS5A蛋白的功能的化合物的组合，包含这些组合的组合物，以及用于抑制NS5A的功能的方法 蛋白。
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29.发明授权Pyrazolopyrimidine macrocycles as inhibitors of human immunodeficiency virus replication 有权吡唑并嘧啶大环化合物作为人类免疫缺陷病毒复制的抑制剂公开(公告)号：US09273067B2
公开(公告)日：2016-03-01
申请号：US14619728
申请日：2015-02-11
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： B. Narasimhulu Naidu , Michael A. Walker , Margaret E. Sorenson , Manoj Patel , Zhizhen Barbara Zheng , John F. Kadow , Bin Zheng , Martin D. Eastgate , Ke Chen , Francisco Gonzalez-Bobes
IPC: C07D498/22 , C07D211/48
CPC classification number: C07D498/22 , C07D211/48
Abstract: The disclosure generally relates to compounds of formula I, including compositions and methods for treating human immunodeficiency virus (HIV) infection. The disclosure provides novel inhibitors of HIV, pharmaceutical compositions containing such compounds, and methods for making and using these compounds in the treatment of HIV infection.
Abstract translation: 本公开一般涉及式I化合物，包括用于治疗人类免疫缺陷病毒（HIV）感染的组合物和方法。 本公开提供了HIV的新型抑制剂，含有这些化合物的药物组合物，以及制备和使用这些化合物治疗HIV感染的方法。
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30.发明授权Cyano containing azabenzofuran compounds for the treatment of hepatitis C 有权含有氮杂苯并呋喃化合物的Cyano用于治疗丙型肝炎公开(公告)号：US09249152B2
公开(公告)日：2016-02-02
申请号：US14663497
申请日：2015-03-20
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Tao Wang , Kyle J. Eastman , Zhongxing Zhang , Kyle E. Parcella , Zhiwei Yin , John F. Kadow
IPC: C07D491/048 , C07D491/04
CPC classification number: C07D491/048 , C07D491/04
Abstract: Compounds of Formula I, including their salts, as well as compositions and methods of using the compounds are set forth. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV:
Abstract translation: 阐述了式I化合物，包括它们的盐，以及使用该化合物的组合物和方法。 该化合物具有抗丙型肝炎病毒（HCV）的活性，可用于治疗HCV感染者：
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