公开(公告)号：US20100073680A1

公开(公告)日：2010-03-25

申请号：US12626577

申请日：2009-11-25

申请人： Benjamin D. Pless

发明人： Benjamin D. Pless

IPC分类号： G01B9/02

CPC分类号： G06K9/2036 ,  G06K9/00577

摘要： Disclosed are a method and system for performing device identification and a medical device susceptible to identification using interference patterns for performing device identification. A source signal may be directed from an energy source towards the surface of a device for reflection therefrom. An interference pattern may be detected from the surface of the device, such as by a sensor. A determination as to whether a match exists between the representation of the interference pattern and a stored representation of an interference pattern may be performed. If a match exists, the device may be identified based on the stored representation of the interference pattern. Otherwise, a representation of the interference pattern may be stored and a unique identifier may be assigned to the stored representation of the interference pattern.

摘要翻译： 公开了用于执行设备识别的方法和系统以及易于使用用于执行设备识别的干扰图案的识别的医疗设备。 源信号可以从能量源朝向装置的表面引导以从其反射。 可以从设备的表面（例如通过传感器）检测干涉图案。 可以执行关于在干涉图案的表示和存储的干涉图案的表示之间是否存在匹配的确定。 如果存在匹配，则可以基于存储的干涉图案的表示来识别该设备。 否则，可以存储干扰图案的表示，并且可以将唯一标识符分配给所存储的干涉图案的表示。

公开(公告)号：US20080319511A1

公开(公告)日：2008-12-25

申请号：US11767432

申请日：2007-06-22

申请人： Benjamin D. Pless

发明人： Benjamin D. Pless

IPC分类号： A61N1/36 ,  A61B5/04

CPC分类号： A61N1/37247 ,  A61B5/0008 ,  A61B5/0031 ,  A61B5/021 ,  A61B5/0476 ,  A61B5/11 ,  A61B5/4094 ,  A61B2562/0219 ,  A61N1/36071

摘要： An implantable neurostimulator for treating disorders such as epilepsy, pain, movement disorders and depression includes a detection subsystem capable of detecting a physiological condition and a therapy subsystem capable of providing a course of therapy in response to the condition. The therapy subsystem includes an auto-adjust module for automatically adjusting one or more parameters of the therapy so that the therapy subsystem can provide an adjusted parameter to the patient and solicit the patient's feedback concerning the adjustment without requiring the presence of, or immediate involvement with, a clinician or physician. The patient feedback can be analyzed by computer, clinician or a combination of both to determine an optimal range of parameters for subsequent courses of therapy. In this manner, information useful in tuning the neurostimulator therapy parameters to optimize them for individual patient can be acquired automatically outside of the traditional clinical setting, saving time and minimizing patient fatigue that otherwise would be experience in marathon, in-clinic tuning sessions. The auto-adjust module also can be configured to prompt the patient to provide feedback even when parameters are not being adjusted, so as to acquire information for a baseline or about any placebo effect when the patient is otherwise expecting changes to the therapy to be made.

摘要翻译： 用于治疗诸如癫痫，疼痛，运动障碍和抑郁症的疾病的可植入神经刺激器包括能够检测生理状况的检测子系统和能够响应于该病症提供治疗过程的治疗子系统。 治疗子系统包括用于自动调整治疗的一个或多个参数的自动调整模块，使得治疗子系统可以向患者提供经调整的参数，并征求患者关于调整的反馈，而不需要存在或立即参与 ，临床医生或医师。 患者反馈可以由计算机，临床医师或两者的组合进行分析，以确定后续治疗疗程的最佳参数范围。 以这种方式，可以在传统临床环境之外自动获取调整神经刺激器治疗参数以优化个体患者的信息的有用信息，节省时间并最大限度地减少患者疲劳，否则将在马拉松，临床内调整课程中体验。 自动调整模块还可以被配置为即使在参数未被调整的情况下也提示患者提供反馈，以便当患者以其他方式期望改变治疗时获得基线信息或约为任何安慰剂效应 。

公开(公告)号：US20080195227A1

公开(公告)日：2008-08-14

申请号：US11704549

申请日：2007-02-08

申请人： C. Lance Boling ,  Daniel Chao ,  Martha J. Morrell ,  Benjamin D. Pless ,  Thomas K. Tcheng ,  Brett M. Wingeier

发明人： C. Lance Boling ,  Daniel Chao ,  Martha J. Morrell ,  Benjamin D. Pless ,  Thomas K. Tcheng ,  Brett M. Wingeier

IPC分类号： A61F2/00 ,  B05D3/00 ,  B22F3/11

CPC分类号： A61N1/0529 ,  A61N1/0536 ,  A61N1/0539 ,  A61N1/0551 ,  A61N1/36082 ,  B22F3/10 ,  B22F2003/241 ,  B22F2003/242 ,  B22F2998/10 ,  B22F3/24

摘要： Medical electrical lead systems and related methods are described. The lead systems may be configured to be at least partially implanted in neural tissue of a subject, such as a brain of a subject. Some variations of the lead systems may comprise a lead body, an electrode connected to the lead body, and a bioactive agent. The electrode and/or lead body may comprise a substrate, and the bioactive agent may be supported by the substrate (e.g., by a substantial portion of the area of the substrate). Examples of bioactive agents that may be used in the lead system include antiproliferative agents, bactericidal agents, bacteriostatic agents, antiepileptic agents, and/or antifungal agents. Methods described herein may comprise coating a lead body and/or an electrode of a medical electrical lead system with at least one bioactive agent, where the lead body and the electrode are connected to each other.

摘要翻译： 描述医用电引线系统及相关方法。 引导系统可以被配置为至少部分地植入受试者的神经组织，例如受试者的脑部。 引线系统的一些变型可以包括引线体，连接到引线主体的电极和生物活性剂。 电极和/或引线主体可以包括衬底，并且生物活性剂可以由衬底支撑（例如，通过衬底的大部分区域）。 可用于引导系统的生物活性剂的实例包括抗增殖剂，杀菌剂，抑菌剂，抗癫痫剂和/或抗真菌剂。 本文所述的方法可以包括用至少一种生物活性剂涂覆医疗电引线系统的引线体和/或电极，其中引线体和电极彼此连接。

公开(公告)号：US20080123098A1

公开(公告)日：2008-05-29

申请号：US11556357

申请日：2006-11-03

申请人： Benjamin D. Pless

发明人： Benjamin D. Pless

IPC分类号： G01B9/02

CPC分类号： G06K9/2036 ,  G06K9/00577

摘要： A method and system for performing device identification is disclosed. A source signal may be directed from an energy source towards the surface of a device for reflection therefrom. An interference pattern may be detected from the surface of the device, such as by a sensor. A determination as to whether a match exists between the representation of the interference pattern and a stored representation of an interference pattern may be performed. If a match exists, the device may be identified based on the stored representation of the interference pattern. Otherwise, a representation of the interference pattern may be stored and a unique identifier may be assigned to the stored representation of the interference pattern.

摘要翻译： 公开了一种用于执行设备识别的方法和系统。 源信号可以从能量源朝向装置的表面引导以从其反射。 可以从设备的表面（例如通过传感器）检测干涉图案。 可以执行关于在干涉图案的表示和存储的干涉图案的表示之间是否存在匹配的确定。 如果存在匹配，则可以基于存储的干涉图案的表示来识别该设备。 否则，可以存储干扰图案的表示，并且可以将唯一标识符分配给所存储的干涉图案的表示。

公开(公告)号：US07089059B1

公开(公告)日：2006-08-08

申请号：US09706322

申请日：2000-11-03

申请人： Benjamin D. Pless

发明人： Benjamin D. Pless

IPC分类号： A61N1/32

CPC分类号： A61B5/6864 ,  A61B5/0031 ,  A61B5/0484 ,  A61B5/4094 ,  A61B5/7203 ,  A61N1/36064 ,  A61N1/36135

摘要： A system and method for determining and predicting a patient's susceptibility to neurological dysfunction based on measured electrophysiological parameters employs a self-contained implantable device with depth electrodes implanted in desired locations in the patient's brain. The patient's neurological tissue is stimulated to determine excitability and refractoriness (or inhibition period) parameters, which are employed to identify susceptibility to abnormal neurological activity, particularly epileptic seizures.

摘要翻译： 基于测量的电生理参数来确定和预测患者对神经功能障碍的敏感性的系统和方法使用具有植入患者大脑中期望位置的深度电极的独立可植入装置。 刺激患者的神经组织以确定兴奋性和耐受性（或抑制期）参数，其用于鉴定对异常神经活动的敏感性，特别是癫痫发作。

公开(公告)号：US06480743B1

公开(公告)日：2002-11-12

申请号：US09962940

申请日：2001-09-24

申请人： Bruce Kirkpatrick ,  Benjamin D. Pless

发明人： Bruce Kirkpatrick ,  Benjamin D. Pless

IPC分类号： A61N136

CPC分类号： A61N1/36135 ,  A61N1/36064 ,  A61N1/3615 ,  A61N1/36167

摘要： An implantable neurostimulator adapted to provide adaptive electrical brain stimulation includes a detection subsystem for isolating an electrographic signal characteristic and a stimulation system for applying an adaptive stimulation signal based at least in part upon the electrographic signal characteristic and correlated with the electrographic signal. Undesired learning of and acclimation to stimulation characteristics are avoided and stimulation efficacy is improved by adapting or otherwise varying the adaptive stimulation signal in relation to the electrographic signal.

摘要翻译： 适于提供自适应电脑刺激的可植入神经刺激器包括用于隔离电摄影信号特征的检测子系统和用于至少部分地基于电摄影信号特征并与电摄影信号相关联的施加自适应刺激信号的刺激系统。 避免对刺激特征的不期望的学习和适应，并且通过适应或以其它方式改变与电摄影信号相关的自适应刺激信号来提高刺激功效。

公开(公告)号：US06256535B1

公开(公告)日：2001-07-03

申请号：US09342796

申请日：1999-06-29

申请人： Rose Province ,  Benjamin D. Pless

发明人： Rose Province ,  Benjamin D. Pless

IPC分类号： A61N139

CPC分类号： A61N1/3925 ,  A61N1/3956

摘要： A method for delivering cardiac therapy, particularly defibrillation therapy, using an implantable cardioverter-defibrillator (ICD) or other cardiac therapy device. The method can be used either alone or in conjunction with any other suitable defibrillation (or other cardiac) therapy regimen. If used in conjunction with a conventional or other suitable defibrillation therapy regimen, the method can be considered to precondition the heart in advance of delivery of the defibrillation shock(s), in order to reduce the defibrillation threshold (DFT), and thus reduce the overall energy required for delivery of effective defibrillation therapy. In either case, in accordance with the method, the voltage gradients (VGs) across a plurality of different regions of the heart are sensed, e.g., using an endocardial sensor array (ESA), and a respective plurality of electrograms (EGMs) are produced in respective EGM channels. The excitable gaps (i.e., the intervals between successive activations) in the different VG regions of the heart are then brought into phase alignment with one another by appropriately timing the delivery of electrical stimulation (e.g., one or more pulses). In this connection, either the timing of the next activation interval can be advanced by delivering an electrical stimulus (pulse) during the excitable gap or in the late repolarization phase of the previous activation, or the activation interval can be extended by delivering an electrical stimulus earlier in the repolarization phase of the previous activation, leading to an extension of the refractory period (i.e., RPE). If three or more EGM channels are used, the excitable gaps in the different VG regions are preferably brought into phase with one another by first bringing the region associated with the near-field EGM channel into phase alignment with the region associated with the EGM channel of the adjacent (next highest) VG region and then successively entraining the thusly entrained regions with the regions associated with the EGM channels corresponding to the successively more distant VG regions, until the regions associated with all EGM channels are brought into phase alignment with one another. Also disclosed is a cardiac therapy device (e.g., an ICD) for implementing this method.

公开(公告)号：US5922215A

公开(公告)日：1999-07-13

申请号：US732651

申请日：1996-10-15

申请人： Benjamin D. Pless ,  William H. Elias ,  Sam Parler ,  J. Scott McCall

发明人： Benjamin D. Pless ,  William H. Elias ,  Sam Parler ,  J. Scott McCall

IPC分类号： A61N1/39 ,  H01G9/00 ,  B44C1/22 ,  C23F1/00

CPC分类号： H01G9/0029 ,  H01G9/00 ,  A61N1/3956

摘要： A method for making anode foil plates for use with layered electrolytic capacitors and capacitors made with such plates. A high purity aluminum foil is provided for generation of anode foil plates. Sheets of the foil are highly etched to provide a very high surface area. Following the etch process, the foil is partially cut or punched into plates from the etched sheets in the general shape of the finished capacitor housing with a portion remaining connected to the supporting foil. The supporting foil with the partially punched-out etched plates are subjected to a forming process by applying a voltage to the plates in the presence of an electrolyte to provide formed anode foil plates with edges which do not have to be reformed during capacitor aging and which do not have any particulates at cut edges. The formed anode plates are layered with cathode plates and separators in a capacitor housing with an electrolyte to provide a finished capacitor.

摘要翻译： 一种用于制造用这种板制成的层状电解电容器和电容器的阳极箔板的方法。 提供高纯度铝箔来生成阳极箔片。 箔的片被高度蚀刻以提供非常高的表面积。 在蚀刻工艺之后，将箔从被蚀刻的片材以完整的电容器壳体的大致形状部分地切割或冲压成板，其中一部分保持连接到支撑箔。 通过在电解质存在下向板上施加电压来对具有部分冲压蚀刻板的支撑箔进行成形处理，以在电容器老化期间提供具有不必重整的边缘的形成的阳极箔板，并且其中 在切割边缘没有任何颗粒物。 形成的阳极板与阴极板和分离器层叠在具有电解质的电容器壳体中以提供成品电容器。

公开(公告)号：US5763911A

公开(公告)日：1998-06-09

申请号：US658431

申请日：1996-06-05

申请人： M. Dean Matthews ,  Benjamin D. Pless

发明人： M. Dean Matthews ,  Benjamin D. Pless

IPC分类号： H01G2/16 ,  H01G2/14 ,  H01G4/30 ,  H01L27/108

CPC分类号： H01G2/14 ,  H01G4/306 ,  Y10S257/905 ,  Y10S257/908 ,  Y10S257/909

摘要： A capacitor optimized for use in an implantable medical device such as an implantable defibrillator is disclosed. In its simplest form, the capacitor comprises a thin planar dielectric sheet that has an array of cells open to one or both sides. Metallization is applied to the surface of the cells such that the walls of adjacent cells form a capacitor with the wall that separates the cells serving as the dielectric. The metallization pattern that forms the electrical connection to the cells may be patterned to limit the allowable current flow to each individual cell, thereby providing a fuse in the case of local dielectric failure.

摘要翻译： 公开了一种优化用于植入式除颤器的可植入医疗装置的电容器。 在其最简单的形式中，电容器包括薄平面电介质片，其具有向一侧或两侧敞开的单元阵列。 金属化被施加到电池的表面，使得相邻电池的壁与隔离用作电介质的电池的壁形成电容器。 形成与电池的电连接的金属化图案可以被图案化以限制到每个单独电池的容许电流，从而在局部电介质故障的情况下提供熔丝。

公开(公告)号：US5723969A

公开(公告)日：1998-03-03

申请号：US660259

申请日：1996-06-07

申请人： Stephen T. Archer ,  Kenneth J. Carroll ,  Benjamin D. Pless

发明人： Stephen T. Archer ,  Kenneth J. Carroll ,  Benjamin D. Pless

IPC分类号： H02J7/00 ,  H01M10/44 ,  H01M10/46

CPC分类号： H02J7/0093

摘要： A high voltage charger operates in a three-phase cycle. In a first phase, the high voltage charger operates at a fixed frequency. In a second phase, the high voltage charger operates at a variable frequency designed to draw a substantially constant average current from a power source. In the third phase, the high voltage charger returns to fixed frequency operation. The variable frequency is the reciprocal of the sum of an on-time and an off-time of the switch. In one embodiment, the on-time is provided by the time required for the switch to reach a predetermined maximum and the off-time is provided by the time over which a magnetic field in a transformer collapses.

摘要翻译： 高压充电器以三相循环工作。 在第一阶段，高压充电器以固定频率工作。 在第二阶段中，高压充电器以设计成从电源绘制基本恒定的平均电流的可变频率工作。 在第三阶段，高压充电器返回固定频率运行。 可变频率是开关的导通时间和关断时间之和的倒数。 在一个实施例中，导通时间由开关达到预定最大值所需的时间提供，并且关断时间由变压器中的磁场塌陷的时间提供。