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公开(公告)号：US20110004282A1
公开(公告)日：2011-01-06
申请号：US12871865
申请日：2010-08-30
申请人： C. Lance Boling , Daniel Chao , Martha J. Morrell , Benjamin D. Pless , Thomas K. Tcheng , Brett M. Wingeier
发明人： C. Lance Boling , Daniel Chao , Martha J. Morrell , Benjamin D. Pless , Thomas K. Tcheng , Brett M. Wingeier
IPC分类号： A61N1/05
CPC分类号： A61N1/0529 , A61N1/0536 , A61N1/0539 , A61N1/0551 , A61N1/36082 , B22F3/10 , B22F2003/241 , B22F2003/242 , B22F2998/10 , B22F3/24
摘要： Medical electrical lead systems and related methods are described. The lead systems may be configured to be at least partially implanted in neural tissue of a subject, such as a brain of a subject. Some variations of the lead systems may comprise a lead body, an electrode connected to the lead body, and a bioactive agent. The electrode and/or lead body may comprise a substrate, and the bioactive agent may be supported by the substrate (e.g., by a substantial portion of the area of the substrate). Examples of bioactive agents that may be used in the lead system include bioactive agents that promote neural adhesion and living cells that have been biologically manipulated, engineered cells, and cells of a particular phenotype and/or adapted to induce a desired neural or glial response. Methods described herein may comprise contacting the substrate of a lead body and/or an electrode of a medical electrical lead system with at least one bioactive agent, where the lead body and the electrode are connected to each other.
摘要翻译： 描述医用电引线系统及相关方法。 引导系统可以被配置为至少部分地植入受试者的神经组织，例如受试者的脑部。 引线系统的一些变型可以包括引线体，连接到引线主体的电极和生物活性剂。 电极和/或引线主体可以包括衬底，并且生物活性剂可以由衬底支撑（例如，通过衬底的大部分区域）。 可用于引导系统的生物活性剂的实例包括促进神经粘附的生物活性剂和已被生物操作的工程细胞，特定表型的细胞和/或适于诱导所需神经或神经胶质反应的活细胞。 本文描述的方法可以包括将铅体的基底和/或医用电引线系统的电极与至少一种生物活性剂接触，其中引线体和电极彼此连接。
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公开(公告)号：US20080195227A1
公开(公告)日：2008-08-14
申请号：US11704549
申请日：2007-02-08
申请人： C. Lance Boling , Daniel Chao , Martha J. Morrell , Benjamin D. Pless , Thomas K. Tcheng , Brett M. Wingeier
发明人： C. Lance Boling , Daniel Chao , Martha J. Morrell , Benjamin D. Pless , Thomas K. Tcheng , Brett M. Wingeier
CPC分类号： A61N1/0529 , A61N1/0536 , A61N1/0539 , A61N1/0551 , A61N1/36082 , B22F3/10 , B22F2003/241 , B22F2003/242 , B22F2998/10 , B22F3/24
摘要： Medical electrical lead systems and related methods are described. The lead systems may be configured to be at least partially implanted in neural tissue of a subject, such as a brain of a subject. Some variations of the lead systems may comprise a lead body, an electrode connected to the lead body, and a bioactive agent. The electrode and/or lead body may comprise a substrate, and the bioactive agent may be supported by the substrate (e.g., by a substantial portion of the area of the substrate). Examples of bioactive agents that may be used in the lead system include antiproliferative agents, bactericidal agents, bacteriostatic agents, antiepileptic agents, and/or antifungal agents. Methods described herein may comprise coating a lead body and/or an electrode of a medical electrical lead system with at least one bioactive agent, where the lead body and the electrode are connected to each other.
摘要翻译： 描述医用电引线系统及相关方法。 引导系统可以被配置为至少部分地植入受试者的神经组织，例如受试者的脑部。 引线系统的一些变型可以包括引线体，连接到引线主体的电极和生物活性剂。 电极和/或引线主体可以包括衬底，并且生物活性剂可以由衬底支撑（例如，通过衬底的大部分区域）。 可用于引导系统的生物活性剂的实例包括抗增殖剂，杀菌剂，抑菌剂，抗癫痫剂和/或抗真菌剂。 本文所述的方法可以包括用至少一种生物活性剂涂覆医疗电引线系统的引线体和/或电极，其中引线体和电极彼此连接。
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公开(公告)号：US07844345B2
公开(公告)日：2010-11-30
申请号：US11704549
申请日：2007-02-08
申请人： C. Lance Boling , Daniel Chao , Martha J. Morrell , Benjamin D. Pless , Thomas K. Tcheng , Brett M. Wingeier
发明人： C. Lance Boling , Daniel Chao , Martha J. Morrell , Benjamin D. Pless , Thomas K. Tcheng , Brett M. Wingeier
IPC分类号： A61N1/00
CPC分类号： A61N1/0529 , A61N1/0536 , A61N1/0539 , A61N1/0551 , A61N1/36082 , B22F3/10 , B22F2003/241 , B22F2003/242 , B22F2998/10 , B22F3/24
摘要： Medical electrical lead systems and related methods are described. The lead systems may be configured to be at least partially implanted in neural tissue of a subject, such as a brain of a subject. Some variations of the lead systems may comprise a lead body, an electrode connected to the lead body, and a bioactive agent. The electrode and/or lead body may comprise a substrate, and the bioactive agent may be supported by the substrate (e.g., by a substantial portion of the area of the substrate). Examples of bioactive agents that may be used in the lead system include antiproliferative agents, bactericidal agents, bacteriostatic agents, antiepileptic agents, and/or antifungal agents. Methods described herein may comprise coating a lead body and/or an electrode of a medical electrical lead system with at least one bioactive agent, where the lead body and the electrode are connected to each other.
摘要翻译： 描述医用电引线系统及相关方法。 引导系统可以被配置为至少部分地植入受试者的神经组织，例如受试者的脑部。 引线系统的一些变型可以包括引线体，连接到引线主体的电极和生物活性剂。 电极和/或引线主体可以包括衬底，并且生物活性剂可以由衬底支撑（例如，通过衬底的大部分区域）。 可用于引导系统的生物活性剂的实例包括抗增殖剂，杀菌剂，抑菌剂，抗癫痫剂和/或抗真菌剂。 本文所述的方法可以包括用至少一种生物活性剂涂覆医疗电引线系统的引线体和/或电极，其中引线体和电极彼此连接。
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公开(公告)号：US08423156B2
公开(公告)日：2013-04-16
申请号：US13370269
申请日：2012-02-09
申请人： C. Lance Boling , Daniel Chao , Martha J. Morrell , Benjamin D. Pless , Thomas K. Tcheng , Brett M. Wingeier
发明人： C. Lance Boling , Daniel Chao , Martha J. Morrell , Benjamin D. Pless , Thomas K. Tcheng , Brett M. Wingeier
IPC分类号： A61N1/00
CPC分类号： A61N1/0529 , A61N1/0536 , A61N1/0539 , A61N1/0551 , A61N1/36082 , B22F3/10 , B22F2003/241 , B22F2003/242 , B22F2998/10 , B22F3/24
摘要： Medical electrical lead systems and related methods are described. The lead systems may be configured to be at least partially implanted in neural tissue of a subject, such as a brain of a subject. Some variations of the lead systems may comprise a lead body, an electrode connected to the lead body, and a bioactive agent. The electrode and/or lead body may comprise a substrate, and the bioactive agent may be supported by the substrate (e.g., by a substantial portion of the area of the substrate). Methods described herein may comprise contacting the substrate of a lead body and/or an electrode of a medical electrical lead system with at least one bioactive agent, where the lead body and the electrode are connected to each other.
摘要翻译： 描述医用电引线系统及相关方法。 引导系统可以被配置为至少部分地植入受试者的神经组织，例如受试者的脑部。 引线系统的一些变型可以包括引线体，连接到引线主体的电极和生物活性剂。 电极和/或引线主体可以包括衬底，并且生物活性剂可以由衬底支撑（例如，通过衬底的大部分区域）。 本文描述的方法可以包括将铅体的基底和/或医用电引线系统的电极与至少一种生物活性剂接触，其中引线体和电极彼此连接。
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公开(公告)号：US20120232628A1
公开(公告)日：2012-09-13
申请号：US13370269
申请日：2012-02-09
申请人： C. Lance Boling , Daniel Chao , Martha J. Morrell , Benjamin D. Pless , Thomas K. Tcheng , Brett M. Wingeier
发明人： C. Lance Boling , Daniel Chao , Martha J. Morrell , Benjamin D. Pless , Thomas K. Tcheng , Brett M. Wingeier
IPC分类号： A61N1/05
CPC分类号： A61N1/0529 , A61N1/0536 , A61N1/0539 , A61N1/0551 , A61N1/36082 , B22F3/10 , B22F2003/241 , B22F2003/242 , B22F2998/10 , B22F3/24
摘要： Medical electrical lead systems and related methods are described. The lead systems may be configured to be at least partially implanted in neural tissue of a subject, such as a brain of a subject. Some variations of the lead systems may comprise a lead body, an electrode connected to the lead body, and a bioactive agent. The electrode and/or lead body may comprise a substrate, and the bioactive agent may be supported by the substrate (e.g., by a substantial portion of the area of the substrate). Methods described herein may comprise contacting the substrate of a lead body and/or an electrode of a medical electrical lead system with at least one bioactive agent, where the lead body and the electrode are connected to each other.
摘要翻译： 描述医用电引线系统及相关方法。 引导系统可以被配置为至少部分地植入受试者的神经组织，例如受试者的脑部。 引线系统的一些变型可以包括引线体，连接到引线主体的电极和生物活性剂。 电极和/或引线主体可以包括衬底，并且生物活性剂可以由衬底支撑（例如，通过衬底的大部分区域）。 本文描述的方法可以包括将铅体的基底和/或医用电引线系统的电极与至少一种生物活性剂接触，其中引线体和电极彼此连接。
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公开(公告)号：US20120253417A1
公开(公告)日：2012-10-04
申请号：US13523855
申请日：2012-06-14
CPC分类号： A61N1/36135 , A61B5/0006 , A61B5/0022 , A61B5/0031 , A61B5/021 , A61B5/026 , A61B5/04012 , A61B5/0476 , A61B5/0488 , A61B5/076 , A61B5/14542 , A61B5/14546 , A61B5/4812 , A61B5/4836 , A61B5/686 , A61B5/743 , A61M5/14276 , A61N1/0529 , A61N1/0531 , A61N1/0539 , A61N1/36064 , A61N1/36067 , A61N1/36078 , A61N1/36139
摘要： An implantable neurostimulator system adapted to provide therapy for various neurological disorders is capable of varying therapy delivery strategies based on the context, physiological or otherwise, into which the therapy is to be delivered. Responsive and scheduled therapies can be varied depending on various sensor measurements, calculations, inferences, and device states (including elapsed times and times of day) to deliver an appropriate course of therapy under the circumstances.
摘要翻译： 适用于为各种神经障碍提供治疗的可植入神经刺激器系统能够基于要递送治疗的上下文（生理或其他）改变治疗递送策略。 根据各种传感器测量，计算，推断和设备状态（包括经过时间和时间），在这种情况下提供适当的治疗方案，响应和预定的治疗方法可以不同。
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公开(公告)号：US07136695B2
公开(公告)日：2006-11-14
申请号：US09977052
申请日：2001-10-12
申请人： Benjamin D. Pless , Thomas K. Tcheng , Eyad Kishawi , Barbara Gibb , Javier Echauz , Rosana Esteller
发明人： Benjamin D. Pless , Thomas K. Tcheng , Eyad Kishawi , Barbara Gibb , Javier Echauz , Rosana Esteller
IPC分类号： A61B5/0476 , A61N1/18
CPC分类号： G06F19/3418 , A61B5/0476 , A61B5/4094 , A61B5/7217 , G06F19/00
摘要： An epileptiform activity patient-specific template creation system permits a user to efficiently develop an optimized set of patient-specific parameters for epileptiform activity detection algorithms. The epileptiform activity patient template creation system is primarily directed for use with an implantable neurostimulator system having EEG storage capability, in conjunction with a computer software program operating within a computer workstation having a processor, disk storage and input/output facilities for storing, processing and displaying patient EEG signals. The implantable neurostimulator is operative to store records of EEG data when neurological events are detected, when it receives external commands to record, or at preset or random times. The computer workstation operates on stored and uploaded records of EEG data to derive the patient-specific templates.
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公开(公告)号：US20110004268A1
公开(公告)日：2011-01-06
申请号：US12881143
申请日：2010-09-13
IPC分类号： A61N1/36
CPC分类号： A61N1/36067 , A61N1/36135
摘要： An implantable neurostimulator system for treating movement disorders includes a sensor, a detection subsystem capable of identifying episodes of a movement disorder by analyzing a signal received from the sensor, and a therapy subsystem capable of supplying therapeutic electrical stimulation to treat the movement disorder. The system treats movement disorders by detecting physiological conditions characteristic of an episode of symptoms of the movement disorder and selectively initiating therapy when such conditions are detected.
摘要翻译： 用于治疗运动障碍的可植入神经刺激器系统包括传感器，能够通过分析从传感器接收的信号来识别运动障碍发作的检测子系统，以及能够提供治疗性电刺激以治疗运动障碍的治疗子系统。 该系统通过检测运动障碍症状发作特征的生理条件来治疗运动障碍，并且当检测到这种病症时选择性地开始治疗。
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公开(公告)号：US20100331717A1
公开(公告)日：2010-12-30
申请号：US12880138
申请日：2010-09-12
申请人： Benjamin D. Pless , Stephen T. Archer , Craig M. Baysinger , Barbara Gibb , Suresh Gurunathan , Bruce Kirkpatrick , Thomas K. Tcheng
发明人： Benjamin D. Pless , Stephen T. Archer , Craig M. Baysinger , Barbara Gibb , Suresh Gurunathan , Bruce Kirkpatrick , Thomas K. Tcheng
IPC分类号： A61B5/0476
CPC分类号： A61B5/4094 , A61B5/04012 , A61B5/0476 , A61B5/0478 , A61B5/6868 , A61B5/7203 , A61B5/7242 , A61B5/7246 , A61B5/7264 , A61B5/7275
摘要： A system and method for detecting and predicting neurological events with an implantable device uses a relatively low-power central processing unit in connection with signal processing circuitry to identify features (including half waves) and calculate window-based characteristics (including line lengths and areas under the curve of the waveform) in an electrographic signal received from a patient's brain. The features and window-based characteristics are combinable in various ways according to the invention to detect and predict neurological events in real time, enabling responsive action by the implantable device.
摘要翻译： 使用可植入装置检测和预测神经病学的系统和方法使用与信号处理电路相关联的相对低功率的中央处理单元来识别特征（包括半波）并计算基于窗口的特征（包括线路长度和面积 在从患者的大脑接收的电图信号中波形的曲线）。 根据本发明的特征和基于窗口的特征可以以各种方式组合以实时检测和预测神经病学事件，从而能够实现可植入装置的响应动作。
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公开(公告)号：US07747318B2
公开(公告)日：2010-06-29
申请号：US11635885
申请日：2006-12-07
IPC分类号： A61N1/00
CPC分类号： A61N1/0529 , A61B8/0808 , A61N1/0531 , A61N1/0534 , A61N1/0539
摘要： Described here are intracranial ferrules, systems, and methods for sensing and stimulating neural tissues. The ferrules are generally designed to include a holding area for retaining an implantable device. In some variations, the ferrule itself may perform the sensing and stimulating functions. In other variations, the ferrule may function to sense data from neural tissues and the implantable device may function to stimulate neural tissues. In yet other variations, the ferrule may function to stimulate, and the implantable device may function to sense data from, the neural tissues. The sensing and stimulating functions may be used to detect and/or treat various neurological conditions.
摘要翻译： 这里描述了用于感测和刺激神经组织的颅内套圈，系统和方法。 套圈通常设计成包括用于保持可植入装置的保持区域。 在一些变型中，套圈本身可以执行感测和刺激功能。 在其他变型中，套圈可用于感测来自神经组织的数据，并且可植入装置可用于刺激神经组织。 在另外的变型中，套圈可以起刺激的作用，并且可植入装置可用于从神经组织感测数据。 感测和刺激功能可用于检测和/或治疗各种神经疾病。
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