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    COMBINATION THERAPY
    22.
    发明申请
    COMBINATION THERAPY 有权
    组合治疗

    公开(公告)号：US20120148533A1

    公开(公告)日：2012-06-14

    申请号：US13313042

    申请日：2011-12-07

    Applicant: Kapil Dhingra ,  Brian Higgins ,  Kenneth Kolinsky ,  Richard J. Lee ,  Brian Lestini ,  Kathryn Packman ,  Fei Su

    Inventor： Kapil Dhingra ,  Brian Higgins ,  Kenneth Kolinsky ,  Richard J. Lee ,  Brian Lestini ,  Kathryn Packman ,  Fei Su

    IPC: A61K38/21 ,  A61P35/00

    CPC classification number: A61K38/212 ,  A61K31/437 ,  A61K38/21 ,  A61K2300/00

    Abstract: The present invention relates to a combination therapy of propane-1-sulfonic acid{3-[5-(4-chloro-phenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl-2,4-difluoro-phenyl]-amide}, or a pharmaceutically acceptable salt thereof, and an interferon for treating a patient suffering from a proliferative disorder, in particular a solid tumor, for example, colorectal cancer, melanoma, and thyroid cancer. In particular, the present invention relates to such a therapy wherein the interferon is peginterferon alfa-2a and the disorder is melanoma containing the V600E b-Raf mutation.

    Abstract translation: 本发明涉及丙烷-1-磺酸{3- [5-（4-氯 - 苯基）-1H-吡咯并[2,3-b]吡啶-3-羰基-2,4-二氟 - 苯基] - 酰胺}或其药学上可接受的盐，以及用于治疗患有增殖性疾病，特别是实体瘤例如结肠直肠癌，黑素瘤和甲状腺癌的患者的干扰素。 特别地，本发明涉及这样的治疗，其中干扰素是聚乙二醇化干扰素α-2a，该病症是含有V600E b-Raf突变的黑素瘤。

    Combined treatment with irinotecan and an epidermal growth factor receptor kinase inhibitor
    27.
    发明申请
    Combined treatment with irinotecan and an epidermal growth factor receptor kinase inhibitor 审中-公开
    伊立替康和表皮生长因子受体激酶抑制剂联合治疗

    公开(公告)号：US20050272737A1

    公开(公告)日：2005-12-08

    申请号：US11144855

    申请日：2005-06-03

    Applicant: Jianping Chen ,  Brian Higgins ,  Kenneth Kolinsky

    Inventor： Jianping Chen ,  Brian Higgins ,  Kenneth Kolinsky

    IPC: A61K31/4706 ,  A61K31/4745 ,  A61K31/498 ,  A61K31/517 ,  A61K31/519 ,  A61K31/5377 ,  A61K39/395 ,  A61K45/06

    CPC classification number: A61K31/519 ,  A61K31/4706 ,  A61K31/4745 ,  A61K31/517 ,  A61K31/5377 ,  A61K45/06 ,  A61K2300/00

    Abstract: The present invention provides a method for treating tumors or tumor metastases in a patient, comprising administering to the patient simultaneously or sequentially a therapeutically effective amount of an EGFR kinase inhibitor and irinotecan combination, with or without additional agents or treatments, such as other anti-cancer drugs or radiation therapy. The invention also encompasses a pharmaceutical composition that is comprised of an EGFR kinase inhibitor and irinotecan combination in combination with a pharmaceutically acceptable carrier. A preferred example of an EGFR kinase inhibitor that can be used in practicing this invention is the compound erlotinib HCl (also known as Tarceva™).

    Abstract translation: 本发明提供了一种用于治疗患者的肿瘤或肿瘤转移的方法，其包括向所述患者同时或相继施用治疗有效量的EGFR激酶抑制剂和伊立替康组合，所述另外的药物或治疗剂， 癌症药物或放射治疗。 本发明还包括由EGFR激酶抑制剂和伊立替康组合与药学上可接受的载体组合的药物组合物。 可用于实施本发明的EGFR激酶抑制剂的优选实例是化合物厄洛替尼HCl（也称为Tarceva TM）。

    Trolley wheel assembly
    28.
    发明申请
    Trolley wheel assembly 失效
    手推车轮组件

    公开(公告)号：US20050087944A1

    公开(公告)日：2005-04-28

    申请号：US10474216

    申请日：2002-03-28

    Applicant: Brian Higgins

    Inventor： Brian Higgins

    IPC: B60B33/00 ,  B62B3/14 ,  B62D39/00

    CPC classification number: B60B33/0073 ,  B60B33/0007 ,  B60B33/0021 ,  B60B33/0028 ,  B60B33/0039 ,  B60B33/0042 ,  B60B33/0049 ,  B60B33/0057 ,  B60B33/0068 ,  B62B3/1404 ,  B62B3/1492 ,  B62B2301/08

    Abstract: A trolley includes a front wheel assemblie (12) and a rear wheel assembly both assemblies mounted on a trolley frame. The front wheel assembly (12) includes a fixed wheel assembly (24) to aid control of the trolley. In one form the front wheel assembly (12) includes a pair of swivel castors (18) and a fixed wheel assembly (24) disposed between the castors (18). The front wheel assembly (12) is designed so that when the castors (18) swivel from their orientation for forward travel, the fixed wheel assembly (24) is caused to be lifted off the ground. The trolley also includes a camming device which is operative to lift the front wheel assembly (12) off the ground when the trolley is moved into a nested configuration with a like trolley.

    Abstract translation: 手推车包括前轮组件（12）和后轮组件，两个组件安装在手推车框架上。 前轮组件（12）包括固定轮组件（24），以帮助控制台车。 在一种形式中，前轮组件（12）包括一对旋转脚轮（18）和设置在脚轮（18）之间的固定轮组件（24）。 前轮组件（12）被设计成使得当脚轮（18）从其定向向后转动时，固定轮组件（24）被提升离开地面。 手推车还包括一个凸轮装置，当手推车被移动到具有类似手推车的嵌套构型中时，该凸轮装置可操作以将前轮组件（12）提升离开地面。

    Memory device with efficient redundancy using sense amplifiers
    29.
    发明授权
    Memory device with efficient redundancy using sense amplifiers 失效
    使用读出放大器高效冗余的存储器件

    公开(公告)号：US5920514A

    公开(公告)日：1999-07-06

    申请号：US918508

    申请日：1997-08-22

    Applicant: Hank H. Lim ,  Brian Higgins

    Inventor： Hank H. Lim ,  Brian Higgins

    IPC: G11C7/06 ,  G11C7/10 ,  G11C11/4091 ,  G11C29/00 ,  G11C13/00

    CPC classification number: G11C29/848 ,  G11C11/4091 ,  G11C7/06 ,  G11C7/10

    Abstract: A memory device is described which has memory storage cells coupled to data bit lines. Sense amplifier circuits are provided to receive input from the data bit lines and produce an output in response thereto. The memory includes circuitry which shifts the input to the sense amplifiers. Data bit lines from a neighboring sense amplifier is shifted to another sense amplifier such that redundant memory storage cells and data bit lines can be substituted for defective ones.

    Abstract translation: 描述了具有耦合到数据位线的存储器存储单元的存储器件。 提供感测放大器电路以从数据位线接收输入并响应于此产生输出。 存储器包括将输入移位到读出放大器的电路。 来自相邻读出放大器的数据位线被移位到另一个读出放大器，使得可以用冗余存储器存储单元和数据位线代替有缺陷的存储单元。

    Semiconductor wafers having test circuitry for individual dies
    30.
    发明授权
    Semiconductor wafers having test circuitry for individual dies 失效
    具有用于各个管芯的测试电路的半导体晶片

    公开(公告)号：US5391892A

    公开(公告)日：1995-02-21

    申请号：US134264

    申请日：1993-10-08

    Applicant: Kevin M. Devereaux ,  Mark Bunn ,  Brian Higgins

    Inventor： Kevin M. Devereaux ,  Mark Bunn ,  Brian Higgins

    IPC: G01R31/28 ,  H01L21/66 ,  H01L21/60

    CPC classification number: H01L22/20 ,  G01R31/2884 ,  G01R31/2886

    Abstract: A semiconductor wafer comprises a plurality of individual dies containing integrated circuits which are substantially isolated from each other. The wafer is severable between the dies to physically singulate the dies from each other. The wafer includes test cycling circuitry for test cycling the individual dies. A Vcc bus and a Vss bus overly a passivation layer and are electrically connected through the passivation layer with Vcc and Vss pads associated with the individual dies.

    Abstract translation: 半导体晶片包括多个彼此基本隔离的集成电路的单个管芯。 晶片可以在管芯之间切割以将管芯彼此物理地分开。 该晶片包括测试循环电路，用于测试单个模具的循环。 Vcc总线和Vss总线过钝化层，并且通过钝化层与与各个管芯相关联的Vcc和Vss焊盘电连接。

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