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    Multi-layer, light markable media and method and apparatus for using same
    25.
    发明授权
    Multi-layer, light markable media and method and apparatus for using same 有权
    多层可点光介质及其使用方法和装置

    公开(公告)号：US07837823B2

    公开(公告)日：2010-11-23

    申请号：US11511103

    申请日：2006-08-28

    申请人： Neil Griffin ,  Sam Hyde ,  Aylwyn Scally ,  Roger Clarke ,  M. Scott Howarth ,  Richard Calusdian ,  Wilson B. Murray ,  Richard Hirst ,  Richard Evans

    发明人： Neil Griffin ,  Sam Hyde ,  Aylwyn Scally ,  Roger Clarke ,  M. Scott Howarth ,  Richard Calusdian ,  Wilson B. Murray ,  Richard Hirst ,  Richard Evans

    IPC分类号： B32B37/00

    CPC分类号： B65C9/46 ,  B41M5/282 ,  B41M2205/04 ,  G09F3/02 ,  G11B23/40 ,  Y10T156/1707

    摘要： A multi-layer laminate media is provided on which information may be applied in machine or human readable form on a visible front surface by the output of one or more lasers, or other high intensity light source. In a preferred embodiment, the media has three layers including a substrate, a thermochromic layer and a light absorbent layer such as carbon black located intermediate the media substrate and the thermochromic layer. The light absorbent layer is adapted to absorb light from the light source and convert the absorbed light into heat. The heat is immediately conducted into selected portions of the thermochromic layer which is in thermal contact with the light absorbent layer, causing portions of the thermochromic layer to change visual appearance such as color to create the desired mark. The invention includes a method and apparatus for using the media in conjunction with labeling produce items.

    摘要翻译： 提供了多层层压介质，其上可以通过一个或多个激光器或其它高强度光源的输出以机器或人类可读的形式在可视前表面上应用信息。 在优选的实施方案中，介质具有三层，包括基材，热变色层和位于介质基底和热致变色层之间的诸如炭黑的光吸收层。 吸光层适于吸收来自光源的光，并将吸收的光转换成热。 立即将热量导入热吸收层热接触的热变色层的选定部分，使得热变色层的一部分改变视觉外观，例如颜色，以产生所需的标记。 本发明包括一种方法和装置，用于结合标记产品而使用该介质。

    System and method for wireless remote control of locomotives
    26.
    发明授权
    System and method for wireless remote control of locomotives 有权
    机车无线遥控系统及方法

    公开(公告)号：US07529201B2

    公开(公告)日：2009-05-05

    申请号：US10702062

    申请日：2003-11-05

    申请人： Robert C. Aiken, II ,  Richard Evans ,  Carl L. Verholek ,  William Ducklin ,  Steve McDonald ,  Dana Conner ,  Scott Lordo ,  Curt Bellotti ,  Robert Rader

    发明人： Robert C. Aiken, II ,  Richard Evans ,  Carl L. Verholek ,  William Ducklin ,  Steve McDonald ,  Dana Conner ,  Scott Lordo ,  Curt Bellotti ,  Robert Rader

    IPC分类号： H04L12/56 ,  H04B7/212

    CPC分类号： B61L3/127 ,  B61L2205/04

    摘要： A system and method for remotely controlling an increased number of subsystems having an onboard locomotive control unit (LCU) and two associated operator control units (OCUs) on a single wireless channel. A time slot is assigned to each subsystem for making two-way transmissions to control the locomotive. A signal from an external timing source synchronizes each subsystem to minimize interference between transmissions from different subsystems. Time slots are assigned manually or automatically over a wireless network or by the LCU after monitoring the channel. The LCU automatically selects the direct or repeater transmission path depending upon whether or not it receives polling message responses from its associated OCUs. A GPS receiver in each subsystem receives the synchronization signal and provides geographic positioning data so the LCU can determine when to execute predefined, position-based commands. The secondary OCU may be turned off and rejoined to the subsystem without ceasing operation.

    摘要翻译： 一种用于在单个无线信道上远程控制具有机载机车控制单元（LCU）和两个相关联的运营商控制单元（OCU）的子系统的数量增加的系统和方法。 分配给每个子系统的时隙进行双向传输以控制机车。 来自外部定时源的信号使每个子系统同步以最小化来自不同子系统的传输之间的干扰。 通过无线网络或LCU监控频道后，手动或自动分配时隙。 根据是否从其相关联的OCU接收到轮询消息响应，LCU自动选择直接或中继传输路径。 每个子系统中的GPS接收器接收同步信号并提供地理定位数据，以便LCU可以确定何时执行预定义的基于位置的命令。 次级OCU可以关闭并重新连接到子系统而不停止运行。

    PHARMACEUTICAL LATRUNCULIN FORMULATIONS
    30.
    发明申请
    PHARMACEUTICAL LATRUNCULIN FORMULATIONS 有权
    药物LATRUNCULIN配方

    公开(公告)号：US20070225343A1

    公开(公告)日：2007-09-27

    申请号：US11680893

    申请日：2007-03-01

    申请人： Ramesh Krishnamoorthy ,  Leo Trevino ,  Richard Evans

    发明人： Ramesh Krishnamoorthy ,  Leo Trevino ,  Richard Evans

    IPC分类号： A61K31/427

    CPC分类号： A61K31/427 ,  A61K9/0048 ,  A61K9/08 ,  A61K47/10 ,  A61K47/26 ,  A61K47/34

    摘要： The present invention relates to an aqueous pharmaceutical formulation comprising at least one latrunculin and the formulation does not contain a substantial amount of dimethyl sulfoxide. In one embodiment, the present invention is directed to an aqueous pharmaceutical formulation comprising at least one latrunculin in an amount of 0.001-2% w/v, a non-ionic surfactant in an amount of 0.01-2% w/v, and a tonicity agent to maintain a tonicity between 200-400 mOsm/kG, at a pH between 4 to 8, wherein the latrunculin, the surfactant, and the tonicity agent are compatible in the formulation, and the formulation does not contain a substantial amount of dimethyl sulfoxide. The formulation is stable for at least six month at refrigerated temperature. The present invention further provides a method of reducing intraocular pressure, a method of treating glaucoma, a method of inhibiting wound healing after trabeculectomy, and a method of inhibiting angiogenesis.

    摘要翻译： 本发明涉及含有至少一种梭菌素的水性药物制剂，并且所述制剂不含有大量的二甲基亚砜。 在一个实施方案中，本发明涉及包含0.001-2％w / v的量的至少一种latrunculin的水性药物制剂，0.01-2％w / v的量的非离子表面活性剂，和 张力剂以保持200-400mOsm / kG之间的张力，在4至8之间的pH下，其中所述莱特乐宁，表面活性剂和张力剂在制剂中相容，并且制剂中不含有大量的二甲基 亚砜。 该制剂在冷藏温度下稳定至少6个月。 本发明还提供降低眼内压的方法，治疗青光眼的方法，小梁切除术后抑制伤口愈合的方法以及抑制血管发生的方法。