公开(公告)号：US08178677B2

公开(公告)日：2012-05-15

申请号：US11885005

申请日：2006-02-22

申请人： Tushar A. Kshirsagar ,  Bryon A. Merrill ,  Scott E. Langer ,  Kyle J. Lindstrom ,  Sarah J. Slania ,  Gregory J. Marszalek ,  Karl J. Manske ,  Philip D. Heppner ,  Gregory D. Lundquist, Jr.

发明人： Tushar A. Kshirsagar ,  Bryon A. Merrill ,  Scott E. Langer ,  Kyle J. Lindstrom ,  Sarah J. Slania ,  Gregory J. Marszalek ,  Karl J. Manske ,  Philip D. Heppner ,  Gregory D. Lundquist, Jr.

IPC分类号： C07D471/00 ,  A61K31/535

CPC分类号： C07D471/04

摘要： Certain imidazoquinolines with a hydroxymethyl or hydroxyethyl substituent at the 2-position, pharmaceutical compositions containing the compounds, intermediates, methods of making and methods of use of these compounds as immunomodulators, for preferentially inducing IFN-α biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

摘要翻译： 具有2-位羟基甲基或羟乙基取代基的某些咪唑并喹啉，含有化合物的药物组合物，中间体，制备方法以及这些化合物作为免疫调节剂的使用方法，用于优先诱导动物中的IFN-α生物合成和治疗疾病 包括病毒和肿瘤疾病。

公开(公告)号：US08138173B2

公开(公告)日：2012-03-20

申请号：US11887526

申请日：2006-03-31

申请人： Bryon A. Merrill ,  Michael E. Danielson ,  David S. Hays ,  David T. Amos ,  Philip D. Heppner ,  Tushar A. Kshirsagar ,  Gregory D. Lundquist, Jr. ,  William H. Moser

发明人： Bryon A. Merrill ,  Michael E. Danielson ,  David S. Hays ,  David T. Amos ,  Philip D. Heppner ,  Tushar A. Kshirsagar ,  Gregory D. Lundquist, Jr. ,  William H. Moser

IPC分类号： A61K31/55 ,  A61K31/437 ,  C07D471/04

CPC分类号： C07D471/04

摘要： Pyrazolo[3,4-c]quinolines, pyrazolo[4,5-c]naphthyridines, and analogs thereof, eg., 6,7,8,9-tetrahydro pyrazolo[3,4-c]quinolines, and, pharmaceutical compositions containing the compounds, intermediates, methods of making these compounds, and methods of use of these compounds as immunomodulators, for inhibiting cytokine biosynthesis in animals and in the therapeutic or prophylactic treatment of diseases by inhibiting cytokine biosynthesis are disclosed.

摘要翻译： 吡唑并[3,4-c]喹啉，吡唑并[4,5-c]萘啶及其类似物，例如6,7,8,9-四氢吡唑并[3,4-c]喹啉，以及药物组合物 公开了含有化合物，中间体，制备这些化合物的方法，以及这些化合物作为免疫调节剂的用途，用于抑制动物中的细胞因子生物合成以及通过抑制细胞因子生物合成来治疗或预防性治疗疾病。

公开(公告)号：US06720334B2

公开(公告)日：2004-04-13

申请号：US10358017

申请日：2003-02-04

申请人： Joseph F. Dellaria ,  Chad A. Haraldson ,  Philip D. Heppner ,  Kyle J. Lindstrom ,  Bryon A. Merrill

发明人： Joseph F. Dellaria ,  Chad A. Haraldson ,  Philip D. Heppner ,  Kyle J. Lindstrom ,  Bryon A. Merrill

IPC分类号： A61K31437

CPC分类号： C07D471/04

摘要： Imidazopyridine compounds that contain urea or thiourea functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.

摘要翻译： 在1位含有脲或硫脲官能团的咪唑并吡啶化合物可用作免疫应答调节剂。 本发明的化合物和组合物可以诱导各种细胞因子的生物合成，并且可用于治疗各种病症，包括病毒性疾病和肿瘤性疾病。

公开(公告)号：US06525064B1

公开(公告)日：2003-02-25

申请号：US10165002

申请日：2002-06-07

申请人： Joseph F. Dellaria ,  Chad A. Haraldson ,  Philip D. Heppner ,  Kyle J. Lindstrom ,  Bryon A. Merrill

发明人： Joseph F. Dellaria ,  Chad A. Haraldson ,  Philip D. Heppner ,  Kyle J. Lindstrom ,  Bryon A. Merrill

IPC分类号： A61K31437

CPC分类号： C07D471/04

摘要： Imidazopyridine compounds that contain sulfonamide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.

摘要翻译： 在1位含有磺酰胺官能团的咪唑并吡啶化合物可用作免疫应答调节剂。 本发明的化合物和组合物可以诱导各种细胞因子的生物合成，并且可用于治疗各种病症，包括病毒性疾病和肿瘤性疾病。

公开(公告)号：US06716988B2

公开(公告)日：2004-04-06

申请号：US10357777

申请日：2003-02-04

申请人： Joseph F. Dellaria ,  Chad A. Haraldson ,  Kyle J. Lindstrom ,  Bryon A. Merrill

发明人： Joseph F. Dellaria ,  Chad A. Haraldson ,  Kyle J. Lindstrom ,  Bryon A. Merrill

IPC分类号： C07D213643

CPC分类号： C07D471/04

摘要： Imidazopyridine compounds that contain urea or thiourea functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.

公开(公告)号：US06545016B1

公开(公告)日：2003-04-08

申请号：US10165229

申请日：2002-06-07

申请人： Joseph F. Dellaria ,  Chad A. Haraldson ,  Philip D. Heppner ,  Kyle J. Lindstrom ,  Bryon A. Merrill

发明人： Joseph F. Dellaria ,  Chad A. Haraldson ,  Philip D. Heppner ,  Kyle J. Lindstrom ,  Bryon A. Merrill

IPC分类号： A61K31437

CPC分类号： C07D471/04

摘要： Imidazopyridine compounds that contain amide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.

公开(公告)号：US07598382B2

公开(公告)日：2009-10-06

申请号：US11275553

申请日：2006-01-13

申请人： David S. Hays ,  Tushar Kshirsagar ,  Philip D. Heppner ,  Bryon A. Merrill ,  Michael E. Danielson ,  John F. Gerster ,  Chad A. Haraldson ,  Sarah Johannessen ,  Maureen A. Kavanagh ,  Kyle J. Lindstrom ,  Michael J. Rice ,  David J. Squire ,  Sarah A. Strong ,  Joshua R. Wurst

发明人： David S. Hays ,  Tushar Kshirsagar ,  Philip D. Heppner ,  Bryon A. Merrill ,  Michael E. Danielson ,  John F. Gerster ,  Chad A. Haraldson ,  Sarah Johannessen ,  Maureen A. Kavanagh ,  Kyle J. Lindstrom ,  Michael J. Rice ,  David J. Squire ,  Sarah A. Strong ,  Joshua R. Wurst

IPC分类号： C07D471/00

CPC分类号： C07D471/04

摘要： Aryl substituted imidazoquinoline compounds, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral, and neoplastic, are disclosed.

摘要翻译： 公开了芳基取代的咪唑并喹啉化合物，含有化合物的化合物的药物组合物，中间体和这些化合物作为免疫调节剂的用途，用于诱导或抑制动物中的细胞因子生物合成和治疗包括病毒和肿瘤的疾病。

公开(公告)号：US06720422B2

公开(公告)日：2004-04-13

申请号：US10357733

申请日：2003-02-04

申请人： Joseph F. Dellaria ,  Chad A. Haraldson ,  Kyle J. Lindstrom ,  Bryon A. Merrill

发明人： Joseph F. Dellaria ,  Chad A. Haraldson ,  Kyle J. Lindstrom ,  Bryon A. Merrill

IPC分类号： C07D47104

CPC分类号： C07D471/04

摘要： Imidazopyridine compounds that contain amide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.

摘要翻译： 在1位含有酰胺官能团的咪唑并吡啶化合物可用作免疫应答调节剂。 本发明的化合物和组合物可以诱导各种细胞因子的生物合成，并且可用于治疗各种病症，包括病毒性疾病和肿瘤性疾病。

公开(公告)号：US06720333B2

公开(公告)日：2004-04-13

申请号：US10357995

申请日：2003-02-04

申请人： Joseph F. Dellaria ,  Chad A. Haraldson ,  Philip D. Heppner ,  Kyle J. Lindstrom ,  Bryon A. Merrill

发明人： Joseph F. Dellaria ,  Chad A. Haraldson ,  Philip D. Heppner ,  Kyle J. Lindstrom ,  Bryon A. Merrill

IPC分类号： A61K31437

CPC分类号： C07D471/04

摘要： Imidazopyridine compounds that contain amide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.

公开(公告)号：US06545017B1

公开(公告)日：2003-04-08

申请号：US10165453

申请日：2002-06-07

申请人： Joseph F. Dellaria ,  Chad A. Haraldson ,  Philip D. Heppner ,  Kyle J. Lindstrom ,  Bryon A. Merrill

发明人： Joseph F. Dellaria ,  Chad A. Haraldson ,  Philip D. Heppner ,  Kyle J. Lindstrom ,  Bryon A. Merrill

IPC分类号： A61K31437

CPC分类号： C07D471/04

摘要： Imidazopyridine compounds that contain urea or thiourea functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.