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公开(公告)号：US11426155B2
公开(公告)日：2022-08-30
申请号：US16680739
申请日：2019-11-12
Applicant: CARDIOVALVE LTD.
Inventor： Gil Hacohen , Yossi Gross , Tal Reich
Abstract: A transluminal sheath is advanced into a femoral vein of a subject, through an inferior vena cava of the subject, into a right atrium of a heart of the subject, and transseptally into a left atrium of the heart. A surrounding-sheath is advanced out of a distal end of the transluminal sheath, into the left atrium, and toward a commissure of a mitral valve of the heart. A commissural helix is implanted at the commissure by advancing the commissural helix out of the surrounding-sheath and through the commissure into a left ventricle of the heart, such that the commissural helix wraps around at least some chordae tendineae at the commissure and facilitates sealing of the commissure. Subsequently to the implantation of the commissural helix, the surrounding-sheath is extracted from the heart. Other embodiments are also described.
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公开(公告)号：US11344410B2
公开(公告)日：2022-05-31
申请号：US17366711
申请日：2021-07-02
Applicant: CARDIOVALVE LTD.
Inventor： Gil Hacohen , Yossi Gross
Abstract: Implantable first atrial and ventricular arms are articulatable at a first articulation site to clamp a first heart valve leaflet. A first implantable elongate transitioning member is (a) connected at a fixed connection point at a portion of the first ventricular arm farthest from the first articulation site, (b) has a portion that faces an opposite surface of the first ventricular arm, and (c) is controllable to move the first ventricular arm. Implantable second atrial and ventricular arms are articulatable at a second articulation site to clamp a second leaflet. A second implantable elongate transitioning member is (a) connected at a fixed connection point at a portion of the second ventricular arm farthest from the second articulation site, (b) has a portion that faces an opposite surface of the second ventricular arm, and (c) is controllable to move the second ventricular arm. Other embodiments are also described.
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公开(公告)号：US20210393402A1
公开(公告)日：2021-12-23
申请号：US17466785
申请日：2021-09-03
Applicant: CARDIOVALVE LTD.
Inventor： Tal HAMMER , Yuval Zipory , Tal Reich , Yaron Herman , Gil Hacohen , Eran Miller , Rotem Neeman , Natalia Kruglova
IPC: A61F2/24
Abstract: Apparatus is provided, including: (A) a valve body (204) including a first frame (206) shaped to define a lumen therethrough, and a valve member (205) disposed within the lumen, (B) an upstream support (210), configured to be placed against an upstream surface of a native heart valve, and (C) a flexible sheet (214) that couples the upstream support to the valve body. The valve body has a compressed state in which the first frame has a first diameter, and an expanded state in which the first frame has a second diameter that is greater than the first diameter. The support includes a second frame (212) that has a compressed state, and an expanded state in which the second frame is annular, has an inner perimeter that defines an opening through the second frame, and has an outer perimeter. Other embodiments are also described.
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公开(公告)号：US10925595B2
公开(公告)日：2021-02-23
申请号：US16740659
申请日：2020-01-13
Applicant: CARDIOVALVE LTD.
Inventor： Gil Hacohen , Yossi Gross , Tal Reich
Abstract: Prosthetic heart valves and methods of use of prosthetic heart valves may be provided. In one implementation, a prosthetic heart valve may include an annular spacer configured for implantation with a native heart valve opening and a central valve section configured for disposal within the annular spacer. The central valve section may include at least one anchoring protrusion configured to anchor the central valve section against axial movement relative to the annular spacer. During deployment, the central valve section may be advanced downstream beyond the implanted annular spacer, and moved upstream until the anchoring protrusion engages the annular spacer.
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公开(公告)号：US20200078002A1
公开(公告)日：2020-03-12
申请号：US16680739
申请日：2019-11-12
Applicant: CARDIOVALVE LTD.
Inventor： Gil Hacohen , Yossi Gross , Tal Reich
Abstract: A transluminal sheath is advanced into a femoral vein of a subject, through an inferior vena cava of the subject, into a right atrium of a heart of the subject, and transseptally into a left atrium of the heart. A surrounding-sheath is advanced out of a distal end of the transluminal sheath, into the left atrium, and toward a commissure of a mitral valve of the heart. A commissural helix is implanted at the commissure by advancing the commissural helix out of the surrounding-sheath and through the commissure into a left ventricle of the heart, such that the commissural helix wraps around at least some chordae tendineae at the commissure and facilitates sealing of the commissure. Subsequently to the implantation of the commissural helix, the surrounding-sheath is extracted from the heart. Other embodiments are also described.
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Patent Agency Ranking
公开(公告)号：US10376361B2
公开(公告)日：2019-08-13
申请号：US16045059
申请日：2018-07-25
Applicant: CARDIOVALVE LTD.
Inventor： Yossi Gross , Gil Hacohen , Eran Miller , Yuval Zipory
Abstract: Apparatus is provided for use with a native valve of a heart of a subject. The apparatus includes: (1) an annular upstream support portion, comprising an expandable first frame, the upstream support portion configured to be placed against an upstream surface of the native valve; (2) a flexible polyester connector; and (3) an anchoring element, flexibly coupled to the upstream support portion by the connector, and configured to anchor the upstream support portion to the native valve by engaging tissue of the native valve.
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公开(公告)号：US10245143B2
公开(公告)日：2019-04-02
申请号：US15213791
申请日：2016-07-19
Applicant: CARDIOVALVE LTD.
Inventor： Yossi Gross , Gil Hacohen , Eran Miller , Yuval Zipory , Tal Reich , Meir Kutzik , Rotem Neeman
Abstract: Apparatus for use at a native heart valve of a subject is described. For some applications, the apparatus comprises a prosthetic valve support, configured (a) to be implanted at the native valve, (b) to facilitate, at a first period, implantation at the native valve of a first prosthetic valve, and (c) to facilitate, at a second period, implantation at the native valve of a second prosthetic valve. Other embodiments are also described.
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公开(公告)号：US10226341B2
公开(公告)日：2019-03-12
申请号：US15197069
申请日：2016-06-29
Applicant: CARDIOVALVE LTD.
Inventor： Yossi Gross , Gil Hacohen , Eran Miller , Yuval Zipory , Tal Reich , Meir Kutzik , Rotem Neeman
Abstract: For some applications, apparatus is provided for facilitating implantation of a prosthetic valve at a native heart valve of a subject, the apparatus comprising a prosthetic valve support, the prosthetic valve support (a) being configured to be transluminally-deliverable to the native valve and to be deployable at the native valve, and (b) comprising one or more tissue-engaging elements, configured to couple the prosthetic valve support to leaflets of the native valve without eliminating check valve functionality of the native valve. Other embodiments are also described.
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公开(公告)号：US11690712B2
公开(公告)日：2023-07-04
申请号：US16881350
申请日：2020-05-22
Applicant: CARDIOVALVE LTD.
Inventor： Gil Hacohen
CPC classification number: A61F2/2418 , A61F2/246 , A61F2/2409 , A61F2/2436 , A61F2/2439 , A61F2/2433 , A61F2/2442 , A61F2/848 , A61F2220/0008 , A61F2220/0016 , A61F2220/0025 , A61F2220/0091 , A61F2230/005 , A61F2230/0013 , A61F2230/0054 , A61F2230/0078 , A61F2250/006 , A61F2250/0015 , A61F2250/0069 , A61F2250/0071
Abstract: An implant includes a primary structural element, and two clips coupled to the primary structural element, on opposite lateral sides of the primary structural element from each other, each of the clips having a first clip element and a second clip element. The implant is transluminally advanced to a heart valve of a subject. The implant is coupled to leaflets of the valve (i) by, for each of the clips, closing the clip around a central part of a respective leaflet of the valve by causing deflection between the first clip element and the second clip element, thereby sandwiching the central part of the respective leaflet between the first clip element and the second clip element, and (ii) such that the leaflets form a double orifice configuration, with the primary structural element disposed between the central parts of the leaflets. Other embodiments are also described.
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公开(公告)号：US11369469B2
公开(公告)日：2022-06-28
申请号：US17394807
申请日：2021-08-05
Applicant: CARDIOVALVE LTD.
Inventor： Yossi Gross , Gil Hacohen
Abstract: A method includes advancing apparatus including a core toward a patient's heart valve. The core tapers in a distal direction toward the smallest perimeter of the core. The apparatus includes a first ventricular arm, which is articulatable with respect to a first atrial arm at a first articulation site, and a second ventricular arm, which is articulatable with respect to a second atrial arm at a second articulation site. The articulation sites are adjacent to the smallest perimeter. The tapering of the core defines a minimum nonzero angle of the atrial arms with respect to a central longitudinal axis of the core. The method also includes clamping the first and second leaflets between the respective atrial arms and the respective ventricular arms. Other embodiments are also described.
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