公开(公告)号：US20220372045A1

公开(公告)日：2022-11-24

申请号：US17729881

申请日：2022-04-26

Applicant: CHDI Foundation, Inc.

Inventor： Longbin Liu ,  Celia Dominguez ,  Jonathan Bard ,  Vinod Khetarpal ,  Ashley Jarvis ,  Sarah Hayes ,  John E. Mangette

IPC: C07D498/04 ,  A61K51/04

Abstract: Provided herein are certain compounds and imaging agents useful for detecting a disease or condition associated with protein aggregation, compositions thereof, and methods of their use.

公开(公告)号：US20210380608A1

公开(公告)日：2021-12-09

申请号：US17353627

申请日：2021-06-21

Applicant: CHDI Foundation, Inc.

Inventor： Celia Dominguez ,  John Wityak ,  Jonathan Bard ,  Alex Kiselyov ,  Christopher John Brown ,  Michael Edward Prime ,  Peter David Johnson ,  Daniel Clark-Frew

IPC: C07D519/00 ,  C07D471/04 ,  A61K51/04

Abstract: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.

公开(公告)号：US20210379211A1

公开(公告)日：2021-12-09

申请号：US17353611

申请日：2021-06-21

Applicant: CHDI Foundation, Inc.

Inventor： Celia Dominguez ,  John Wityak ,  Jonathan Bard ,  Christopher John Brown ,  Thomas Martin Krulle ,  Daniel Clark-Frew ,  Sarah Hayes

IPC: A61K51/04 ,  C07D401/14 ,  C07D403/04 ,  C07D401/04 ,  C07D487/04 ,  C07D513/04 ,  C07D513/14

Abstract: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.

公开(公告)号：US20170056535A1

公开(公告)日：2017-03-02

申请号：US15249223

申请日：2016-08-26

Applicant: CHDI Foundation, Inc.

Inventor： Celia Dominguez ,  John Wityak ,  Jonathan Bard ,  Christopher John Brown ,  Michael Edward Prime ,  Peter David Johnson ,  Thomas Martin Krulle ,  Daniel Clark-Frew ,  Duane Higgins ,  Matthew Robert Mills ,  Richard Waldron Marston ,  Samuel Coe ,  Samantha Louise Jones Green ,  Sarah Hayes

IPC: A61K51/04 ,  C07D487/04 ,  C07D513/14 ,  C07D513/04

CPC classification number: A61K51/0455 ,  A61K51/0459 ,  C07B59/002 ,  C07D487/04 ,  C07D513/04 ,  C07D513/14

Abstract: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.

Abstract translation: 提供了包含式I化合物或其药学上可接受的盐的成像剂及其使用方法。 （一世）。