公开(公告)号：US20210236663A1

公开(公告)日：2021-08-05

申请号：US17125905

申请日：2020-12-17

Applicant: CHDI Foundation, Inc.

Inventor： Longbin Liu ,  Matthew Lee ,  Celia Dominguez ,  Peter David Johnson ,  Christopher John Brown ,  Sarah Hayes ,  Adrian Kotey ,  Matthew Robert Mills ,  Michael Edward Prime

IPC: A61K51/04 ,  C07D401/14 ,  C07D401/06 ,  C07D471/04 ,  C07D401/12 ,  C07D491/107 ,  C07D487/04 ,  C07D413/14 ,  C07B59/00

Abstract: Provided herein are certain compounds and imaging agents useful for detecting a condition or disorder associated with protein aggregation, compositions thereof, and methods of their use.

公开(公告)号：US11059836B2

公开(公告)日：2021-07-13

申请号：US16530594

申请日：2019-08-02

Applicant: CHDI Foundation, Inc.

Inventor： Celia Dominguez ,  Samuel Coe ,  Peter David Johnson ,  Michael Edward Prime ,  Christopher John Brown ,  Sébastien René Gabriel Galan ,  Paul Richard Giles ,  Jonathan Bard ,  Elise Luciennen Paulette Gadouleau ,  Thomas Martin Krülle ,  Daniel Clark-Frew ,  John Wityak ,  Alex Kiselyov ,  Sarah Hayes

IPC: C07D513/04 ,  C07D413/14 ,  C07D417/04 ,  A61K51/04 ,  C07D413/12 ,  C07D263/57 ,  C07D498/04 ,  C07D405/14 ,  C07D413/04 ,  C07D471/04

Abstract: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.

公开(公告)号：US20210060187A1

公开(公告)日：2021-03-04

申请号：US16987277

申请日：2020-08-06

Applicant: CHDI Foundation, Inc.

Inventor： Celia Dominguez ,  John Wityak ,  Jonathan Bard ,  Christopher John Brown ,  Michael Edward Prime ,  Peter David Johnson ,  Thomas Martin Krulle ,  Daniel Clark-Frew ,  Duane Higgins ,  Matthew Robert Mills ,  Richard Waldron Marston ,  Samuel Coe ,  Samantha Brown ,  Sarah Hayes

IPC: A61K51/04 ,  C07D513/04 ,  C07D487/04 ,  C07D513/14 ,  C07B59/00

Abstract: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.

公开(公告)号：US09649310B2

公开(公告)日：2017-05-16

申请号：US15042964

申请日：2016-02-12

Applicant: CHDI Foundation, Inc.

Inventor： Celia Dominguez ,  Leticia M. Toledo-Sherman ,  Stephen Martin Courtney ,  Michael Prime ,  William Mitchell ,  Christopher John Brown ,  Paula C. De Aguiar Pena ,  Peter Johnson

IPC: A61K31/506 ,  A61K31/505 ,  A61K31/5377 ,  A61K31/513

CPC classification number: A61K31/506 ,  A61K31/505 ,  A61K31/513 ,  A61K31/5377 ,  C07D239/26 ,  C07D239/28 ,  C07D239/42 ,  C07D401/04 ,  C07D403/04 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D491/044 ,  C07D491/048 ,  C07D491/052

Abstract: Certain chemical entities are provided herein. Also provided are pharmaceutical compositions comprising at least one chemical entity and one or more pharmaceutically acceptable vehicle. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of KMO activity are described, which comprise administering to such patients an amount of at least one chemical entity effective to reduce signs or symptoms of the disease or disorder are disclosed. These diseases include neurodegenerative disorders such as Huntington's disease. Also described are methods of treatment include administering at least one chemical entity as a single active agent or administering at least one chemical entity in combination with one or more other therapeutic agents. Also provided are methods for screening compounds capable of inhibiting KMO activity.

公开(公告)号：US12258355B2

公开(公告)日：2025-03-25

申请号：US17881895

申请日：2022-08-05

Applicant: CHDI Foundation, Inc.

Inventor： Celia Dominguez ,  Samuel Coe ,  Peter David Johnson ,  Michael Edward Prime ,  Christopher John Brown ,  Sébastien René Gabriel Galan ,  Paul Richard Giles ,  Jonathan Bard ,  Elise Lucienne Paulette Gadouleau ,  Thomas Martin Krülle ,  Daniel Clark-Frew ,  John Wityak ,  Alex Kiselyov ,  Sarah Hayes

IPC: C07D513/04 ,  A61B5/00 ,  A61B6/03 ,  A61K51/04 ,  C07D263/57 ,  C07D405/14 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14 ,  C07D471/04 ,  C07D498/04

Abstract: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.

公开(公告)号：US20220339302A1

公开(公告)日：2022-10-27

申请号：US17715661

申请日：2022-04-07

Applicant: CHDI Foundation, Inc.

Inventor： Longbin Liu ,  Celia Dominguez ,  Jonathan Bard ,  Christopher John Brown ,  Xuemei Chen ,  Daniel Clark-Frew ,  Matthew Robert Mills ,  Peter David Johnson ,  Elise Gadouleau

IPC: A61K51/04 ,  A61P25/28 ,  C07D401/14

Abstract: Provided herein are certain isoindolinone compounds and imaging agents useful for detecting a disease or condition associated with protein aggregation, compositions thereof, and methods of their use.

公开(公告)号：US11071793B2

公开(公告)日：2021-07-27

申请号：US15507214

申请日：2015-08-28

Applicant: CHDI Foundation, Inc.

Inventor： Celia Dominguez ,  John Wityak ,  Jonathan Bard ,  Christopher John Brown ,  Thomas Martin Krülle ,  Daniel Clark-Frew ,  Sarah Hayes

IPC: A61K51/00 ,  A61M36/14 ,  A61K51/04 ,  C07D401/14 ,  C07D403/04 ,  C07D401/04 ,  C07D487/04 ,  C07D513/04 ,  C07D513/14

Abstract: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.

公开(公告)号：US10907197B2

公开(公告)日：2021-02-02

申请号：US15507217

申请日：2015-08-28

Applicant: CHDI Foundation, Inc.

Inventor： Celia Dominguez ,  John Wityak ,  Jonathan Bard ,  Christopher John Brown ,  Michael Edward Prime ,  Derek Alexander Weddell ,  Daryl Simon Walter ,  Paul Richard Giles ,  Ian James Wigginton ,  Malcolm George Taylor ,  Sébastien René Gabriel Galan ,  Peter David Johnson ,  Thomas Martin Krülle ,  Inaki Morao ,  Daniel Clark-Frew

IPC: C07D253/08 ,  C07D401/04 ,  C07D473/00 ,  C12Q1/6823 ,  A61K51/04

Abstract: Provided are imaging agents comprising a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and methods of their use.

公开(公告)号：US10479802B2

公开(公告)日：2019-11-19

申请号：US15507208

申请日：2015-08-28

Applicant: CHDI Foundation, Inc.

Inventor： Celia Dominguez ,  Samuel Coe ,  Jonathan Bard ,  Peter David Johnson ,  Michael Edward Prime ,  Christopher John Brown ,  Sébastien René Gabriel Galan ,  Paul Richard Giles ,  Elise Luciennen Paulette Gadouleau ,  Thomas Martin Krülle ,  Daniel Clark-Frew ,  John Wityak ,  Alex Kiselyov ,  Sarah Hayes

IPC: C07D513/04 ,  C07D413/14 ,  C07D471/04 ,  A61K51/04 ,  C07D413/12 ,  C07D263/57 ,  C07D498/04 ,  C07D405/14 ,  C07D413/04

Abstract: Provided are imaging agents comprising a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and methods of their use.

公开(公告)号：US20170283439A1

公开(公告)日：2017-10-05

申请号：US15507203

申请日：2015-08-28

Applicant: CHDI Foundation, Inc.

Inventor： Celia Dominguez ,  John Wityak ,  Jonathan Bard ,  Alex Kiselyov ,  Christopher John Brown ,  Michael Edward Prime ,  Peter David Johnson ,  Daniel CLark-Frew

IPC: C07D519/00 ,  A61K51/04 ,  C07D471/04

CPC classification number: C07D519/00 ,  A61K51/0455 ,  A61K51/0459 ,  C07D471/04

Abstract: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.