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公开(公告)号:US20210236663A1
公开(公告)日:2021-08-05
申请号:US17125905
申请日:2020-12-17
发明人: Longbin Liu , Matthew Lee , Celia Dominguez , Peter David Johnson , Christopher John Brown , Sarah Hayes , Adrian Kotey , Matthew Robert Mills , Michael Edward Prime
IPC分类号: A61K51/04 , C07D401/14 , C07D401/06 , C07D471/04 , C07D401/12 , C07D491/107 , C07D487/04 , C07D413/14 , C07B59/00
摘要: Provided herein are certain compounds and imaging agents useful for detecting a condition or disorder associated with protein aggregation, compositions thereof, and methods of their use.
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公开(公告)号:US11059836B2
公开(公告)日:2021-07-13
申请号:US16530594
申请日:2019-08-02
发明人: Celia Dominguez , Samuel Coe , Peter David Johnson , Michael Edward Prime , Christopher John Brown , Sébastien René Gabriel Galan , Paul Richard Giles , Jonathan Bard , Elise Luciennen Paulette Gadouleau , Thomas Martin Krülle , Daniel Clark-Frew , John Wityak , Alex Kiselyov , Sarah Hayes
IPC分类号: C07D513/04 , C07D413/14 , C07D417/04 , A61K51/04 , C07D413/12 , C07D263/57 , C07D498/04 , C07D405/14 , C07D413/04 , C07D471/04
摘要: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.
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公开(公告)号:US20210060187A1
公开(公告)日:2021-03-04
申请号:US16987277
申请日:2020-08-06
发明人: Celia Dominguez , John Wityak , Jonathan Bard , Christopher John Brown , Michael Edward Prime , Peter David Johnson , Thomas Martin Krulle , Daniel Clark-Frew , Duane Higgins , Matthew Robert Mills , Richard Waldron Marston , Samuel Coe , Samantha Brown , Sarah Hayes
IPC分类号: A61K51/04 , C07D513/04 , C07D487/04 , C07D513/14 , C07B59/00
摘要: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.
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公开(公告)号:US11104691B2
公开(公告)日:2021-08-31
申请号:US15507203
申请日:2015-08-28
发明人: Celia Dominguez , John Wityak , Jonathan Bard , Alex Kiselyov , Christopher John Brown , Michael Edward Prime , Peter David Johnson , Daniel Clark-Frew
IPC分类号: A61K51/00 , A61M36/14 , C07D519/00 , C07D471/04 , A61K51/04
摘要: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.
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公开(公告)号:US10765764B2
公开(公告)日:2020-09-08
申请号:US16172425
申请日:2018-10-26
发明人: Celia Dominguez , John Wityak , Jonathan Bard , Christopher John Brown , Michael Edward Prime , Peter David Johnson , Thomas Martin Krulle , Daniel Clark-Frew , Duane Higgins , Matthew Robert Mills , Richard Waldron Marston , Samuel Coe , Samantha Brown , Sarah Hayes
IPC分类号: A61K51/04 , C07D513/04 , C07D487/04 , C07D513/14 , C07B59/00
摘要: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.
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公开(公告)号:US20190167821A1
公开(公告)日:2019-06-06
申请号:US16172425
申请日:2018-10-26
发明人: Celia Dominguez , John Wityak , Jonathan Bard , Christopher John Brown , Michael Edward Prime , Peter David Johnson , Thomas Martin Krulle , Daniel Clark-Frew , Duane Higgins , Matthew Robert Mills , Richard Waldron Marston , Samuel Coe , Samantha Brown , Sarah Hayes
IPC分类号: A61K51/04 , C07B59/00 , C07D513/04 , C07D487/04 , C07D513/14
摘要: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.
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公开(公告)号:US10137211B2
公开(公告)日:2018-11-27
申请号:US15249223
申请日:2016-08-26
发明人: Celia Dominguez , John Wityak , Jonathan Bard , Christopher John Brown , Michael Edward Prime , Peter David Johnson , Thomas Martin Krulle , Daniel Clark-Frew , Duane Higgins , Matthew Robert Mills , Richard Waldron Marston , Samuel Coe , Samantha Brown , Sarah Hayes
IPC分类号: A61K51/04 , C07D513/04 , C07D487/04 , C07D513/14 , C07B59/00
摘要: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use
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公开(公告)号:US20240342317A1
公开(公告)日:2024-10-17
申请号:US18402399
申请日:2024-01-02
发明人: Longbin Liu , Matthew Lee , Celia Dominguez , Peter David Johnson , Catherine Jane Greenaway , Kanika Khurana , Matthew Robert Mills , Filippo Rota
IPC分类号: A61K51/04 , C07B59/00 , C07D231/12 , C07D471/04 , C07D487/04 , C07D487/14 , C07D519/00
CPC分类号: A61K51/0459 , A61K51/0455 , A61K51/0463 , C07B59/002 , C07D231/12 , C07D471/04 , C07D487/04 , C07D487/14 , C07D519/00 , C07B2200/05
摘要: Provided herein are certain compounds and imaging agents useful for detecting a disease or condition associated with protein aggregation, compositions thereof, and methods of their use.
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公开(公告)号:US11918662B2
公开(公告)日:2024-03-05
申请号:US17344582
申请日:2021-06-10
发明人: Longbin Liu , Matthew Lee , Celia Dominguez , Peter David Johnson , Catherine Jane Greenaway , Kanika Khurana , Matthew Robert Mills , Filippo Rota
IPC分类号: A61K51/04 , C07B59/00 , C07D231/12 , C07D471/04 , C07D487/04 , C07D487/14 , C07D519/00
CPC分类号: A61K51/0459 , A61K51/0455 , A61K51/0463 , C07B59/002 , C07D231/12 , C07D471/04 , C07D487/04 , C07D487/14 , C07D519/00 , C07B2200/05
摘要: Provided herein are certain compounds and imaging agents useful for detecting a disease or condition associated with protein aggregation, compositions thereof, and methods of their use.
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公开(公告)号:US20220339302A1
公开(公告)日:2022-10-27
申请号:US17715661
申请日:2022-04-07
发明人: Longbin Liu , Celia Dominguez , Jonathan Bard , Christopher John Brown , Xuemei Chen , Daniel Clark-Frew , Matthew Robert Mills , Peter David Johnson , Elise Gadouleau
IPC分类号: A61K51/04 , A61P25/28 , C07D401/14
摘要: Provided herein are certain isoindolinone compounds and imaging agents useful for detecting a disease or condition associated with protein aggregation, compositions thereof, and methods of their use.
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