公开(公告)号：US11059836B2

公开(公告)日：2021-07-13

申请号：US16530594

申请日：2019-08-02

Applicant: CHDI Foundation, Inc.

Inventor： Celia Dominguez ,  Samuel Coe ,  Peter David Johnson ,  Michael Edward Prime ,  Christopher John Brown ,  Sébastien René Gabriel Galan ,  Paul Richard Giles ,  Jonathan Bard ,  Elise Luciennen Paulette Gadouleau ,  Thomas Martin Krülle ,  Daniel Clark-Frew ,  John Wityak ,  Alex Kiselyov ,  Sarah Hayes

IPC: C07D513/04 ,  C07D413/14 ,  C07D417/04 ,  A61K51/04 ,  C07D413/12 ,  C07D263/57 ,  C07D498/04 ,  C07D405/14 ,  C07D413/04 ,  C07D471/04

Abstract: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.

公开(公告)号：US20210060187A1

公开(公告)日：2021-03-04

申请号：US16987277

申请日：2020-08-06

Applicant: CHDI Foundation, Inc.

Inventor： Celia Dominguez ,  John Wityak ,  Jonathan Bard ,  Christopher John Brown ,  Michael Edward Prime ,  Peter David Johnson ,  Thomas Martin Krulle ,  Daniel Clark-Frew ,  Duane Higgins ,  Matthew Robert Mills ,  Richard Waldron Marston ,  Samuel Coe ,  Samantha Brown ,  Sarah Hayes

IPC: A61K51/04 ,  C07D513/04 ,  C07D487/04 ,  C07D513/14 ,  C07B59/00

Abstract: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.

公开(公告)号：US11344637B2

公开(公告)日：2022-05-31

申请号：US16987277

申请日：2020-08-06

Applicant: CHDI Foundation, Inc.

Inventor： Celia Dominguez ,  John Wityak ,  Jonathan Bard ,  Christopher John Brown ,  Michael Edward Prime ,  Peter David Johnson ,  Thomas Martin Krulle ,  Daniel Clark-Frew ,  Duane Higgins ,  Matthew Robert Mills ,  Richard Waldron Marston ,  Samuel Coe ,  Samantha Brown ,  Sarah Hayes

IPC: A61K51/04 ,  C07D513/04 ,  C07D487/04 ,  C07D513/14 ,  C07B59/00

Abstract: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.

公开(公告)号：US20170283436A1

公开(公告)日：2017-10-05

申请号：US15507208

申请日：2015-08-28

Applicant: Celia DOMINGUEZ ,  John WITYAK ,  Jonathan BARD ,  Alex KISELYOV ,  Christopher John BROWN ,  Sebastien Rene Gabriel GALAN ,  Michael Edward PRIME ,  Paul Richard GILES ,  Elise Luciennen Paulette GADOULEAU ,  Thomas Martin KRÜLLE ,  Daniel CLARKFREW ,  Peter David JOHNSON ,  Sabinc SCHAERTI ,  Steffen Kaspar GRIMM ,  Jan Dirk KAHMANN ,  Christoph SCHEICH ,  Samuel COE ,  Sarah HAYES ,  CHDI Foundation, Inc.

Inventor： Celia Dominguez ,  John Wityak ,  Jonathan Bard ,  Alex Kiselyov ,  Christopher John Brown ,  Sébastien René Gabriel Galan ,  Michael Edward Prime ,  Paul Richard Giles ,  Elise Luciennen Paulette Gadouleau ,  Thomas Martin Krülle ,  Daniel Clark-Frew ,  Peter David Johnson ,  Samuel Coe ,  Sarah Hayes

IPC: C07D513/04 ,  C07D413/04 ,  C07D413/14 ,  A61K51/04 ,  C07D498/04 ,  C07D405/14 ,  C07D471/04 ,  C07D263/57 ,  C07D413/12

CPC classification number: C07D513/04 ,  A61K51/0455 ,  A61K51/0459 ,  A61K51/0463 ,  C07D263/57 ,  C07D405/14 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14 ,  C07D471/04 ,  C07D498/04

Abstract: Provided are imaging agents comprising a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and methods of their use.

公开(公告)号：US12258355B2

公开(公告)日：2025-03-25

申请号：US17881895

申请日：2022-08-05

Applicant: CHDI Foundation, Inc.

Inventor： Celia Dominguez ,  Samuel Coe ,  Peter David Johnson ,  Michael Edward Prime ,  Christopher John Brown ,  Sébastien René Gabriel Galan ,  Paul Richard Giles ,  Jonathan Bard ,  Elise Lucienne Paulette Gadouleau ,  Thomas Martin Krülle ,  Daniel Clark-Frew ,  John Wityak ,  Alex Kiselyov ,  Sarah Hayes

IPC: C07D513/04 ,  A61B5/00 ,  A61B6/03 ,  A61K51/04 ,  C07D263/57 ,  C07D405/14 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14 ,  C07D471/04 ,  C07D498/04

Abstract: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.

公开(公告)号：US20220339302A1

公开(公告)日：2022-10-27

申请号：US17715661

申请日：2022-04-07

Applicant: CHDI Foundation, Inc.

Inventor： Longbin Liu ,  Celia Dominguez ,  Jonathan Bard ,  Christopher John Brown ,  Xuemei Chen ,  Daniel Clark-Frew ,  Matthew Robert Mills ,  Peter David Johnson ,  Elise Gadouleau

IPC: A61K51/04 ,  A61P25/28 ,  C07D401/14

Abstract: Provided herein are certain isoindolinone compounds and imaging agents useful for detecting a disease or condition associated with protein aggregation, compositions thereof, and methods of their use.

公开(公告)号：US11071793B2

公开(公告)日：2021-07-27

申请号：US15507214

申请日：2015-08-28

Applicant: CHDI Foundation, Inc.

Inventor： Celia Dominguez ,  John Wityak ,  Jonathan Bard ,  Christopher John Brown ,  Thomas Martin Krülle ,  Daniel Clark-Frew ,  Sarah Hayes

IPC: A61K51/00 ,  A61M36/14 ,  A61K51/04 ,  C07D401/14 ,  C07D403/04 ,  C07D401/04 ,  C07D487/04 ,  C07D513/04 ,  C07D513/14

Abstract: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.

公开(公告)号：US10907197B2

公开(公告)日：2021-02-02

申请号：US15507217

申请日：2015-08-28

Applicant: CHDI Foundation, Inc.

Inventor： Celia Dominguez ,  John Wityak ,  Jonathan Bard ,  Christopher John Brown ,  Michael Edward Prime ,  Derek Alexander Weddell ,  Daryl Simon Walter ,  Paul Richard Giles ,  Ian James Wigginton ,  Malcolm George Taylor ,  Sébastien René Gabriel Galan ,  Peter David Johnson ,  Thomas Martin Krülle ,  Inaki Morao ,  Daniel Clark-Frew

IPC: C07D253/08 ,  C07D401/04 ,  C07D473/00 ,  C12Q1/6823 ,  A61K51/04

Abstract: Provided are imaging agents comprising a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and methods of their use.

公开(公告)号：US10479802B2

公开(公告)日：2019-11-19

申请号：US15507208

申请日：2015-08-28

Applicant: CHDI Foundation, Inc.

Inventor： Celia Dominguez ,  Samuel Coe ,  Jonathan Bard ,  Peter David Johnson ,  Michael Edward Prime ,  Christopher John Brown ,  Sébastien René Gabriel Galan ,  Paul Richard Giles ,  Elise Luciennen Paulette Gadouleau ,  Thomas Martin Krülle ,  Daniel Clark-Frew ,  John Wityak ,  Alex Kiselyov ,  Sarah Hayes

IPC: C07D513/04 ,  C07D413/14 ,  C07D471/04 ,  A61K51/04 ,  C07D413/12 ,  C07D263/57 ,  C07D498/04 ,  C07D405/14 ,  C07D413/04

Abstract: Provided are imaging agents comprising a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and methods of their use.

公开(公告)号：US11104691B2

公开(公告)日：2021-08-31

申请号：US15507203

申请日：2015-08-28

Applicant: CHDI Foundation, Inc.

Inventor： Celia Dominguez ,  John Wityak ,  Jonathan Bard ,  Alex Kiselyov ,  Christopher John Brown ,  Michael Edward Prime ,  Peter David Johnson ,  Daniel Clark-Frew

IPC: A61K51/00 ,  A61M36/14 ,  C07D519/00 ,  C07D471/04 ,  A61K51/04

Abstract: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.