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    Responsive neurostimulation for the treatment of chronic cardiac dysfunction
    21.
    发明授权
    Responsive neurostimulation for the treatment of chronic cardiac dysfunction 有权
    响应性神经刺激治疗慢性心脏功能障碍

    公开(公告)号：US09446237B2

    公开(公告)日：2016-09-20

    申请号：US14861390

    申请日：2015-09-22

    申请人： CYBERONICS, INC. ,  East Tennessee State University

    发明人： Imad Libbus ,  Badri Amurthur ,  Bruce H. KenKnight ,  Jeffrey L. Ardell

    IPC分类号： A61N1/00 ,  A61N1/36 ,  A61N1/372

    CPC分类号： A61N1/36114 ,  A61N1/36053 ,  A61N1/36135 ,  A61N1/36139 ,  A61N1/3615 ,  A61N1/37217 ,  A61N1/37264

    摘要： Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. The implanted stimulation device includes a physiological sensor for monitoring the patient's response to the neurostimulation therapy on an ambulatory basis over extended periods of time and a control system for adjusting stimulation parameters to maintain stimulation in the neural fulcrum zone based on detected changes in the physiological response to stimulation.

    摘要翻译： 提供系统和方法用于向患者提供神经刺激疗法用于治疗慢性心力衰竭。 识别神经支点区域，并在神经支点区域内递送正在进行的神经刺激治疗。 植入的刺激装置包括生理传感器，用于在延长的时间段内基于动态监测患者对神经刺激疗法的反应，以及控制系统，用于根据检测到的生理反应的变化调整刺激参数以维持神经支点区域中的刺激 刺激。

    NEUROSTIMULATION TITRATION PROCESS
    22.
    发明申请
    NEUROSTIMULATION TITRATION PROCESS 有权
    神经病学调查过程

    公开(公告)号：US20160045742A1

    公开(公告)日：2016-02-18

    申请号：US14457807

    申请日：2014-08-12

    申请人： CYBERONICS, INC.

    发明人： Imad Libbus ,  Bruce H. KenKnight ,  Badri Amurthur

    IPC分类号： A61N1/36

    CPC分类号： A61N1/36157 ,  A61B5/0205 ,  A61B5/02055 ,  A61B5/0245 ,  A61B5/4836 ,  A61N1/36114 ,  A61N1/36132 ,  A61N1/36139 ,  A61N1/36171 ,  A61N1/36175

    摘要： Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A titration process is used to gradually increase the stimulation intensity to a desired therapeutic level. This titration process can minimize the amount of time required to complete titration so as to begin delivery of the stimulation at therapeutically desirable levels.

    摘要翻译： 提供系统和方法用于向患者提供神经刺激疗法用于治疗慢性心力衰竭。 使用滴定过程将刺激强度逐渐增加到所需的治疗水平。 该滴定过程可以最小化完成滴定所需的时间，以便以治疗期望的水平开始递送刺激。

    IMPLANTABLE NEUROSTIMULATOR-IMPLEMENTED METHOD FOR MANAGING HYPERTENSION THROUGH RENAL DENERVATION AND VAGUS NERVE STIMULATION
    23.
    发明申请
    IMPLANTABLE NEUROSTIMULATOR-IMPLEMENTED METHOD FOR MANAGING HYPERTENSION THROUGH RENAL DENERVATION AND VAGUS NERVE STIMULATION 有权
    用于管理通过肾功能衰竭和VAGUS神经刺激引起的高血压的可植入神经细胞实施方法

    公开(公告)号：US20150196762A1

    公开(公告)日：2015-07-16

    申请号：US14154962

    申请日：2014-01-14

    申请人： CYBERONICS, INC.

    发明人： Badri Amurthur ,  Imad Libbus ,  Bruce H. KenKnight

    IPC分类号： A61N1/36 ,  A61B18/04 ,  A61M37/00 ,  A61B18/14

    CPC分类号： A61N1/36117 ,  A61B18/1492 ,  A61B2018/00434 ,  A61N1/0551 ,  A61N1/36053 ,  A61N1/37235

    摘要： A method for managing hypertension through renal nerve denervation and vagus nerve stimulation is provided. Renal nerves are disrupted to inhibit a sympathetic nervous system. Thereafter, an implantable neurostimulator, including a pulse generator, is configured to deliver electrical therapeutic stimulation in a manner that results in creation and propagation (in both afferent and efferent directions) of action potentials within neuronal fibers of a patient's cervical vagus nerve. A maintenance dose of the electrical therapeutic stimulation is delivered to the vagus nerve via the pulse generator to restore cardiac autonomic balance through continuously-cycling, intermittent and periodic electrical pulses.

    摘要翻译： 提供了一种通过肾神经去神经支配和迷走神经刺激来控制高血压的方法。 肾神经被破坏以抑制交感神经系统。 此后，包括脉冲发生器的可植入神经刺激器被配置为以导致患者的颈部迷走神经的神经元纤维内的动作电位的产生和传播（在传入和传出方向上）的方式递送电疗治疗刺激。 通过脉冲发生器将电治疗刺激的维持剂量输送到迷走神经，以通过连续循环，间歇和周期性电脉冲恢复心脏自主平衡。

    IMPLANTABLE NEUROSTIMULATOR-IMPLEMENTED METHOD FOR MANAGING BRADYCARDIA THROUGH VAGUS NERVE STIMULATION
    24.
    发明申请
    IMPLANTABLE NEUROSTIMULATOR-IMPLEMENTED METHOD FOR MANAGING BRADYCARDIA THROUGH VAGUS NERVE STIMULATION 有权

    公开(公告)号：US20140155949A1

    公开(公告)日：2014-06-05

    申请号：US14177542

    申请日：2014-02-11

    申请人： CYBERONICS, INC.

    发明人： Imad Libbus ,  Badri Amurthur ,  Bruce H. KenKnight

    IPC分类号： A61N1/365

    CPC分类号： A61N1/365 ,  A61B5/0464 ,  A61N1/36114 ,  A61N1/36139 ,  A61N1/36167 ,  A61N1/36171 ,  A61N1/36175

    摘要： A method for managing bradycardia through vagus nerve stimulation is provided. An implantable neurostimulator configured to deliver electrical therapeutic stimulation in both afferent and efferent directions of a patient's cervical vagus nerve is provided. An operating mode is stored, which includes parametrically defining a maintenance dose of the electrical therapeutic stimulation tuned to restore cardiac autonomic balance through continuously-cycling, intermittent and periodic electrical pulses. The maintenance dose is delivered via a pulse generator through a pair of helical electrodes via an electrically coupled nerve stimulation therapy lead independent of cardiac cycle. The patient's physiology is monitored, and upon sensing a condition indicative of bradycardia, the delivery of the maintenance dose is suspended. A progressively increasing amount of time is spent waiting via a controller and, upon sensing a condition indicative of an absence or termination of the bradycardia, a progressively increasing partial maintenance dose is delivered via the pulse generator.

    Implantable neurostimulator-implemented method for managing tachyarrhythmic risk during sleep through vagus nerve stimulation
    30.
    发明授权
    Implantable neurostimulator-implemented method for managing tachyarrhythmic risk during sleep through vagus nerve stimulation 有权

    公开(公告)号：US09643011B2

    公开(公告)日：2017-05-09

    申请号：US13828486

    申请日：2013-03-14

    申请人： CYBERONICS, INC.

    发明人： Imad Libbus ,  Badri Amurthur ,  Bruce H. Kenknight

    IPC分类号： A61N1/00 ,  A61N1/362 ,  A61N1/36

    CPC分类号： A61N1/3621 ,  A61N1/36114

    摘要： A patient suffering from congestive heart failure is at increased risk of cardiac arrhythmogenesis during sleep, particularly if experiencing central sleep apnea as a co-morbidity. Low intensity peripheral neurostimulation therapies that target imbalance of the autonomic nervous system have been shown to improve clinical outcomes. Thus, bi-directional autonomic regulation therapy is delivered to the cervical vagus nerve at an intensity that is insufficient to elicit pathological or acute physiological side effects and without the requirement of an enabling physiological feature or triggering physiological marker. The patient's physiology is monitored to identify periods of sleep. In one embodiment, upon sensing a condition indicative of tachyarrhythmia following a period of bradycardia, as naturally occurs during sleep, an enhanced “boost” dose of bi-directional neural stimulation intended to “break” the tachyarrhythmic condition is delivered. In a further embodiment, the boost dose is delivered upon sensing a physiological pattern indicative of Cheyne-Stokes respiration.