公开(公告)号：US20220175526A1

公开(公告)日：2022-06-09

申请号：US17399594

申请日：2021-08-11

Applicant: CARDIOVALVE LTD.

Inventor： Michael ALBITOV ,  Maxim KARALNIK ,  Meni IAMBERGER ,  Ilia HARITON ,  Tal HAMMER

IPC: A61F2/24 ,  A61F2/95

Abstract: A delivery tool including a shaft and a proximal capsule and a distal capsule is dimensioned for percutaneous delivery to the heart. An open end of the proximal capsule faces the open end of the distal capsule. The capsules are coupled to the shaft in a manner that allows axial movement of the capsule with respect to the shaft. A prosthetic heart valve includes a tubular portion that defines a lumen and prosthetic leaflets disposed within the lumen. The prosthetic heart valve is restrainable in a compressed state by the delivery tool, such that a downstream end of the tubular portion is disposed within the distal capsule. The distal capsule is shaped so as to define an opening for visualizing ensheathing of at least a portion of the downstream end of the tubular portion within the distal capsule. Other embodiments are also described.

公开(公告)号：US20210196461A1

公开(公告)日：2021-07-01

申请号：US17181722

申请日：2021-02-22

Applicant: CARDIOVALVE LTD.

Inventor： Ilia HARITON ,  Boaz HARARI ,  Maxim KARALNIK ,  Michael ALBITOV ,  Meni IAMBERGER

IPC: A61F2/24 ,  A61F2/966

Abstract: A delivery tool includes a nosepiece that is fixed to a shaft, and distal to an implant, and an expandable element proximal to the nosepiece. Maximally-expanded, the expandable element (i) has an expanded external diameter at its widest part that is smaller than the expanded internal diameter of a lumen of the frame of the implant, (ii) tapers proximally away from the widest part and from the nosepiece, and (iii) is dimensioned to slide proximally through the lumen of the implant in its expanded state, between leaflets of the implant, and out of the lumen. When non-expanded, the widest part of the expandable element has a non-expanded external diameter that is smaller than the expanded external diameter of the expandable element. In a compressed state of the implant a portion of the expandable element is disposed within the lumen of the frame. Other applications are also described.

公开(公告)号：US20200146824A1

公开(公告)日：2020-05-14

申请号：US16746489

申请日：2020-01-17

Applicant: CARDIOVALVE LTD.

Inventor： Tal HAMMER ,  Meni IAMBERGER ,  Yuval ZIPORY ,  Michael ALBITOV ,  Tal REICH ,  Ilia HARITON

IPC: A61F2/24

Abstract: Embodiments of the present disclosure provide an apparatus comprising a delivery tool and a prosthetic valve, the prosthetic valve comprising a first frame, and a second frame coupled to the first frame. The delivery tool comprises a first catheter, a second catheter, and a rod. A steerable portion of the second catheter extends out of the first catheter, and a steerable distal portion of the rod extends out of the second catheter. An extracorporeal rod-controller is operably coupled to the rod such that operating the extracorporeal rod-controller steers the steerable distal portion of the rod. In a delivery state of the apparatus, the prosthetic valve is compressed onto the rod, distal to the distal end of the second catheter, and the apparatus is transfemorally and transseptally advanceable into a left atrium of a heart of a subject. Other embodiments are also described.

公开(公告)号：US20190083263A1

公开(公告)日：2019-03-21

申请号：US16135619

申请日：2018-09-19

Applicant: CARDIOVALVE LTD.

Inventor： Ilia HARITON ,  Meni IAMBERGER ,  Aviram BAUM ,  Boaz HARARI

IPC: A61F2/24

Abstract: A prosthetic valve delivery system may be provided. The prosthetic valve delivery system may include a first catheter and a first steering mechanism configured to bend the first catheter within a first steering plane. The prosthetic valve delivery system may also include a second catheter coaxially arranged within the first catheter and a second steering mechanism configured to bend the second catheter within a second steering plane, different from the first steering plane. Moreover, the prosthetic valve delivery system may include a capsule positioned distal to both the first catheter and the second catheter. The capsule may be configured to retain a prosthetic valve therein during transvascular advancement of the capsule.

公开(公告)号：US20240407917A1

公开(公告)日：2024-12-12

申请号：US18775395

申请日：2024-07-17

Applicant: Cardiovalve Ltd.

Inventor： Ilia HARITON ,  Meni IAMBERGER ,  Aviram BAUM ,  Boaz HARARI ,  Yelena KASIMOV

IPC: A61F2/24

Abstract: A method for assembling a prosthetic valve includes obtaining (1) a frame assembly that includes a tubular portion and ventricular legs that extend radially outward from the tubular portion, and (2) a piece of flat, flexible material shaped to define (i) a belt, and (ii) strips extending from the belt along a respective strip-axis. Each strip is folded into a pocket by folding the strip over itself, about a fold-line that is orthogonal to the strip-axis, thereby forming (i) a first strip-portion that extends from the belt to the fold-line, and (ii) a second strip-portion that extends from the fold-line back toward the belt, and stitching together the first and second strip-portions at the first edge, and the first and second strip-portions at the second edge. Each leg is slid into a pocket. The belt is wrapped around the tubular portion. Other embodiments are also described.

公开(公告)号：US20240081983A1

公开(公告)日：2024-03-14

申请号：US18371191

申请日：2023-09-21

Applicant: CARDIOVALVE LTD.

Inventor： Ilia HARITON ,  Meni IAMBERGER ,  Aviram BAUM ,  Boaz HARARI

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2/2412 ,  A61F2/2427 ,  A61F2/243 ,  A61F2/2436

Abstract: A prosthetic valve includes a tubular portion coupled to an upstream support portion, and ventricular legs. The prosthetic valve is transitionable from a compressed state into a partially-expanded state in which (1) a downstream surface of the support portion defines (i) an annular concave region extending radially between a concave-region inner radius and a concave-region outer radius, and (ii) an annular convex region, radially outward from the annular concave region, extending radially between a convex-region inner radius and a convex-region outer radius, and (2) the tip of each leg is disposed radially between the concave-region inner radius and the concave- region outer radius. In a fully-expanded state each leg's tip is disposed radially between the convex-region inner radius and the convex-region outer radius. Other embodiments are also described.

公开(公告)号：US20210251759A1

公开(公告)日：2021-08-19

申请号：US17307176

申请日：2021-05-04

Applicant: CARDIOVALVE LTD.

Inventor： Yonatan KISLEV ,  Or COHEN ,  Meni IAMBERGER

IPC: A61F2/24

Abstract: A method of using a computer processor for grouping prosthetic valve leaflets of an aggregate of prosthetic valve leaflets is provided. For each leaflet of the aggregate, in response to an image parameter of the leaflet, a leaflet-flexibility value is derived. At least some of the leaflets of the aggregate are designated into leaflet groups, based on similarity between the respective leaflet-flexibility value of each leaflet of the aggregate. For each of the designated leaflet groups, the flexibility value of each leaflet in the designated leaflet group is within the intra-group tolerance with respect to the leaflet-flexibility value of each other leaflet in the designated leaflet group. An indication of the designated leaflet groups is outputted. Other embodiments are also described.

公开(公告)号：US20200085578A1

公开(公告)日：2020-03-19

申请号：US16132937

申请日：2018-09-17

Applicant: CARDIOVALVE LTD.

Inventor： Yonatan KISLEV ,  Or COHEN ,  Meni IAMBERGER

IPC: A61F2/24

Abstract: Embodiments of the present disclosure provide an apparatus for testing a plurality of prosthetic heart valve leaflets. The apparatus includes a vertical mount, and a plurality of horizontal bars are movably coupled to the mount. Each bar extends away from the mount along a respective bar-axis that lies on a respective vertical bar-plane. Each bar is configured to support a respective leaflet along the respective bar-axis such that the respective leaflet drapes over the respective bar. The apparatus further includes an image sensor, positioned opposite the mount, facing the plurality of bars and the mount so as to be oriented to acquire an image that includes the plurality of leaflets draped over the plurality of bars. Other embodiments are also described.

公开(公告)号：US20190083254A1

公开(公告)日：2019-03-21

申请号：US16136150

申请日：2018-09-19

Applicant: CARDIOVALVE LTD.

Inventor： Ilia HARITON ,  Meni IAMBERGER ,  Aviram BAUM ,  Boaz HARARI

IPC: A61F2/24

Abstract: A prosthetic valve configured for implantation within a native valve may be provided. The prosthetic valve may include an expandable valve body having an inner lumen extending along a longitudinal axis of the valve body. The prosthetic valve may additionally include a plurality of ventricular tissue anchors configured to extend from the valve body to ventricular anchor distal ends, as well as a plurality of atrial tissue anchors configured to extend from the valve body to atrial anchor distal ends. Each atrial tissue anchor may include a rigid portion, and a flexible portion situated between a distal end of the rigid portion and the atrial anchor distal end. The ventricular anchor distal end of a ventricular tissue anchor and the distal end of the rigid portion of an atrial tissue anchor may be configured to be equidistant from the longitudinal axis of the valve body.

公开(公告)号：US20190083248A1

公开(公告)日：2019-03-21

申请号：US16135969

申请日：2018-09-19

Applicant: CARDIOVALVE LTD.

Inventor： Ilia HARITON ,  Meni IAMBERGER ,  Aviram BAUM ,  Boaz HARARI

IPC: A61F2/24

Abstract: A prosthetic valve for implantation within a native mitral valve may be provided. The prosthetic valve may include an annular valve body and a plurality of atrial anchoring arms and a plurality of ventricular anchoring legs configured to extend radially outward from the annular valve body. The prosthetic valve may also include a blood-inflatable cuff situated between the arms and legs and fastened to at least one arm. The cuff may be configured to extend radially outward beyond a terminal end of at least one arm when fully inflated with blood.