公开(公告)号：US5251635A

公开(公告)日：1993-10-12

申请号：US753564

申请日：1991-09-03

申请人： Charles L. Dumoulin ,  Robert D. Darrow

发明人： Charles L. Dumoulin ,  Robert D. Darrow

IPC分类号： A61B5/06 ,  A61B6/00 ,  H04N13/00 ,  A61B5/00

CPC分类号： H04N13/0221 ,  A61B5/06 ,  A61B6/487 ,  H04N13/0253 ,  H04N13/0296 ,  H04N13/0434

摘要： During an X-ray procedure, the position and orientation of an invasive device, such as a catheter are measured with radio frequency fields and displayed stereoscopically. Instantaneous three-dimensional positions of the invasive device are displayed by superposition of a graphic symbol on static X-ray images obtained at two different view angles. The X-ray images are obtained only when deemed necessary by the operator to minimize X-ray dose. A single X-ray source and detector may be implemented since it is not necessary to obtain the X-ray images simultaneously.

摘要翻译： 在X射线过程中，诸如导管的侵入性装置的位置和取向用射频场测量并立体显示。 通过将图形符号叠加在以两个不同视角获得的静态X射线图像上来显示侵入性装置的瞬时三维位置。 仅当操作者认为必要时才能获得X射线图像以最小化X射线剂量。 可以实现单个X射线源和检测器，因为不需要同时获得X射线图像。

公开(公告)号：US5211165A

公开(公告)日：1993-05-18

申请号：US753565

申请日：1991-09-03

申请人： Charles L. Dumoulin ,  Robert D. Darrow ,  John F. Schenck ,  Steven P. Souza

发明人： Charles L. Dumoulin ,  Robert D. Darrow ,  John F. Schenck ,  Steven P. Souza

IPC分类号： A61B5/06 ,  A61B6/12 ,  G01V3/10

CPC分类号： A61B5/06 ,  A61B6/12 ,  G01V3/104 ,  A61B2034/2051

摘要： A tracking system in which radiofrequency signals emitted by an invasive device such as a catheter are detected and used to measure the position and orientation of the invasive device within a subject. Detection of the radiofrequency signals is accomplished with coils having sensitivity profiles which vary approximately linearly with position. The invasive device has a transmit coil attached near its end and is driven by a low power RF source to produce a dipole electromagnetic field that can be detected by an array of receive coils distributed around a region of interest of the subject. The position and orientation of the device as determined by the tracking system are superimposed upon independently acquired Medical Diagnostic images, thereby minimizing the diagnostic exposure times. One or more invasive devices can be simultaneously tracked.

摘要翻译： 检测由诸如导管的侵入性装置发射的射频信号并用于测量受试者内的侵入性装置的位置和取向的跟踪系统。 射频信号的检测是用具有随位置近似线性变化的灵敏度分布的线圈来实现的。 侵入性装置具有靠近其端部附接的发射线圈，并且由低功率RF源驱动以产生可以通过分布在受试者的感兴趣区域周围的接收线圈阵列来检测的偶极电磁场。 由跟踪系统确定的设备的位置和方向叠加在独立获取的医学诊断图像上，从而最小化诊断曝光时间。 可以同时跟踪一个或多个入侵设备。

公开(公告)号：US20120253176A1

公开(公告)日：2012-10-04

申请号：US13509324

申请日：2010-11-04

申请人： Charles L. Dumoulin

发明人： Charles L. Dumoulin

IPC分类号： A61N7/00 ,  A61B6/02 ,  A61B5/055 ,  A61B8/13 ,  A61B6/00 ,  A61B5/01

CPC分类号： A61N7/02 ,  A61B8/565 ,  A61B2017/00084 ,  A61B2090/374 ,  A61N2007/0008 ,  A61N2007/0065 ,  A61N2007/0082

摘要： Systems and methods for debulking visceral fat within a subject, include: providing a focused ultrasound transducer configured to focus ultrasonic power at a focal spot; positioning the focused ultrasound transducer with respect to the subject so that the focused ultrasound transducer is enabled to transfer ultrasonic power into the subject; locating the focal spot of the focused ultrasound transducer with respect to at least one target region containing visceral fat within the subject; and debulking visceral fat within the target region by applying ultrasonic energy from the focused ultrasound transducer with sufficient power to cause the death of visceral fat tissue within the target region.

摘要翻译： 用于在受试者内减毒内脏脂肪的系统和方法包括：提供配置成在焦斑处聚焦超声波功率的聚焦超声波换能器; 将聚焦的超声换能器相对于对象定位，使得聚焦的超声换能器能够将超声功率传送到被摄体中; 相对于在受试者内含有内脏脂肪的至少一个目标区域定位聚焦超声换能器的焦点; 并通过从聚焦的超声换能器中施加超声波能量以足够的力量引起目标区域内脏脂肪组织的死亡，从而在目标区域内减压内脏脂肪。

公开(公告)号：US5611340A

公开(公告)日：1997-03-18

申请号：US537571

申请日：1995-10-02

申请人： Steven P. Souza ,  Charles L. Dumoulin

发明人： Steven P. Souza ,  Charles L. Dumoulin

IPC分类号： A61B5/055

CPC分类号： A61B5/055

摘要： A magnetic resonance (MR) active invasive device system employs a small, high-field polarizing magnet, and a large low-field magnetic resonance (MR) imaging magnet for the purpose of generating MR angiograms of selected blood vessels. A subject is positioned in a large low-field MR imaging magnet. A catheter is inserted into the patient at or near the root of a vessel tree desired to be imaged. A hydrogen gas is first cooled and condensed into a liquid state, and then passed through the small high-field polarizing magnet where it becomes highly polarized. A contrast fluid is then made by chemically combining the polarized hydrogen with oxygen to obtain highly polarized water. The water is then heated to physiologic temperatures and, if desired, made more physiologically compatible with the addition of substances such as salts. The physiologically conditioned polarized fluid is then introduced into the subject through the catheter. Radiofrequency (RF) pulses and magnetic field gradients are then applied to the patient as in conventional MR imaging. Since the fluid has a larger longitudinal magnetization than tissue which has not passed through the polarizing magnet, the fluid produces a much larger MR response signal than other tissue resulting in the vessel tree being imaged with excellent contrast.

摘要翻译： 磁共振（MR）主动侵入性装置系统采用小型，高场极化磁体和大型低场磁共振（MR）成像磁体，以产生选定血管的MR血管造影。 受试者位于大型低场MR成像磁体中。 在期望成像的血管树的根部处或附近将导管插入患者体内。 首先将氢气冷却并冷凝成液态，然后通过小型高场极化磁铁，在其中高度极化。 然后通过将偏振氢与氧化学组合来获得高极化水来制造造影剂。 然后将水加热至生理温度，并且如果需要，与物质例如盐的添加相比更具生理学相容性。 然后通过导管将生理调节的极化流体引入受试者。 然后将射频（RF）脉冲和磁场梯度应用于患者，如在常规MR成像中。 由于流体具有比没有通过偏振磁体的组织更大的纵向磁化强度，所以流体产生比其它组织大得多的MR响应信号，导致血管树以优异的对比度成像。

公开(公告)号：US5419325A

公开(公告)日：1995-05-30

申请号：US264282

申请日：1994-06-23

申请人： Charles L. Dumoulin ,  Steven P. Souza

发明人： Charles L. Dumoulin ,  Steven P. Souza

IPC分类号： A61B5/055 ,  G01R33/28 ,  G01R33/422 ,  G01R33/561 ,  G01R33/563 ,  G06T1/00

CPC分类号： G01R33/285 ,  G01R33/563 ,  G01R33/422 ,  G01R33/5617

摘要： A magnetic resonance (MR) angiography system employs a Faraday catheter for generating MR angiograms of selected blood vessels. A subject is first placed in a polarizing magnetic field. The Faraday catheter is then inserted into a selected blood vessel of the subject at or near the root of a vessel tree desired to be imaged. An MR imaging pulse sequence is then applied to the subject to obtain image information from the region containing the desired vessel tree. Fluid inside the Faraday catheter is shielded from the RF pulses of the MR imaging sequence allowing the fluid to be in a relaxed state, while tissue outside the Faraday catheter is on a steady-state. As the fluid exits the catheter, and before it reaches steady-state, it produces an increased MR response signal causing the desired vessel tree to be imaged.

摘要翻译： 磁共振（MR）血管造影系统采用法拉第导管来产生选定血管的MR血管造影。 首先将被摄体置于极化磁场中。 然后将法拉第导管插入受试者的选定血管中，该血管中希望成像的血管树根部处或附近。 然后将MR成像脉冲序列应用于受试者以从包含所需血管树的区域获得图像信息。 法拉第导管内的流体与MR成像序列的RF脉冲屏蔽，允许流体处于松弛状态，而法拉第导管外的组织处于稳态。 当流体离开导管并且在其达到稳定状态之前，其产生增加的MR响应信号，从而使所需的血管树成像。

公开(公告)号：US5285260A

公开(公告)日：1994-02-08

申请号：US909275

申请日：1992-07-06

申请人： Charles L. Dumoulin

发明人： Charles L. Dumoulin

IPC分类号： G01N21/25 ,  G01B17/04 ,  G01N21/17 ,  G01N25/16 ,  G01N29/00 ,  G01J3/52

CPC分类号： G01N21/1702 ,  G01B17/04 ,  G01N21/171 ,  A61B5/0066

摘要： An optical interferometer and an ultrasonic distance measuring subsystem are used to obtain spectra from the surface of a sample. The interferometer uses a broadband electromagnetic radiation source and modulates the radiation at a frequency which is inversely proportional to wavelength. The modulated radiation impinges on the surface of interest where it is absorbed. The absorption of radiation causes the surface of the sample to expand. This change in dimension is then detected by the ultrasonic distance measuring subsystem which employs a single frequency acoustic radiation source to measure the instantaneous distance between the sample surface and the ultrasonic distance measurement subsystem. The detected changes in distance relate to amplitude of absorption at a given wavelength, thereby allowing absorption spectra for surface point to be generated indicating the chemical composition of each point of the surface.

摘要翻译： 使用光学干涉仪和超声波距离测量子系统从样品的表面获得光谱。 干涉仪使用宽带电磁辐射源，并以与波长成反比的频率调制辐射。 调制的辐射照射在感兴趣的表面上，在其被吸收的地方。 辐射的吸收导致样品的表面膨胀。 然后，超声波距离测量子系统检测尺寸变化，该子系统采用单声频辐射源来测量样品表面和超声波距离测量子系统之间的瞬时距离。 检测到的距离变化与给定波长处的吸收幅度有关，从而允许产生指示表面各点的化学成分的表面点的吸收光谱。

公开(公告)号：US5214380A

公开(公告)日：1993-05-25

申请号：US767584

申请日：1991-09-30

申请人： Charles L. Dumoulin

发明人： Charles L. Dumoulin

IPC分类号： G01R33/46 ,  G01R33/563

CPC分类号： G01R33/56308 ,  G01R33/4625 ,  G01R33/4633 ,  G01R33/56316

摘要： NMR spectroscopy employing flow-encoding magnetic field gradient pulses provide velocity sensitivity. Spectroscopic analysis of constituents of a sample can be obtained and separated by velocity. Fluid samples to be analyzed are passed through a chromatography column in order to cause different constituents of the sample to pass at different velocities. The sample is then subjected to a velocity sensitive NMR encoding sequence. Data is acquired from the sample which allows a spectroscopic analysis of a constituent of the sample. Signals from molecules of a constituent travelling at a desired velocity can be selectively detected, thereby providing information concerning the molecular weight of the detected molecule. NMR spectra of a mixture of molecules having differing molecular weights and absorption properties can be resolved into their individual constituents. The velocity sensitive NMR encoding and data acquisition may also be employed to determine the chemical composition of a fluid such as blood moving through a living organism.

摘要翻译： 采用流动编码磁场梯度脉冲的NMR光谱提供速度灵敏度。 可以获得样品成分的光谱分析，并通过速度分离。 要分析的流体样品通过色谱柱，以使样品的不同组分以不同的速度通过。 然后对样品进行速度敏感的NMR编码序列。 从样品中获取数据，其允许对样品的成分进行光谱分析。 可以选择性地检测以期望速度行进的组分的分子的信号，由此提供关于检测到的分子的分子量的信息。 具有不同分子量和吸收性质的分子的混合物的NMR光谱可以被分解成它们的各个成分。 还可以使用速度敏感NMR编码和数据采集来确定诸如通过活生物体移动的血液的流体的化学组成。

公开(公告)号：US5060248A

公开(公告)日：1991-10-22

申请号：US546281

申请日：1990-06-29

申请人： Charles L. Dumoulin

发明人： Charles L. Dumoulin

IPC分类号： G01N23/06 ,  G01N27/00 ,  G01Q90/00

CPC分类号： G01Q30/02 ,  B82Y35/00

摘要： A scanning spectral-analysis micro-probe subsystem, for a surface imaging system, utilizes a micro-probe to detect the precise position of a point on a sample object surface having surface dimensions changing responsive to surface absorption of incident radiation from a modulated radiation source. The modulated incident radiation causes the sample region dimensions, in the vicinity of the micro-probe, to be modulated, so that the micro-probe detects this dimensional modulation, with a detected modulation strength directly proportional to the incident radiation absorption.

摘要翻译： 用于表面成像系统的扫描光谱分析微探针子系统利用微探针来检测样品物体表面上的点的精确位置，其具有响应于来自调制辐射源的入射辐射的表面吸收的表面尺寸而变化 。 调制的入射辐射导致在微探针附近的样品区域尺寸被调制，使得微探针检测到该尺寸调制，其检测的调制强度与入射辐射吸收成正比。

公开(公告)号：US5025788A

公开(公告)日：1991-06-25

申请号：US497290

申请日：1990-03-22

申请人： Charles L. Dumoulin

发明人： Charles L. Dumoulin

IPC分类号： G01R33/563

CPC分类号： G01R33/563

摘要： Several sequences of radio-frequency and magnetic field gradients are presented for obtaining from a sample multiple response echo signals from which to obtain a plurality of independent angiograms, which can be combined or separately analyzed to provide more information than an individual angiogram, but in substantially the same amount of time as a single angiogram. For example, a series of angiograms, each with a different projection axis, can be obtained in the time required to obtain a single angiogram using a single echo method. If the view angle of each echo is the same, then the acquired angiograms can be added to enhance the signal-to-noise ratio. Another pulse sequence simultaneously obtains two or more angiograms, each sensitive to one of two orthogonal flow components of the overall blood flow; the angiograms are then added to give an angiogram which is sensitive to total flow in all directions. Multiple velocity ranges are accommodated in a fourth sequence form.

摘要翻译： 呈现射频和磁场梯度的几个序列用于从样本多响应回波信号获得多个独立血管造影图，其可以被组合或单独分析以提供比单个血管造影更多的信息，但是基本上 与单次血管造影相同的时间量。 例如，可以在使用单回波方法获得单个血管造影所需的时间内获得每一个具有不同投影轴的血管造影图。 如果每个回波的视角相同，则可以添加获取的血管造影以提高信噪比。 另一个脉冲序列同时获得两个或更多个血管造影图，每个血管造影检查对于整个血流的两个正交流分量之一敏感; 然后加入血管造影以产生对所有方向的总流量敏感的血管造影。 多个速度范围以第四顺序形式被容纳。

公开(公告)号：US20140364722A1

公开(公告)日：2014-12-11

申请号：US14376523

申请日：2012-08-24

申请人： Charles L. Dumoulin

发明人： Charles L. Dumoulin

IPC分类号： A61B5/055 ,  G01G19/44 ,  A61B5/00 ,  A61G11/00

CPC分类号： A61B5/0555 ,  A61B5/0046 ,  A61B2503/045 ,  A61G11/005 ,  G01G19/44

摘要： The present disclosure relates to a transfer table assembly suitable for use in association with an MR scanner. The transfer table assembly includes a transfer table attached to a transfer table base that may releasably engage an incubator. The transfer table may be dimensionally constructed such that it may be inserted directly into an MR scanner.

摘要翻译： 本公开涉及适于与MR扫描仪相关联使用的转印台组件。 传送台组件包括附接到可释放地接合培养箱的转台台的转台。 传送台可以是尺寸构造的，使得其可以直接插入到MR扫描仪中。