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公开(公告)号：US08242442B2
公开(公告)日：2012-08-14
申请号：US12695111
申请日：2010-01-27
申请人： Clinton Alawn Krueger , Ching Wu
发明人： Clinton Alawn Krueger , Ching Wu
CPC分类号： G01N27/622
摘要： The present invention involves a series of shifting reagents that selectively interact with a targeted functional group of biological molecules, pharmaceutical drugs, small molecules, chemicals, chemical agents, or explosives resulting in a structure selective based drift time shift in the IMS. The invention allows detecting and confirming samples using one or more ion mobility based spectrometers.
摘要翻译： 本发明涉及一系列转移试剂，其选择性地与生物分子，药物，小分子，化学品，化学试剂或爆炸物的目标官能团相互作用，导致IMS中基于结构选择性的漂移时间偏移。 本发明允许使用一种或多种基于离子迁移率的光谱仪检测和确认样品。
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公开(公告)号：US11417507B2
公开(公告)日：2022-08-16
申请号：US17107481
申请日：2020-11-30
申请人： Mark A Osgood , Ching Wu
发明人： Mark A Osgood , Ching Wu
IPC分类号： H01J49/00 , G01N27/622 , H01J49/06 , C07B63/00 , H01J49/04
摘要： The present invention relates to improving the ability of a hyphenated instrument to analyze a sample benefiting from having the first instrument's analysis of the same sample. A fast switching mechanism can be used as the interface between an ion mobility spectrometer (IMS) and a mass spectrometer (MS) such that the obtained IMS spectrum is converted into a timing diagram that controls the vacuum inlet's size dynamically during analysis of a neutral and/or charged chemical and/or biological species such that a smaller pumping system can be used. In various operational modes of the IMS-MS device, mobility-separated ions are allowed to pass through an ion gate and the vacuum inlet for mass analysis.
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公开(公告)号：US10276358B2
公开(公告)日：2019-04-30
申请号：US15665421
申请日：2017-07-31
申请人： Ching Wu , Mark A Osgood
发明人： Ching Wu , Mark A Osgood
摘要： An ion mobility spectrometry apparatus and method wherein ions are selected using an AC gate, then separated along a drift axis while providing a drift gas flow in a direction that is substantially neither in the direction of the drift axis nor opposite to the drift axis.
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公开(公告)号：US20160005581A1
公开(公告)日：2016-01-07
申请号：US14742653
申请日：2015-06-17
CPC分类号： H01J49/0031 , G01N27/622 , G01N30/7233 , H01J49/004
摘要： A second gate in an Ion Mobility Spectrometer is used to select or block different time windows of the ion mobility spectrum. A second gate in the Ion Mobility Mass Spectrometer is used to modulate peak intensities in the IMS spectrum, allowing each peak in the IMS spectrum to be unambiguously matched with its set of fragment ions in a subsequent MS-MS mass spectrum.
摘要翻译： 离子移动光谱仪中的第二个门用于选择或阻止离子迁移谱的不同时间窗。 离子迁移质谱仪中的第二个栅极用于调制IMS光谱中的峰值强度，允许IMS光谱中的每个峰与其随后的MS-MS质谱中的碎片离子组明确匹配。
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公开(公告)号：US20150303043A1
公开(公告)日：2015-10-22
申请号：US14703868
申请日：2015-05-04
申请人： Mark A. Osgood , Ching Wu
发明人： Mark A. Osgood , Ching Wu
CPC分类号： H01J49/004 , C07B63/00 , G01N27/622 , H01J49/0027 , H01J49/0031 , H01J49/0495 , H01J49/067
摘要： The present invention relates to improving the ability of a hyphenated instrument to analyze a sample benefiting from having the first instrument's analysis of the same sample. A fast switching mechanism can be used as the interface between an ion mobility spectrometer (IMS) and a mass spectrometer (MS) such that the obtained IMS spectrum is converted into a timing diagram that controls the vacuum inlet's size dynamically during analysis of a neutral and/or charged chemical and/or biological species such that a smaller pumping system can be used.
摘要翻译： 本发明涉及提高连字的仪器分析从具有第一仪器对相同样品的分析而受益的样品的能力。 可以将快速切换机制用作离子迁移谱仪（IMS）和质谱仪（MS）之间的界面，使得所获得的IMS光谱被转换成时序图，其在中性分析期间动态地控制真空入口的尺寸， /或带电的化学和/或生物物质，使得可以使用较小的泵送系统。
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公开(公告)号：US20100200745A1
公开(公告)日：2010-08-12
申请号：US12763092
申请日：2010-04-19
申请人： Mark A. Osgood , Ching Wu
发明人： Mark A. Osgood , Ching Wu
CPC分类号： H01J49/061 , C07B63/00 , G01N27/622 , Y10T29/49227
摘要： The present invention generally relates to systems and methods for transmitting beams of charged particles, and in particular to such systems and methods that employ defecting at least one set of grid elements into the same plane to form an ion gate. In addition, an operation method of closing a gate involving alternating voltages on the adjacent gate wires is described.
摘要翻译： 本发明一般涉及用于传送带电粒子束的系统和方法，特别涉及这样的系统和方法，该系统和方法使用将至少一组栅格元件缺陷到同一平面中以形成离子门。 此外，描述了在相邻栅极线上闭合涉及交流电压的栅极的操作方法。
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公开(公告)号：US09236234B2
公开(公告)日：2016-01-12
申请号：US14214558
申请日：2014-03-14
申请人： Ching Wu , Mark A Osgood
发明人： Ching Wu , Mark A Osgood
CPC分类号： H01J49/061 , C07B63/00 , G01N27/622 , H01J49/0027
摘要： The present invention uses an AC voltage instead of DC voltage on an ion gate to filter/selectively pass ions. The ions that pass through the AC ion gate can be further separated in a spectrometric instrument. An ion mobility spectrometer using the AC ion gate can achieve better gating performance. For a time of flight ion mobility spectrometer with an AC ion gate, a narrow pulse of selected ions can be passed into a drift tube where they are separated based on their low field ion mobility. Moreover, when the AC voltage at the AC ion gate has a waveform as used for differential ion mobility spectrometry, the time of flight ion mobility spectrometer is converted into a two dimensional separation spectrometer, where ions are first separated based on their high field ion mobility and then further separated based on their low field ion mobility.
摘要翻译： 本发明在离子浇口上使用交流电压而不是直流电压来过滤/选择性地通过离子。 通过AC离子浇口的离子可以在光谱仪器中进一步分离。 使用AC离子浇口的离子迁移谱仪可以获得更好的门控性能。 对于具有AC离子浇口的飞行时间离子迁移谱仪，选择的离子的窄脉冲可以被传送到漂移管中，基于它们的低场离子迁移率，它们被分离。 此外，当AC离子浇口处的AC电压具有用于差示离子迁移率光谱法的波形时，将飞行时间离子迁移谱仪转换成二维分离光谱仪，其中离子首先基于它们的高场离子迁移率而被分离 然后基于它们的低场离子迁移率进一步分离。
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公开(公告)号：US10049865B2
公开(公告)日：2018-08-14
申请号：US14703868
申请日：2015-05-04
申请人： Mark A Osgood , Ching Wu
发明人： Mark A Osgood , Ching Wu
摘要： The present invention relates to improving the ability of a hyphenated instrument to analyze a sample benefiting from having the first instrument's analysis of the same sample. A fast switching mechanism can be used as the interface between an ion mobility spectrometer (IMS) and a mass spectrometer (MS) such that the obtained IMS spectrum is converted into a timing diagram that controls the vacuum inlet's size dynamically during analysis of a neutral and/or charged chemical and/or biological species such that a smaller pumping system can be used.
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公开(公告)号：US09859105B2
公开(公告)日：2018-01-02
申请号：US14742653
申请日：2015-06-17
CPC分类号： H01J49/0031 , G01N27/622 , G01N30/7233 , H01J49/004
摘要： A second gate in an Ion Mobility Spectrometer is used to select or block different time windows of the ion mobility spectrum. A second gate in the Ion Mobility Mass Spectrometer is used to modulate peak intensities in the IMS spectrum, allowing each peak in the IMS spectrum to be unambiguously matched with its set of fragment ions in a subsequent MS-MS mass spectrum.
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公开(公告)号：US09177770B2
公开(公告)日：2015-11-03
申请号：US12763092
申请日：2010-04-19
申请人： Mark A. Osgood , Ching Wu
发明人： Mark A. Osgood , Ching Wu
CPC分类号： H01J49/061 , C07B63/00 , G01N27/622 , Y10T29/49227
摘要： The present invention generally relates to systems and methods for transmitting beams of charged particles, and in particular to such systems and methods that employ defecting at least one set of grid elements into the same plane to form an ion gate. In addition, an operation method of closing a gate involving alternating voltages on the adjacent gate wires is described.
摘要翻译： 本发明一般涉及用于传送带电粒子束的系统和方法，特别涉及这样的系统和方法，该系统和方法使用将至少一组栅格元件缺陷到同一平面中以形成离子门。 此外，描述了在相邻栅极线上闭合涉及交流电压的栅极的操作方法。
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