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    Compounds containing matrix metalloproteinase substrates and methods of their use
    21.
    发明申请
    Compounds containing matrix metalloproteinase substrates and methods of their use 审中-公开
    含有基质金属蛋白酶底物的化合物及其使用方法

    公开(公告)号：US20050106100A1

    公开(公告)日：2005-05-19

    申请号：US10931627

    申请日：2004-09-01

    申请人： Thomas Harris ,  Padmaja Yalamanchili

    发明人： Thomas Harris ,  Padmaja Yalamanchili

    IPC分类号： A61K49/00 ,  A61K51/00 ,  A61K51/08 ,  C07K16/46

    CPC分类号： A61K51/0495 ,  A61K49/0002 ,  A61K51/08

    摘要： Compounds for use in a diagnostic agent for detecting, imaging, and/or monitoring a pathological disorder associated with matrix metalloproteinase activity at a site of interest in a patient are disclosed. Compositions and kits containing the compounds are also disclosed. In addition, methods of detecting, imaging, and/or monitoring the presence of matrix metalloproteinase or a pathological disorder associated with matrix metalloprotainase activity in a patient are disclosed.

    摘要翻译： 公开了用于诊断用于检测，成像和/或监测与患者感兴趣部位的基质金属蛋白酶活性相关的病理学障碍的化合物。 还公开了含有这些化合物的组合物和试剂盒。 此外，公开了检测，成像和/或监测基质金属蛋白酶的存在或与患者中的基质金属蛋白酶活性相关的病理学障碍的方法。

    Concrete mixing drum cleanout apparatus and method
    26.
    发明申请
    Concrete mixing drum cleanout apparatus and method 审中-公开
    混凝土搅拌筒清洗装置及方法

    公开(公告)号：US20070086270A1

    公开(公告)日：2007-04-19

    申请号：US11252144

    申请日：2005-10-17

    申请人： Thomas Harris ,  Aaron Meyer

    发明人： Thomas Harris ,  Aaron Meyer

    IPC分类号： B28C5/42

    CPC分类号： B28C5/4203 ,  B08B9/08 ,  B08B9/0813

    摘要： An integrally mounted apparatus for washing out vehicle-mounted concrete mixing drums is disclosed. The washout apparatus includes an open-ended elongate, relatively rigid shaped hollow guide tube mounted in fixed relation to the support structure support of an inclined mixing drum and extending in fixed relation to the open end of the drum between the fins and charge hopper. A flexible hollow hose is threaded through the guide tube. The hose has a receiving end connected with a source of cleaning fluid under pressure and a discharge end which protrudes from the end of the guide tube as it ends inside the open end of the mixing drum. A forward hose stop is provided for preventing the hose from slipping back down through the guide tube and a rear hose stop is provided for limiting the travel of the discharge end of the hose outward from the end of the guide tube.

    摘要翻译： 公开了一种用于清洗车载混凝土搅拌筒的整体安装的装置。 冲洗装置包括开口的细长相对刚性的中空导管，其以倾斜的混合鼓的支撑结构支撑件固定的关系安装，并且在固定的关系上延伸到在翅片和充电料斗之间的滚筒的开口端。 柔性中空软管穿过导管。 软管具有与压力下的清洁流体源连接的接收端以及当引导管的端部在混合鼓的开口端内部时突出的排出端。 提供一个前向软管止挡件，用于防止软管通过引导管向下滑动，并且提供一个后软管止动件，用于限制软管的排放端从引导管的端部向外的行进。

    Method for designing modulators of flexible multi-domain protein kinases
    27.
    发明申请
    Method for designing modulators of flexible multi-domain protein kinases 审中-公开
    用于设计灵活多结构域蛋白激酶调节剂的方法

    公开(公告)号：US20060292681A1

    公开(公告)日：2006-12-28

    申请号：US11450295

    申请日：2006-06-12

    申请人： Thomas Harris

    发明人： Thomas Harris

    IPC分类号： C12N9/99 ,  G06F19/00

    CPC分类号： C12Q1/485 ,  C12N9/1205

    摘要： The present invention describes novel methods of designing protein kinase modulators, particularly modulators that interact at the interface between two protein kinase domains. In some embodiments, the methods comprise determining the position of at least one site between the first domain and the second domain, wherein the modulator binds to the at least one site and wherein the at least one site is not an ATP binding site.

    摘要翻译： 本发明描述了设计蛋白激酶调节剂的新方法，特别是在两个蛋白激酶结构域之间的界面相互作用的调节剂。 在一些实施方案中，所述方法包括确定第一结构域和第二结构域之间的至少一个位点的位置，其中所述调节剂结合所述至少一个位点，并且其中所述至少一个位点不是ATP结合位点。

    Coalescing filter elements comprising self-sustaining, bonded fiber structures
    28.
    发明申请
    Coalescing filter elements comprising self-sustaining, bonded fiber structures 审中-公开
    聚合过滤元件包括自持式粘结纤维结构

    公开(公告)号：US20060207234A1

    公开(公告)日：2006-09-21

    申请号：US11377071

    申请日：2006-03-15

    申请人： Bennett Ward ,  Jian Xiang ,  Thomas Harris ,  Ronald Binshtok

    发明人： Bennett Ward ,  Jian Xiang ,  Thomas Harris ,  Ronald Binshtok

    IPC分类号： B01D39/14

    CPC分类号： B01D39/163 ,  B01D17/045 ,  B01D17/10 ,  B01D39/02

    摘要： Filter elements are provided for removing a liquid challenge material dispersed in a carrier fluid. The filter element comprises a three dimensional, self-sustaining, fluid transmissive body comprising a plurality of thermoplastic fibers bonded to each other at spaced apart points of contact. The fibers collectively define a tortuous fluid flow path through the fluid transmissive body from a fluid inlet surface to a fluid outlet surface. At least a portion of the thermoplastic fibers comprise a surface-forming material having a surface energy that is less than a surface tension of the challenge material.

    摘要翻译： 提供过滤元件用于去除分散在载体流体中的液体挑战物质。 过滤元件包括一个三维的，自持的流体传递体，其包括在间隔开的接触点处彼此结合的多个热塑性纤维。 纤维共同地限定了从流体入口表面到流体出口表面的通过流体传递体的曲折的流体流动路径。 至少一部分热塑性纤维包括具有小于攻击材料的表面张力的表面能的表面形成材料。

    Methods and apparatuses for implantable medical device telemetry power management
    29.
    发明申请
    Methods and apparatuses for implantable medical device telemetry power management 有权
    用于植入式医疗设备遥测功率管理的方法和装置

    公开(公告)号：US20060025834A1

    公开(公告)日：2006-02-02

    申请号：US11244273

    申请日：2005-10-05

    申请人： Jeffrey Von Arx ,  David Yonce ,  Scott Mazar ,  Karen Lent ,  Thomas Harris

    发明人： Jeffrey Von Arx ,  David Yonce ,  Scott Mazar ,  Karen Lent ,  Thomas Harris

    IPC分类号： A61N1/08

    CPC分类号： A61N1/37 ,  A61N1/08 ,  A61N1/37223 ,  A61N1/37276 ,  A61N1/3925 ,  A61N1/3962 ,  G06F19/00 ,  G06F19/3418

    摘要： An implantable medical device includes a radio-frequency (RF) telemetry circuit connected to an energy source through a power connection module to obtain power when a user initiates an RF telemetry session. After the session is completed, the power connection module shuts off the at least one portion of the RF telemetry circuit. Power-on examples include a wireless telemetry activation signal received by a low power radio receiver in the implantable device, a physical motion detected by an activity sensor therein, an activation of an inductive telemetry circuit therein, a magnetic field detected by a magnetic field detector therein, and/or a telemetry activation signal detected by a sensing circuit included therein. Power-off examples include a wireless termination signal received by the implantable device, a delay timeout after the session, and/or a signal received by an inductive telemetry circuit in the implantable device.

    摘要翻译： 可植入医疗装置包括通过电力连接模块连接到能量源的射频（RF）遥测电路，以在用户发起RF遥测会话时获得电力。 会话完成后，电源连接模块关闭RF遥测电路的至少一部分。 上电示例包括由可植入装置中的低功率无线电接收器接收的无线遥测激活信号，由其中的活动传感器检测到的物理运动，其中的感应遥测电路的激活，由磁场检测器检测的磁场 和/或由其中包括的感测电路检测到的遥测激活信号。 断电示例包括由可植入装置接收的无线终端信号，会话之后的延迟超时和/或由可植入装置中的感应遥测电路接收的信号。

    Hydrotreating of fischer-tropsch derived feeds prior to oligomerization using an ionic liquid catalyst
    30.
    发明申请
    Hydrotreating of fischer-tropsch derived feeds prior to oligomerization using an ionic liquid catalyst 审中-公开
    在使用离子液体催化剂进行低聚反应之前，加热加热费托衍生的原料

    公开(公告)号：US20050245778A1

    公开(公告)日：2005-11-03

    申请号：US11154498

    申请日：2005-06-15

    申请人： David Johnson ,  Thomas Harris ,  Michael Driver

    发明人： David Johnson ,  Thomas Harris ,  Michael Driver

    IPC分类号： C07C2/00 ,  C07C2/04 ,  C10G2/00 ,  C10G9/00 ,  C10G45/02 ,  C10G45/58 ,  C10G50/02 ,  C10G57/02 ,  C10G69/06 ,  C10G69/12

    CPC分类号： C10G45/02 ,  C10G2/32 ,  C10G9/00 ,  C10G45/58 ,  C10G50/02 ,  C10G57/02 ,  C10G69/06 ,  C10G69/12

    摘要： A process for oligomerizing a Fischer-Tropsch derived feed containing oxygenates which comprises (a) reducing significantly the oxygenates present in the Fischer-Tropsch derived feed by contacting said feed with a hydrotreating catalyst under hydrotreating conditions in a hydrotreating zone and recovering from the hydrotreating zone a Fischer-Tropsch derived hydrotreated feed which contains a significantly reduced amount of oxygenates as compared to the Fischer-Tropsch derived feed and also a significant amount of paraffins; (b) pyrolyzing the Fischer-Tropsch derived hydrotreated feed in a thermal cracking zone under thermal cracking conditions pre-selected to crack the paraffin molecules to form olefins and collecting an olefin-enriched Fischer-Tropsch feed from the thermal cracking zone; (c) contacting the olefin-enriched Fischer-Tropsch feed with a Lewis acid ionic liquid catalyst in an oligomerization zone under oligomerization reaction conditions; and (d) recovering from the oligomerization zone a Fischer-Tropsch derived product having molecules characterized by a higher average molecular weight and increased branching as compared to the Fischer-Tropsch derived feed.

    摘要翻译： 一种使含有含氧化合物的费 - 托衍生的原料低聚的方法，其包括（a）通过在加氢处理区中在加氢处理条件下使所述进料与加氢处理催化剂接触并显着地还原费 - 托衍生的进料中存在的含氧化合物，并从加氢处理区回收 费 - 托衍生的加氢处理的饲料，其与费 - 托衍生的饲料相比含有显着减少量的含氧化合物，并且还含有大量的链烷烃; （b）在预先选择的热裂解条件下在热裂解区中热解费 - 托衍生的加氢处理的原料，以裂解石蜡分子以形成烯烃并从热裂解区收集富烯烃的费 - 托进料; （c）在低聚反应条件下，在低聚区中使含烯烃的费 - 托进料与路易斯酸离子液体催化剂接触; 和（d）与费 - 托衍生的原料相比，具有分子特征在于较高的平均分子量和增加的支化的费 - 托衍生产物从低聚区回收。