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    Injectable physiological monitoring system
    1.
    发明授权
    Injectable physiological monitoring system 有权
    注射生理监测系统

    公开(公告)号：US09186089B2

    公开(公告)日：2015-11-17

    申请号：US12209479

    申请日：2008-09-12

    申请人： Scott Mazar ,  Mark Bly

    发明人： Scott Mazar ,  Mark Bly

    IPC分类号： A61B5/02 ,  A61B5/07 ,  A61B5/00 ,  A61B5/145 ,  A61B5/0205 ,  A61B5/053 ,  A61N1/372

    CPC分类号： A61B5/7282 ,  A61B5/0031 ,  A61B5/0205 ,  A61B5/02055 ,  A61B5/0422 ,  A61B5/053 ,  A61B5/07 ,  A61B5/076 ,  A61B5/1118 ,  A61B5/14503 ,  A61B5/4875 ,  A61B5/686 ,  A61B5/7232 ,  A61B2560/0214 ,  A61B2560/0468 ,  A61B2562/0219 ,  A61B2562/04 ,  A61B2562/06 ,  A61B2562/16 ,  A61N1/37205 ,  G06F19/00

    摘要： A system and method for decompensation prediction of a heart failure patient with one or more injectable detecting systems communicating wirelessly with a remote monitoring system. The system includes one or more injectable detecting systems having a plurality of sensors that provide an indication of at least one physiological event of a patient, a wireless communication device coupled to the one or more injectable detecting systems and configured to transfer patient data directly or indirectly from the one or more injectable detecting systems to a remote monitoring system, and a remote monitoring system coupled to the wireless communication device, the remote monitoring system using processed data to determine heart failure status and predict impending decompensation of the patient.

    摘要翻译： 一种用于与一个或多个与远程监测系统无线通信的可注射检测系统的心力衰竭患者的失代偿预测的系统和方法。 该系统包括一个或多个可注射检测系统，其具有提供患者至少一个生理事件的指示的多个传感器，耦合到该一个或多个可注射检测系统并被配置为直接或间接转移患者数据的无线通信设备 从所述一个或多个可注射检测系统到远程监控系统以及耦合到所述无线通信设备的所述远程监控系统，所述远程监控系统使用处理的数据来确定心力衰竭状态并预测所述患者的即将失代偿失调。

    Systems and methods for timing-based communication between implantable medical devices
    2.
    发明授权
    Systems and methods for timing-based communication between implantable medical devices 有权
    可植入式医疗设备之间基于定时通信的系统和方法

    公开(公告)号：US08374693B2

    公开(公告)日：2013-02-12

    申请号：US11186245

    申请日：2005-07-21

    申请人： Abhijeet V. Chavan ,  Jeffrey A. Von Arx ,  Scott Mazar

    发明人： Abhijeet V. Chavan ,  Jeffrey A. Von Arx ,  Scott Mazar

    IPC分类号： A61N1/32

    CPC分类号： A61M5/14276 ,  A61M2205/3523 ,  A61M2205/3569 ,  A61M2205/8212 ,  A61N1/37276 ,  A61N1/378 ,  A61N1/3962 ,  A61N1/3975

    摘要： A method carried out by an implantable medical device (IMD) for coordinating performance of one or more designated functions includes waiting in a low-power state for a predetermined event, detecting the predetermined event, and, responsive to detecting the predetermined event, searching for a wake-up command from a coordinating device implanted in the human body. The method further includes, receiving the wake-up command, and responsive to receiving the wake-up command, performing the one or more designated functions, and returning to the low-power state. A system includes a network of one or more implantable medical devices (IMDs) implanted in a human body. The system includes a satellite IMD operable to change between a plurality of power states, search for a wake-up command, and transmit an identification signal. The system may include a primary unit operable to receive the signal and coordinate a wake-up time based on the signal.

    摘要翻译： 用于协调一个或多个指定功能的性能的可植入医疗装置（IMD）执行的方法包括在低功率状态下等待预定事件，检测预定事件，并且响应于检测到预定事件，搜索 来自植入人体的协调装置的唤醒命令。 该方法还包括：接收唤醒命令，并响应于接收到唤醒命令，执行一个或多个指定功能，并返回到低功率状态。 一种系统包括植入人体内的一个或多个可植入医疗装置（IMD）的网络。 该系统包括可操作以在多个功率状态之间切换，搜索唤醒命令并发送识别信号的卫星IMD。 系统可以包括主单元，其可操作以接收信号并且基于该信号来协调唤醒时间。

    METHOD AND APPARATUS FOR ESTABLISHING CONTEXT AMONG EVENTS AND OPTIMIZING IMPLANTED MEDICAL DEVICE PERFORMANCE
    4.
    发明申请
    METHOD AND APPARATUS FOR ESTABLISHING CONTEXT AMONG EVENTS AND OPTIMIZING IMPLANTED MEDICAL DEVICE PERFORMANCE 有权
    建立事件背景和优化医疗器械性能的方法和装置

    公开(公告)号：US20060195163A1

    公开(公告)日：2006-08-31

    申请号：US11381051

    申请日：2006-05-01

    申请人： Bruce KenKnight ,  Eric Lovett ,  Robert Sweeney ,  Scott Mazar ,  Yatheendhar Manicka

    发明人： Bruce KenKnight ,  Eric Lovett ,  Robert Sweeney ,  Scott Mazar ,  Yatheendhar Manicka

    IPC分类号： A61N1/08

    CPC分类号： A61N1/36514 ,  A61N1/3627 ,  A61N1/37211 ,  A61N1/37235 ,  A61N1/37282 ,  G06F19/00

    摘要： An apparatus and method for adjusting the performance of an implanted device based on data including contextual information. Contextual information, including operational and performance data concerning the implanted device as well as the patient with the implanted device, is stored by a portable electronic device. In one embodiment, the portable electronic device is adapted for battery operation and includes a personal digital assistant (PDA). The portable electronic device is adapted for use as an interface to conduct wireless communications with the implanted device. In one embodiment, the portable electronic device interfaces with a clinical programmer for use by a physician.

    摘要翻译： 一种用于基于包括上下文信息的数据来调整植入装置的性能的装置和方法。 上下文信息，包括关于植入装置的操作和性能数据以及具有植入装置的患者，由便携式电子装置存储。 在一个实施例中，便携式电子设备适用于电池操作并且包括个人数字助理（PDA）。 便携式电子设备适于用作与植入的设备进行无线通信的接口。 在一个实施例中，便携式电子设备与临床程序员接口以供医生使用。

    Systems and methods for deriving relative physiologic measurements using a backend computing system
    6.
    发明申请
    Systems and methods for deriving relative physiologic measurements using a backend computing system 有权
    使用后端计算系统导出相对生理测量的系统和方法

    公开(公告)号：US20060064143A1

    公开(公告)日：2006-03-23

    申请号：US10943627

    申请日：2004-09-17

    申请人： Jeffrey Von Arx ,  Scott Mazar ,  Abhi Chavan

    发明人： Jeffrey Von Arx ,  Scott Mazar ,  Abhi Chavan

    IPC分类号： A61N1/08

    CPC分类号： A61N1/37252 ,  A61B5/0031 ,  A61M5/14276 ,  A61M5/1723 ,  A61M2205/3523 ,  A61M2205/52 ,  A61M2230/30 ,  A61N1/37217 ,  A61N1/37223 ,  G06F19/00

    摘要： One embodiment of the present invention relates to a system for deriving physiologic measurement values that are relative to ambient conditions. In one embodiment, the system comprises an implantable medical device (“IMD”), an external computing device, and a backend computing system. The IMD determines an absolute physiologic parameter value within a patient's body, and communicates the absolute physiologic parameter value outside the patient's body, for example, to the external computing device. Further, the external computing device receives the absolute physiologic parameter from the IMD and communicates it to the backend computing system. The backend computing system receives the absolute physiologic parameter value and obtains an ambient condition value outside the body that can affect the absolute physiologic parameter value. The backend computing system then calculates a relative physiologic parameter value from the ambient condition value and the absolute physiologic parameter value, and in some embodiments, stores the relative physiologic parameter value in a storage location, such as a memory or database.

    摘要翻译： 本发明的一个实施例涉及用于导出相对于环境条件的生理测量值的系统。 在一个实施例中，该系统包括可植入医疗装置（“IMD”），外部计算装置和后端计算系统。 IMD确定患者体内的绝对生理参数值，并将例如外部计算设备的绝对生理参数值传达到患者体外。 此外，外部计算设备从IMD接收绝对生理参数并将其传送到后端计算系统。 后端计算系统接收绝对生理参数值，并获得可能影响绝对生理参数值的身体外部的环境条件值。 后端计算系统然后根据环境条件值和绝对生理参数值计算相对生理参数值，并且在一些实施例中，将相对生理参数值存储在诸如存储器或数据库的存储位置中。

    Implantable sensor with biocompatible coating for controlling or inhibiting tissue growth
    7.
    发明授权
    Implantable sensor with biocompatible coating for controlling or inhibiting tissue growth 有权
    具有生物相容性涂层的植入式传感器，用于控制或抑制组织生长

    公开(公告)号：US08696564B2

    公开(公告)日：2014-04-15

    申请号：US10888340

    申请日：2004-07-09

    申请人： Abhi Chavan ,  Jeffrey Ross ,  Cynthia Morrissey ,  Scott Mazar ,  Donald Palme

    发明人： Abhi Chavan ,  Jeffrey Ross ,  Cynthia Morrissey ,  Scott Mazar ,  Donald Palme

    IPC分类号： A61B5/04

    CPC分类号： B82Y30/00 ,  A61B5/00 ,  A61B5/0031 ,  B82Y15/00

    摘要： All or a portion of a surface of an implantable sensor is covered with a biocompatible coating formed at least partially of a biomaterial matrix having properties that promote a substantially even growth of tissue cells over the surface of the coating. Additional materials, such as growth factors, agents that recruit endogenous stem cells, and cell adhesion motif arginine, glycine, aspartic acid may be included in the coating. Autologous cells may be added to the coating prior to implantation. The sensor surface may also be textured, by etching or abrading, in order to promote even tissue growth. Alternatively, the sensor surface may be covered with a coating having properties that inhibit the growth of tissue. These coatings may include a biomaterial, a biomaterial matrix having a drug, such as a sirolimus or a steroid, an active component, or a self assembled monolayer.

    摘要翻译： 可植入传感器的表面的全部或一部分被至少部分地由具有促进组织细胞在涂层表面上的基本均匀生长的特性的生物材料基质形成的生物相容性涂层覆盖。 另外的材料，例如生长因子，招募内源性干细胞的药剂，细胞粘附基序精氨酸，甘氨酸，天冬氨酸可以包括在涂层中。 自体细胞可以在植入之前加入到涂层中。 为了促进均匀的组织生长，传感器表面也可以通过蚀刻或研磨进行纹理化。 或者，传感器表面可以被具有抑制组织生长的性质的涂层覆盖。 这些涂层可以包括生物材料，具有药物的生物材料基质，例如西罗莫司或类固醇，活性成分或自组装单层。

    Injectable Physiological Monitoring System
    8.
    发明申请
    Injectable Physiological Monitoring System 有权
    注射生理监测系统

    公开(公告)号：US20090076401A1

    公开(公告)日：2009-03-19

    申请号：US12209479

    申请日：2008-09-12

    申请人： Scott Mazar ,  Mark Bly

    发明人： Scott Mazar ,  Mark Bly

    IPC分类号： A61B5/02

    CPC分类号： A61B5/7282 ,  A61B5/0031 ,  A61B5/0205 ,  A61B5/02055 ,  A61B5/0422 ,  A61B5/053 ,  A61B5/07 ,  A61B5/076 ,  A61B5/1118 ,  A61B5/14503 ,  A61B5/4875 ,  A61B5/686 ,  A61B5/7232 ,  A61B2560/0214 ,  A61B2560/0468 ,  A61B2562/0219 ,  A61B2562/04 ,  A61B2562/06 ,  A61B2562/16 ,  A61N1/37205 ,  G06F19/00

    摘要： A system and method are provided for decompensation prediction of a heart failure patient with one or more injectable detecting systems communicating wirelessly with a remote monitoring system. The system includes one or more injectable detecting systems having a plurality of sensors that provide an indication of at least one physiological event of a patient, a wireless communication device coupled to the one or more injectable detecting systems and configured to transfer patient data directly or indirectly from the one or more injectable detecting systems to a remote monitoring system, and a remote monitoring system coupled to the wireless communication device, the remote monitoring system using processed data to determine heart failure status and predict impending decompensation of the patient.

    摘要翻译： 提供了一种用于使用一个或多个与远程监视系统无线通信的可注射检测系统的心力衰竭患者的失代偿预测的系统和方法。 该系统包括一个或多个可注射检测系统，其具有提供患者至少一个生理事件的指示的多个传感器，耦合到该一个或多个可注射检测系统并被配置为直接或间接地转移患者数据的无线通信设备 从所述一个或多个可注射检测系统到远程监控系统以及耦合到所述无线通信设备的所述远程监控系统，所述远程监控系统使用处理的数据来确定心力衰竭状态并预测所述患者的即将失代偿失调。

    SYSTEM AND METHOD FOR CORRELATING BIOMETRIC TRENDS WITH A RELATED TEMPORAL EVENT
    9.
    发明申请
    SYSTEM AND METHOD FOR CORRELATING BIOMETRIC TRENDS WITH A RELATED TEMPORAL EVENT 有权
    将相关时间事件与生物量趋势相关联的系统和方法

    公开(公告)号：US20080027757A1

    公开(公告)日：2008-01-31

    申请号：US11869611

    申请日：2007-10-09

    申请人： Scott Mazar ,  Bruce Kenknight

    发明人： Scott Mazar ,  Bruce Kenknight

    IPC分类号： G06Q50/00

    CPC分类号： A61B5/0002 ,  G06F19/00 ,  G06Q50/22

    摘要： Systems and methods for correlating biometric trends with a related temporal event are disclosed. A preferred embodiment utilizes an implantable medical device comprising at least one sensor in electronic communication with a patient management system adapted to temporally analyze and correlate biometric data. Some embodiments of a system disclosed herein also can be configured as an Advanced Patient Management system that helps better monitor, predict and manage chronic diseases.

    摘要翻译： 公开了将生物识别趋势与相关时间事件相关联的系统和方法。 优选实施例利用可植入医疗装置，其包括至少一个传感器，该传感器与患者管理系统进行电子通信，患者管理系统适于暂时分析和关联生物特征数据。 本文公开的系统的一些实施例还可以被配置为有助于更好地监测，预测和管理慢性疾病的高级患者管理系统。

    Quick starting external programmer for implantable medical device
    10.
    发明授权
    Quick starting external programmer for implantable medical device 有权
    快速启动可植入医疗设备的外部编程器

    公开(公告)号：US07111159B2

    公开(公告)日：2006-09-19

    申请号：US11172283

    申请日：2005-06-30

    申请人： Richard E. Stein ,  Eugene Khenson ,  Scott Mazar

    发明人： Richard E. Stein ,  Eugene Khenson ,  Scott Mazar

    IPC分类号： G06F15/177

    CPC分类号： G06F9/4418

    摘要： A system and method for restoring a microprocessor-based system to a previously booted target state in which an image of memory and the processor registers in the previously booted state is saved and stored in a storage device. A restore routine executing in ROM retrieves the image from the storage device and restores the system memory and processor registers to the target state. An operating system return routine then returns control of the system to the operating system software. In an exemplary implementation, a system in accordance with the invention is incorporated into a microprocessor-based external programmer for a cardiac rhythm management device in order to allow quick starting of the programmer from a powered down condition without going through a time consuming boot process.

    摘要翻译： 一种用于将基于微处理器的系统恢复到先前引导的目标状态的系统和方法，其中存储器和处理器在先前引导状态下登记的映像被保存并存储在存储设备中。 在ROM中执行的恢复例程从存储设备检索图像，并将系统存储器和处理器寄存器恢复到目标状态。 操作系统返回例程，然后将系统的控制权返回给操作系统软件。 在示例性实现中，根据本发明的系统被并入用于心律管理设备的基于微处理器的外部编程器中，以便允许程序员从断电状态快速启动，而不经历耗时的启动过程。