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公开(公告)号：US06872714B1
公开(公告)日：2005-03-29
申请号：US09743561
申请日：1999-07-08
申请人： Dominique Schols
发明人： Dominique Schols
IPC分类号： A61K31/381 , A61K31/395 , A61K31/4178 , A61K31/4353 , A61K31/44 , A61K31/4427 , A61K31/4433 , A61K31/444 , A61K31/496 , A61K31/497 , A61K31/52 , A61K31/675 , A61P1/00 , A61P19/02 , A61P21/02 , A61P25/00 , A61P31/12 , A61P31/18 , A61P35/00 , C07D257/02 , C07D401/06 , C07D401/12 , C07D403/12 , C07D409/12 , C07D471/06 , C07D471/08 , C07D473/00 , C07D487/08 , A61K31/33
CPC分类号： C07D473/00 , C04B35/632 , C07D257/02 , C07D401/06 , C07D401/12 , C07D403/12 , C07D409/12 , C07D471/06
摘要： The present invention is drawn to novel antiviral compounds, pharmaceutical compositions and their use. More specifically this invention is drawn to derivatives of monocyclic polyamines which have activity in standard tests against HIV- or FIV-infected cells as well as other biological activity related to binding of ligands to chemokine receptors that medicate a number of mammalian embryonic developmental processes.
摘要翻译： 本发明涉及新的抗病毒化合物，药物组合物及其应用。 更具体地，本发明涉及在针对HIV或FIV感染的细胞的标准测试中具有活性的单环多胺的衍生物以及与配制剂对许多哺乳动物胚胎发育过程的趋化因子受体的结合相关的其它生物活性。
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公开(公告)号：US06835731B2
公开(公告)日：2004-12-28
申请号：US09957654
申请日：2001-09-17
申请人： Gary Bridger , Renato Skerlj , Al Kaller , Curtis Harwig , David Bogucki , Trevor R. Wilson , Jason Crawford , Ernest J. McEachern , Bem Atsma , Siqiao Nan , Yuanxi Zhou , Dominique Schols , Christopher Dennis , Rosaria Maria Di Fluri
发明人： Gary Bridger , Renato Skerlj , Al Kaller , Curtis Harwig , David Bogucki , Trevor R. Wilson , Jason Crawford , Ernest J. McEachern , Bem Atsma , Siqiao Nan , Yuanxi Zhou , Dominique Schols , Christopher Dennis , Rosaria Maria Di Fluri
IPC分类号： A61K31541
CPC分类号： C07D213/38 , C07D213/65 , C07D213/81 , C07D215/40 , C07D401/12 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D491/04
摘要： Tertiary amines containing a multiplicity of heteroaromatic substituents are useful as chemokine receptor modulators.
摘要翻译： 含有多个杂芳族取代基的叔胺可用作趋化因子受体调节剂。
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公开(公告)号：US06756391B2
公开(公告)日：2004-06-29
申请号：US10143692
申请日：2002-05-09
申请人： Gary James Bridger , Eva Maria Boehringer , Zhongren Wang , Dominique Schols , Renato Tony Skerlj , David Earl Bogucki
发明人： Gary James Bridger , Eva Maria Boehringer , Zhongren Wang , Dominique Schols , Renato Tony Skerlj , David Earl Bogucki
IPC分类号： A61K31675
CPC分类号： C07D473/00 , C04B35/632 , C07D257/02 , C07D401/06 , C07D401/12 , C07D403/12 , C07D409/12 , C07D471/06
摘要： The present invention is drawn to novel antiviral compounds, pharmaceutical compositions and their use. More specifically this invention is drawn to derivatives of monocyclic polyamines which have activity in standard tests against HIV-infected cells as well as other biological activity related to binding of ligands to chemokine receptors that mediate a number of mammalian embryonic developmental processes.
摘要翻译： 本发明涉及新的抗病毒化合物，药物组合物及其应用。 更具体地，本发明涉及在针对HIV感染细胞的标准测试中具有活性的单环多胺衍生物以及与介导多种哺乳动物胚胎发育过程的配体与趋化因子受体的结合相关的其它生物活性。
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公开(公告)号：US06667320B2
公开(公告)日：2003-12-23
申请号：US09740050
申请日：2000-12-15
申请人： Gary James Bridger , Eva Maria Boehringer , Zhongren Wang , Dominique Schols , Renato Tony Skerlj , David Earl Bogucki
发明人： Gary James Bridger , Eva Maria Boehringer , Zhongren Wang , Dominique Schols , Renato Tony Skerlj , David Earl Bogucki
IPC分类号： A61K3144
CPC分类号： C07D401/12 , A61K31/33 , A61K31/4439 , A61K31/496 , A61K31/52 , C07D257/02 , C07D403/12 , C07D413/12 , C07D417/12 , Y02A50/411
摘要： The present invention is drawn to novel antiviral compounds, pharmaceutical compositions and their use. More specifically this invention is drawn to derivatives of monocyclic polyamines which have activity in standard tests against HIV- or FIV-infected cells as well as other biological activity related to binding of ligands to chemokine receptors that mediate a number of mammalian embryonic developmental processes.
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25.发明授权公开(公告)号：US08778967B2
公开(公告)日：2014-07-15
申请号：US13358041
申请日：2012-01-25
申请人： Gary Bridger , Renato T Skelj , Al Kaller , Curtis Harwig , David Bogucki , Trevor R Wilson , Jason B Crawford , Ernest J McEachern , Bem Atsma , Siqiao Nan , Yuanxi Zhou , Dominique Schols , Christopher Dennis Smith , Maria R Di Fluri
发明人： Gary Bridger , Renato T Skelj , Al Kaller , Curtis Harwig , David Bogucki , Trevor R Wilson , Jason B Crawford , Ernest J McEachern , Bem Atsma , Siqiao Nan , Yuanxi Zhou , Dominique Schols , Christopher Dennis Smith , Maria R Di Fluri
IPC分类号： A61K31/4709 , C07D403/12
CPC分类号： A61K31/4184 , A61K31/415 , A61K31/436 , A61K31/47 , A61K31/4709 , A61K31/4725 , A61K31/495 , A61K31/497 , A61K31/4985 , A61K31/50 , A61K31/502 , A61K31/506 , A61K31/5377 , C07D235/14 , C07D401/12 , C07D401/14 , C07D403/12 , C07D471/04 , C07D471/06 , C07D491/04 , C07D491/052 , Y02A50/411
摘要： The invention relates to heterocyclic compounds consisting of a core nitrogen atom surrounded by three pendant groups, wherein two of the three pendant groups are preferably benzimidazolyl methyl and tetrahydroquinolyl, and the third pendant group contains N and optionally contains additional rings. The compounds bind to chemokine receptors, including CXCR4 and CCR5, and demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).
摘要翻译： 本发明涉及由三个侧基包围的核心氮原子组成的杂环化合物，其中三个侧基中的两个优选为苯并咪唑基甲基和四氢喹啉基，第三侧基含有N并且任选地含有另外的环。 这些化合物与趋化因子受体结合，包括CXCR4和CCR5，并表现出针对人类免疫缺陷病毒（HIV）感染靶细胞的保护作用。
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公开(公告)号：US07709486B2
公开(公告)日：2010-05-04
申请号：US12182044
申请日：2008-07-29
申请人： Gary J. Bridger , Eva Maria Boehringer , Zhongren Wang , Dominique Schols , Renato Tony Skerlj , David Earl Bogucki
发明人： Gary J. Bridger , Eva Maria Boehringer , Zhongren Wang , Dominique Schols , Renato Tony Skerlj , David Earl Bogucki
IPC分类号： A61P19/02 , A61P1/00 , A61P35/00 , A61K31/497 , A61K31/395 , A61K31/33 , A61K31/44 , A61K31/675 , C07D257/02 , C07D487/08
CPC分类号： C07D473/00 , C04B35/632 , C07D257/02 , C07D401/06 , C07D401/12 , C07D403/12 , C07D409/12 , C07D471/06
摘要： The present invention is drawn to novel antiviral compounds, pharmaceutical compositions and their use. More specifically this invention is drawn to derivatives of monocyclic polyamines which have activity in standard tests against HIV- or FIV-infected cells as well as other biological activity related to binding of ligands to chemokine receptors that mediate a number of mammalian embryonic developmental processes.
摘要翻译： 本发明涉及新的抗病毒化合物，药物组合物及其应用。 更具体地，本发明涉及在针对HIV或FIV感染的细胞的标准测试中具有活性的单环多胺的衍生物以及与介导多种哺乳动物胚胎发育过程的配体与趋化因子受体的结合相关的其它生物活性。
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公开(公告)号：US07414065B2
公开(公告)日：2008-08-19
申请号：US10991944
申请日：2004-11-17
申请人： Gary J. Bridger , Eva Maria Boehringer , Zhongren Wang , Dominique Schols , Renato Tony Skerlj , David Earl Bogucki
发明人： Gary J. Bridger , Eva Maria Boehringer , Zhongren Wang , Dominique Schols , Renato Tony Skerlj , David Earl Bogucki
IPC分类号： A61K31/395 , C07D257/02 , A61P19/02
CPC分类号： C07D473/00 , C04B35/632 , C07D257/02 , C07D401/06 , C07D401/12 , C07D403/12 , C07D409/12 , C07D471/06
摘要： The present invention is drawn to novel antiviral compounds, pharmaceutical compositions and their use. More specifically this invention is drawn to derivatives of monocyclic polyamines which have activity in standard tests against HIV- or FIV-infected cells as well as other biological activity related to binding of ligands to chemokine receptors that mediate a number of mammalian embryonic developmental processes.
摘要翻译： 本发明涉及新的抗病毒化合物，药物组合物及其应用。 更具体地，本发明涉及在针对HIV或FIV感染的细胞的标准测试中具有活性的单环多胺的衍生物以及与介导多种哺乳动物胚胎发育过程的配体与趋化因子受体的结合相关的其它生物活性。
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公开(公告)号：US07183273B2
公开(公告)日：2007-02-27
申请号：US10837467
申请日：2004-04-30
申请人： Gary J. Bridger , Renato Skerlj , Al Kaller , Curtis Harwig , David Bogucki , Trevor R. Wilson , Jason Crawford , Ernest J. McEachern , Bem Atsma , Siqiao Nan , Yuanxi Zhou , Dominique Schols
发明人： Gary J. Bridger , Renato Skerlj , Al Kaller , Curtis Harwig , David Bogucki , Trevor R. Wilson , Jason Crawford , Ernest J. McEachern , Bem Atsma , Siqiao Nan , Yuanxi Zhou , Dominique Schols
IPC分类号： A61K31/55 , A61K31/47 , A61K31/445 , A61P19/02 , A61P31/18
CPC分类号： C07D239/42 , A61K45/06 , C07D213/38 , C07D215/40 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D451/04 , C07D471/04 , C07D487/04
摘要： Heterocyclic compounds that bind chemokine receptors and inhibit the binding of their natural ligands are disclosed. The invention compounds are protective against infection by HIV and exert effects characteristic of antagonists to the CXCR4 receptor.
摘要翻译： 公开了结合趋化因子受体并抑制其天然配体结合的杂环化合物。 本发明化合物可防止HIV感染并发挥拮抗剂对CXCR4受体特征的作用。
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公开(公告)号：US07160872B2
公开(公告)日：2007-01-09
申请号：US10872735
申请日：2004-06-21
申请人： Gary Bridger , Eva Maria Boehringer , Zhongren Wang , Dominique Schols , Renato Skerlj , David Bogucki
发明人： Gary Bridger , Eva Maria Boehringer , Zhongren Wang , Dominique Schols , Renato Skerlj , David Bogucki
IPC分类号： A61K31/675 , A61K31/44 , A61K31/33 , A61P31/12 , C07D243/14
CPC分类号： C07D473/00 , C04B35/632 , C07D257/02 , C07D401/06 , C07D401/12 , C07D403/12 , C07D409/12 , C07D471/06
摘要： The present invention is drawn to novel antiviral compounds, pharmaceutical compositions and their use. More specifically this invention is drawn to derivatives of monocyclic polyamines which have activity in standard tests against HIV-infected cells as well as other biological activity related to binding of ligands to chemokine receptors that mediate a number of mammalian embryonic developmental processes.
摘要翻译： 本发明涉及新的抗病毒化合物，药物组合物及其应用。 更具体地，本发明涉及在针对HIV感染细胞的标准测试中具有活性的单环多胺衍生物以及与介导多种哺乳动物胚胎发育过程的配体与趋化因子受体的结合相关的其它生物活性。
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公开(公告)号：US20050026942A1
公开(公告)日：2005-02-03
申请号：US10914663
申请日：2004-08-09
申请人： Gary Bridger , Renato Skerlj , Al Kaller , Curtis Harwig , David Bogucki , Trevor Wilson , Jason Crawford , Ernest McEachern , Bem Atsma , Siqiao Nan , Yuanxi Zhou , Dominique Schols , Christopher Smith , Maria Di Fluri
发明人： Gary Bridger , Renato Skerlj , Al Kaller , Curtis Harwig , David Bogucki , Trevor Wilson , Jason Crawford , Ernest McEachern , Bem Atsma , Siqiao Nan , Yuanxi Zhou , Dominique Schols , Christopher Smith , Maria Di Fluri
IPC分类号： A61K31/444 , A61K31/4545 , A61K31/455 , A61K31/4706 , A61K31/4709 , A61K31/506 , A61P1/04 , A61P3/10 , A61P5/14 , A61P9/00 , A61P11/00 , A61P11/02 , A61P11/06 , A61P13/12 , A61P17/00 , A61P17/02 , A61P17/04 , A61P17/06 , A61P19/00 , A61P19/02 , A61P21/00 , A61P21/04 , A61P29/00 , A61P31/04 , A61P31/12 , A61P31/18 , A61P31/22 , A61P33/00 , A61P33/02 , A61P33/06 , A61P33/10 , A61P35/00 , A61P35/02 , A61P37/00 , A61P37/02 , A61P37/08 , A61P43/00 , C07D213/81 , C07D215/40 , C07D401/12 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D491/04 , C07D491/052 , C07D471/02 , A61K31/47 , C07D491/02 , C07D498/02
CPC分类号： C07D213/38 , C07D213/65 , C07D213/81 , C07D215/40 , C07D401/12 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D491/04
摘要： Tertiary amines containing a multiplicity of heteroaromatic substituents are useful as chemokine receptor modulators.
摘要翻译： 含有多个杂芳族取代基的叔胺可用作趋化因子受体调节剂。
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