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21.发明授权Use of a composition comprising a non-fermented rice peptidic hydrolyzate for stimulating hair growth 有权包含非发酵米肽水解产物的组合物用于刺激毛发生长的用途公开(公告)号：US08541374B2
公开(公告)日：2013-09-24
申请号：US13505488
申请日：2010-11-02
CPC分类号： A61K36/899 , A61K8/645 , A61Q5/00 , A61Q7/00
摘要： The present invention relates to the use of a composition comprising at least one non-fermented rice peptidic hydrolyzate as an active agent for slowing down and limiting hair loss and/or stimulating hair growth. Said composition is also intended to protect the follicular adult stem cells as well as their specific microenvironment. In addition, the composition according to the invention combats the aging and particularly the photoaging of hair. Lastly, the present invention relates to several non-therapeutic treatment methods utilizing said composition.
摘要翻译： 本发明涉及包含至少一种非发酵米肽水解产物的组合物作为减缓和限制脱发和/或刺激毛发生长的活性剂的用途。 所述组合物还旨在保护滤泡成体干细胞及其特异性微环境。 此外，根据本发明的组合物与头发的老化特别是光老化相抗衡。 最后，本发明涉及利用所述组合物的几种非治疗性治疗方法。
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22.发明授权Anti-aging peptides and cosmetic and/or pharmaceutical composition containing same 有权抗衰老肽和含有其的化妆品和/或药物组合物公开(公告)号：US08435950B2
公开(公告)日：2013-05-07
申请号：US13143741
申请日：2010-01-07
CPC分类号： A61K8/64 , A61K38/00 , A61Q19/004 , A61Q19/08 , C07K5/1013 , C07K7/06
摘要： The present invention relates to peptide compounds of general formula (I) R1-X1-X2-Ser-Pro-Leu-Gln-X3-X4-R2. The present invention also relates, on the one hand, to a cosmetic or pharmaceutical composition comprising at least one peptide of general formula (I) in a cosmetically or dermatologically acceptable medium, and on the other hand to its use in order to prevent or treat the cutaneous signs of aging and to protect the skin against the harmful effects caused by UV radiation.The invention lastly relates to a cosmetic treatment method for preventing and/or combatting cutaneous signs of aging and for protecting the skin against the harmful effects caused by UV radiation.
摘要翻译： 本发明涉及通式（Ⅰ）R1-X1-X2-Ser-Pro-Leu-Gln-X3-X4-R2的肽化合物。 一方面，本发明还涉及在化妆品或皮肤病学可接受的培养基中包含至少一种通式（I）的肽的化妆品或药物组合物，另一方面涉及其用于预防或治疗 皮肤老化迹象，并保护皮肤免受紫外线辐射引起的有害影响。 本发明最后涉及一种用于预防和/或抵抗皮肤老化症状并用于保护皮肤免受紫外线辐射引起的有害影响的美容治疗方法。
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23.发明申请公开(公告)号：US20130029917A1
公开(公告)日：2013-01-31
申请号：US13640827
申请日：2011-04-14
CPC分类号： A61Q19/00 , A61K8/97 , A61K36/48 , A61Q19/007 , A61Q19/08
摘要： The invention relates to the cosmetic use of a peptide hydrolysate of pea (Pisum sativum L.), as skin-moisturizing active agent. The invention also relates to the use of a cosmetic composition comprising an effective amount of active agent according to the invention in a physiologically acceptable medium, for preventing dryness of the skin or restoring moisturization of the skin. The invention also relates to the use of this novel active agent for preparing a pharmaceutical, in particular dermatological, composition intended for treating pathological dryness of the skin.
摘要翻译： 本发明涉及豌豆（Pisum sativum L.）的肽水解产物作为皮肤保湿活性剂的美容应用。 本发明还涉及包含有效量的根据本发明的活性剂在生理学上可接受的介质中用于预防皮肤干燥或恢复皮肤保湿的化妆品组合物的用途。 本发明还涉及这种新型活性剂用于制备旨在治疗皮肤病理干燥的药物，特别是皮肤病学组合物的用途。
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24.发明申请USE OF A COMPOSITION COMPRISING A NON-FERMENTED RICE PEPTIDE HYDROLYZATE FOR STIMULATING HAIR GROWTH 有权使用包含非发酵的米糠酯水解产物的组合物刺激头发生长公开(公告)号：US20120214746A1
公开(公告)日：2012-08-23
申请号：US13505488
申请日：2010-11-02
CPC分类号： A61K36/899 , A61K8/645 , A61Q5/00 , A61Q7/00
摘要： The present invention relates to the use of a composition comprising at least one non-fermented rice peptidic hydrolyzate as an active agent for slowing down and limiting hair loss and/or stimulating hair growth. Said composition is also intended to protect the follicular adult stem cells as well as their specific microenvironment. In addition, the composition according to the invention combats the aging and particularly the photoaging of hair. Lastly, the present invention relates to several non-therapeutic treatment methods utilizing said composition.
摘要翻译： 本发明涉及包含至少一种非发酵米肽水解产物的组合物作为减缓和限制脱发和/或刺激毛发生长的活性剂的用途。 所述组合物还旨在保护滤泡成体干细胞及其特异性微环境。 此外，根据本发明的组合物与头发的老化特别是光老化相抗衡。 最后，本发明涉及利用所述组合物的几种非治疗性治疗方法。
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25.发明申请公开(公告)号：US20120100086A1
公开(公告)日：2012-04-26
申请号：US13265034
申请日：2010-04-22
CPC分类号： C07K5/08 , A61K8/64 , A61K8/645 , A61K9/0014 , A61K38/06 , A61K38/07 , A61K38/08 , A61Q19/00 , A61Q19/004 , A61Q19/02 , A61Q19/08 , C07K5/0819 , C07K5/10 , C07K5/101 , C07K5/1021 , C07K7/00 , C07K7/06 , C07K14/415
摘要： The present invention relates to a peptidic hydrolyzate enriched in bioactive peptides, said hydrolyzate being a proteasome activator. In addition, the present invention relates to, on the one hand, a cosmetic or pharmaceutical composition comprising said hydrolyzate in a physiologically acceptable medium and, on the other hand, its use to depigment, lighten and/or whiten the skin and prevent or treat hyperpigmentation blemishes as well as cutaneous signs due to photo-aging. Lastly, the invention applies to a cosmetic treatment method utilizing said peptidic hydrolyzate.
摘要翻译： 本发明涉及富含生物活性肽的肽水解产物，所述水解产物是蛋白酶体活化剂。 此外，本发明一方面涉及在生理上可接受的培养基中包含所述水解产物的化妆品或药物组合物，另一方面涉及其用于脱色，减轻和/或增白皮肤并预防或治疗 色素沉着过度瑕疵以及光老化引起的皮肤征象。 最后，本发明适用于利用所述肽水解产物的美容处理方法。
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26.发明申请COSMETIC AND/OR PHARMACEUTICAL COMPOSITION COMPRISING A PEPTIDIC HYDROLYZATE THAT CAN REINFORCE THE BARRIER FUNCTION 有权化妆品和/或药物组合物包含可以增强阻隔功能的多肽水解产物公开(公告)号：US20120094920A1
公开(公告)日：2012-04-19
申请号：US13264035
申请日：2010-04-15
IPC分类号： A61K8/64 , C07K7/06 , A61K38/03 , C07K4/00 , A61K8/97 , C07K4/06 , A61Q19/00 , A61P17/00 , A61Q19/08 , C07K5/103 , C07K4/10
CPC分类号： C07K5/10 , A61K8/64 , A61K8/97 , A61K38/011 , A61K38/07 , A61K38/08 , A61Q17/00 , A61Q17/04 , A61Q19/004 , A61Q19/005 , A61Q19/08 , C07K4/06 , C07K4/10 , C07K5/1008 , C07K7/06
摘要： The invention relates to a peptidic hydrolyzate enriched in bioactive peptide, capable of reinforcing the skin barrier function and stimulating epidermal differentiation. The invention is also relative to a cosmetic and/or pharmaceutical composition comprising, in a physiologically acceptable medium, said hydrolyzate as active principle. The invention further relates to the use, in a cosmetic composition, of the active principle according to the invention to activate the HMG-CoA reductase in the cutaneous cells, and to prevent and combat the cutaneous signs of aging and photo-aging.
摘要翻译： 本发明涉及富含生物活性肽的肽水解产物，其能够增强皮肤屏障功能并刺激表皮分化。 本发明还涉及在生理学上可接受的介质中包含所述水解产物作为活性成分的化妆品和/或药物组合物。 本发明还涉及在化妆品组合物中使用根据本发明的活性成分来激活皮肤细胞中的HMG-CoA还原酶，并且防止和抵抗老化和光老化的皮肤征象。
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27.发明申请NOVEL SIRTUIN 6 ACTIVATING PEPTIDES AND COSMETIC OR PHARMACEUTICAL COMPOSITION CONTAINING THEM 有权新型SIRTUIN 6活性肽和化妆品或药物组合物公开(公告)号：US20110318284A1
公开(公告)日：2011-12-29
申请号：US13166836
申请日：2011-06-23
摘要： The present invention relates to sirtuin 6 activating peptides, derived from highly conserved regions of human SIRT proteins, and to a cosmetic or pharmaceutical composition comprising at least one sirtuin 6 activating peptide in a physiologically acceptable medium. The invention further relates to the utilization of a cosmetic composition to prevent and/or repair DNA degradation, improve telomere maintenance and reduce cellular senescence. The invention also applies to a cosmetic treatment process intended to prevent and/or treat the cutaneous signs of aging and photo aging.
摘要翻译： 本发明涉及衍生自人SIRT蛋白的高度保守区域的沉默调节蛋白6活化肽，以及在生理学上可接受的培养基中包含至少一种sirtuin 6激活肽的化妆品或药物组合物。 本发明还涉及化妆品组合物用于预防和/或修复DNA降解，改善端粒维持和减少细胞衰老的用途。 本发明还适用于旨在预防和/或治疗老化和照片老化的皮肤征象的美容治疗方法。
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28.发明申请PEPTIDES DERIVED FROM HMG-COA REDUCTASE AND COSMETIC AND/OR PHARMACEUTICAL COMPOSITION CONTAINING SAME 有权衍生自HMG-COA还原酶的化合物和含有其的化妆品和/或药物组合物公开(公告)号：US20110286991A1
公开(公告)日：2011-11-24
申请号：US13141358
申请日：2009-12-23
CPC分类号： A61Q17/00 , A61K8/64 , A61K38/00 , A61Q19/08 , C12N9/0006 , C12Y101/01088
摘要： The present invention relates to peptides derived from human HMG-CoA reductase of general formula (I): R1-(AA)n-X1-Gly-Lys-X2-(AA)p-R2, And of sequence SEQ ID No. 1 to SEQ ID No. 10.The present invention also relates to a cosmetic or pharmaceutical composition comprising at least one peptide of general formula (I), in a physiologically suitable medium.The present invention further relates to the use of this novel peptide as an active principle that activates human HMG-CoA reductase in a cosmetic composition intended to strengthen the barrier function of the skin and to stimulate epidermal differentiation. The invention further applies to a cosmetic treatment method intended to prevent and/or combat the external stresses and signs of cutaneous aging.
摘要翻译： 本发明涉及由通式（I）的人HMG-CoA还原酶衍生的肽：R1-（AA）n-X1-Gly-Lys-X2-（AA）p-R2，序列SEQ ID No.1 本发明还涉及包含至少一种通式（I）的肽的化妆品或药物组合物，在生理学合适的培养基中。 本发明还涉及这种新型肽作为在化妆品组合物中激活人类HMG-CoA还原酶的活性成分的用途，其旨在增强皮肤的屏障功能并刺激表皮分化。 本发明还适用于旨在预防和/或抵抗皮肤老化的外部压力和体征的美容治疗方法。
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29.发明申请USE OF AN ACTIVE PRINCIPLE FROM FLAX FOR USE IN A COMPOSITION FOR ACTIVATING CYTOCHROME C 有权使用FLAX中的活性原理用于激活细胞色素C的组合物公开(公告)号：US20100279946A1
公开(公告)日：2010-11-04
申请号：US12669836
申请日：2008-07-21
CPC分类号： A61K36/55 , A61K8/645 , A61K9/0014 , A61Q19/00 , A61Q19/004 , A61Q19/08
摘要： The present invention concerns the use, in a cosmetic composition, of an effective quantity of active principle originating from flax (genus Linum) to activate cytochrome c and to stimulate the functions of the mitochondria. The active principle originates from the hydrolysis of flax proteins and contains principally polypeptides or peptides. It can be used alone or in association with at least one other active principle. The invention further relates to a method of cosmetic treatment intended to protect the skin and the appendages from external aggressions and to combat against cutaneous ageing.
摘要翻译： 本发明涉及在化妆品组合物中使用有效量的源自亚麻（亚麻属）的活性成分以活化细胞色素c并刺激线粒体功能的用途。 活性成分起源于亚麻蛋白的水解，主要包含多肽或肽。 它可以单独使用或与至少一种其他活性成分结合使用。 本发明还涉及旨在保护皮肤和附属物免受外部侵蚀并抵抗皮肤老化的美容治疗方法。
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公开(公告)号：US20100261658A1
公开(公告)日：2010-10-14
申请号：US12808266
申请日：2008-12-17
IPC分类号： A61K38/08 , C07K7/06 , C07K5/10 , C07K5/08 , A61K38/07 , A61K38/06 , A61K8/64 , A61P17/00 , A61P17/16 , A61P17/18 , A61Q19/08
CPC分类号： C07K4/00 , A61K8/64 , A61K38/00 , A61Q19/00 , A61Q19/007 , A61Q19/08 , C07K5/06 , C07K5/08 , C07K5/0819 , C07K5/0823 , C07K5/1021
摘要： The present invention concerns a peptide of the general formula (I): R1-(AA)nX1—X2—X3-Pro-X4—X5—X7-(AA)p-R2, capable of activating the synthesis of proteins of the family of aquaporins. The present invention also concerns a cosmetic, nutraceutical or pharmaceutical composition, comprising a peptide of general formula (I) as active principle. The invention also relates to the use of this new active principle in a cosmetic or nutraceutical composition, intended to improve the moisturizing and the barrier function of the epidermis and intended to stimulate cutaneous regeneration. The invention also relates to the use of this new active principle to realize a pharmaceutical composition, and in particular a dermatological composition, intended to regulate and/or stimulate the activity of the aquaporins and to thus treat the pathological dryness of the skin or mucosa. The invention also relates to a method of cosmetic treatment intended to prevent or combat against dryness of the skin and mucosa, and the manifestations of cutaneous ageing.
摘要翻译： 本发明涉及能够激活家族蛋白质合成的通式（I）的肽：R1-（AA）nX1-X2-X3-Pro-X4-X5-X7-（AA）p-R2 的水通道蛋白。 本发明还涉及包含通式（I）的肽作为活性成分的化妆品，营养药物或药物组合物。 本发明还涉及这种新的活性成分在化妆品或营养组合物中的用途，其旨在改善表皮的保湿和屏障功能并且旨在刺激皮肤再生。 本发明还涉及这种新的活性成分用于实现旨在调节和/或刺激水通道蛋白的活性并因此治疗皮肤或粘膜的病理干燥的药物组合物，特别是皮肤病学组合物的用途。 本发明还涉及旨在预防或防止皮肤和粘膜干燥以及皮肤老化表现的美容治疗方法。
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