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公开(公告)号：US11918667B2
公开(公告)日：2024-03-05
申请号：US16771945
申请日：2018-12-10
发明人： Viktor Dubovoy , Long Pan , Ravi Subramanyam
CPC分类号： A61K8/28 , A61K8/0275 , A61K8/26 , A61K8/44 , A61Q5/02 , A61Q5/12 , A61Q15/00 , A61Q19/10 , A61K2800/30 , A61K2800/805
摘要： Described herein are zirconium oxychloride clusters comprising zirconium oxychloride and a basic amino acid. Personal care compositions comprising the same, and methods of making and using the same are also described.
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公开(公告)号：US11826448B2
公开(公告)日：2023-11-28
申请号：US17249523
申请日：2021-03-04
发明人： Zhigang Hao , Chi-Yuan Cheng , Tatiana Brinzari , Long Pan , Ravi Subramanyam
摘要： The disclosure provides a zinc-arginine complex, methods of making the same, and methods of using the same in oral care compositions.
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23.发明授权公开(公告)号：US11583485B2
公开(公告)日：2023-02-21
申请号：US16771519
申请日：2017-12-14
发明人： Daniel Schankel , Viktor Dubovoy , Richard Adams , Sandra Wadeer , Christine Boyke , Long Pan , Ravi Subramanyam
摘要： Antiperspirant and/or deodorant compositions and methods for the same are provided. The compositions may include an antiperspirant active or a deodorant active, water, and a preservative system. The antiperspirant active may include aluminum, and the preservative system may include a biodegradable amino carboxylate. The methods may include substituting or replacing a conventional chelant, such as EDTA, with a biodegradable chelant, such as HIDS. The methods may also include applying one of the compositions to an axillary area of a person.
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公开(公告)号：US11117906B2
公开(公告)日：2021-09-14
申请号：US16714903
申请日：2019-12-16
发明人： Zhigang Hao , Chi-Yuan Cheng , Tatiana Brinzari , Long Pan , Ravi Subramanyam , Lauren Evans , Sergio Leite
IPC分类号： C07F3/06 , A61K8/27 , A61K8/44 , C07C229/26
摘要： Disclosed herein are improved methods for the synthesis of zinc-amino acid-halide complexes via reaction of zinc oxide and amino acid hydrochloride in a solvent comprising a polyol, as well as oral care compositions comprising said complexes made according to said method.
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公开(公告)号：US10857083B2
公开(公告)日：2020-12-08
申请号：US16216533
申请日：2018-12-11
发明人： Long Pan , Donghui Wu , Ravi Subramanyam , Hongwei Shen , Chi-Yuan Cheng , Tatiana Brinzari
IPC分类号： A61K8/44 , A61Q11/00 , C07C271/06 , C07C279/14 , C07C269/04 , A61K31/4172 , A61K8/21 , A61K33/16 , A61K31/198 , A61K8/49 , A61K8/19
摘要： Disclosed herein are amino acid carbamate complexes, methods of synthesis thereof, oral care compositions comprising the same, and methods of making and using thereof.
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公开(公告)号：US10703766B2
公开(公告)日：2020-07-07
申请号：US16216677
申请日：2018-12-11
发明人： Viktor Dubovoy , Long Pan , Ravi Subramanyam , Tatiana Brinzari
摘要： Described herein are complexes comprising a cationic antibacterial agent and a metal salt; oral care compositions comprising same; along with methods of making and using these complexes and compositions.
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公开(公告)号：US10646422B2
公开(公告)日：2020-05-12
申请号：US16284498
申请日：2019-02-25
发明人： Ravi Subramanyam , Suzanne Jogun , Mahmoud Hassan , Navin Lewis , Xiao Yi Huang , Shao Peng Xu
IPC分类号： A61K8/27 , A61K8/37 , A61K8/21 , A61K8/19 , A61K8/04 , A61K8/02 , A61Q11/00 , A61K8/365 , A61K8/25
摘要： The present invention provides an oral care composition comprising: (a) a first composition comprising a silica abrasive and a first zinc compound selected from zinc citrate, zinc chloride, zinc acetate, zinc lactate, zinc salicylate, zinc sulfate, and zinc nitrate; and (b) a second composition comprising a calcium carbonate abrasive; wherein the first composition and/or the second composition further comprises a second zinc compound selected from zinc oxide, zinc carbonate and zinc tartrate; and wherein the oral care composition optionally further comprises from 0.1 to 1.75 weight % of a tartar control agent, based on the total weight of the oral care composition.
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公开(公告)号：US09750667B2
公开(公告)日：2017-09-05
申请号：US14243170
申请日：2014-04-02
发明人： Steve Misner , Long Pan , Diana Scala , Regina Hourigan , Ravi Subramanyam , Dennis Fletcher , Patricia Hall-Puzio , Shamim Ansari , Derek Le
IPC分类号： A61K8/02 , C11D3/12 , C11D3/18 , C11D3/382 , C11D3/48 , C11D17/00 , A61Q19/10 , A61K8/24 , A61K8/25
CPC分类号： A61K8/0216 , A61K8/24 , A61K8/25 , A61Q19/10 , C11D3/126 , C11D3/18 , C11D3/382 , C11D3/48 , C11D17/006
摘要： A cleansing bar comprising at least one member chosen from clay and talc, wherein a total amount of clay and talc is present in an amount that is greater than any other material in the cleansing bar, at least one cleanser chosen from soap and surfactant, and a binder present in an amount to structure the cleansing bar into a bar.
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公开(公告)号：US20160178527A1
公开(公告)日：2016-06-23
申请号：US14580510
申请日：2014-12-23
IPC分类号： G01N21/78
摘要： A method of measuring the relative rates of release of a target metal ion from two or more samples includes: (i) providing at least two aliquots of a solution including an indicator, the indicator having a colour; (ii) dispersing a sample into each aliquot; and (iii) during step (ii), monitoring the colour of the indicator in situ to determine the rates of release of the target metal ions from the samples relative to one another. Each sample comprises at least one source of the target metal ion. The indicator comprises zincon. The samples are oral care compositions selected from a toothpaste, a tooth gel, and a tooth powder. The target metal ion is selected from the stannous and zinc (II).
摘要翻译： 测量来自两个或更多个样品的靶金属离子的相对释放速率的方法包括：（i）提供包含指示剂的溶液的至少两个等分试样，所述指示剂具有颜色; （ii）将样品分散到每个等分试样中; 和（iii）在步骤（ii）期间，在现场监测指示剂的颜色以确定目标金属离子从样品相对于彼此的释放速率。 每个样品包含至少一种目标金属离子源。 指标包括zincon。 样品是选自牙膏，牙胶和牙粉的口腔护理组合物。 目标金属离子选自亚锡和锌（II）。
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公开(公告)号：US20140312232A1
公开(公告)日：2014-10-23
申请号：US14322897
申请日：2014-07-02
CPC分类号： G01N21/33 , A46B15/0002 , A46B15/0004 , A46B15/0034 , A46B2200/1066 , A61B5/0075 , A61B5/4547 , A61B5/4552 , A61B5/6887 , G01N21/359
摘要： Improved analytical, diagnostic, monitoring, and other methods (and their associated devices) for evaluating the extent of deposition of an agent onto a substrate are described. Exemplary methods may be used in the in the monitoring of the dental health of patients or in the fast, efficient screening and/or characterization of formulations in terms of their use for depositing oral actives onto tooth surfaces. The methods involve the direct or in situ analysis of substrates, onto which agents are deposited, using Near-IR spectroscopy and/or UV spectroscopy.
摘要翻译： 描述了用于评估试剂沉积到基底上的程度的改进的分析，诊断，监测和其它方法（及其相关的装置）。 就口服活性成分在牙齿表面上的使用而言，可以使用示例性的方法来监测患者的牙齿健康状况，或用于快速有效地筛选和/或表征制剂。 该方法涉及使用近红外光谱和/或紫外光谱直接或原位分析沉积有试剂的底物。
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