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公开(公告)号：US20200170814A1
公开(公告)日：2020-06-04
申请号：US16203892
申请日：2018-11-29
Applicant: Cook Medical Technologies LLC
Inventor： John Neilan , David Murray , James Butler
Abstract: A medical device such as a stent or medical balloon is functionalised prior to coating with a bioactive material, specifically by carboxylic acidification of the contact surface or surfaces of the medical device. The preferred process involves washing a stent or other medical device in a washing solution which may be sodium hydroxide, soaking in a carboxylic acid solution, rinsing in water to remove excess carboxylic acid, allowing to dry before applying a bioactive agent layer. It has been found that washing after functionalisation removes excess carboxylic acid and enhances the retention of bioactive agent on the contact surface or surfaces of the medical device leading to a more uniform and consistent layer of bioactive agent.
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公开(公告)号：US20200016299A1
公开(公告)日：2020-01-16
申请号：US16510352
申请日：2019-07-12
Applicant: Cook Medical Technologies LLC
Inventor： John Neilan , David Murray , James Butler
Abstract: A medical device such as a stent (10) or medical balloon (40) is at least partially coated with a saturated carboxylic acid layer in order to enhance biocompatibility, reduce thrombogenesis and increase endothelialisation. The coating is preferably of citric acid in non-crosslinked form and preferably non-porous so as to mask the underlying structure of the medical device. The acid coating forms an outer surface of at least a part of the medical device, that is has no other layer or material overlying it, save for in some embodiments a partial coating of a bioactive material.
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公开(公告)号：US20200016298A1
公开(公告)日：2020-01-16
申请号：US16033765
申请日：2018-07-12
Applicant: Cook Medical Technologies LLC
Inventor： John Neilan , David Murray , James Butler
Abstract: A medical device such as a stent (10) or medical balloon (40) is at least partially coated with a carboxylic acid layer in order to enhance biocompatibility, reduce thrombogenesis and increase endothelialisation. The coating is preferably of citric acid in non-crosslinked form and preferably non-porous so as to mask the underlying structure of the medical device. The acid coating forms an outer surface of at least a part of the medical device, that is has no other layer or material overlying it, save for in some embodiments a partial coating of a bioactive material.
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公开(公告)号：US10226279B2
公开(公告)日：2019-03-12
申请号：US15146178
申请日：2016-05-04
Applicant: Cook Medical Technologies LLC
Inventor： Fionán Keady , John Neilan , James Butler , Shay Joseph Lavelle
Abstract: A single-wire stylet may be constructed as an elongate single-wire, memory-metal alloy body with a generally cylindrical body profile, extending distally from a proximal end terminus, where embodiments include a polymeric distal tip member fixedly attached directly at a distal end of the single-wire body. At least one lengthwise portion of the single-wire body is at least partially in martensitic phase at operating temperatures at and below about 37° C. Where present, the polymeric distal tip member has a generally cylindrical body profile circumferentially bounded by an outer circumference substantially equal to or greater than that of the metal body. The polymeric distal tip member may be overmolded upon a distal-end tip length of an elongate single-wire, memory-metal alloy stylet body, where the distal end and/or discrete intermediate distal-portion length(s) that include martensitic-phase alloy and any polymeric member have greater flexibility than a proximal-most length of the alloy stylet body.
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公开(公告)号：US20180353310A1
公开(公告)日：2018-12-13
申请号：US16104633
申请日：2018-08-17
Applicant: Cook Medical Technologies LLC
Inventor： Sean Cummins , Darach McGrath , Olivia Ryan , James Butler , Joe Hayes
CPC classification number: A61F2/95 , A61B2017/00407 , A61F2/844 , A61F2/962 , A61F2/966 , A61F2002/9517 , A61F2230/0069
Abstract: A vascular intervention device delivery system, such as for implanting a self expanding stent, includes a thumbwheel rotatably mounted in a handle. A catheter has a proximal end attached to the handle and a distal carrier segment for mounting a stent thereon. A retractable sheath is movable to a position retracted proximally to uncover the distal carrier segment. A pull with a curved cross section extends between the thumbwheel and the retractable sheath. An idler wheel with a perimeter notch is rotatably mounted in the handle proximal to the thumbwheel. A pin is movably in the handle between a first position received in the perimeter notch to block rotation of the idler wheel, and a second position outside of the perimeter notch to permit rotation of the idler wheel. The pull wraps around the idler wheel to return in a direction for being wound onto a spool of the thumbwheel.
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Patent Agency Ranking
26.发明申请公开(公告)号：US20180078742A1
公开(公告)日：2018-03-22
申请号：US15709680
申请日：2017-09-20
Applicant: Cook Medical Technologies LLC
Inventor： James Butler , John Neilan
IPC: A61M25/09
CPC classification number: A61M25/09 , A61F2250/0098 , A61L29/02 , A61L29/106 , A61L29/123 , A61L29/18 , A61L31/022 , A61L31/082 , A61L31/088 , A61L31/124 , A61L31/18 , A61L2400/16 , A61M2025/09108 , A61M2025/09166 , B21C37/045
Abstract: A radiopaque composite wire for medical applications comprises a core comprising a rare earth metal, an outer layer comprising a nickel-titanium alloy disposed over the core, and a diffusion barrier comprising a barrier material between the core and the outer layer. A method of making a radiopaque composite wire includes cold drawing a composite billet through a die, where the composite billet includes a tube comprising a nickel-titanium alloy disposed about a rod comprising a rare earth metal, and a barrier layer comprising a barrier material disposed between the tube and the rod. After cold drawing, the composite billet is annealed to relieve strain. After multiple passes of the cold drawing and annealing, a radiopaque composite wire having a core comprising the rare earth metal, an outer layer comprising the nickel-titanium alloy, and a diffusion barrier comprising the barrier material between the core and the outer layer is formed.
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公开(公告)号：US20170203011A1
公开(公告)日：2017-07-20
申请号：US15398184
申请日：2017-01-04
Applicant: COOK MEDICAL TECHNOLOGIES LLC
Inventor： John Neilan , David Murray , James Butler
Abstract: A medical device such as a stent (10) or medical balloon (40) is functionalised prior to coating with a bioactive material (54), specifically by acidification or basification of the contact surface or surfaces (50) of the medical device. Functionalisation with subsequent coating of bioactive agent directly onto the functionalised surface provides a significantly more consistent and reliable coating of bioactive agent on a medical device without requiring containment or time release devices.
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公开(公告)号：US20160022456A1
公开(公告)日：2016-01-28
申请号：US14805575
申请日：2015-07-22
Applicant: Cook Medical Technologies LLC
Inventor： James Butler , Sean Cummins , Donagh O'Sullivan , Shane Holland
IPC: A61F2/962
CPC classification number: A61F2/962 , A61F2002/9522
Abstract: A method is provided for loading and delivering a self-expanding stent. The stent is compressed from its expanded diameter to a smaller delivery diameter. While compressed, the stent is pushed from the proximal end through the proximal end opening of a restraining sheath. The restraining sheath retains the stent in the delivery diameter. In order to deliver the stent, the proximal end of the stent is pushed and the restraining sheath is withdrawn proximally from the stent. As a result, the stent is released from the distal end opening of the restraining sheath.
Abstract translation: 提供了用于装载和递送自扩张支架的方法。 支架从其膨胀直径被压缩到较小的输送直径。 在压缩的同时，支架从近端推动通过限制鞘的近端开口。 限制护套将支架保持在输送直径中。 为了输送支架，支架的近端被推动并且约束护套从支架向近侧退出。 结果，支架从限制护套的远端开口释放。
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公开(公告)号：US11752019B2
公开(公告)日：2023-09-12
申请号：US16203892
申请日：2018-11-29
Applicant: Cook Medical Technologies LLC
Inventor： John Neilan , David Murray , James Butler
CPC classification number: A61F2/90 , A61L29/16 , A61L31/022 , C22C19/03 , A61L2300/606
Abstract: A medical device such as a stent or medical balloon is functionalised prior to coating with a bioactive material, specifically by carboxylic acidification of the contact surface or surfaces of the medical device. The preferred process involves washing a stent or other medical device in a washing solution which may be sodium hydroxide, soaking in a carboxylic acid solution, rinsing in water to remove excess carboxylic acid, allowing to dry before applying a bioactive agent layer. It has been found that washing after functionalisation removes excess carboxylic acid and enhances the retention of bioactive agent on the contact surface or surfaces of the medical device leading to a more uniform and consistent layer of bioactive agent.
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公开(公告)号：US11193202B2
公开(公告)日：2021-12-07
申请号：US16200870
申请日：2018-11-27
Applicant: Cook Medical Technologies LLC
Inventor： John Neilan , David Murray , James Butler
IPC: A61L27/00 , C23C16/02 , A61L31/02 , A61L31/08 , A61L31/16 , A61L27/30 , A61L27/06 , A61L27/54 , A61F2/82 , C23C16/40 , C23C16/50 , H01J37/32
Abstract: A method of modifying a surface of a medical device for implantation or disposition inside a patient is described. The medical device comprises a structure having at least one surface. The method includes the steps of: placing the medical device into a plasma chamber substantially free from contaminants and substantially sealing the plasma chamber from the atmosphere; removing at least an outermost layer of any oxide layer from the at least one surface of the structure by a plasma oxide-removal process, whilst maintaining the plasma chamber under seal from the atmosphere; and subsequently forming a new oxide layer at the least one surface of the structure by introducing at least one gas into the plasma chamber, whilst maintaining the plasma chamber under seal from the atmosphere. A medical device including a bulk material and an oxide layer disposed over at least one surface of the medical device. The oxide layer is substantially pure and free from contaminants.
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