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公开(公告)号：US07674467B2
公开(公告)日：2010-03-09
申请号：US11661689
申请日：2004-09-03
IPC分类号： A61K39/12
CPC分类号： A61K39/12 , A61K39/0275 , A61K2039/552 , A61K2039/70 , C12N7/00 , C12N2710/16334 , Y02A50/482
摘要： The present invention is directed to isolated Salmonella bacteriophage, and methods of using Salmonella bacteriophage, or polynucleotides and polypeptides derived therefrom, to control the growth or contamination of food products by Salmonella. The present invention also contemplates the use of Salmonella bacteriophage, and polynucleotides and polypeptides derived therefrom, for the treatment of host infections or environmental contamination by Salmonella.
摘要翻译： 本发明涉及分离的沙门氏菌噬菌体，以及使用沙门氏菌噬菌体或由其衍生的多核苷酸和多肽来控制沙门氏菌食物生长或污染的方法。 本发明还考虑了沙门氏菌噬菌体及其衍生的多核苷酸和多肽用于治疗宿主感染或沙门氏菌的环境污染。
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公开(公告)号：US07635584B2
公开(公告)日：2009-12-22
申请号：US11806353
申请日：2007-05-31
IPC分类号： C12N7/00
CPC分类号： C12N7/00 , C12N2795/00021 , C12N2795/00043 , C12N2795/00051
摘要： The present invention is directed to isolated bacteriophage having strong lytic activity against strains of E. coli O157:H7, and methods of using that bacteriophage, and/or progeny or derivatives derived therefrom, to control the growth of E. coli O157:H7 in various settings.
摘要翻译： 本发明涉及对大肠杆菌O157：H7菌株具有强溶解活性的分离的噬菌体，以及使用该噬菌体和/或其衍生物或其衍生物的方法来控制大肠杆菌O157：H7的生长 各种设置。
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公开(公告)号：US07625741B2
公开(公告)日：2009-12-01
申请号：US11955176
申请日：2007-12-12
IPC分类号： C12N7/00
CPC分类号： A01N63/00 , C12N7/00 , C12N2795/00021
摘要： The present invention is directed to isolated bacteriophage having strong lytic activity against strains of E. coli O157:H7, and methods of using that bacteriophage, and/or progeny or derivatives derived therefrom, to control the growth of E. coli O157:H7 in various settings.
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公开(公告)号：US07622293B2
公开(公告)日：2009-11-24
申请号：US11764608
申请日：2007-06-18
IPC分类号： C12N7/00
CPC分类号： C12N7/00 , C12N2795/00051
摘要： The present invention is directed to isolated bacteriophage having strong lytic activity against strains of Pseudomonas aeruginosa, and methods of using that bacteriophage, and/or progeny or derivatives derived therefrom, to control the growth of Pseudomonas aeruginosa in various settings.
摘要翻译： 本发明涉及对铜绿假单胞菌菌株具有强烈裂解活性的分离噬菌体，以及使用该噬菌体和/或其衍生物或衍生自其衍生物的衍生物在各种环境中控制绿脓假单胞菌生长的方法。
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公开(公告)号：US06699701B1
公开(公告)日：2004-03-02
申请号：US09757687
申请日：2001-01-11
申请人： Alexander Sulakvelidze , J. Glenn Morris, Jr. , Zemphira Alavidze , Gary R. Pasternack , Torrey C. Brown
发明人： Alexander Sulakvelidze , J. Glenn Morris, Jr. , Zemphira Alavidze , Gary R. Pasternack , Torrey C. Brown
IPC分类号： C12N701
CPC分类号： C08L77/12 , A01N63/00 , A23B4/22 , A23B7/155 , A23G9/30 , A23L3/34635 , A23L3/3571 , A61K9/7007 , A61K35/76 , A61K38/164 , A61L2/00 , A61L2/0005 , A61L2/18 , A61L2/22 , A61L15/225 , A61L15/26 , A61L15/38 , A61L15/44 , A61L26/0019 , A61L26/0052 , A61L26/0066 , A61L2300/404 , C08G69/44 , C12N7/00 , C12N2795/00032 , C12N2795/00051 , Y02A50/473 , Y02A50/481
摘要： Methods and devices for sanitation using bacteriophage are disclosed. According to one embodiment of the present invention, a method for sanitation using at least one bacteriophage includes the steps of (1) storing the at least one bacteriophage in a container; and (2) applying the at least one bacteriophage to a surface to be sanitized with a dispersing mechanism. According to another embodiment of the present invention, a sanitation device that dispenses at least one bacteriophage includes a container, at least one bacteriophage stored in the container, and a dispersing mechanism that disperses the at least one bacteriophage from the container.
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公开(公告)号：US20130164374A1
公开(公告)日：2013-06-27
申请号：US13772573
申请日：2013-02-21
申请人： J. Glenn MORRIS , Alexander Sulakvelidze , Zemphira Alavidze , Gary R. Pasternack , Torrey C. Brown
发明人： J. Glenn MORRIS , Alexander Sulakvelidze , Zemphira Alavidze , Gary R. Pasternack , Torrey C. Brown
IPC分类号： A61K35/76
CPC分类号： C08L77/12 , A01N63/00 , A23B4/22 , A23B7/155 , A23G9/30 , A23L3/34635 , A23L3/3571 , A61K9/7007 , A61K35/76 , A61K38/164 , A61L2/00 , A61L2/0005 , A61L2/18 , A61L2/22 , A61L15/225 , A61L15/26 , A61L15/38 , A61L15/44 , A61L26/0019 , A61L26/0052 , A61L26/0066 , A61L2300/404 , C08G69/44 , C12N7/00 , C12N2795/00032 , C12N2795/00051 , Y02A50/473 , Y02A50/481
摘要： The present invention provides a method for reducing the risk of bacterial infection or sepsis in a susceptible patient by treating the susceptible patient with a pharmaceutical composition containing bacteriophage of one or more strains which produce lytic infections in pathogenic bacteria. Preferably, treatment of the patient reduces the level of colonization with pathogenic bacteria susceptible to the bacteriophage by at least one log. In a typical embodiment, the susceptible patient is an immunocompromised patient selected from the group consisting of leukemia patients, lymphoma patients, carcinoma patients, sarcoma patients, allogeneic transplant patients, congenital or acquired immunodeficiency patients, cystic fibrosis patients, and AIDS patients. In a preferred mode, the patients treated by this method are colonized with the pathogenic bacteria subject to infection by said bacteriophage.
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27.发明授权公开(公告)号：US08003323B2
公开(公告)日：2011-08-23
申请号：US12264582
申请日：2008-11-04
申请人： J. Glenn Morris , Alexander Sulakvelidze , Zemphira Alavidze , Gary R. Pasternack , Torrey C. Brown
发明人： J. Glenn Morris , Alexander Sulakvelidze , Zemphira Alavidze , Gary R. Pasternack , Torrey C. Brown
CPC分类号： C08L77/12 , A01N63/00 , A23B4/22 , A23B7/155 , A23G9/30 , A23L3/34635 , A23L3/3571 , A61K9/7007 , A61K35/76 , A61K38/164 , A61L2/00 , A61L2/0005 , A61L2/18 , A61L2/22 , A61L15/225 , A61L15/26 , A61L15/38 , A61L15/44 , A61L26/0019 , A61L26/0052 , A61L26/0066 , A61L2300/404 , C08G69/44 , C12N7/00 , C12N2795/00032 , C12N2795/00051 , Y02A50/473 , Y02A50/481
摘要： The present invention provides a method for reducing the risk of bacterial infection or sepsis in a susceptible patient by treating the susceptible patient with a pharmaceutical composition containing bacteriophage of one or more strains which produce lytic infections in pathogenic bacteria. Preferably, treatment of the patient reduces the level of colonization with pathogenic bacteria susceptible to the bacteriophage by at least one log. In a typical embodiment, the susceptible patient is an immunocompromised patient selected from the group consisting of leukemia patients, lymphoma patients, carcinoma patients, sarcoma patients, allogeneic transplant patients, congenital or acquired immunodeficiency patients, cystic fibrosis patients, and AIDS patients. In a preferred mode, the patients treated by this method are colonized with the pathogenic bacteria subject to infection by said bacteriophage.
摘要翻译： 本发明提供了一种通过用含有在病原菌中产生溶解性感染的一种或多种菌株的噬菌体的药物组合物治疗易感患者来降低易感患者细菌感染或败血症风险的方法。 优选地，患者的治疗通过至少一个对数降低对噬菌体敏感的致病细菌的定植水平。 在典型的实施方案中，易感患者是选自白血病患者，淋巴瘤患者，癌症患者，肉瘤患者，同种异体移植患者，先天性或后天免疫缺陷病人，囊性纤维化患者和艾滋病患者的免疫受损患者。 在优选的模式中，通过该方法治疗的患者被所述噬菌体感染的致病细菌定植。
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公开(公告)号：US20090297561A1
公开(公告)日：2009-12-03
申请号：US11658397
申请日：2004-09-03
IPC分类号： A61K39/108 , A61K39/02 , A61K39/112 , C12N7/00
CPC分类号： A61K39/12 , A61K39/0275 , A61K2039/552 , A61K2039/70 , C12N7/00 , C12N2710/16334 , Y02A50/482
摘要： The invention provides methods of generating phage lysate bacterins, as well as phage lysate bacterin compositions. The invention further encompasses methods of vaccination comprising administering phage lysate bacterin to an animal in need thereof. The invention further encompasses methods of reducing infection or colonization of poultry or poultry eggs using phage bacterin lysates.Method of vaccination comprising administering to an animal in need of immunization an amount of phage lysate bacterin to induce an immune response.
摘要翻译： 本发明提供了产生噬菌体裂解物菌苗以及噬菌体裂解物菌苗组合物的方法。 本发明还包括接种疫苗的方法，包括将噬菌体裂解物菌苗施用于有需要的动物。 本发明还包括使用噬菌体菌苗裂解物减少家禽或家禽卵的感染或定殖的方法。 疫苗接种方法，包括向需要免疫的动物施用一定量的噬菌体裂解物菌苗以诱导免疫应答。
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公开(公告)号：US07625740B2
公开(公告)日：2009-12-01
申请号：US11840563
申请日：2007-08-17
IPC分类号： C12N7/00
CPC分类号： C12N7/00 , C12N2795/00021
摘要： The present invention is directed to isolated bacteriophage having strong lytic activity against strains of Clostridium perfringens, and methods of using that bacteriophage, and/or progeny or derivatives derived therefrom, to control the growth of Clostridium perfringens in various settings.
摘要翻译： 本发明涉及对产气荚膜梭菌菌株具有强烈裂解活性的分离的噬菌体，以及使用该噬菌体和/或其衍生物或其衍生物的方法来控制产气荚膜梭菌在各种环境中的生长。
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公开(公告)号：US07625739B2
公开(公告)日：2009-12-01
申请号：US11838625
申请日：2007-08-14
IPC分类号： C12N7/00
CPC分类号： C12N7/00 , A61K35/13 , C12N2795/10021
摘要： The present invention is directed to isolated bacteriophage having strong lytic activity against strains of Clostridium perfringens, and methods of using that bacteriophage, and/or progeny or derivatives derived therefrom, to control the growth of Clostridium perfringens in various settings.
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