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    Listeria monocytogenes bacteriophage and uses thereof
    1.
    发明授权
    Listeria monocytogenes bacteriophage and uses thereof 有权
    单核细胞增生利斯特氏菌噬菌体及其用途

    公开(公告)号：US07507571B2

    公开(公告)日：2009-03-24

    申请号：US11764587

    申请日：2007-06-18

    Applicant: Gary R. Pasternack ,  Alexander Sulakvelidze

    Inventor： Gary R. Pasternack ,  Alexander Sulakvelidze

    IPC: C12N7/00

    CPC classification number: C12N7/00 ,  C12N2795/00021

    Abstract: The present invention is directed to isolated Listeria monocytogenes bacteriophage, and methods of using Listeria monocytogenes bacteriophage, or polynucleotides and polypeptides derived therefrom, to control the growth or contamination of food products by Listeria monocytogenes. The present invention also contemplates the use of Listeria monocytogenes bacteriophage, and polynucleotides and polypeptides derived therefrom, for the treatment of host infections or environmental contamination by Listeria monocytogenes.

    Abstract translation: 本发明涉及分离的单核细胞增生利斯特氏菌噬菌体，以及使用单核细胞增生利斯特氏菌噬菌体或其衍生的多核苷酸和多肽控制单核细胞增生利斯特氏菌的食物生长或污染的方法。 本发明还考虑了单核细胞增生利斯特氏菌噬菌体及其衍生的多核苷酸和多肽用于治疗单核细胞增多性李斯特菌的宿主感染或环境污染的用途。

    Antimicrobial compounds
    2.
    发明授权
    Antimicrobial compounds 失效
    抗菌化合物

    公开(公告)号：US07385086B2

    公开(公告)日：2008-06-10

    申请号：US10764451

    申请日：2004-01-27

    Applicant: Craig A. Townsend ,  James D. Dick ,  Gary R. Pasternack ,  Francis P. Kuhajda ,  Nicole M. Parrish

    Inventor： Craig A. Townsend ,  James D. Dick ,  Gary R. Pasternack ,  Francis P. Kuhajda ,  Nicole M. Parrish

    IPC: C07C317/00 ,  C07C317/02 ,  C07C317/04 ,  C07C317/06 ,  C07C317/08

    CPC classification number: C40B40/04 ,  C07C311/06 ,  C07C317/44

    Abstract: This invention provides compounds and methods for treating, with said compound, a mycobacterial infection by administering to an animal a pharmaceutical composition containing a compound having the formula R—SOn-Z-CO—Y, where R is an alkyl groups having 6-20 carbon atoms, unsaturated hydrocarbon groups having 6-20 carbon atoms, or alkyl groups having 6-20 carbon atoms interrupted by at least one aromatic ring; Z is —CH2—, —CH2CH2—, —NH—NH—, —O—, ——NH—, —O—NH—, —CH2—NH—, —CH2—O—, —NH—O—, —NH—CH2—, —O—CH2—, and —CH═CH—; Y is —NH2, —O—CH2—C6H5, —CO—CO—O—CH3, and —O—CH3; and n is 1 or 2. It has been discovered that these compounds treat microbially-based infections caused by corynebacteria, nocardiae, rhodococcus, and mycobacteria. These compounds may be used to treat mycobacterial cells, such as Mycobacteria tuberculosis, drug resistant M. tuberculosis, M. avium intracellulare, M. leprae, M. paratuberculosis, and pathogenic Mycobacteria sp.

    Abstract translation: 本发明提供了通过向动物施用含有具有式R-SO n -Z-CO-Y的化合物的药物组合物，通过向所述化合物处理分枝杆菌感染的化合物和方法，其中R 是具有6-20个碳原子的烷基，具有6-20个碳原子的不饱和烃基或具有6-20个碳原子的烷基被至少一个芳环中断; Z是-CH 2 - ， - CH 2 CH 2 - ， - NH-NH-， - O - ， - NH-， -O-NH-，-CH 2 -NH-，-CH 2 -O-，-NH-O-，-NH-CH 2， -O - CH 2 - 和-CH-CH-; Y是-NH 2，-O-CH 2 -C 6 H 5，-CO-CO- O-CH 3，和-O-CH 3; 已发现这些化合物治疗由棒状杆菌，诺卡氏菌，罗红球菌和分枝杆菌引起的基于微生物的感染。 这些化合物可用于治疗分枝杆菌细胞，例如结核分枝杆菌，耐药性结核分枝杆菌，胞内分枝杆菌，麻疯病，副结核分枝杆菌和致病性分枝杆菌属。

    Nucleic acid encoding a novel mammalian protein associated with uncontrolled cell division
    3.
    发明授权
    Nucleic acid encoding a novel mammalian protein associated with uncontrolled cell division 失效
    编码与不受控细胞分裂相关的新型哺乳动物蛋白的核酸

    公开(公告)号：US6040173A

    公开(公告)日：2000-03-21

    申请号：US466743

    申请日：1995-06-06

    Applicant: Gary R. Pasternack

    Inventor： Gary R. Pasternack

    IPC: A61K38/00 ,  C07K14/47 ,  C07K16/04 ,  C07K16/18 ,  C07K16/30 ,  C12Q1/68 ,  C12N15/00 ,  C07H21/04

    CPC classification number: C07K16/30 ,  C07K14/47 ,  C07K16/04 ,  C07K16/18 ,  C12Q1/68 ,  C12Q1/6886 ,  A61K38/00 ,  C12N2799/026 ,  C12Q2600/112 ,  C12Q2600/136 ,  Y10S530/828

    Abstract: Three mammalian proteins are disclosed which are useful in the diagnosis and prognosis of tumors of lymphoid and epithelial origin. The three proteins are immunologically related to each other. The level of expression of the proteins correlates with the malignant potential of lymphoid and epithelial tumors. In addition, in some cases the subcellular location of the proteins is indicative of malignant potential. Antibodies reactive with the proteins are disclosed as diagnostic tools, as are nucleic acid probes and primers for quantitating the messenger RNAs encoding the proteins. Methods for preparing and purifying the proteins are also taught.

    Abstract translation: 公开了三种哺乳动物蛋白质，其可用于淋巴和上皮起源的肿瘤的诊断和预后。 三种蛋白质在免疫学上相互关联。 蛋白质的表达水平与淋巴样和上皮性肿瘤的恶性潜能相关。 此外，在一些情况下，蛋白质的亚细胞位置指示恶性潜能。 公开了与蛋白质反应的抗体作为诊断工具，核酸探针和引物用于定量编码蛋白质的信使RNA。 还教导了制备和纯化蛋白质的方法。

    Assay for a novel mammalian protein associated with uncontrolled cell division
    4.
    发明授权
    Assay for a novel mammalian protein associated with uncontrolled cell division 失效
    测定与不受控制的细胞分裂相关的新型哺乳动物蛋白质

    公开(公告)号：US5874234A

    公开(公告)日：1999-02-23

    申请号：US466717

    申请日：1995-06-06

    Applicant: Gary R. Pasternack

    Inventor： Gary R. Pasternack

    IPC: A61K38/00 ,  C07K14/47 ,  C07K16/04 ,  C07K16/18 ,  C07K16/30 ,  C12Q1/68 ,  G01N33/574 ,  C07K14/435

    CPC classification number: C07K16/30 ,  C07K14/47 ,  C07K16/04 ,  C07K16/18 ,  C12Q1/68 ,  C12Q1/6886 ,  A61K38/00 ,  C12N2799/026 ,  C12Q2600/118 ,  C12Q2600/136 ,  Y10S530/828

    Abstract: Three mammalian are disclosed which are useful in the diagnosis and prognosis of tumors of lymphoid and epithelial origin. The three proteins are immunologically related to each other. The level of expression of the proteins correlates with the malignant potential of lymphoid and epithelial tumors. In addition, in some cases the subcellular location of the proteins is indicative of malignant potential. Antibodies reactive with the proteins are disclosed as diagnostic tools, as are nucleic acid probes and primers for quantitating the messenger RNAs encoding the proteins. Methods for preparing and purifying the proteins are also taught.

    Abstract translation: 公开了三种哺乳动物，其可用于淋巴和上皮起源的肿瘤的诊断和预后。 三种蛋白质在免疫学上相互关联。 蛋白质的表达水平与淋巴样和上皮性肿瘤的恶性潜能相关。 此外，在一些情况下，蛋白质的亚细胞位置指示恶性潜能。 公开了与蛋白质反应的抗体作为诊断工具，核酸探针和引物用于定量编码蛋白质的信使RNA。 还教导了制备和纯化蛋白质的方法。

    Method for vaccination of poultry by bacteriophage lysate bacterin
    7.
    发明申请
    Method for vaccination of poultry by bacteriophage lysate bacterin 审中-公开
    通过噬菌体裂解物菌苗接种家禽的方法

    公开(公告)号：US20090297561A1

    公开(公告)日：2009-12-03

    申请号：US11658397

    申请日：2004-09-03

    Applicant: Gary R. Pasternack ,  Alexander Sulakvelidze ,  Torrey Brown

    Inventor： Gary R. Pasternack ,  Alexander Sulakvelidze ,  Torrey Brown

    IPC: A61K39/108 ,  A61K39/02 ,  A61K39/112 ,  C12N7/00

    CPC classification number: A61K39/12 ,  A61K39/0275 ,  A61K2039/552 ,  A61K2039/70 ,  C12N7/00 ,  C12N2710/16334 ,  Y02A50/482

    Abstract: The invention provides methods of generating phage lysate bacterins, as well as phage lysate bacterin compositions. The invention further encompasses methods of vaccination comprising administering phage lysate bacterin to an animal in need thereof. The invention further encompasses methods of reducing infection or colonization of poultry or poultry eggs using phage bacterin lysates.Method of vaccination comprising administering to an animal in need of immunization an amount of phage lysate bacterin to induce an immune response.

    Abstract translation: 本发明提供了产生噬菌体裂解物菌苗以及噬菌体裂解物菌苗组合物的方法。 本发明还包括接种疫苗的方法，包括将噬菌体裂解物菌苗施用于有需要的动物。 本发明还包括使用噬菌体菌苗裂解物减少家禽或家禽卵的感染或定殖的方法。 疫苗接种方法，包括向需要免疫的动物施用一定量的噬菌体裂解物菌苗以诱导免疫应答。

    Clostridium perfringens bacteriophage and uses thereof
    8.
    发明授权
    Clostridium perfringens bacteriophage and uses thereof 有权
    产气荚膜梭菌噬菌体及其用途

    公开(公告)号：US07625740B2

    公开(公告)日：2009-12-01

    申请号：US11840563

    申请日：2007-08-17

    Applicant: Gary R. Pasternack ,  Alexander Sulakvelidze

    Inventor： Gary R. Pasternack ,  Alexander Sulakvelidze

    IPC: C12N7/00

    CPC classification number: C12N7/00 ,  C12N2795/00021

    Abstract: The present invention is directed to isolated bacteriophage having strong lytic activity against strains of Clostridium perfringens, and methods of using that bacteriophage, and/or progeny or derivatives derived therefrom, to control the growth of Clostridium perfringens in various settings.

    Abstract translation: 本发明涉及对产气荚膜梭菌菌株具有强烈裂解活性的分离的噬菌体，以及使用该噬菌体和/或其衍生物或其衍生物的方法来控制产气荚膜梭菌在各种环境中的生长。

    Inhibition of fatty acid synthase as a means to reduce adipocyte mass
    10.
    发明授权
    Inhibition of fatty acid synthase as a means to reduce adipocyte mass 失效
    抑制脂肪酸合酶作为减少脂肪细胞质量的手段

    公开(公告)号：US5981575A

    公开(公告)日：1999-11-09

    申请号：US157

    申请日：1998-01-27

    Applicant: Francis P. Kuhajda ,  Gary R. Pasternack ,  Craig A. Townsend ,  Neelakandha S. Mani

    Inventor： Francis P. Kuhajda ,  Gary R. Pasternack ,  Craig A. Townsend ,  Neelakandha S. Mani

    IPC: A61K31/00 ,  A61K31/365 ,  A61K31/381 ,  A61K31/4025 ,  A01K31/04

    CPC classification number: A61K31/4025 ,  A61K31/00 ,  A61K31/365 ,  A61K31/381

    Abstract: Weight loss was noted in nude mice treated with cerulenin, a non-competitive inhibitor of FAS. Sustained reduction of adipocyte mass in humans without toxicity would significantly impact disease prevention worldwide. Aside from psychological and self-esteem improvement, weight loss via reduction of adipocyte mass may: (1) ameliorate hyperglycemia associated with non-insulin-dependent diabetes mellitus thereby reducing diabetic complications such as arterial disease, blindness, cataracts, etc., (2) reduce hypertension, (3) reduce risk of coronary artery vascular disease and stroke, and (4) reduce the risk of other complications of massive obesity such as osteoarthritis, surgical complications, etc. There is also potential use in livestock and poultry to reduce the saturated fat content of meat products. Therefore FAS inhibitors are disclosed herein as novel agents for weight reduction. A family of compounds (.gamma.-substituted-.alpha.-methylene-.beta.-carboxy-.gamma.-butyrolactones) whose synthesis was based on the cerulenin motif is shown herein to inhibit fatty acid synthesis, inhibit growth in certain susceptible tumor cells, and induce weight loss.

    Abstract translation: PCT No.PCT / US96 / 17678 Sec。 371日期：1998年1月27日 102（e）日期1998年1月27日PCT 1996年11月15日PCT PCT。 第WO97 / 18806号公报 日期1997年5月29日在使用非竞争性FAS抑制剂的木瓜素治疗的裸小鼠中观察到重度损失。 持续减少人体脂肪细胞质量无毒性将严重影响全球疾病预防。 除了心理和自尊心的改善之外，通过减少脂肪细胞质量可以减轻体重：（1）改善与非胰岛素依赖性糖尿病相关的高血糖，从而减少糖尿病并发症，如动脉疾病，失明，白内障等（2 ）降低高血压，（3）降低冠状动脉血管疾病和中风的风险，（4）降低骨质疏松，手术并发症等巨大肥胖的其他并发症的风险。畜禽养殖也有可能减少 肉制品的饱和脂肪含量。 因此，本文公开了FAS抑制剂作为减轻体重的新型药剂。 本文显示了其合成基于苏氨酸基序的化合物（γ-取代-α-亚甲基-β-羧基-γ-丁内酯）家族，以抑制脂肪酸合成，抑制某些易感的肿瘤细胞中的生长，并诱导体重减轻 。

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