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1.发明申请Reduction In Bacterial Colonization By Administering Bacteriophage Compositions 审中-公开通过管理噬菌体组合物减少细菌殖民化公开(公告)号：US20120148505A1
公开(公告)日：2012-06-14
申请号：US13214579
申请日：2011-08-22
申请人： J. Glenn Morris , Alexander Sulakvelidze , Zemphira Alavidze , Gary R. Pasternack , Torrey C. Brown
发明人： J. Glenn Morris , Alexander Sulakvelidze , Zemphira Alavidze , Gary R. Pasternack , Torrey C. Brown
CPC分类号： C08L77/12 , A01N63/00 , A23B4/22 , A23B7/155 , A23G9/30 , A23L3/34635 , A23L3/3571 , A61K9/7007 , A61K35/76 , A61K38/164 , A61L2/00 , A61L2/0005 , A61L2/18 , A61L2/22 , A61L15/225 , A61L15/26 , A61L15/38 , A61L15/44 , A61L26/0019 , A61L26/0052 , A61L26/0066 , A61L2300/404 , C08G69/44 , C12N7/00 , C12N2795/00032 , C12N2795/00051 , Y02A50/473 , Y02A50/481
摘要： The present invention provides a method for reducing the risk of bacterial infection or sepsis in a susceptible patient by treating the susceptible patient with a pharmaceutical composition containing bacteriophage of one or more strains which produce lytic infections in pathogenic bacteria. Preferably, treatment of the patient reduces the level of colonization with pathogenic bacteria susceptible to the bacteriophage by at least one log. In a typical embodiment, the susceptible patient is an immunocompromised patient selected from the group consisting of leukemia patients, lymphoma patients, carcinoma patients, sarcoma patients, allogeneic transplant patients, congenital or acquired immunodeficiency patients, cystic fibrosis patients, and AIDS patients. In a preferred mode, the patients treated by this method are colonized with the pathogenic bacteria subject to infection by said bacteriophage.
摘要翻译： 本发明提供了一种通过用含有在病原菌中产生溶解性感染的一种或多种菌株的噬菌体的药物组合物治疗易感患者来降低易感患者细菌感染或败血症风险的方法。 优选地，患者的治疗通过至少一个对数降低对噬菌体敏感的致病细菌的定植水平。 在典型的实施方案中，易感患者是选自白血病患者，淋巴瘤患者，癌症患者，肉瘤患者，同种异体移植患者，先天性或后天免疫缺陷病人，囊性纤维化患者和艾滋病患者的免疫受损患者。 在优选的模式中，通过该方法治疗的患者被所述噬菌体感染的致病细菌定植。
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公开(公告)号：US06699701B1
公开(公告)日：2004-03-02
申请号：US09757687
申请日：2001-01-11
申请人： Alexander Sulakvelidze , J. Glenn Morris, Jr. , Zemphira Alavidze , Gary R. Pasternack , Torrey C. Brown
发明人： Alexander Sulakvelidze , J. Glenn Morris, Jr. , Zemphira Alavidze , Gary R. Pasternack , Torrey C. Brown
IPC分类号： C12N701
CPC分类号： C08L77/12 , A01N63/00 , A23B4/22 , A23B7/155 , A23G9/30 , A23L3/34635 , A23L3/3571 , A61K9/7007 , A61K35/76 , A61K38/164 , A61L2/00 , A61L2/0005 , A61L2/18 , A61L2/22 , A61L15/225 , A61L15/26 , A61L15/38 , A61L15/44 , A61L26/0019 , A61L26/0052 , A61L26/0066 , A61L2300/404 , C08G69/44 , C12N7/00 , C12N2795/00032 , C12N2795/00051 , Y02A50/473 , Y02A50/481
摘要： Methods and devices for sanitation using bacteriophage are disclosed. According to one embodiment of the present invention, a method for sanitation using at least one bacteriophage includes the steps of (1) storing the at least one bacteriophage in a container; and (2) applying the at least one bacteriophage to a surface to be sanitized with a dispersing mechanism. According to another embodiment of the present invention, a sanitation device that dispenses at least one bacteriophage includes a container, at least one bacteriophage stored in the container, and a dispersing mechanism that disperses the at least one bacteriophage from the container.
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3.发明申请公开(公告)号：US20090053144A1
公开(公告)日：2009-02-26
申请号：US12264582
申请日：2008-11-04
申请人： J. Glenn MORRIS , Alexander Sulakvelidze , Zemphira Alavidze , Gary R. Pasternack , Torrey C. Brown
发明人： J. Glenn MORRIS , Alexander Sulakvelidze , Zemphira Alavidze , Gary R. Pasternack , Torrey C. Brown
CPC分类号： C08L77/12 , A01N63/00 , A23B4/22 , A23B7/155 , A23G9/30 , A23L3/34635 , A23L3/3571 , A61K9/7007 , A61K35/76 , A61K38/164 , A61L2/00 , A61L2/0005 , A61L2/18 , A61L2/22 , A61L15/225 , A61L15/26 , A61L15/38 , A61L15/44 , A61L26/0019 , A61L26/0052 , A61L26/0066 , A61L2300/404 , C08G69/44 , C12N7/00 , C12N2795/00032 , C12N2795/00051 , Y02A50/473 , Y02A50/481
摘要： The present invention provides a method for reducing the risk of bacterial infection or sepsis in a susceptible patient by treating the susceptible patient with a pharmaceutical composition containing bacteriophage of one or more strains which produce lytic infections in pathogenic bacteria. Preferably, treatment of the patient reduces the level of colonization with pathogenic bacteria susceptible to the bacteriophage by at least one log. In a typical embodiment, the susceptible patient is an immunocompromised patient selected from the group consisting of leukemia patients, lymphoma patients, carcinoma patients, sarcoma patients, allogeneic transplant patients, congenital or acquired immunodeficiency patients, cystic fibrosis patients, and AIDS patients. In a preferred mode, the patients treated by this method are colonized with the pathogenic bacteria subject to infection by said bacteriophage.
摘要翻译： 本发明提供了一种通过用含有在病原菌中产生溶解性感染的一种或多种菌株的噬菌体的药物组合物治疗易感患者来降低易感患者细菌感染或败血症风险的方法。 优选地，患者的治疗通过至少一个对数降低对噬菌体敏感的致病细菌的定植水平。 在典型的实施方案中，易感患者是选自白血病患者，淋巴瘤患者，癌症患者，肉瘤患者，同种异体移植患者，先天性或后天免疫缺陷病人，囊性纤维化患者和艾滋病患者的免疫受损患者。 在优选的模式中，通过该方法治疗的患者被所述噬菌体感染的致病细菌定植。
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4.发明授权公开(公告)号：US07459272B2
公开(公告)日：2008-12-02
申请号：US10724900
申请日：2003-12-02
申请人： J. Glenn Morris , Alexander Sulakvelidze , Zemphira Alavidze , Gary R. Pasternack , Torrey C. Brown
发明人： J. Glenn Morris , Alexander Sulakvelidze , Zemphira Alavidze , Gary R. Pasternack , Torrey C. Brown
CPC分类号： C08L77/12 , A01N63/00 , A23B4/22 , A23B7/155 , A23G9/30 , A23L3/34635 , A23L3/3571 , A61K9/7007 , A61K35/76 , A61K38/164 , A61L2/00 , A61L2/0005 , A61L2/18 , A61L2/22 , A61L15/225 , A61L15/26 , A61L15/38 , A61L15/44 , A61L26/0019 , A61L26/0052 , A61L26/0066 , A61L2300/404 , C08G69/44 , C12N7/00 , C12N2795/00032 , C12N2795/00051 , Y02A50/473 , Y02A50/481
摘要： The present invention provides a method for reducing the risk of bacterial infection or sepsis in a susceptible patient by treating the susceptible patient with a pharmaceutical composition containing bacteriophage of one or more strains which produce lytic infections in pathogenic bacteria. Preferably, treatment of the patient reduces the level of colonization with pathogenic bacteria susceptible to the bacteriophage by at least one log. In a typical embodiment, the susceptible patient is an immunocompromised patient selected from the group consisting of leukemia patients, lymphoma patients, carcinoma patients, sarcoma patients, allogeneic transplant patients, congenital or acquired immunodeficiency patients, cystic fibrosis patients, and AIDS patients. In a preferred mode, the patients treated by this method are colonized with the pathogenic bacteria subject to infection by said bacteriophage.
摘要翻译： 本发明提供了一种通过用含有在病原菌中产生溶解性感染的一种或多种菌株的噬菌体的药物组合物治疗易感患者来降低易感患者细菌感染或败血症风险的方法。 优选地，患者的治疗通过至少一个对数降低对噬菌体敏感的致病细菌的定植水平。 在典型的实施方案中，易感患者是选自白血病患者，淋巴瘤患者，癌症患者，肉瘤患者，同种异体移植患者，先天性或后天免疫缺陷病人，囊性纤维化患者和艾滋病患者的免疫受损患者。 在优选的模式中，通过该方法治疗的患者被所述噬菌体感染的致病细菌定植。
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公开(公告)号：US20130164374A1
公开(公告)日：2013-06-27
申请号：US13772573
申请日：2013-02-21
申请人： J. Glenn MORRIS , Alexander Sulakvelidze , Zemphira Alavidze , Gary R. Pasternack , Torrey C. Brown
发明人： J. Glenn MORRIS , Alexander Sulakvelidze , Zemphira Alavidze , Gary R. Pasternack , Torrey C. Brown
IPC分类号： A61K35/76
CPC分类号： C08L77/12 , A01N63/00 , A23B4/22 , A23B7/155 , A23G9/30 , A23L3/34635 , A23L3/3571 , A61K9/7007 , A61K35/76 , A61K38/164 , A61L2/00 , A61L2/0005 , A61L2/18 , A61L2/22 , A61L15/225 , A61L15/26 , A61L15/38 , A61L15/44 , A61L26/0019 , A61L26/0052 , A61L26/0066 , A61L2300/404 , C08G69/44 , C12N7/00 , C12N2795/00032 , C12N2795/00051 , Y02A50/473 , Y02A50/481
摘要： The present invention provides a method for reducing the risk of bacterial infection or sepsis in a susceptible patient by treating the susceptible patient with a pharmaceutical composition containing bacteriophage of one or more strains which produce lytic infections in pathogenic bacteria. Preferably, treatment of the patient reduces the level of colonization with pathogenic bacteria susceptible to the bacteriophage by at least one log. In a typical embodiment, the susceptible patient is an immunocompromised patient selected from the group consisting of leukemia patients, lymphoma patients, carcinoma patients, sarcoma patients, allogeneic transplant patients, congenital or acquired immunodeficiency patients, cystic fibrosis patients, and AIDS patients. In a preferred mode, the patients treated by this method are colonized with the pathogenic bacteria subject to infection by said bacteriophage.
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6.发明授权公开(公告)号：US08003323B2
公开(公告)日：2011-08-23
申请号：US12264582
申请日：2008-11-04
申请人： J. Glenn Morris , Alexander Sulakvelidze , Zemphira Alavidze , Gary R. Pasternack , Torrey C. Brown
发明人： J. Glenn Morris , Alexander Sulakvelidze , Zemphira Alavidze , Gary R. Pasternack , Torrey C. Brown
CPC分类号： C08L77/12 , A01N63/00 , A23B4/22 , A23B7/155 , A23G9/30 , A23L3/34635 , A23L3/3571 , A61K9/7007 , A61K35/76 , A61K38/164 , A61L2/00 , A61L2/0005 , A61L2/18 , A61L2/22 , A61L15/225 , A61L15/26 , A61L15/38 , A61L15/44 , A61L26/0019 , A61L26/0052 , A61L26/0066 , A61L2300/404 , C08G69/44 , C12N7/00 , C12N2795/00032 , C12N2795/00051 , Y02A50/473 , Y02A50/481
摘要： The present invention provides a method for reducing the risk of bacterial infection or sepsis in a susceptible patient by treating the susceptible patient with a pharmaceutical composition containing bacteriophage of one or more strains which produce lytic infections in pathogenic bacteria. Preferably, treatment of the patient reduces the level of colonization with pathogenic bacteria susceptible to the bacteriophage by at least one log. In a typical embodiment, the susceptible patient is an immunocompromised patient selected from the group consisting of leukemia patients, lymphoma patients, carcinoma patients, sarcoma patients, allogeneic transplant patients, congenital or acquired immunodeficiency patients, cystic fibrosis patients, and AIDS patients. In a preferred mode, the patients treated by this method are colonized with the pathogenic bacteria subject to infection by said bacteriophage.
摘要翻译： 本发明提供了一种通过用含有在病原菌中产生溶解性感染的一种或多种菌株的噬菌体的药物组合物治疗易感患者来降低易感患者细菌感染或败血症风险的方法。 优选地，患者的治疗通过至少一个对数降低对噬菌体敏感的致病细菌的定植水平。 在典型的实施方案中，易感患者是选自白血病患者，淋巴瘤患者，癌症患者，肉瘤患者，同种异体移植患者，先天性或后天免疫缺陷病人，囊性纤维化患者和艾滋病患者的免疫受损患者。 在优选的模式中，通过该方法治疗的患者被所述噬菌体感染的致病细菌定植。
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公开(公告)号：US20050244383A1
公开(公告)日：2005-11-03
申请号：US11173082
申请日：2005-07-01
IPC分类号： A01N63/00 , A23B4/22 , A23B7/155 , A23G9/30 , A23L3/3463 , A23L3/3571 , A61K9/70 , A61K45/00 , A61L2/00 , A61L2/18 , A61L2/22 , A61L15/22 , A61L15/26 , A61L15/38 , A61L15/44 , A61L26/00 , C08G69/44 , C08L77/12
CPC分类号： C08L77/12 , A01N63/00 , A23B4/20 , A23B4/22 , A23B5/16 , A23B7/154 , A23B7/155 , A23G9/30 , A23L3/3463 , A23L3/34635 , A23L3/3472 , A23L3/3571 , A61K9/7007 , A61L2/00 , A61L2/0005 , A61L2/18 , A61L2/22 , A61L15/225 , A61L15/26 , A61L15/38 , A61L15/44 , A61L26/0019 , A61L26/0052 , A61L26/0066 , A61L2300/404 , C08G69/44 , Y02A50/473 , Y02A50/481
摘要： Methods and devices for sanitation using bacteriophage are disclosed. According to one embodiment of the present invention, a method for sanitation using at least one bacteriophage includes the steps of (1) storing the at least one bacteriophage in a container; and (2) applying the at least one bacteriophage to a surface to be sanitized with a dispersing mechanism. According to another embodiment of the present invention, a sanitation device that dispenses at least one bacteriophage includes a container, at least one bacteriophage stored in the container, and a dispersing mechanism that disperses the at least one bacteriophage from the container.
摘要翻译： 公开了使用噬菌体的卫生方法和装置。 根据本发明的一个实施方案，使用至少一种噬菌体的卫生方法包括以下步骤：（1）将至少一种噬菌体储存在容器中; 和（2）用分散机构将至少一种噬菌体施用于待消毒的表面。 根据本发明的另一个实施方案，分配至少一种噬菌体的卫生装置包括容器，存储在容器中的至少一种噬菌体以及从容器中分散至少一种噬菌体的分散机构。
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公开(公告)号：US20070248724A1
公开(公告)日：2007-10-25
申请号：US11752864
申请日：2007-05-23
IPC分类号： A23L3/3463 , A23B4/22 , A23B5/16 , A23B7/155 , A23B9/28
CPC分类号： C08L77/12 , A01N63/00 , A23B4/20 , A23B4/22 , A23B5/16 , A23B7/154 , A23B7/155 , A23G9/30 , A23L3/3463 , A23L3/34635 , A23L3/3472 , A23L3/3571 , A61K9/7007 , A61L2/00 , A61L2/0005 , A61L2/18 , A61L2/22 , A61L15/225 , A61L15/26 , A61L15/38 , A61L15/44 , A61L26/0019 , A61L26/0052 , A61L26/0066 , A61L2300/404 , C08G69/44 , Y02A50/473 , Y02A50/481
摘要： Methods and devices for sanitation using bacteriophage are disclosed. According to one embodiment of the present invention, a method for sanitation using at least one bacteriophage includes the steps of (1) storing the at least one bacteriophage in a container; and (2) applying the at least one bacteriophage to a surface to be sanitized with a dispersing mechanism. According to another embodiment of the present invention, a sanitation device that dispenses at least one bacteriophage includes a container, at least one bacteriophage stored in the container, and a dispersing mechanism that disperses the at least one bacteriophage from the container.
摘要翻译： 公开了使用噬菌体的卫生方法和装置。 根据本发明的一个实施方案，使用至少一种噬菌体的卫生方法包括以下步骤：（1）将至少一种噬菌体储存在容器中; 和（2）用分散机构将至少一种噬菌体施用于待消毒的表面。 根据本发明的另一个实施方案，分配至少一种噬菌体的卫生装置包括容器，存储在容器中的至少一种噬菌体和从容器中分散至少一种噬菌体的分散机构。
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公开(公告)号：US20050175991A1
公开(公告)日：2005-08-11
申请号：US10655217
申请日：2003-09-05
申请人： Alexander Sulakvelidze , J. Morris , Zemphira Alavidze , Gary Pasternack , Torrey Brown , Britta Leverentz , William Conway , Wojciech Janisiewicz
发明人： Alexander Sulakvelidze , J. Morris , Zemphira Alavidze , Gary Pasternack , Torrey Brown , Britta Leverentz , William Conway , Wojciech Janisiewicz
IPC分类号： A61K47/34 , A01N63/00 , A23B4/22 , A23B7/155 , A23G9/30 , A23L3/3463 , A23L3/3571 , A61K9/70 , A61K35/76 , A61K38/16 , A61K47/42 , A61L2/00 , A61L2/18 , A61L2/22 , A61L15/22 , A61L15/26 , A61L15/38 , A61L15/44 , A61L26/00 , A61P17/02 , C08G69/44 , C08L77/12 , C12N7/01 , C12N7/02 , C12Q1/70 , C12N7/00
CPC分类号： C08L77/12 , A01N63/00 , A23B4/22 , A23B7/155 , A23G9/30 , A23L3/34635 , A23L3/3571 , A61K9/7007 , A61K35/76 , A61K38/164 , A61L2/00 , A61L2/0005 , A61L2/18 , A61L2/22 , A61L15/225 , A61L15/26 , A61L15/38 , A61L15/44 , A61L26/0019 , A61L26/0052 , A61L26/0066 , A61L2300/404 , C08G69/44 , C12N7/00 , C12N2795/00032 , C12N2795/00051 , Y02A50/473 , Y02A50/481
摘要： A method for produce sanitation using bacteriophages is disclosed. According to one embodiment of the present invention, the method includes the steps of (1) providing at least one bacteriophage; and (2) applying the bacteriophage to the produce. The produce may include fruits and vegetables. The produce may be freshly-cut produce, damaged produce, diseased produce, or contaminated produce. The produce may be sprayed with bacteriophage, washed with bacteriphage, immersed in a liquid containing bacteriophage, etc. The bacteriophage may be applied once, periodically or continuously. In one embodiment, chemical sanitizers may also be applied to the produce.
摘要翻译： 公开了使用噬菌体产生卫生的方法。 根据本发明的一个实施方案，该方法包括以下步骤：（1）提供至少一种噬菌体; 和（2）将噬菌体施用于产品。 产品可能包括水果和蔬菜。 产品可能是新鲜切割的产品，损坏的产品，患病的产品或受污染的产品。 该产品可以用噬菌体喷洒，用噬菌体洗涤，浸入含有噬菌体的液体等中。噬菌体可以施用一次，定期或连续。 在一个实施方案中，化学消毒剂也可以施用于产品。
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10.发明授权公开(公告)号：US06703040B2
公开(公告)日：2004-03-09
申请号：US09757704
申请日：2001-01-11
申请人： Ramaz Katsarava , Zemphira Alavidze
发明人： Ramaz Katsarava , Zemphira Alavidze
IPC分类号： A61L1500
CPC分类号： C08L77/12 , A01N63/00 , A23B4/22 , A23B7/155 , A23G9/30 , A23L3/34635 , A23L3/3571 , A61K9/1641 , A61K9/1694 , A61K9/7007 , A61K47/34 , A61L2/00 , A61L2/0005 , A61L2/18 , A61L2/22 , A61L15/225 , A61L15/26 , A61L15/38 , A61L15/44 , A61L26/0019 , A61L26/0052 , A61L26/0066 , A61L2300/402 , A61L2300/404 , C08G69/44
摘要： The present invention provides bioerodable constructs for controlled release of bioactive materials. In a preferred mode, the constructs may be utilized adjacent to a biological surface. The constructs are based on a blend of two or more poly(ester-amide) polymers (PEA). Such polymers may be prepared by polymerization of a diol (D), a dicarboxylic acid (C) and an alpha-amino acid (A) through ester and amide links in the form (DACA)n. An example of a (DACA)n polymer is shown below in formula II. Suitable amino acids include any natural or synthetic alpha-amino acid, preferably neutral amino acids.
摘要翻译： 本发明提供用于生物活性材料的控制释放的生物侵蚀性构建体。 在优选的模式中，构建体可以邻近生物表面使用。 所述构建体基于两种或多种聚（酯 - 酰胺）聚合物（PEA）的共混物。 这样的聚合物可以通过二醇（D），二羧酸（C）和α-氨基酸（A）通过（DACA）n形式的酯和酰胺链进行聚合来制备。 （DACA）n聚合物的实例如下式II所示。 合适的氨基酸包括任何天然或合成的α-氨基酸，优选中性氨基酸。
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