COATING COMPOSITIONS HAVING IMPROVED PERFORMANCE

    公开(公告)号:US20090246250A1

    公开(公告)日:2009-10-01

    申请号:US12413241

    申请日:2009-03-27

    CPC分类号: A61K38/16 A61K2300/00

    摘要: The presently disclosed subject matter provides compositions comprising a first substrate-binding domain (a peptide or a polymer) having binding affinity for a tissue or a medical device, a second substrate-binding domain having binding affinity for a target molecule, and the target molecule. In some embodiments, the first and second substrate-binding domains are covalently linked. The first and second substrate-binding domains are covalently coupled to at least one hydrophobic interaction tag, negatively charged interaction tag, or positively charged interaction tag. When the substrate-binding domains are combined and coated onto the tissue or medical device, the hydrophobic interaction tags interact with each other and the charged interaction tags interact with the oppositely charged interaction tags or the oppositely charged substrate binding polymers, to form a macromolecular network of non-covalently coupled substrate-binding domains to load the target molecule onto the tissue or medical device.

    COATING COMPOSITIONS HAVING IMPROVED PERFORMANCE
    23.
    发明申请
    COATING COMPOSITIONS HAVING IMPROVED PERFORMANCE 审中-公开
    具有改进性能的涂料组合物

    公开(公告)号:US20090246248A1

    公开(公告)日:2009-10-01

    申请号:US12413195

    申请日:2009-03-27

    IPC分类号: A61L27/54 A61K38/16

    CPC分类号: A61K38/16 A61K2300/00

    摘要: The presently disclosed subject matter provides compositions comprising a first substrate-binding domain (a peptide or a polymer) having binding affinity for a tissue or a medical device, a second substrate-binding domain having binding affinity for a target molecule, and the target molecule. In some embodiments, the first and second substrate-binding domains are covalently linked. The first and second substrate-binding domains are covalently coupled to at least one hydrophobic interaction tag, negatively charged interaction tag, or positively charged interaction tag. When the substrate-binding domains are combined and coated onto the tissue or medical device, the hydrophobic interaction tags interact with each other and the charged interaction tags interact with the oppositely charged interaction tags or the oppositely charged substrate binding polymers, to form a macromolecular network of non-covalently coupled substrate-binding domains to load the target molecule onto the tissue or medical device.

    摘要翻译: 目前公开的主题提供了包含对组织或医疗装置具有结合亲和力的第一底物结合结构域(肽或聚合物),对靶分子具有结合亲和力的第二底物结合结构域和靶分子 。 在一些实施方案中,第一和第二底物结合结构域共价连接。 第一和第二底物结合结构域与至少一个疏水相互作用标签,带负电荷的相互作用标签或带正电荷的相互作用标签共价偶联。 当底物结合域被组合并涂覆在组织或医疗装置上时,疏水性相互作用标签相互作用,并且带电相互作用标签与相反电荷的相互作用标签或相反电荷的底物结合聚合物相互作用以形成大分子网络 的非共价偶联的底物结合结构域以将靶分子加载到组织或医疗装置上。

    Treatment of presbyopia with picolinic acid and its analogs
    25.
    发明申请
    Treatment of presbyopia with picolinic acid and its analogs 审中-公开
    用吡啶甲酸及其类似物治疗老花眼

    公开(公告)号:US20070178062A1

    公开(公告)日:2007-08-02

    申请号:US11544647

    申请日:2006-10-10

    摘要: Compositions and methods for inhibiting the growth of lens epithelial cells are provided. The compositions provided include a chelating agent in an amount sufficient for inhibiting the growth of lens epithelial cells. The compositions and methods provided may also be used for the treatment of disorders of the eye, especially in the treatment of presbyopia.

    摘要翻译: 提供了抑制晶状体上皮细胞生长的组合物和方法。 提供的组合物包括足以抑制晶状体上皮细胞生长的量的螯合剂。 所提供的组合物和方法也可用于治疗眼睛疾病,特别是在治疗老花眼中。

    Continuous seal vehicular exhaust distribution system for building
    26.
    发明授权
    Continuous seal vehicular exhaust distribution system for building 失效
    连续密封车辆排气分配系统

    公开(公告)号:US5655962A

    公开(公告)日:1997-08-12

    申请号:US589241

    申请日:1996-01-22

    摘要: An exhaust fumes distribution system for use within a structure adjacent to a space in which a vehicle having an engine coupled to a vertically oriented, open ended, exhaust stack is to be located to discharge exhaust fumes out of the structure. The system comprises an blower, an elongated, hollow guide tube having a slot extending the length thereof. The guide tube includes a pair of sealing members located along the slot for forming a sealed interface through which the exhaust stack is arranged to enter, so that fumes from the stack are carried down the guide tube and vented out of the structure by the blower. The sealing members are of generally C-shape in cross section so that peripheral portions thereof abut along the length of the slot to form the sealed interface. The interface is arranged to open at any point along the length thereof for receipt of the open end of the exhaust stack of the vehicle, with the remaining portions of the interface remaining sealed so that the exhaust fumes cannot gain ingress into the interior of the structure through the interface.

    摘要翻译: 一种排气烟雾分配系统,用于在与其中具有连接到垂直取向的开放式排气叠层的发动机的车辆位于相邻的结构内的结构内使用,以将废气排出结构。 该系统包括鼓风机,细长的中空导管,其具有延伸其长度的狭槽。 引导管包括沿着槽定位的一对密封构件,用于形成密封界面,排气叠层布置成通过该密封界面进入,使得来自堆叠的烟雾被引导导管并由鼓风机排出结构。 密封构件的截面通常为C形,使得其周边部分沿着狭槽的长度邻接以形成密封界面。 接口布置成在其长度的任何点处打开以接收车辆的排气叠层的开口端,其中界面的其余部分保持密封,使得排气不能进入结构的内部 通过界面。

    Vehicle exhaust distribution system for buildings
    27.
    发明授权
    Vehicle exhaust distribution system for buildings 失效
    建筑物车辆排气分配系统

    公开(公告)号:US5362273A

    公开(公告)日:1994-11-08

    申请号:US183554

    申请日:1994-01-19

    IPC分类号: B08B15/00

    CPC分类号: B08B15/002 Y10S454/903

    摘要: An exhaust fumes distribution system for use within a structure adjacent to a space in which a vehicle having an engine coupled to a vertically oriented, open ended, exhaust stack is to be located to discharge exhaust fumes out of the structure. The system comprises an actuatable blower, an elongated guide tube, a collapsible conduit, and a wireless transmitter and receiver. The guide tube has a hollow interior and a slot extending therealong and is mounted horizontally above the space so that the slot extends from a first position adjacent an entrance to the structure to a second, remote position. The collapsible conduit is located within the guide tube and is coupled to the blower. The conduit has an end portion including an inlet opening and is biased into an extended position within the guide tube so that the inlet opening is located adjacent the first position to receive the open end of the stack through the slot. The conduit is collapsible so that the open end of the stack remains within the inlet opening in the conduit when the vehicle is moved in the structure from the first position to the second position. The wireless transmitter is arranged for actuating the receiver, which is coupled to the blower, so that upon operation of the vehicle's ignition switch the blower is actuated to vent fumes in the stack through the conduit and out of the structure.

    摘要翻译: 一种排气烟雾分配系统,用于在与其中具有连接到垂直取向的开放式排气叠层的发动机的车辆位于相邻的结构内的结构内使用,以将废气排出结构。 该系统包括可致动鼓风机,细长引导管,可折叠导管和无线发射器和接收器。 引导管具有中空的内部和沿其延伸的狭槽,并且水平地安装在空间上方,使得狭槽从邻近结构的入口的第一位置延伸到第二远程位置。 可折叠管道位于引导管内并联接到鼓风机。 导管具有包括入口开口的端部并且被偏压到引导管内的延伸位置,使得入口开口位于第一位置附近以通过狭槽接收堆叠的开口端。 导管是可折叠的,使得当车辆在结构中从第一位置移动到第二位置时,堆叠的开口端保持在管道中的入口开口内。 无线发射器被布置成用于致动接收器,该接收器耦合到鼓风机,使得在车辆的点火开关的操作时,鼓风机被致动以通过导管排出烟囱中的烟雾并排出结构。

    Agency payment system
    29.
    发明申请

    公开(公告)号:US20110202448A1

    公开(公告)日:2011-08-18

    申请号:US13065121

    申请日:2011-03-15

    IPC分类号: G06Q40/00

    CPC分类号: G06Q40/00 G06Q40/04

    摘要: An agency payment system for transactions covered by a virtual market control entity between participants. The system determines all payments required to be made by each virtual market control entity participant on a given day. It nets all of each of the participant's required payments to be made with the payments received by the virtual market control entity on the previous day due to each participant to obtain a net cash movement, either from the virtual market control entity to the participant's account or from the participant's account to the virtual market control entity. It transfers between the participant's account and the virtual market control entity's account and each participant's account the net cash movements to the virtual market control entity's account. It then transfers between the virtual market control entity's account and each participant's account the net cash movements to the participant's account.

    Peptide compositions for coating metal medical devices with vancomycin
    30.
    发明授权
    Peptide compositions for coating metal medical devices with vancomycin 失效
    用万古霉素涂覆金属医疗器械的肽组合物

    公开(公告)号:US07972615B2

    公开(公告)日:2011-07-05

    申请号:US12413285

    申请日:2009-03-27

    CPC分类号: A61K38/16 A61K2300/00

    摘要: The presently disclosed subject matter provides compositions comprising a first substrate-binding domain (a peptide or a polymer) having binding affinity for a tissue or a medical device, a second substrate-binding domain having binding affinity for a target molecule, and the target molecule. In some embodiments, the first and second substrate-binding domains are covalently linked. The first and second substrate-binding domains are covalently coupled to at least one hydrophobic interaction tag, negatively charged interaction tag, or positively charged interaction tag. When the substrate-binding domains are combined and coated onto the tissue or medical device, the hydrophobic interaction tags interact with each other and the charged interaction tags interact with the oppositely charged interaction tags or the oppositely charged substrate binding polymers, to form a macromolecular network of non-covalently coupled substrate-binding domains to load the target molecule onto the tissue or medical device.

    摘要翻译: 目前公开的主题提供了包含对组织或医疗装置具有结合亲和力的第一底物结合结构域(肽或聚合物),对靶分子具有结合亲和力的第二底物结合结构域和靶分子 。 在一些实施方案中,第一和第二底物结合结构域共价连接。 第一和第二底物结合结构域与至少一个疏水相互作用标签,带负电荷的相互作用标签或带正电荷的相互作用标签共价偶联。 当底物结合域被组合并涂覆在组织或医疗装置上时,疏水性相互作用标签相互作用,并且带电相互作用标签与相反电荷的相互作用标签或相反电荷的底物结合聚合物相互作用以形成大分子网络 的非共价偶联的底物结合结构域以将靶分子加载到组织或医疗装置上。