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公开(公告)号：US06630575B2
公开(公告)日：2003-10-07
申请号：US09910174
申请日：2001-07-20
IPC分类号： C07K14705
CPC分类号： C07K14/70532 , Y10S435/81
摘要： B7-Like polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length B7-like proteins, the invention further provides isolated B7-like fusion proteins, antigenic peptides, and anti-B7-like antibodies. The invention also provides B7-like nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a B7-like gene has been introduced or disrupted. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译： 公开了B7样多肽，蛋白质和核酸分子。 除了分离的全长B7样蛋白之外，本发明还提供分离的B7样融合蛋白，抗原肽和抗B7样抗体。 本发明还提供了B7样核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，以及引入或破坏了B7样基因的非人类转基因动物 。 还提供了利用本发明组合物的诊断，筛选和治疗方法。
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公开(公告)号：US20140296101A1
公开(公告)日：2014-10-02
申请号：US14268722
申请日：2014-05-02
IPC分类号： C07K14/475 , G01N33/68 , C07K16/22
CPC分类号： C07K14/475 , A61K38/00 , A61K39/00 , C07H21/04 , C07K14/47 , C07K14/4705 , C07K14/52 , C07K14/705 , C07K16/18 , C07K16/22 , C07K16/28 , C12N15/86 , C12N2800/10 , C12Q1/025 , C12Q1/6813 , C12Q1/686 , G01N33/53 , G01N33/68 , G01N33/6872 , Y10T436/143333
摘要： The invention provides isolated nucleic acid molecules, designated TANGO 228 nucleic acid molecules, which encode secreted proteins with homology to the rat MCA-32 protein, isolated nucleic acid molecules, designated TANGO 240 nucleic acid molecules, which encode secreted proteins with homology to the Mycobacterium tuberculosis hypothetical protein Rv0712, and isolated nucleic acid molecules, designated TANGO 243 nucleic acid molecules, which encode proteins with homology to human PLAP (phospholipase A2-activating protein).The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供分离的核酸分子，称为TANGO 228核酸分子，其编码与大鼠MCA-32蛋白同源的分泌蛋白，分离的核酸分子，称为TANGO 240核酸分子，其编码与分枝杆菌具有同源性的分泌蛋白 结核分枝杆菌假想蛋白Rv0712和分离的核酸分子，命名为TANGO 243核酸分子，其编码与人PLAP（磷脂酶A2激活蛋白）具有同源性的蛋白质。 本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或 中断了 本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。 还提供利用本发明组合物的诊断，筛选和治疗方法。
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23.发明授权Long term xenogeneic myeloid and lymphoid cell production in chimeric immunocompromised mice 失效在嵌合免疫受损小鼠中长期异种骨髓和淋巴细胞产生公开(公告)号：US06455756B1
公开(公告)日：2002-09-24
申请号：US08290038
申请日：1994-08-12
IPC分类号： A01K6700
CPC分类号： G01N33/56977 , A01K67/0271
摘要： Immunocompromised mammalian hosts are sub-cutaneously implanted with a combination of human fetal bone and spleen. The chimeric animals can produce human B-cells, myeloid cells and T-cells for up to 9 months in vivo when supplied with an allogeneic human fetal thymic fragment at the same site. Grafts contain cell populations expressing CD4 and CD8, CD19 or CD33, CD14 and CD15, all of which also express the HLA type of the fetal bone/spleen. T-cells derived from progenitors in the fetal bone/spleen contain both mature single positive CD4+CD8−, CD8+CD4− as well as a high percentage of immature double positive CD4+CD8+ populations.
摘要翻译： 免疫受损的哺乳动物宿主用人胎儿骨和脾的组合皮下植入。 当在同一位点供给同种异体的人胎儿胸腺胸片时，嵌合动物可以在体内产生长达9个月的人B细胞，骨髓细胞和T细胞。 移植物含有表达CD4和CD8，CD19或CD33，CD14和CD15的细胞群，所有这些细胞群也表达胎儿骨/脾的HLA型。 来自胎儿骨/脾脏祖细胞的T细胞既含有成熟的单一阳性CD4 + CD8-，CD8 + CD4-以及高比例的未成熟双阳性CD4 + CD8 +群体。
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公开(公告)号：US20130123122A1
公开(公告)日：2013-05-16
申请号：US13462600
申请日：2012-05-02
IPC分类号： C07K14/47 , C07K16/28 , G01N33/53 , C12Q1/68 , C12Q1/02 , C07K16/18 , C07K14/705 , G01N33/68
CPC分类号： C07K14/475 , A61K38/00 , A61K39/00 , C07H21/04 , C07K14/47 , C07K14/4705 , C07K14/52 , C07K14/705 , C07K16/18 , C07K16/22 , C07K16/28 , C12N15/86 , C12N2800/10 , C12Q1/025 , C12Q1/6813 , C12Q1/686 , G01N33/53 , G01N33/68 , G01N33/6872 , Y10T436/143333
摘要： The invention provides isolated nucleic acid molecules, designated TANGO 228 nucleic acid molecules, which encode secreted proteins with homology to the rat MCA-32 protein, isolated nucleic acid molecules, designated TANGO 240 nucleic acid molecules, which encode secreted proteins with homology to the Mycobacterium tuberculosis hypothetical protein Rv0712, and isolated nucleic acid molecules, designated TANGO 243 nucleic acid molecules, which encode proteins with homology to human PLAP (phospholipase A2-activating protein).The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供分离的核酸分子，命名为TANGO 228核酸分子，其编码与大鼠MCA-32蛋白同源的分泌蛋白，分离的核酸分子，称为TANGO 240核酸分子，其编码与分枝杆菌具有同源性的分泌蛋白 结核分枝杆菌假想蛋白Rv0712和分离的核酸分子，命名为TANGO 243核酸分子，其编码与人PLAP（磷脂酶A2激活蛋白）具有同源性的蛋白质。 本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或 中断了 本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。 还提供利用本发明组合物的诊断，筛选和治疗方法。
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公开(公告)号：US20110081656A1
公开(公告)日：2011-04-07
申请号：US12386835
申请日：2009-04-23
IPC分类号： G01N33/53 , C07H21/04 , C12N15/63 , C12N5/071 , C07K14/00 , C07K16/00 , C12P21/00 , G01N33/50
CPC分类号： C07K14/475 , A61K38/00 , A61K39/00 , C07H21/04 , C07K14/47 , C07K14/4705 , C07K14/52 , C07K14/705 , C07K16/18 , C07K16/22 , C07K16/28 , C12N15/86 , C12N2800/10 , C12Q1/025 , C12Q1/6813 , C12Q1/686 , G01N33/53 , G01N33/68 , G01N33/6872 , Y10T436/143333
摘要： The invention provides isolated nucleic acid molecules, designated TANGO 228 nucleic acid molecules, which encode secreted proteins with homology to the rat MCA-32 protein, isolated nucleic acid molecules, designated TANGO 240 nucleic acid molecules, which encode secreted proteins with homology to the Mycobacterium tuberculosis hypothetical protein Rv0712, and isolated nucleic acid molecules, designated TANGO 243 nucleic acid molecules, which encode proteins with homology to human PLAP (phospholipase A2-activating protein).The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供分离的核酸分子，命名为TANGO 228核酸分子，其编码与大鼠MCA-32蛋白同源的分泌蛋白，分离的核酸分子，称为TANGO 240核酸分子，其编码与分枝杆菌具有同源性的分泌蛋白 结核分枝杆菌假想蛋白Rv0712和分离的核酸分子，命名为TANGO 243核酸分子，其编码与人PLAP（磷脂酶A2激活蛋白）具有同源性的蛋白质。 本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或 中断了 本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。 还提供利用本发明组合物的诊断，筛选和治疗方法。
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公开(公告)号：US07459530B2
公开(公告)日：2008-12-02
申请号：US11491318
申请日：2006-07-21
IPC分类号： C07K14/00
CPC分类号： C07K14/47
摘要： The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods using compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.
摘要翻译： 本发明提供编码具有诊断，预防，治疗和其它用途的各种蛋白质的分离的核酸。 这些核酸和蛋白质可用于诊断，预防和治疗许多人类和其他动物疾病。 本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或 中断了 本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。 还提供了使用本发明组合物的诊断，筛选和治疗方法。 本发明的核酸和多肽可用作调节各种细胞过程的调节剂。
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公开(公告)号：US07282209B2
公开(公告)日：2007-10-16
申请号：US10929150
申请日：2004-08-27
CPC分类号： C07K14/475 , A61K38/00 , A61K39/00 , C07H21/04 , C07K14/47 , C07K14/4705 , C07K14/52 , C07K14/705 , C07K16/18 , C07K16/22 , C07K16/28 , C12N15/86 , C12N2800/10 , C12Q1/025 , C12Q1/6813 , C12Q1/686 , G01N33/53 , G01N33/68 , G01N33/6872 , Y10T436/143333
摘要： The invention provides isolated nucleic acid molecules, designated TANGO 228 nucleic acid molecules, which encode secreted proteins with homology to the rat MCA-32 protein, isolated nucleic acid molecules, designated TANGO 240 nucleic acid molecules, which encode secreted proteins with homology to the Mycobacterium tuberculosis hypothetical protein Rv0712, and isolated nucleic acid molecules, designated TANGO 243 nucleic acid molecules, which encode proteins with homology to human PLAP (phospholipase A2-activating protein).The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供分离的核酸分子，命名为TANGO 228核酸分子，其编码与大鼠MCA-32蛋白同源的分泌蛋白，分离的核酸分子，称为TANGO 240核酸分子，其编码与分枝杆菌具有同源性的分泌蛋白 结核分枝杆菌假想蛋白Rv0712和分离的核酸分子，命名为TANGO 243核酸分子，其编码与人PLAP（磷脂酶A2激活蛋白）具有同源性的蛋白质。 本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或 中断了 本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。 还提供利用本发明组合物的诊断，筛选和治疗方法。
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公开(公告)号：US06635750B1
公开(公告)日：2003-10-21
申请号：US09620461
申请日：2000-07-20
IPC分类号： C07H2104
CPC分类号： C07K14/70532 , Y10S435/81
摘要： B7-like polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length B7-like proteins, the invention further provides isolated B7-like fusion proteins, antigenic peptides, and anti-B7-like antibodies. The invention also provides B7-like nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a B7-like gene has been introduced or disrupted. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译： 公开了B7样多肽，蛋白质和核酸分子。 除了分离的全长B7样蛋白之外，本发明还提供分离的B7样融合蛋白，抗原肽和抗B7样抗体。 本发明还提供了B7样核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，以及引入或破坏了B7样基因的非人类转基因动物 。 还提供了利用本发明组合物的诊断，筛选和治疗方法。
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