公开(公告)号：US10813757B2

公开(公告)日：2020-10-27

申请号：US16028172

申请日：2018-07-05

Applicant: Edwards Lifesciences Corporation

Inventor： Alexander H. Cooper ,  David Robert Landon ,  Kevin M. Stewart ,  Garrett Dallas Johnson ,  Glen T. Rabito ,  Tarannum Ishaq Gutierrez ,  Hiroshi Okabe ,  Ramon Aguilar, Jr. ,  Jesse Robert Edwards ,  Taylor Jacob Scheinblum ,  Patrick Chow ,  Julio Cesar Sanchez ,  Hieu Minh Luong

IPC: A61F2/24 ,  A61M25/00 ,  A61M25/01 ,  A61F2/95

Abstract: Devices, systems and methods are described herein to provide improved steerability for delivering a prosthesis to a body location, for example, for delivering a replacement mitral valve to a native mitral valve location. The steerable delivery system can contain a steerable rail configured for multi-plane bending to direct a distal end of the delivery system.

公开(公告)号：US20240366372A1

公开(公告)日：2024-11-07

申请号：US18626109

申请日：2024-04-03

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Matthew Michael Becerra ,  Kevin M. Stewart ,  Richard D. White ,  David Robert Landon ,  Jonathan Yeh ,  Harish Manickam Srinimukesh ,  Matthew A. Peterson ,  Munci Muhsin Inonu ,  Christopher Aguayo ,  Parth Himanshu Parikh

IPC: A61F2/24

Abstract: A system including a delivery apparatus, a crimping device, and a loading assembly. The crimping device includes a housing disposed over a distal end portion of the delivery apparatus for receiving a radially expandable and compressible prosthetic heart valve. The housing includes a funnel segment, a pusher member, and an actuator releasably coupled to the pusher member. Movement of the actuator causes the pusher member to advance the prosthetic heart valve through the funnel segment for radially compressing at least a portion of the prosthetic heart valve. Compression of the prosthetic heart valve facilitates secure attachment of the prosthetic heart valve to the delivery apparatus. The loading assembly can include an additional funnel member for fully crimping and loading the prosthetic heart valve into the delivery apparatus for advancement through a patient's vasculature.

公开(公告)号：US20240299166A1

公开(公告)日：2024-09-12

申请号：US18664760

申请日：2024-05-15

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Alexander H. Cooper ,  Juliet Laura Schwartz ,  Hannah Marie Glas ,  Matthew Michael Becerra ,  David Robert Landon ,  Siddharth Vad ,  Taylor Jacob Scheinblum ,  Matthew A. Peterson ,  Wei Gan

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2/2436 ,  A61F2220/0016 ,  A61F2230/0041 ,  A61F2230/0093 ,  A61F2250/001

Abstract: A prosthetic valve includes an expandable valve frame and leaflets supported therein. A plurality of elongate anchor arms extends from an outlet end portion of the valve frame. Each elongate anchor arm includes anchoring protrusions, such as barbs, for engaging surrounding tissue. During delivery to the treatment site, the anchoring protrusions face inwardly. When released from the delivery catheter, the anchoring arms evert such that the anchoring protrusions reverse orientation and face outwardly. In this position, the protrusions can engage surrounding tissue and thereby secure the prosthetic valve within a native heart valve.

公开(公告)号：US20240245511A1

公开(公告)日：2024-07-25

申请号：US18627364

申请日：2024-04-04

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Matthew Michael Becerra ,  David Robert Landon ,  Payam Saffari ,  Yevgeniy Davidovich Kaufman ,  Jesse Robert Edwards ,  David M. Taylor ,  Scott Louis Shary ,  Richard D. White

IPC: A61F2/24

CPC classification number: A61F2/2436 ,  A61F2/2412

Abstract: A prosthetic heart valve delivery system having one or more features which facilitate access to a target annulus and improve maneuverability. The system may have a flexible access sheath having an inner lumen and a proximal handle attached to an elongated flexible catheter extending distally therefrom and having an outer diameter sized to fit through the access sheath. An expandable prosthetic heart valve is crimped and positioned in an inner lumen and near the distal end of the delivery catheter. A distal tapered nose cone attaches to the delivery catheter and facilitates passage through the patient's vasculature. An inner tube extends from the proximal handle through the delivery catheter inner lumen, through the prosthetic heart valve, and attaches to the nose cone. Finally, the system has a guidewire that extends through the proximal handle along the delivery catheter and projects distally from the nose cone. The system is especially useful for transfemoral atrioventricular valve replacements.

公开(公告)号：US11833040B2

公开(公告)日：2023-12-05

申请号：US17825071

申请日：2022-05-26

Applicant: Edwards Lifesciences Corporation

Inventor： David Robert Landon ,  Glen T. Rabito ,  Hieu Minh Luong

IPC: A61F2/24 ,  B21D39/04 ,  A61F2/95

CPC classification number: A61F2/2418 ,  A61F2/2412 ,  A61F2/9525 ,  B21D39/04 ,  A61F2/2436 ,  A61F2/9522 ,  A61F2210/0014 ,  A61F2250/0069

Abstract: Embodiments of a crimping device for crimping a radially expandable and compressible prosthetic valve are disclosed. A crimping device can comprise a housing configured to receive a prosthetic valve in a radially expanded state. The housing member can include a funnel segment and an outlet in communication with the funnel segment. The crimping device can further comprise an actuator rotatably coupled to the housing, wherein rotation of the actuator relative to the housing causes the prosthetic valve to move axially through the funnel segment such that at least a portion of the prosthetic valve compresses radially by engagement with the funnel segment and exits the crimping device via the outlet.

公开(公告)号：US20230200980A1

公开(公告)日：2023-06-29

申请号：US18111278

申请日：2023-02-17

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Matthew A. Peterson ,  Siddharth Vad ,  Scott Louis Shary ,  Taylor Jacob Scheinblum ,  Kevin M. Golemo ,  Yevgeniy Davidovich Kaufman ,  David Robert Landon

IPC: A61F2/24

CPC classification number: A61F2/2409 ,  A61F2220/0008 ,  A61F2250/0039 ,  A61F2250/007

Abstract: Apparatuses, systems, and methods for prosthetic valves. Embodiments of prosthetic valves may include sealing bodies configured for an anchor to at least partially pass through. The pass through may allow for the sealing body to seal to a portion of a patient's heart in the event of a miscapture of a leaflet by the anchor. Embodiments may include modular valve systems and prosthetic valves including anchors for coupling to chordae, trabeculae, or papillary structures of a patient's heart. Embodiments may include prosthetic valves including anchors for engaging calcification of a patient's native valve.

公开(公告)号：US20230157814A1

公开(公告)日：2023-05-25

申请号：US18099209

申请日：2023-01-19

Applicant: Edwards Lifesciences Corporation

Inventor： Travis Zenyo Oba ,  Matthew A. Peterson ,  Glen T. Rabito ,  Alexander H. Cooper ,  David Robert Landon ,  J. Brent Ratz ,  Seung-Beom Yi

IPC: A61F2/24 ,  A61L27/36 ,  A61L27/04

CPC classification number: A61F2/2409 ,  A61F2/2418 ,  A61L27/04 ,  A61L27/3625 ,  A61F2/2412 ,  A61F2/2436 ,  A61F2220/0008 ,  A61F2220/0075 ,  A61F2230/0093 ,  A61F2250/0018 ,  A61F2250/0039 ,  A61F2250/0063 ,  A61L2430/20

Abstract: A replacement mitral valve prosthesis includes a support structure and a valve body having three flexible leaflets. The support structure preferably includes an internal valve frame and an external sealing frame. The valve frame supports the flexible leaflets. The sealing frame is adapted to conform to the shape of the native mitral valve annulus. The sealing frame may be coupled to an inlet end of the valve frame, an outlet end of the valve frame, or both. A plurality of anchors is coupled to the outlet end of the valve frame. The anchors extend radially outwardly for placement behind native leaflets. The prosthesis preferably includes a skirt disposed along an exterior of the external sealing frame. The prosthesis is collapsible for delivery into the heart via a delivery catheter. The prosthesis is configured to self-expand for deployment in the heart when released from the delivery catheter.

公开(公告)号：US20230000624A1

公开(公告)日：2023-01-05

申请号：US17940868

申请日：2022-09-08

Applicant: Edwards Lifesciences Corporation

Inventor： Hiroshi Okabe ,  Hieu Minh Luong ,  Julio Cesar Sanchez ,  Jesse Robert Edwards ,  Alexander H. Cooper ,  David Robert Landon

IPC: A61F2/24

Abstract: Disclosed are embodiments of delivery systems for delivery of replacement heart valves. This can include mitral, aortic, tricuspid, and pulmonary valves. The delivery systems can include one or more different components and configurations that advantageously improve placement of the replacement heart valves during the operation of the delivery system.

公开(公告)号：US20210386544A1

公开(公告)日：2021-12-16

申请号：US17390762

申请日：2021-07-30

Applicant: Edwards Lifesciences Corporation

Inventor： Alexander H. Cooper ,  J. Brent Ratz ,  Kevin M. Stewart ,  David Robert Landon ,  Garrett Dallas Johnson ,  Harish Manickam Srinimukesh ,  Deena Walid Jamal

IPC: A61F2/24

Abstract: Guide wire apparatuses and methods. Guide wires may be utilized for guiding a delivery apparatus, for example a transcatheter mitral valve delivery apparatus to replace a native mitral valve. A guide wire may include a core body having a length, and an outer layer having a length and extending around the core body and along the length of the core body. A guide wire may include an intermediate layer positioned between the core body and the outer layer and configured to be retracted relative to the core body and the outer layer along the length of the core body and the length of the outer layer.

公开(公告)号：US20200345494A1

公开(公告)日：2020-11-05

申请号：US16934879

申请日：2020-07-21

Applicant: Edwards Lifesciences Corporation

Inventor： Harish Manickam Srinimukesh ,  Travis Zenyo Oba ,  David Robert Landon ,  Glen T. Rabito

IPC: A61F2/24

Abstract: Disclosed herein are embodiments of a delivery system which can be used to recapture and/or reposition a replacement valve, such as a replacement mitral valve, after initial deployment of the valve. Embodiments of the disclosure can use the crimping/tensioning of sutures in order to re-crimp the replacement valve after release, though longitudinal or rotational forces.