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公开(公告)号：US20190290426A1
公开(公告)日：2019-09-26
申请号：US16435288
申请日：2019-06-07
发明人： David Maimon , Michael R. Bialas , Mindy Lee Ann Black , Tamir S. Levi , Linda Thai , Yidong M. Zhu
摘要： Disclosed herein are embodiments of a balloon shaped to have one or more enlarged recons to selectively increase expansion forces on an implant. For example, the balloon may have a central portion that is enlarged to exert more force on the center of a stent-mounted prosthetic heart valve. This overcomes the stent-mounted prosthetic heart valve's tendency to expand with flared ends. This forms a more cylindrical or barrel shaped stent frame during expansion of the balloon—reducing or eliminating the instance wherein the cylindrical stent frame has flared ends. Alternatively, the balloon may have conical flares placed to cause or enhance flared ends of the cylindrical implant to enhance its anchoring capabilities.
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公开(公告)号：US20190030299A1
公开(公告)日：2019-01-31
申请号：US16149697
申请日：2018-10-02
发明人： Pu Zhou , Erik Bulman , Timothy A. Geiser , Michael G. Valdez , Yidong M. Zhu , Baigui Bian , Sonny Tran , Richard D. White , Thanh Huy Le , Tung T. Le , Alpana K. Gowdar , Yong Gao , David D. Williams
摘要： A delivery sheath includes an outer tubular layer and an initially folded inner tubular layer. When an implant passes therethrough, the outer tubular layer expands and the inner tubular layer unfolds into an expanded lumen diameter. The sheath may also include selectively placed longitudinal support rods that mediate friction between the inner and outer tubular layers to facilitate easy expansion, thereby reducing the push force needed to advance the implant through the sheath's lumen.
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公开(公告)号：US20190030296A1
公开(公告)日：2019-01-31
申请号：US16149650
申请日：2018-10-02
发明人： Pu Zhou , Erik Bulman , Timothy A. Geiser , Michael G. Valdez , Yidong M. Zhu , Baigui Bian , Sonny Tran , Richard D. White , Thanh Huy Le , Tung T. Le , Alpana K. Gowdar , Yong Gao , David D. Williams
CPC分类号： A61M25/0662 , A61F2/2433 , A61F2/958 , A61F2002/011 , A61M25/0023 , A61M2025/0024
摘要： A delivery sheath includes an outer tubular layer and an initially folded inner tubular layer. When an implant passes therethrough, the outer tubular layer expands and the inner tubular layer unfolds into an expanded lumen diameter. The sheath may also include selectively placed longitudinal support rods that mediate friction between the inner and outer tubular layers to facilitate easy expansion, thereby reducing the push force needed to advance the implant through the sheath's lumen.
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公开(公告)号：US20170071736A1
公开(公告)日：2017-03-16
申请号：US15260192
申请日：2016-09-08
发明人： Yidong M. Zhu , Erik Bulman , Baigui Bian , Sam Sok , Pu Zhou
CPC分类号： A61F2/2433 , A61F2/2418 , A61M25/1002 , A61M25/1011 , A61M2025/1086 , A61M2025/1095 , A61M2025/1097
摘要： Disclosed herein are designs for improved inflatable structures for use during minimally invasive cardiovascular procedures. These inflatable structures facilitate the perfusion of blood through an anatomical structure, such as a heart valve, during the cardiovascular procedure. The inflatable structures are formed of a plurality of balloons arranged radially around a central location. The plurality of balloons form a lumen through which blood flows. Each balloon of the plurality is shaped or configured to stabilize the adjacent balloons, limiting their movement relative to each other. For example, some embodiments can feature balloons with a keystone shape that limits movement of the balloons inward toward the lumen. Some implementations can also include a support coil running through the lumen. The support coil holds enables the lumen to be open to perfusion even in the early stages of balloon inflation.
摘要翻译： 本文公开了用于在微创心血管程序中使用的改进的可充气结构的设计。 在心血管手术过程中，这些充气结构有助于通过解剖结构（例如心脏瓣膜）灌注血液。 可膨胀结构由围绕中心位置径向排列的多个气球形成。 多个气球形成血液流过的内腔。 多个的每个气囊被成形或构造成稳定相邻气球，限制它们相对于彼此的运动。 例如，一些实施例可以具有限制气囊朝着内腔向内移动的梯形形状的气球。 一些实施方案还可以包括穿过管腔的支撑线圈。 即使在球囊充气的早期阶段，支撑线圈支架也能使内腔开放以灌注。
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公开(公告)号：US20160144156A1
公开(公告)日：2016-05-26
申请号：US14938761
申请日：2015-11-11
发明人： Pu Zhou , Bin Tian , Yidong M. Zhu
IPC分类号： A61M25/10 , B23K26/402 , B23K26/362
CPC分类号： A61M25/1029 , A61M2025/1031 , A61M2025/1086 , B23K26/0624 , B23K26/361 , B23K26/362 , B23K26/402 , B23K2103/42 , B23K2103/50
摘要： Inflatable devices are disclosed including a surface which has a network of polymer chains and is configured to be inflatable into a therapeutically or diagnostically useful shape, and at least one ultrashort laser pulse-formed modification in the surface. The network can, for example, include a network morphology that is substantially unchanged by modification with the ultrashort pulse laser. Ultrashort laser pulses can be laser pulses equal to or less than 1000 picoseconds in duration. Advantageously, the etching process uses a relatively low-heat laser to avoid significant heating of surrounding polymers while modifying the surface (and other structures) of the device. The process is configured so that the polymer chain morphology adjacent the modification is substantially unaffected by the low-heat laser. The resulting inflatable device has customized surface features while still retaining substantially homogenous polymer network morphology. This preserves the elasticity, especially the surface elasticity, of the inflatable device.
摘要翻译： 公开了充气装置，其包括具有聚合物链网络并被配置为可膨胀成治疗或诊断上有用的形状的表面，以及表面中的至少一个超短激光脉冲形成的修饰。 例如，网络可以包括通过使用超短脉冲激光器进行修改而基本上不变的网络形态。 超短激光脉冲可以是等于或小于1000皮秒的激光脉冲。 有利地，蚀刻工艺使用相对低热的激光器来避免周围聚合物的显着加热，同时改变装置的表面（和其它结构）。 该方法被配置成使得邻近修饰的聚合物链形态基本上不受低热激光的影响。 所得到的充气装置具有定制的表面特征，同时仍然保持基本均匀的聚合物网络形态。 这保持了充气装置的弹性，特别是表面弹性。
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公开(公告)号：US20140213970A1
公开(公告)日：2014-07-31
申请号：US14098078
申请日：2013-12-05
CPC分类号： A61M25/1002 , A61M25/1029 , A61M2025/1084 , A61M2025/1086 , B29C48/0017 , B29C48/09 , B29C48/19 , B29C48/20 , B29C49/04 , B29C49/20 , B29C49/22 , B29L2031/7543
摘要： A process for forming a catheter balloon includes subjecting a tubular parison in a mold to molding fluid pressure. The resulting catheter balloon includes a balloon portion having two ends and tubular leg portions extending from either end. The ends of the balloon portion are tapered to the tubular leg portions. The tapered ends have alternating elongate areas of greater and lesser resistance to deformation displaced circumferentially about the tapered ends. The elongate areas of greater and lesser resistance to deformation can include ridges which are either longitudinal or spiraled or rods imbedded in the body of the balloon. While in the mold, the tubular legs are drawn axially sufficiently to form permanent creases in the tapered ends. This drawing may be sufficient to cause the material of the tapered ends to exceed the yield strength, particularly with the balloon material in a malleable state.
摘要翻译： 用于形成导管球囊的方法包括使管型坯在模具中成型流体压力。 所得到的导管球囊包括具有两端的球囊部分和从任一端延伸的管状腿部分。 球囊部分的端部与管状腿部成锥形。 锥形端部具有交替的细长区域，其具有更大和更小的抵抗围绕锥形端部周向移位的变形。 具有更大和更小抗变形能力的细长区域可以包括纵向或螺旋形的脊或嵌入气球体内的杆。 在模具中，管状支柱被轴向拉伸以在锥形端部形成永久的折痕。 该图可能足以导致锥形端部的材料超过屈服强度，特别是气球材料在可延展状态下。
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公开(公告)号：US12115067B2
公开(公告)日：2024-10-15
申请号：US17694398
申请日：2022-03-14
发明人： David Maimon , Michael R. Bialas , Mindy Lee Ann Black , Tamir S. Levi , Linda Thai , Yidong M. Zhu
CPC分类号： A61F2/2433 , A61F2/2418 , A61F2/958 , A61F2230/001
摘要： Disclosed herein are embodiments of a balloon shaped to have one or more enlarged regions to selectively increase expansion forces on an implant. For example, the balloon may have a central portion that is enlarged to exert more force on the center of a stent-mounted prosthetic heart valve. This overcomes the stent-mounted prosthetic heart valve's tendency to expand with flared ends. This forms a more cylindrical or barrel shaped stent frame during expansion of the balloon—reducing or eliminating the instance wherein the cylindrical stent frame has flared ends. Alternatively, the balloon may have conical flares placed to cause or enhance flared ends of the cylindrical implant to enhance its anchoring capabilities.
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公开(公告)号：US20240285914A1
公开(公告)日：2024-08-29
申请号：US18649428
申请日：2024-04-29
发明人： Yidong M. Zhu , Erik Bulman
CPC分类号： A61M25/10 , A61F2/2433 , A61M2025/1059 , A61M2025/1075
摘要： Inflatable balloons for balloon catheters are disclosed, the inflatable balloons including varying compliance segments. As one example, an inflatable balloon for a medical catheter includes a first segment that has a first compliance and a second segment that has a second compliance, the first compliance higher than the second compliance. The first segment and the second segment extend axially along a length of the balloon and the first segment is configured to rupture prior to the second segment in an axial direction under pressure from an inflation fluid introduced into the balloon.
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公开(公告)号：US20230149166A1
公开(公告)日：2023-05-18
申请号：US18094273
申请日：2023-01-06
发明人： Yidong M. Zhu , Pu Zhou , Erik Bulman , Baigui Bian
CPC分类号： A61F2/2433 , A61F2/958 , A61M25/104 , A61F2250/0039 , A61M2025/1059 , A61M2025/1081 , A61M25/10187
摘要： The methods and devices disclosed herein promote temporal control of balloon inflation patterns. The devices include a covering for a portion of the balloon that compresses the balloon portion during the inflation process. This enables the distal portion of a balloon to be inflated prior to the proximal portion of a balloon, creating a tapered shape at lower inflation pressures. This is especially useful during transvascular implantation procedures, as it prevents dislodgement of an implant mounted on the balloon. As inflation continues, pressure exerted on the balloon by the covering is overcome such that the proximal region of the balloon inflates, forming a shape with generally straighter sides than the tapered shape, thereby expanding the cardiovascular device.
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公开(公告)号：US20230017997A1
公开(公告)日：2023-01-19
申请号：US17956527
申请日：2022-09-29
发明人： Yidong M. Zhu , Erik Bulman , Baigui Bian , Sam Sok , Pu Zhou
摘要： Disclosed herein are designs for improved inflatable structures for use during minimally invasive cardiovascular procedures. These inflatable structures facilitate the perfusion of blood through an anatomical structure, such as a heart valve, during the cardiovascular procedure. The inflatable structures are formed of a plurality of balloons arranged radially around a central location. The plurality of balloons form a lumen through which blood flows. Each balloon of the plurality is shaped or configured to stabilize the adjacent balloons, limiting their movement relative to each other. For example, some embodiments can feature balloons with a keystone shape that limits movement of the balloons inward toward the lumen. Some implementations can also include a support coil running through the lumen. The support coil holds enables the lumen to be open to perfusion even in the early stages of balloon inflation.
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