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37 条记录 (耗时 0.026 秒)

    Method of treatment of learning deficiency
    21.
    发明授权
    Method of treatment of learning deficiency 失效
    治疗学习缺陷的方法

    公开(公告)号：US5075338A

    公开(公告)日：1991-12-24

    申请号：US420058

    申请日：1989-10-11

    申请人： Jozsef Knoll ,  Antal Simay ,  Eva Szinnyei ,  Eva Somfai ,  Zoltan Torok ,  Karoly Mozsolits ,  Janos Bergmann

    发明人： Jozsef Knoll ,  Antal Simay ,  Eva Szinnyei ,  Eva Somfai ,  Zoltan Torok ,  Karoly Mozsolits ,  Janos Bergmann

    IPC分类号： C07C211/27 ,  A61K31/135 ,  A61K31/137 ,  A61P25/24

    CPC分类号： A61K31/135

    摘要： A method of treating a learning deficiency is disclosed wherein a patient in need of stimulating learning ability is treated with a therapeutically effective amount of a compound of the Formula (I) ##STR1## wherein R.sup.1 is C.sub.1 to C.sub.8 straight or branched chain alkyl, C.sub.7 to C.sub.10 phenylalkyl, phenyl, or C.sub.3 to C.sub.8 cycloalkyl; andR.sup.2 is C.sub.1 to C.sub.8 straight or branched chain alkyl, unsubstituted or substituted by halogen, hydroxy, C.sub.1 to C.sub.4 alkoxy or by 1 or 2 phenyl groups; or is C.sub.3 to C.sub.8 cycloalkyl;with the proviso that R.sup.1 and R.sup.2 together contain at least 3 carbon atoms; or a pharmaceutically acceptable salt thereof.

    摘要翻译： 公开了一种治疗学习缺陷的方法，其中需要刺激学习能力的患者用治疗有效量的式（I）化合物（I）治疗，其中R1为C1至C8直链或支链 烷基，C7至C10苯基烷基，苯基或C3至C8环烷基; R2为C1至C8直链或支链烷基，未取代或被卤素，羟基，C1至C4烷氧基取代或被1或2个苯基取代; 或为C3至C8环烷基; 条件是R1和R2一起含有至少3个碳原子; 或其药学上可接受的盐。

    Antiphlogistic and anticoagulant condensed pyrimidine derivatives
    25.
    发明授权
    Antiphlogistic and anticoagulant condensed pyrimidine derivatives 失效
    消炎和抗凝血嘧啶衍生物

    公开(公告)号：US4460771A

    公开(公告)日：1984-07-17

    申请号：US742464

    申请日：1976-11-17

    申请人： Zoltan Meszaros ,  Jozsef Knoll ,  Peter Szentmiklosi ,  Istvan Hermes ,  Agnes Horvath ,  Sandor Virag ,  Lelle Vasvari nee Debreczy ,  Agoston David

    发明人： Zoltan Meszaros ,  Jozsef Knoll ,  Peter Szentmiklosi ,  Istvan Hermes ,  Agnes Horvath ,  Sandor Virag ,  Lelle Vasvari nee Debreczy ,  Agoston David

    IPC分类号： A61K31/505 ,  A61K31/519 ,  A61P7/02 ,  A61P25/04 ,  A61P29/00 ,  A61P43/00 ,  C07D471/04

    CPC分类号： C07D471/04

    摘要： New optionally racemic or optically active pyrimido(1,2a) heterocyclic compounds of the formula ##STR1## wherein m is 0, 1 or 2,n is 0, 1 or 2,R is an alkyl group containing one to six carbon atoms,R.sup.1 is hydrogen, alkyl containing one to six carbon atoms,R.sup.2 is hydrogen, alkyl containing one to six carbon atoms, optionally substituted amino, optionally substituted hydroxy, carboxy or a group derived from a carboxylic acid orR.sup.1 and R.sup.2 together form a --(CH.dbd.CH).sub.2 -- group attached to the two adjacent carbon atoms of the ring A and the broken line represents a chemical bond,R.sup.3 is hydrogen, optionally substituted alkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heterocycle, optionally substituted cycloalkyl, optionally substituted acyl or optionally substituted hydroxy,R.sup.4 is hydrogen, optionally substituted alkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heterocycle, optionally substituted cycloalkyl, optionally substituted acyl orR.sup.3 and R.sup.4 together with the nitrogen can form an optionally substituted five-, six- or seven-membered ring, which can contain a further heteroatom or heteroatoms,R.sup.5 is oxygen or an optionally substituted imino group are disclosed as well as a process for the preparation thereof.

    摘要翻译： 新的任选的外消旋或光学活性嘧啶（1,2a）杂环化合物，其中m为0,1或2，n为0,1或2，R为含有1至6个碳原子的烷基，R 1为 是氢，含有1至6个碳原子的烷基，R 2是氢，含1至6个碳原子的烷基，任选取代的氨基，任选取代的羟基，羧基或衍生自羧酸的基团或R 1和R 2一起形成 - （CH = CH）连接到环A的两个相邻碳原子上的2-基团，虚线表示化学键，R 3是氢，任选取代的烷基，任选取代的芳基，任选取代的芳烷基，任选取代的杂环，任选取代的环烷基， 任选取代的酰基或任选取代的羟基，R 4是氢，任选取代的烷基，任选取代的芳基，任选取代的芳烷基，任选取代的杂环，任选取代的环烷基，选择 可以将氮取代的酰基或R3和R4与氮一起形成任选取代的五元，六元或七元环，其可以含有另外的杂原子或杂原子，R5是氧或任选取代的亚氨基， 其制备方法。