公开(公告)号：US4599327A

公开(公告)日：1986-07-08

申请号：US557629

申请日：1983-12-02

申请人： Mihaly Nogradi ,  Dezso Korbonits ,  Agnes Gottsegen ,  Sandor Antus ,  Zsuzsa Furst ,  Jozsef Knoll ,  Jozsef Szejtli ,  Agnes Stadler ,  Gabor Kovacs ,  Katalin Marmarosi

发明人： Mihaly Nogradi ,  Dezso Korbonits ,  Agnes Gottsegen ,  Sandor Antus ,  Zsuzsa Furst ,  Jozsef Knoll ,  Jozsef Szejtli ,  Agnes Stadler ,  Gabor Kovacs ,  Katalin Marmarosi

IPC分类号： A61K31/35 ,  A61K31/352 ,  A61K31/715 ,  A61P1/08 ,  A61P23/00 ,  A61P23/02 ,  A61P25/02 ,  A61P25/04 ,  C07C43/178 ,  C07C43/205 ,  C07C43/23 ,  C07C59/68 ,  C07D221/12 ,  C07D311/78 ,  C07D311/80 ,  C07D311/92 ,  C07D493/10 ,  C08B37/00 ,  C08B37/16 ,  A61K31/70

CPC分类号： C07D493/10 ,  C07C309/00 ,  C07C43/1782 ,  C07C43/1785 ,  C07C43/2055 ,  C07C43/23 ,  C07C59/68 ,  C07D221/12 ,  C07D311/78 ,  C07D311/80 ,  C08B37/0015

摘要： 2,6-di-O-methyl-beta-cyclodextrin complexes of compounds of the formula (1a) ##STR1## wherein R.sup.2' stands for C.sub.1 to C.sub.12 alkyl or a group of the formula ##STR2## in which R.sup.11 is C.sub.1 to C.sub.4 alkyl;R.sup.12 is hydrogen or C.sub.1 to C.sub.4 alkyl;n is 0 or 1;p is 1 to 4;r is 1 to 4; andR.sup.3' and R.sup.4' are each C.sub.1 to C.sub.4 alkyl, or pharmaceutically salts thereof are disclosed, having analgesic activity.

摘要翻译： 式（1a）化合物的2,6-二-O-甲基-β-环糊精复合物其中R 2'代表C 1至C 12烷基或其中R 11为C 1至C 4的式 烷基; R 12是氢或C 1至C 4烷基; n为0或1; p为1〜4; r为1〜4; 和R 3'和R 4'各自为C1至C4烷基，或其药学上可接受的盐，具有止痛活性。

公开(公告)号：US4840949A

公开(公告)日：1989-06-20

申请号：US107693

申请日：1987-10-09

申请人： Dezso Korbonits ,  Emil Minker ,  Zoltan Vargai ,  Gergely Heja ,  Gabor Kovacs ,  Agnes Gottsegen ,  Sandor Antus ,  Sandor Virag ,  Andrea Bolehovszky ,  Jeno Marton ,  Katalin Marmarosi nee Kellner ,  Lorand Debreczeni ,  Laszlo Tardos ,  Peter Kormoczy ,  Vera Gergely ,  Gabor Horvath

发明人： Dezso Korbonits ,  Emil Minker ,  Zoltan Vargai ,  Gergely Heja ,  Gabor Kovacs ,  Agnes Gottsegen ,  Sandor Antus ,  Sandor Virag ,  Andrea Bolehovszky ,  Jeno Marton ,  Katalin Marmarosi nee Kellner ,  Lorand Debreczeni ,  Laszlo Tardos ,  Peter Kormoczy ,  Vera Gergely ,  Gabor Horvath

IPC分类号： C07D473/04 ,  A61K31/52 ,  A61K31/522 ,  A61P11/04 ,  A61P11/14 ,  C07D271/06 ,  C07D273/02 ,  C07D473/06

CPC分类号： C07D473/06

摘要： The invention relates to new oxidiazole-alkyl-purine-derivatives of the Formula I ##STR1## and pharmaceutically acceptable salts thereof wherein A stands for C.sub.1-4 alkylene andR.sup.1 represents C.sub.1-6 alkyl, hydroxyalkyl, halogenoalkyl, carboxyalkyl, C.sub.5-6 cycloalkyl or aminoalkyl of the Formula --(CH.sub.2).sub.n --NR.sup.2 R.sup.3 in which group n is an integer 1-3; R.sup.2 and R.sup.3 each stand for hydrogen or C.sub.1-4 alkyl or together with the adjacent nitrogen atom they are attached to form a 5- or 6-membered nitrogen containing heterocyclic ring which may optionally comprise a further nitrogen atom or an oxygen atom as heteroatom; orR.sup.1 stands for phenyl, hydroxyphenyl, carboxyphenyl, benzyl or dimethoxybenzylThe compounds of the Formula I can be prepared by methods known per se and can be used in therapy as antitussive agents.

摘要翻译： 本发明涉及式I的新型氧化噻唑烷基嘌呤衍生物及其药学上可接受的盐，其中A代表C1-4亚烷基，R1代表C1-6烷基，羟基烷基，卤代烷基，羧基烷基，C5-6环烷基 或其中基团n为整数1-3的式 - （CH 2）n -NR 2 R 3的氨基烷基; R 2和R 3各自代表氢或C 1-4烷基或与它们相连的相邻氮原子一起形成5-或6-元含氮杂环，其可以任选地包含另外的氮原子或氧原子作为杂原子; 或R 1代表苯基，羟基苯基，羧基苯基，苄基或二甲氧基苄基。式I化合物可以通过本身已知的方法制备，并且可用于作为止咳剂的治疗。

公开(公告)号：US4092346A

公开(公告)日：1978-05-30

申请号：US746350

申请日：1976-12-01

申请人： Lorand Farkas ,  Mihaly Nogradi ,  Todor Pfliegel ,  Sandor Antus ,  Agnes Gottsegen

发明人： Lorand Farkas ,  Mihaly Nogradi ,  Todor Pfliegel ,  Sandor Antus ,  Agnes Gottsegen

IPC分类号： A23L27/30 ,  C07C309/11 ,  C07C143/24 ,  A23L1/236

CPC分类号： C07C309/11 ,  A23L27/30

摘要： Compounds of the formula (1), or their salts, ##STR1## are prepared as follows: (A) A COMPOUND OF THE FORMULA (II) ##STR2## is reduced; or (B) A COMPOUND OF THE FORMULA (III) ##STR3## is reacted, e.g. after protecting the phenolic hydroxy group attached to position 3 of the ring, with a compound of the formula (IV), ##STR4## or (C) GROUP R.sup.1 of a compound of the formula (V) ##STR5## is removed in an acidic medium, AND, IF DESIRED, THE COMPOUND OF THE FORMULA (I) is converted into salt, or a salt of a compound of the formula (I) is converted into the free acid or another salt thereof.The compounds of the formula (I) and their salts are valuable artificial sweetening agents.In the above formulae"alkyl" is a C.sub.1-4 alkyl group,R is hydrogen or a protecting group capable of splitting off upon hydrogenolysis, preferably benzyl or benzyloxycarbonyl,M+ is a proton or another cation,X is a group of the general formula O.sup.- M.sup.+,Y is halogen, orX and Y together represent an oxygen atom, andR.sup.1 is a protecting group capable of splitting off in acidic media, such as 2-tetrahydropyranyl or 1-ethoxyethyl.

摘要翻译： 式（1）化合物或其盐，如下制备：

公开(公告)号：US3956375A

公开(公告)日：1976-05-11

申请号：US311666

申请日：1972-12-04

申请人： Lorant Farkas ,  Mihaly Nogradi ,  Agnes Gottsegen ,  Sandor Antus

发明人： Lorant Farkas ,  Mihaly Nogradi ,  Agnes Gottsegen ,  Sandor Antus

IPC分类号： A23L27/30 ,  C07C45/00 ,  C07C45/62 ,  C07C49/76 ,  C07C49/82 ,  C07C49/83 ,  C07C49/84 ,  C07C51/00 ,  C07C59/125 ,  C07C59/64 ,  C07C59/90 ,  C07C65/40 ,  C07C67/00 ,  C07C69/712 ,  C07C69/716 ,  C07C225/22 ,  C07C309/44 ,  C07C65/20

CPC分类号： C07C59/90 ,  C07C309/00 ,  C07C45/62 ,  C07C49/84

摘要： A sweetening agent in the form of a 1,3-diphenyl-propanone-1 derivative of the formula ##SPC1##Wherein R is hydrogen, hydroxyl, alkoxy or carboxyl-substituted, sulphonyl-substituted, phosphonyl-substituted, dialkylamino-substituted, trialkyl ammonium-substituted alkoxy; R.sup.1 is hydrogen or a hydrophylic group but both R and R.sup.1 are not both hydrogen; R.sup.2 and R.sup.3 are hydroxyl or alkoxy.

摘要翻译： 式WHEREIN R的1,3-二苯基 - 丙酮-1-衍生物形式的甜味剂为氢，羟基，烷氧基或羧基取代的磺酰基取代的，膦酰基取代的，二烷基氨基取代的三烷基铵取代的 烷氧基 R1是氢或亲水基，但R和R1都不是氢; R2和R3是羟基或烷氧基。

公开(公告)号：US3949085A

公开(公告)日：1976-04-06

申请号：US497644

申请日：1974-08-15

申请人： Laszlo Feuer ,  Mihaly Nogradi ,  Agnes Gottsegen ,  Borbala Vermes ,  Janos Streliszky ,  Andreas Wolfner ,  Lorant Farkas ,  Sandor Antus ,  Maria Kovaks

发明人： Laszlo Feuer ,  Mihaly Nogradi ,  Agnes Gottsegen ,  Borbala Vermes ,  Janos Streliszky ,  Andreas Wolfner ,  Lorant Farkas ,  Sandor Antus ,  Maria Kovaks

IPC分类号： A23K1/16 ,  C07D311/36 ,  A61K31/35

CPC分类号： C07D311/36 ,  A23K20/121 ,  A23K20/137

摘要： A method of anabolic treatment in humans comprises administering a compound of the following formula: ##SPC1##Wherein R is halosubstituted, nitrosubstituted, or unsubstituted benzyl, R.sup.2 is hydrogen, methyl or carboxy, and R.sup.3 and R.sup.4 are hydrogen, methoxy or nitro. Pharmaceutical compositions are also disclosed.

摘要翻译： 人的合成代谢治疗方法包括施用下式的化合物：

公开(公告)号：US4163746A

公开(公告)日：1979-08-07

申请号：US845680

申请日：1977-10-26

申请人： Laszlo Feuer ,  Lorand Farkas ,  Mihaly Nogradi ,  Borbala Vermes ,  Agnes Gottsegen ,  Andras Wolfner

发明人： Laszlo Feuer ,  Lorand Farkas ,  Mihaly Nogradi ,  Borbala Vermes ,  Agnes Gottsegen ,  Andras Wolfner

IPC分类号： A23K1/16 ,  A23K1/18 ,  A61K31/35 ,  A61K31/352 ,  A61P3/00 ,  C07D311/36 ,  C07D311/02

CPC分类号： C07D311/36 ,  A23K20/121 ,  A23K50/30

摘要： Nonestrogenic 5-methyl-alkoxy-isoflavone, namely, 5-methyl-7-methoxy-isoflavone, 5-methyl-7-ethoxy-isoflavone, 5-methyl-7-isopropoxy-isoflavone, and 5-methyl-7-(2-hydroxy-ethoxy)-isoflavone are useful as weight-gain promoters in feeds from which the 7-methoxy and 7-ethoxy isoflavones have been excluded because of estrogenic effects. They are more effective than 7-isopropoxy-isoflavone as well.

摘要翻译： 非雌激素5-甲基 - 烷氧基异黄酮，即5-甲基-7-甲氧基异黄酮，5-甲基-7-乙氧基异黄酮，5-甲基-7-异丙氧基异黄酮和5-甲基-7-（2 - 羟基 - 乙氧基） - 异黄酮可用作饲料中的体重增加启动子，由于雌激素作用，已经排除了7-甲氧基和7-乙氧基异黄酮。 它们也比7-异丙氧基异黄酮更有效。