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公开(公告)号:US20090041802A1
公开(公告)日:2009-02-12
申请号:US11917610
申请日:2006-06-23
申请人: Ralph Leon Biemans , Dominique Boutriau , Carine Capiau , Philippe Denoel , Pierre Devivier , Jan Poolman
发明人: Ralph Leon Biemans , Dominique Boutriau , Carine Capiau , Philippe Denoel , Pierre Devivier , Jan Poolman
IPC分类号: A61K39/385 , A61P31/04 , A61P31/12
CPC分类号: A61K39/385 , A61K39/0017 , A61K39/0018 , A61K39/05 , A61K39/08 , A61K39/092 , A61K39/095 , A61K39/099 , A61K39/102 , A61K39/116 , A61K39/12 , A61K39/145 , A61K39/292 , A61K2039/545 , A61K2039/55 , A61K2039/575 , A61K2039/6037 , A61K2039/62 , A61K2039/627 , A61K2039/70 , C07H3/00 , C12N7/00 , C12N2730/10134 , C12N2760/16234 , C12N2760/16271 , C12N2770/32634 , Y02A50/466 , Y02A50/472 , Y02A50/484
摘要: The present application discloses an immunogenic composition comprising N. meningitidis capsular polysaccharides from at least one of serogroups A, C, W135 and Y conjugated to a carrier protein to produce a N. meningitidis capsular polysaccharide conjugate, wherein the average size of each N. meningitidis polysaccharide is above 50 kDa.
摘要翻译: 本申请公开了一种免疫原性组合物,其包含来自与载体蛋白缀合的血清群A,C,W135和Y中的至少一种的脑膜炎奈瑟氏球菌荚膜多糖以产生脑膜炎奈瑟氏球菌荚膜多糖缀合物,其中每个脑膜炎奈瑟氏球菌的平均大小 多糖超过50kDa。
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公开(公告)号:US08431136B2
公开(公告)日:2013-04-30
申请号:US11917569
申请日:2006-06-23
申请人: Ralph Leon Biemans , Dominique Boutriau , Carine Capiau , Philippe Denoel , Pierre Duvivier , Jan Poolman
发明人: Ralph Leon Biemans , Dominique Boutriau , Carine Capiau , Philippe Denoel , Pierre Duvivier , Jan Poolman
IPC分类号: A61K39/385 , A61K39/08
CPC分类号: A61K39/385 , A61K39/0017 , A61K39/0018 , A61K39/05 , A61K39/08 , A61K39/092 , A61K39/095 , A61K39/099 , A61K39/102 , A61K39/116 , A61K39/12 , A61K39/145 , A61K39/292 , A61K2039/545 , A61K2039/55 , A61K2039/575 , A61K2039/6037 , A61K2039/62 , A61K2039/627 , A61K2039/70 , C07H3/00 , C12N7/00 , C12N2730/10134 , C12N2760/16234 , C12N2760/16271 , C12N2770/32634 , Y02A50/466 , Y02A50/472 , Y02A50/484
摘要: An immunogenic composition comprising a Hib saccharide conjugate and at least two further bacterial saccharide conjugates is provided, wherein the Hib conjugate is present in a lower saccharide dose than the mean saccharide dose of all the at least two further bacterial saccharide conjugates.
摘要翻译: 提供了包含Hib糖结合物和至少两种其它细菌糖共轭物的免疫原性组合物,其中Hib缀合物以比所有至少两种其它细菌糖共轭物的平均糖剂量更低的糖剂量存在。
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公开(公告)号:US20090252759A1
公开(公告)日:2009-10-08
申请号:US11917709
申请日:2006-06-23
申请人: Ralph Leon Biemans , Dominique ` Boutriau , Carine Capiau , Philippe Denoel , Pierre Duvivier , Jan Poolman
发明人: Ralph Leon Biemans , Dominique ` Boutriau , Carine Capiau , Philippe Denoel , Pierre Duvivier , Jan Poolman
IPC分类号: A61K39/385
CPC分类号: A61K39/385 , A61K39/0017 , A61K39/0018 , A61K39/05 , A61K39/08 , A61K39/092 , A61K39/095 , A61K39/099 , A61K39/102 , A61K39/116 , A61K39/12 , A61K39/145 , A61K39/292 , A61K2039/545 , A61K2039/55 , A61K2039/575 , A61K2039/6037 , A61K2039/62 , A61K2039/627 , A61K2039/70 , C07H3/00 , C12N7/00 , C12N2730/10134 , C12N2760/16234 , C12N2760/16271 , C12N2770/32634 , Y02A50/466 , Y02A50/472 , Y02A50/484
摘要: The present application relates to an immunogenic composition comprising at least 2 conjugates of N. meningitidis capsular saccharide and protein carrier, wherein said conjugates comprise at least 2 different N. meningitidis capsular saccharides selected from the group consisting of MenA, MenC, MenY and MenW, wherein at least one capsular saccharide is conjugated to a protein carrier with a saccharide:protein ratio (w/w) between 1:2-1:5, and wherein at least one different capsular saccharide is conjugated to a protein carrier with a saccharide:protein ratio (w/w) between 5:1-1:1.99.
摘要翻译: 本申请涉及包含脑膜炎奈瑟氏球菌荚膜糖蛋白和蛋白质载体的至少2种缀合物的免疫原性组合物,其中所述缀合物包含选自MenA,MenC,MenY和MenW的至少2种不同的脑膜炎奈瑟氏球菌荚膜糖, 其中至少一种荚膜糖与蛋白质载体结合,其蛋白质比例(w / w)为1:2-1:5,并且其中至少一种不同的荚膜糖与蛋白质载体与糖结合: 蛋白质比(w / w)在5:1-1:1.99之间。
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公开(公告)号:US20090162394A1
公开(公告)日:2009-06-25
申请号:US12296130
申请日:2007-04-05
IPC分类号: A61K39/09
CPC分类号: A61K39/092 , Y02A50/412
摘要: The present invention is in the field of pneumococcal capsular saccharide conjugate vaccines. Specifically, a multivalent Streptococcus pneumoniae immunogenic composition is provided with various (for instance 9 or more) conjugated capsular saccharides from different S. pneumoniae serotypes, wherein the composition comprises conjugated capsular saccharide 18C which is less than 80, 70, 60, 50, 40, 30, 20, 15 or 10% O-Acetylated.
摘要翻译: 本发明在肺炎球菌荚膜糖结合疫苗领域。 具体地说,将多种肺炎链球菌免疫原性组合物与来自不同肺炎链球菌血清型的各种(例如9种或更多种)共轭荚膜糖提供,其中组合物包含小于80,70,60,50,40的共轭荚膜糖18C ,30,20,15或10%O-乙酰化。
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公开(公告)号:US09931397B2
公开(公告)日:2018-04-03
申请号:US11917709
申请日:2006-06-23
申请人: Ralph Leon Biemans , Dominique Boutriau , Carine Capiau , Philippe Denoel , Pierre Duvivier , Jan Poolman
发明人: Ralph Leon Biemans , Dominique Boutriau , Carine Capiau , Philippe Denoel , Pierre Duvivier , Jan Poolman
IPC分类号: A61K39/095 , A61K39/385 , A61K39/00 , A61K39/116 , A61K39/102 , C07H3/00 , A61K39/05 , A61K39/08 , A61K39/09 , A61K39/02 , A61K39/29 , A61K39/145 , C12N7/00 , A61K39/12
CPC分类号: A61K39/385 , A61K39/0017 , A61K39/0018 , A61K39/05 , A61K39/08 , A61K39/092 , A61K39/095 , A61K39/099 , A61K39/102 , A61K39/116 , A61K39/12 , A61K39/145 , A61K39/292 , A61K2039/545 , A61K2039/55 , A61K2039/575 , A61K2039/6037 , A61K2039/62 , A61K2039/627 , A61K2039/70 , C07H3/00 , C12N7/00 , C12N2730/10134 , C12N2760/16234 , C12N2760/16271 , C12N2770/32634 , Y02A50/466 , Y02A50/472 , Y02A50/484
摘要: The present application relates to an immunogenic composition comprising at least 2 conjugates of N. meningitidis capsular saccharide and protein carrier, wherein said conjugates comprise at least 2 different N. meningitidis capsular saccharides selected from the group consisting of MenA, MenC, MenY and MenW, wherein at least one capsular saccharide is conjugated to a protein carrier with a saccharide:protein ratio (w/w) between 1:2-1:5, and wherein at least one different capsular saccharide is conjugated to a protein carrier with a saccharide:protein ratio (w/w) between 5:1-1:1.99.
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公开(公告)号:US09789179B2
公开(公告)日:2017-10-17
申请号:US11917610
申请日:2006-06-23
申请人: Ralph Leon Biemans , Dominique Boutriau , Carine Capiau , Philippe Denoel , Pierre Duvivier , Jan Poolman
发明人: Ralph Leon Biemans , Dominique Boutriau , Carine Capiau , Philippe Denoel , Pierre Duvivier , Jan Poolman
IPC分类号: A61K39/00 , A61K39/385 , A61K39/095 , A61K39/102 , A61K39/116 , C07H3/00 , A61K39/05 , A61K39/08 , A61K39/09 , A61K39/02 , A61K39/29 , A61K39/145 , C12N7/00 , A61K39/12
CPC分类号: A61K39/385 , A61K39/0017 , A61K39/0018 , A61K39/05 , A61K39/08 , A61K39/092 , A61K39/095 , A61K39/099 , A61K39/102 , A61K39/116 , A61K39/12 , A61K39/145 , A61K39/292 , A61K2039/545 , A61K2039/55 , A61K2039/575 , A61K2039/6037 , A61K2039/62 , A61K2039/627 , A61K2039/70 , C07H3/00 , C12N7/00 , C12N2730/10134 , C12N2760/16234 , C12N2760/16271 , C12N2770/32634 , Y02A50/466 , Y02A50/472 , Y02A50/484
摘要: The present application discloses an immunogenic composition comprising N. meningitidis capsular polysaccharides from at least one of serogroups A, C, W135 and Y conjugated to a carrier protein to produce a N. meningitidis capsular polysaccharide conjugate, wherein the average size of each N. meningitidis polysaccharide is above 50 kDa.
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公开(公告)号:US09486515B2
公开(公告)日:2016-11-08
申请号:US11917702
申请日:2006-06-23
申请人: Ralph Leon Biemans , Dominique Boutriau , Carine Capiau , Philippe Denoel , Pierre Duvivier , Jan Poolman
发明人: Ralph Leon Biemans , Dominique Boutriau , Carine Capiau , Philippe Denoel , Pierre Duvivier , Jan Poolman
IPC分类号: A61K39/095 , A61K39/00 , A61K39/116 , A61K39/385 , C07H3/00 , A61K39/102 , A61K39/05 , A61K39/08 , A61K39/09 , A61K39/02 , A61K39/29 , A61K39/12
CPC分类号: A61K39/385 , A61K39/0017 , A61K39/0018 , A61K39/05 , A61K39/08 , A61K39/092 , A61K39/095 , A61K39/099 , A61K39/102 , A61K39/116 , A61K39/12 , A61K39/145 , A61K39/292 , A61K2039/545 , A61K2039/55 , A61K2039/575 , A61K2039/6037 , A61K2039/62 , A61K2039/627 , A61K2039/70 , C07H3/00 , C12N7/00 , C12N2730/10134 , C12N2760/16234 , C12N2760/16271 , C12N2770/32634 , Y02A50/466 , Y02A50/472 , Y02A50/484
摘要: The present application discloses an immunogenic composition comprising at least 2 different N. meningitidis capsular saccharides, wherein one or more is/are selected from a first group consisting of MenA, MenC, MenY and MenW which is/are conjugated to a protein carrier(s) wherein the saccharide:protein ratio (w/w) is between 1:2-1:5, and one or more different saccharides is/are selected from a second group consisting of MenA, MenC, MenY and MenW which is/are conjugated to a protein carrier(s) wherein the saccharide:protein ratio (w/w) is between 5:1-1:1.99.
摘要翻译: 本申请公开了一种免疫原性组合物,其包含至少2种不同的脑膜炎奈瑟氏球菌荚膜糖,其中一种或多种选自MenA,MenC,MenY和MenW组成的第一组,其与蛋白质载体(s ),其中糖:蛋白质比(w / w)为1:2-1:5,并且一种或多种不同的糖选自MenA,MenC,MenY和MenW组成的第二组,其为共轭的 涉及蛋白质载体,其中糖:蛋白质比(w / w)在5:1-1:1.99之间。
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公开(公告)号:US08703148B2
公开(公告)日:2014-04-22
申请号:US12294689
申请日:2007-03-29
IPC分类号: A61K39/385 , A61K39/085 , A61K39/02 , A61K39/00 , A61K39/38 , A61K31/70 , C07H1/00
CPC分类号: A61K39/085 , A61K47/48261 , A61K47/48284 , A61K47/4833 , A61K47/6415 , A61K47/643 , A61K47/646 , A61K2039/55544 , A61K2039/55555 , A61K2039/55572 , A61K2039/55577 , A61K2039/6037 , Y10S424/831
摘要: The present application relates to immunogenic compositions comprising staphylococcal PNAG which is less than 40% N-acetylated and is conjugated to a carrier protein by a linker bonded to an amine group on PNAG to form a PNAG conjugate. Vaccines, methods of treatment using and processes to make an immunogenic composition comprising PNAG and Type 5 and/or 8 capsular polysaccharides are also described.
摘要翻译: 本申请涉及包含小于40%N-乙酰化的葡萄球菌PNAG的免疫原性组合物,并通过与PNAG上的胺基键合的接头与载体蛋白质缀合以形成PNAG缀合物。 还描述了疫苗,治疗方法和制备包含PNAG和5型和/或8型荚膜多糖的免疫原性组合物的方法。
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公开(公告)号:US08574596B2
公开(公告)日:2013-11-05
申请号:US10574297
申请日:2004-10-01
申请人: Cindy Castado , Philippe Denoel , Fabrice Godfroid , Jan Poolman
发明人: Cindy Castado , Philippe Denoel , Fabrice Godfroid , Jan Poolman
CPC分类号: A61K39/099 , Y02A50/466
摘要: The invention provides BASB232 polypeptides and polynucleotides encoding BASB232 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses. The invention further provides immunogenic compositions comprising a plurality of antigens selected from at least two different categories of antigen, having different functions within Bordetella. Examples of such categories of antigen are autotransporter proteins, iron acquisition proteins, lipoproteins, adhesins and toxins/invasins.
摘要翻译: 本发明提供了BASB232多肽和编码BASB232多肽的多核苷酸以及通过重组技术产生这种多肽的方法。 还提供诊断,预防和治疗用途。 本发明进一步提供包含多种抗原的免疫原性组合物,所述多种抗原选自至少两种不同类别的抗原,在博尔特氏菌内具有不同的功能。 这些抗原类别的实例是自身转运蛋白,铁获取蛋白,脂蛋白,粘附素和毒素/侵袭素。
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公开(公告)号:US08398983B2
公开(公告)日:2013-03-19
申请号:US11917726
申请日:2006-06-23
申请人: Ralph Leon Biemans , Dominique Boutriau , Carine Capiau , Philippe Denoel , Pierre Duvivier , Jan Poolman
发明人: Ralph Leon Biemans , Dominique Boutriau , Carine Capiau , Philippe Denoel , Pierre Duvivier , Jan Poolman
IPC分类号: A61K39/00 , A61K39/095 , A61K39/10 , A61K39/29 , A61K39/295 , A61K39/385
CPC分类号: A61K39/385 , A61K39/0017 , A61K39/0018 , A61K39/05 , A61K39/08 , A61K39/092 , A61K39/095 , A61K39/099 , A61K39/102 , A61K39/116 , A61K39/12 , A61K39/145 , A61K39/292 , A61K2039/545 , A61K2039/55 , A61K2039/575 , A61K2039/6037 , A61K2039/62 , A61K2039/627 , A61K2039/70 , C07H3/00 , C12N7/00 , C12N2730/10134 , C12N2760/16234 , C12N2760/16271 , C12N2770/32634 , Y02A50/466 , Y02A50/472 , Y02A50/484
摘要: The present application discloses an immunogenic composition comprising a Hib saccharide conjugate, at least one additional bacterial, for example N. meningitidis, saccharide conjugate(s), and a further antigen selected from the group consisting of whole cell pertussis and hepatitis B surface antigen, wherein the saccharide dose of the Hib saccharide conjugate is less than 5 ug.
摘要翻译: 本申请公开了一种免疫原性组合物,其包含Hib糖结合物,至少一种额外的细菌,例如脑膜炎奈瑟球菌,糖结合物和选自全细胞百日咳和乙型肝炎表面抗原的另外的抗原, 其中Hib糖共轭物的糖剂量小于5μg。
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