VACCINE
    24.
    发明申请
    VACCINE 审中-公开
    疫苗

    公开(公告)号:US20090162394A1

    公开(公告)日:2009-06-25

    申请号:US12296130

    申请日:2007-04-05

    IPC分类号: A61K39/09

    CPC分类号: A61K39/092 Y02A50/412

    摘要: The present invention is in the field of pneumococcal capsular saccharide conjugate vaccines. Specifically, a multivalent Streptococcus pneumoniae immunogenic composition is provided with various (for instance 9 or more) conjugated capsular saccharides from different S. pneumoniae serotypes, wherein the composition comprises conjugated capsular saccharide 18C which is less than 80, 70, 60, 50, 40, 30, 20, 15 or 10% O-Acetylated.

    摘要翻译: 本发明在肺炎球菌荚膜糖结合疫苗领域。 具体地说,将多种肺炎链球菌免疫原性组合物与来自不同肺炎链球菌血清型的各种(例如9种或更多种)共轭荚膜糖提供,其中组合物包含小于80,70,60,50,40的共轭荚膜糖18C ,30,20,15或10%O-乙酰化。

    Pertussis antigens and use thereof in vaccination
    29.
    发明授权
    Pertussis antigens and use thereof in vaccination 有权
    百日咳抗原及其在疫苗接种中的应用

    公开(公告)号:US08574596B2

    公开(公告)日:2013-11-05

    申请号:US10574297

    申请日:2004-10-01

    IPC分类号: A61K39/10 C07H21/02

    CPC分类号: A61K39/099 Y02A50/466

    摘要: The invention provides BASB232 polypeptides and polynucleotides encoding BASB232 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses. The invention further provides immunogenic compositions comprising a plurality of antigens selected from at least two different categories of antigen, having different functions within Bordetella. Examples of such categories of antigen are autotransporter proteins, iron acquisition proteins, lipoproteins, adhesins and toxins/invasins.

    摘要翻译: 本发明提供了BASB232多肽和编码BASB232多肽的多核苷酸以及通过重组技术产生这种多肽的方法。 还提供诊断,预防和治疗用途。 本发明进一步提供包含多种抗原的免疫原性组合物,所述多种抗原选自至少两种不同类别的抗原,在博尔特氏菌内具有不同的功能。 这些抗原类别的实例是自身转运蛋白,铁获取蛋白,脂蛋白,粘附素和毒素/侵袭素。