公开(公告)号：US5006458A

公开(公告)日：1991-04-09

申请号：US135670

申请日：1987-12-21

申请人： Keiko Kato ,  Shigeki Kageyama ,  Yoshikazu Amano ,  Fuminori Arai ,  Harumi Katsuyama

发明人： Keiko Kato ,  Shigeki Kageyama ,  Yoshikazu Amano ,  Fuminori Arai ,  Harumi Katsuyama

IPC分类号： G01N31/22 ,  C12Q1/00 ,  C12Q1/32 ,  G01N33/52

CPC分类号： G01N33/525 ,  Y10S435/805 ,  Y10S436/81 ,  Y10S436/904

摘要： A dry-type analytical element suitable for measuring enzyme activity of in a liquid sample, characterized by incorporating a polyacrylamide, polymethacrylamide or their derivatives into at least one water-permeable layer. The background concentration of the dry-type analytical element exhibits minimal increase even under a fluorescent light, and allows an accurate measured value to be easily obtained.

公开(公告)号：US4956146A

公开(公告)日：1990-09-11

申请号：US321978

申请日：1989-03-10

申请人： Hirokazu Yuhki ,  Kazuhiko Fujiwara ,  Hiroshi Ohnishi ,  Fuminori Arai

发明人： Hirokazu Yuhki ,  Kazuhiko Fujiwara ,  Hiroshi Ohnishi ,  Fuminori Arai

IPC分类号： G01N33/50 ,  C12Q1/00 ,  G01N33/52

CPC分类号： G01N33/52 ,  Y10S435/805 ,  Y10S436/904 ,  Y10T436/206664

摘要： A dry analytical element for use in detecting a specific component contained in a liquid, which element comprises one or more water permeable layers provided on a water impermeable support, at least one layer of the water-permeable layers containing a composition capable of interacting with said specific component contained in said liquid. The composition contains a leuco dye and a dispersion containing said leuco dye is incorporated in the water-permeable layer, which is formed by dissolving the leuco dye in a hydrophobic solvent containing an aliphatic higher alcohol and dispersing the resulting solution in a hydrophilic medium. The leuco dye has the formula: ##STR1## where R.sup.1 represents an unsubstituted or substituted aryl group, R.sup.2 represents an unsubstituted or substituted alkyl group, and R.sup.3 represents an unsubstituted or substituted aryl group. A process for producing said dry analytical element is also disclosed.

公开(公告)号：US4786595A

公开(公告)日：1988-11-22

申请号：US858545

申请日：1986-04-29

申请人： Fuminori Arai ,  Takushi Miyazako ,  Harumi Katsuyama

发明人： Fuminori Arai ,  Takushi Miyazako ,  Harumi Katsuyama

IPC分类号： C12Q1/26 ,  C12Q1/40 ,  C12Q1/60 ,  G01N31/22 ,  G01N33/52 ,  G01N21/77 ,  G01N33/546

CPC分类号： C12Q1/26 ,  C12Q1/40 ,  C12Q1/60 ,  G01N31/22 ,  G01N33/525 ,  Y10S436/805

摘要： An analytical element for quantitative analysis of analyte contained in a body fluid or the like, which has at least one reagent layer comprising a reactive reagent and a binder, characterized in that a portion or whole of the binder is a polycarboxylic acid carrying a nonionic surface active agent attached through ester linkage to at least a portion of the carboxyl groups contained therein.

摘要翻译： 用于定量分析包含在体液等中的分析物的分析元件，其具有至少一个包含反应性试剂和粘合剂的试剂层，其特征在于，所述粘合剂的一部分或全部是携带非离子表面的多元羧酸 活性剂通过酯键连接至其中所含羧基的至少一部分。

公开(公告)号：US4452887A

公开(公告)日：1984-06-05

申请号：US389344

申请日：1982-06-17

申请人： Masao Kitajima ,  Fuminori Arai ,  Harumi Katsuyama

发明人： Masao Kitajima ,  Fuminori Arai ,  Harumi Katsuyama

IPC分类号： C12Q1/26 ,  C12Q1/00 ,  C12Q1/28 ,  C12Q1/54 ,  G01N33/52 ,  G01N33/66

CPC分类号： C12Q1/54 ,  G01N33/526 ,  Y10S435/805

摘要： In a dry-type multilayer liquid analysis material for glucose determination composed of a transparent water-impermeable support having formed thereon in sequence at least a reagent layer containing a reactive component forming a detectable material by the action of hydrogen peroxide, a non-porous light-shielding layer, and a porous spreading layer, the coloring efficiency for colorimetry using the liquid analysis material is improved by incorporating a glucose oxidase enzyme in at least one layer disposed above the reagent layer.

摘要翻译： 在用于葡萄糖测定的干式多层液体分析材料中，其由透明的不透水支持体组成，其中至少在其上形成有通过过氧化氢的作用形成可检测材料的反应性成分的试剂层，非多孔光 并且多孔扩散层，通过在设置在试剂层上方的至少一层中并入葡萄糖氧化酶来提高使用液体分析材料的比色法的着色效率。

公开(公告)号：US4340565A

公开(公告)日：1982-07-20

申请号：US221183

申请日：1980-12-29

申请人： Masao Kitajima ,  Fuminori Arai ,  Asaji Kondo

发明人： Masao Kitajima ,  Fuminori Arai ,  Asaji Kondo

IPC分类号： G01N33/49 ,  G01N31/22 ,  G01N33/48 ,  G01N33/52 ,  G01N33/50

CPC分类号： G01N33/48 ,  G01N33/525

摘要： A hematocrit value determining element comprising, in one embodiment, a water-impermeable planar support having integrally provided thereon a hydrophilic porous spreading layer, the porous spreading layer being such that blood spreads therethrough depending upon the viscosity of the blood and, in a second embodiment, a hematocrit value determining element as described above and a binder layer provided between the planar support and the porous spreading layer.

摘要翻译： 一种血细胞比容值确定元件，在一个实施方案中包括在其上整体设置有亲水性多孔扩散层的不透水平面支撑体，所述多孔扩散层使得血液通过其中的血液扩散，这取决于血液的粘度，并且在第二实施方案中 ，如上所述的血细胞比容值确定元件和设置在平面支撑体和多孔扩散层之间的粘合剂层。

公开(公告)号：US5592290A

公开(公告)日：1997-01-07

申请号：US358486

申请日：1994-11-14

申请人： Fuminori Arai ,  Yoshikazu Amano ,  Kiyoshi Yamada

发明人： Fuminori Arai ,  Yoshikazu Amano ,  Kiyoshi Yamada

IPC分类号： G01N33/52 ,  G01N21/27 ,  G01N21/78 ,  G01N21/86 ,  G01N31/22 ,  G01J3/00

CPC分类号： G01N21/8483 ,  G01N21/274

摘要： A method for correcting an instrumental error due to wavelength error of a spectroscope of an optical analyzer for measuring an optical density reflected from or transmitted through a dry analysis element. One standard color plate having a standard optical density OD.sub.ST is measured by an optical analyzer to be corrected to obtain an measured value OD.sub.M. A measured optical density OD.sub.S of the element applied with a sample through the optical analyzer to be corrected is corrected by using a ratio of OD.sub.M /OD.sub.ST to obtain a corrected measured value OD.sub.C of the sample. The standard color plate to be used contains an indicator dye contained in the non-reacted dry analysis element or a dye having an absorption spectrum same as or similar to that of the indicator dye in the measurement wavelength range. Another correction method in consideration of a layer coefficient of a dry analysis element is also provided.

摘要翻译： 一种用于校正由用于测量从干分析元件反射或透过干光分析元件的光密度的光学分析仪的分光镜引起的波长误差的仪器误差的方法。 通过光学分析器测量具有标准光密度ODST的一个标准色板以进行校正，以获得测量值ODM。 通过使用ODM / ODST的比例来校正通过待校正的光学分析器施加样品的元件的测量光密度ODS，以获得样品的校正测量值ODC。 所使用的标准色板包含未反应干燥分析元件中所含的指示剂染料或在测量波长范围内具有与指示剂染料相同或类似的吸收光谱的染料。 还提供了考虑干分析元件的层系数的另一校正方法。

公开(公告)号：US4781890A

公开(公告)日：1988-11-01

申请号：US11386

申请日：1987-02-05

申请人： Fuminori Arai ,  Kenichiro Yazawa ,  Harumi Katsuyama

发明人： Fuminori Arai ,  Kenichiro Yazawa ,  Harumi Katsuyama

IPC分类号： C12Q1/26 ,  G01N31/22 ,  G01N33/52 ,  C12Q1/54

CPC分类号： C12Q1/26 ,  G01N31/22 ,  G01N33/525 ,  Y10S435/805 ,  Y10T436/144444 ,  Y10T436/25125

摘要： A multilayer chemical analytical element is employable in quantitative analysis of analyte in a biological fluid such as blood. The element consists of a porous spreading layer, a light-blocking layer and a reagent layer on a water-impermeable light-transmissive support in order. The light-blocking layer contains a titanium dioxide fine powder with no provision of aluminum oxide compound or silicon oxide.

摘要翻译： 多层化学分析元件可用于定量分析生物流体如血液中的分析物。 该元件按顺序由不透水的透光支架上的多孔扩散层，遮光层和试剂层组成。 遮光层含有不含氧化铝化合物或氧化硅的二氧化钛细粉末。

公开(公告)号：US4270920A

公开(公告)日：1981-06-02

申请号：US71618

申请日：1979-08-31

申请人： Asaji Kondo ,  Fuminori Arai ,  Masao Kitajima

发明人： Asaji Kondo ,  Fuminori Arai ,  Masao Kitajima

IPC分类号： G01N31/22 ,  G01N33/52 ,  G01N33/62 ,  G01N33/66 ,  G01N33/72

CPC分类号： G01N31/22 ,  G01N33/525

摘要： An integrated material for chemical analysis comprising three or more reagent layer units on a support and a porous spreading layer, said units containing reagents for different chemical analyses and being proximately arranged on a support such that approximately equal portions thereof are within a spreading circle defined by the diffusion of a liquid sample as it passes through the porous spreading layer, and a method for analyzing blood using the same.

摘要翻译： 一种用于化学分析的综合材料，其包括在支撑体上的三个或更多个试剂层单元和多孔扩散层，所述单元包含用于不同化学分析的试剂，并且近似地布置在支撑体上，使得其大致相等的部分在由 液体样品在通过多孔扩散层时的扩散，以及使用其分析血液的方法。

公开(公告)号：US4255384A

公开(公告)日：1981-03-10

申请号：US66363

申请日：1979-08-14

申请人： Masao Kitajima ,  Fuminori Arai ,  Asaji Kondo

发明人： Masao Kitajima ,  Fuminori Arai ,  Asaji Kondo

IPC分类号： G01N33/52 ,  G01N31/22

CPC分类号： G01N33/525

摘要： An integral multilayered element for the chemical analysis of the blood comprising a combination of a porous spreading layer, a reagent layer, and a radiation-blocking layer, said radiation-blocking layer being water-permeable and containing at least one elemental metal or an alloy thereof.

摘要翻译： 一种用于血液化学分析的整体多层元件，包括多孔扩散层，试剂层和辐射阻挡层的组合，所述辐射阻挡层是透水性的并且包含至少一种元素金属或合金 其中。

公开(公告)号：US07022285B2

公开(公告)日：2006-04-04

申请号：US09978109

申请日：2001-10-15

申请人： Takaki Arai ,  Fuminori Arai ,  Keiichi Ishizaki

发明人： Takaki Arai ,  Fuminori Arai ,  Keiichi Ishizaki

IPC分类号： G01N31/00

CPC分类号： G01N31/223 ,  Y10T436/175383

摘要： An integral multilayer analytical element for analysis of ammonia or ammonia-producing substance is provided, which comprises a thin liquid blocking layer having a comparative facility with a thicker liquid blocking layer and is stably fabricated on a common production line employed for different type of slides.In the integral multilayer analytical element for analysis of ammonia or ammonia-producing substance comprising a transparent support, an indicator layer containing an indicator which produces a detectable change by gaseous ammonia, a liquid blocking layer permitting a gaseous ammonia to pass through, a reagent layer containing an alkaline buffering agent and optionally a reagent capable of reacting with said ammonia-producing substance to produce ammonia, and a spreading layer, adhesively laminated in this order, the improvement which comprises that said liquid blocking layer is composed of at least two porous membranes.