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1.发明授权
公开(公告)号：US5592290A
公开(公告)日：1997-01-07
申请号：US358486
申请日：1994-11-14
申请人： Fuminori Arai , Yoshikazu Amano , Kiyoshi Yamada
发明人： Fuminori Arai , Yoshikazu Amano , Kiyoshi Yamada
CPC分类号： G01N21/8483 , G01N21/274
摘要： A method for correcting an instrumental error due to wavelength error of a spectroscope of an optical analyzer for measuring an optical density reflected from or transmitted through a dry analysis element. One standard color plate having a standard optical density OD.sub.ST is measured by an optical analyzer to be corrected to obtain an measured value OD.sub.M. A measured optical density OD.sub.S of the element applied with a sample through the optical analyzer to be corrected is corrected by using a ratio of OD.sub.M /OD.sub.ST to obtain a corrected measured value OD.sub.C of the sample. The standard color plate to be used contains an indicator dye contained in the non-reacted dry analysis element or a dye having an absorption spectrum same as or similar to that of the indicator dye in the measurement wavelength range. Another correction method in consideration of a layer coefficient of a dry analysis element is also provided.
摘要翻译： 一种用于校正由用于测量从干分析元件反射或透过干光分析元件的光密度的光学分析仪的分光镜引起的波长误差的仪器误差的方法。 通过光学分析器测量具有标准光密度ODST的一个标准色板以进行校正，以获得测量值ODM。 通过使用ODM / ODST的比例来校正通过待校正的光学分析器施加样品的元件的测量光密度ODS，以获得样品的校正测量值ODC。 所使用的标准色板包含未反应干燥分析元件中所含的指示剂染料或在测量波长范围内具有与指示剂染料相同或类似的吸收光谱的染料。 还提供了考虑干分析元件的层系数的另一校正方法。
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2.发明授权Analytical element having a polyacrylamide or derivative to minimize background for assaying enzyme activity 失效具有聚丙烯酰胺或衍生物的分析元件以最小化测定酶活性的背景
公开(公告)号：US5006458A
公开(公告)日：1991-04-09
申请号：US135670
申请日：1987-12-21
CPC分类号： G01N33/525 , Y10S435/805 , Y10S436/81 , Y10S436/904
摘要： A dry-type analytical element suitable for measuring enzyme activity of in a liquid sample, characterized by incorporating a polyacrylamide, polymethacrylamide or their derivatives into at least one water-permeable layer. The background concentration of the dry-type analytical element exhibits minimal increase even under a fluorescent light, and allows an accurate measured value to be easily obtained.
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公开(公告)号：US4587100A
公开(公告)日：1986-05-06
申请号：US530207
申请日：1983-09-08
申请人： Yoshikazu Amano , Fuminori Arai , Masao Kitajima
发明人： Yoshikazu Amano , Fuminori Arai , Masao Kitajima
CPC分类号： C12Q1/28 , C12Q1/54 , C12Q1/60 , G01N31/22 , G01N33/525 , C12Q2326/96
摘要： A multilayer analytical element comprising a water-impermeable, light-transmissive support, a reagent layer containing at least a peroxidase, and a porous spreading layer, which are superposed in this order, in which at least one layer other than said support contains a water-soluble monocarboxylic acid or a salt thereof having solubility of not less than 1 g. in 100 g. of water at 25.degree. C.
摘要翻译： 一种多层分析元件，其包含不透水的透光性载体，至少含有过氧化物酶的试剂层和多孔扩散层，其中所述载体中除了所述载体以外的至少一层包含水 - 可溶性单羧酸或其盐的溶解度不小于1g。 在100克。 的水在25℃
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公开(公告)号：US20090202392A1
公开(公告)日：2009-08-13
申请号：US12366683
申请日：2009-02-06
IPC分类号： B01L3/02
CPC分类号： B01L3/0275 , B01L2300/165
摘要： A pipette tip formed by a polypropylene substrate coated with a water repellent agent. The water repellent agent contains a silicone resin containing at least one specific substance selected from the group consisting of diisononyl phthalate, diisodecyl phthalate, trioctyl trimellitate and poly (1,3-butanediol adipate). The total mass of the specific substance is 1-30 mass % of the silicone resin.
摘要翻译： 由涂覆有防水剂的聚丙烯基材形成的吸头。 防水剂含有含有至少一种选自邻苯二甲酸二异壬基酯，邻苯二甲酸二异癸酯，偏苯三酸三辛酯和己二酸1,3-丁二醇酯中的至少一种特定物质的有机硅树脂。 特定物质的总质量为有机硅树脂的1-30质量％。
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公开(公告)号：US5589347A
公开(公告)日：1996-12-31
申请号：US461766
申请日：1995-06-05
申请人： Fuminori Arai , Takeshi Igarashi
发明人： Fuminori Arai , Takeshi Igarashi
CPC分类号： C12Q1/60 , Y10S435/805
摘要： A multilayer analysis element for determination of total cholesterol is prepared having a light-transmissive water-impermeable support, at least one hydrophilic polymer layer on said support and a spreading layer on said hydrophilic polymer layer(s), and containing in one or more of the layers:(a) at least one enzyme having cholesterol esterase activity,(b) cholesterol oxidase,(c) peroxidase,(d) a color reagent composition, which in the presence of hydrogen peroxide and the peroxidase, produces a color change(e) at least one bile acid compound selected from the group consisting of bile acids, bile acid derivatives and salts of said acids and derivatives, and(f) an alkyl phenoxy polyethoxy ethanol containing in the alkyl group 1 to 20, preferably 7 to 10 carbon atoms, and a polyoxyethylene chain composed of at least 16, preferably 30 to 60 oxyethylene units.
摘要翻译： 制备用于测定总胆固醇的多层分析元件，其具有透光不透水支撑体，所述载体上的至少一个亲水性聚合物层和所述亲水性聚合物层上的铺展层，并且包含一个或多个 所述层：（a）至少一种具有胆固醇酯酶活性的酶，（b）胆固醇氧化酶，（c）过氧化物酶，（d）在过氧化氢和过氧化物酶存在下产生颜色变化的着色剂组合物 e）至少一种胆汁酸化合物，其选自胆汁酸，胆汁酸衍生物和所述酸及其衍生物的盐，和（f）烷基苯氧基聚乙氧基乙醇，其含有在烷基1至20，优选7至10 碳原子和由至少16个，优选30-60个氧乙烯单元组成的聚氧乙烯链。
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公开(公告)号：US5215716A
公开(公告)日：1993-06-01
申请号：US667001
申请日：1991-03-11
申请人： Fuminori Arai
发明人： Fuminori Arai
IPC分类号： G01N33/52
CPC分类号： G01N33/525
摘要： An integral multilayer analytical element comprising a reagent layer containing an indicator reagent composition capable of producing a detectable change corresponding to an analyte and a porous spreading layer composed of a fibrous fabric superposed on the reagent layer, wherein the yarn of said fabric comprises fibers having roughed surface, and an integral multilayer analytical element comprising a water-absorptive layer containing a hydrophilic polymer and a porous spreading layer composed of a fibrous fabric containing an indicator reagent composition capable of producing a detectable change corresponding to an analyte superposed on the water-absorptive layer, wherein the yarn of said fabric comprises fibers having roughed surface.The rouging is carried out, for example, by alkali etching.
摘要翻译： 一种整体多层分析元件，其包含试剂层，所述试剂层包含能够产生对应于分析物的可检测变化的指示剂组合物和由叠置在所述试剂层上的纤维织物组成的多孔扩散层，其中所述织物的纱线包含粗糙的纤维 表面和包含含有亲水性聚合物的吸水层和由含有指示剂组合物的纤维织物组成的多孔扩散层的整体多层分析元件，所述指示剂组合物能够产生与叠加在吸水层上的分析物相对应的可检测变化 其中所述织物的纱线包括具有粗糙表面的纤维。 例如，通过碱蚀刻进行粗化。
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公开(公告)号：USH930H
公开(公告)日：1991-06-04
申请号：US321977
申请日：1989-03-10
申请人： Keiko Kato , Fuminori Arai , Harumi Katsuyama
发明人： Keiko Kato , Fuminori Arai , Harumi Katsuyama
CPC分类号： C12Q1/54
摘要： A dry-type quantitative glucose-analyzing element comprising a water-impermeable light-transmissive support having thereon a group of water-permeable layers comprising a reagent layer, an enzyme-containing layer, and a porous spreading layer which are laminated on said support in this order, and a hydrogen peroxide-detecting coloring composition comprising a hydrogen donor and a coupler; whereinsaid reagent layer contains at least said coupler;said enzyme-containing layer contains a glucose oxidase, a peroxidase and a mordant which immobilizes a dye formed by said coloring composition; andsaid hydrogen donor is contained in at least one water-permeable layer of said group. Using the element, quantitative determination of glucose of high concentration is possible with high accuracy.
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公开(公告)号：US5004685A
公开(公告)日：1991-04-02
申请号：US86514
申请日：1987-08-18
申请人： Fuminori Arai , Asaji Kondo
发明人： Fuminori Arai , Asaji Kondo
CPC分类号： G01N33/525 , C12Q1/26 , C12Q1/28 , C12Q2326/96 , Y10S435/805 , Y10S436/81 , Y10S436/904
摘要： A dry-type multilayer analytical element containing a color reagent composition comprising an oxidase specifically reaction with an analyte or derived therefrom to produce hydrogen peroxide, hydrogen peroxide-decomposing enzyme, an alkali metal salt of ferrocyanide and a chromogen which is separated from the hydrogen peroxide-decomposing enzyme, the chromogen being incorporated in a layer nearer to the transparent support of the analytical element than the layer containing the hydrogen peroxide-decomposing enzyme. The analytical element exhibits excellent coloration, color stability, and accuracy and the results are minimally influenced by the presence of hemoglobin in the sample.
摘要翻译： 一种干型多层分析元件，其含有显色试剂组合物，其包含氧化酶与分析物特异性反应或由其衍生产生过氧化氢，过氧化氢分解酶，亚铁氰化物碱金属盐和与过氧化氢分离的色原体 分解酶，色原子被结合在比含有过氧化氢分解酶的层更接近分析元件的透明载体的层中。 分析元素显示出优异的着色，颜色稳定性和准确性，并且结果最小程度地受样品中血红蛋白的存在的影响。
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9.发明授权
公开(公告)号：US4248829A
公开(公告)日：1981-02-03
申请号：US101385
申请日：1979-12-07
申请人： Masao Kitajima , Asaji Kondo , Fuminori Arai
发明人： Masao Kitajima , Asaji Kondo , Fuminori Arai
CPC分类号： G01N33/525 , G01N31/22 , Y10S435/805
摘要： An integrated material for chemically analyzing a liquid sample comprising a supporting plate having provided thereon two or more different analytical units each comprising a reagent layer and a porous spreading layer or a portion of a common porous spreading layer, the units being disposed such that at least a portion of the reagent layers are in contact with or in close proximity to one another with the porous spreading layer(s) of the units being commonly covered with a liquid sample delivering patch.
摘要翻译： 一种用于化学分析液体样品的综合材料，包括其上设置有两个或更多个不同分析单元的支撑板，每个分析单元包括试剂层和多孔扩散层或共同的多孔扩散层的一部分，该单元被设置为使得至少 试剂层的一部分彼此接触或彼此靠近，单元的多孔扩散层通常被液体样品递送贴片覆盖。
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公开(公告)号：US4895704A
公开(公告)日：1990-01-23
申请号：US117355
申请日：1987-10-27
申请人： Fuminori Arai , Takeshi Igarashi
发明人： Fuminori Arai , Takeshi Igarashi
CPC分类号： G01N33/525 , Y10S435/805
摘要： An integral multilayer analytical element which comprises a water-impermeable light-transmissive support, a hydrophilic layer containing a water-absorptive hydrophilic polymer binder and a spreading layer superposed in this order, and contains at least one reagent capable of reacting with a component of a sample to produce a detectable species capable of detecting by light, which is characterized in that light-scattering particulates in an amount to make light transmittance to 10 to 2.5% are contained in the above hydrophilic layer and/or a layer located on the side of the support therefrom. This element may decrease the influence of a conventional reagent layer up to the extent being negligible without lowering the sensitivity. Precision of the measurement at a low concentration range is also high, and reproducibility of the meaurement is well. Manufacture of this element is easy.
摘要翻译： 一种整体多层分析元件，其包含不透水的透光性支撑体，含有吸水性亲水性聚合物粘合剂的亲水层和依次叠加的扩散层，并且含有至少一种能够与 样品以产生能够被光检测的可检测物质，其特征在于将上述亲水层和/或位于上述亲水层侧的层中含有使光透射率达到10至2.5％的量的光散射微粒 其支撑。 该元件可以降低常规试剂层的影响，直到可忽略的程度，而不降低灵敏度。 在低浓度范围内的测量精度也很高，测量的重现性好。 制造这个元素很容易。
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