Substituted 3-aminoquinuclidines
    21.
    发明授权
    Substituted 3-aminoquinuclidines 失效
    取代的3-氨基亚奎宁

    公开(公告)号:US5716965A

    公开(公告)日:1998-02-10

    申请号:US175353

    申请日:1993-12-20

    IPC分类号: C07D453/02 A61K31/445

    CPC分类号: C07D453/02

    摘要: Compounds of the formula ##STR1## wherein W, Ar.sup.1, Ar.sup.2 and Ar.sup.3 are defined as below; and the pharmaceutically acceptable salts of such compounds. These compounds are substance P antagonists and useful in the treatment of gastrointestinal disorders, inflammatory disorders, central nervous system disorders and pain.

    摘要翻译: PCT No.PCT / US92 / 04002 Sec。 371日期:1993年12月20日 102(e)1993年12月20日日期PCT提交1992年5月19日PCT公布。 出版物WO92 / 20676 日期:1992年11月26日其中W,Ar 1,Ar 2和Ar 3如下定义的式(Ⅰ)化合物: 和这些化合物的药学上可接受的盐。 这些化合物是物质P拮抗剂,可用于治疗胃肠道疾病,炎性疾病,中枢神经系统疾病和疼痛。

    Substituted benzylaminoquinuclidines as substance P antagonists
    22.
    发明授权
    Substituted benzylaminoquinuclidines as substance P antagonists 失效
    取代的苄基氨基奎宁啶作为物质P拮抗剂

    公开(公告)号:US5604241A

    公开(公告)日:1997-02-18

    申请号:US416913

    申请日:1995-04-20

    CPC分类号: C07F9/6561 C07D453/02

    摘要: Compounds useful in the treatment of inflammatory disorders, central nervous system disorders and other disorders of the formula I ##STR1## and the pharmaceutically-acceptable salts thereof, wherein Ar.sup.1 and Ar.sup.2 are each independently aryl or substituted aryl; R.sup.1 is alkyl having from 1 to 6 carbon atoms;R.sup.2 is hydrogen or alkyl having from 1 to 6 carbon atoms;and either X and Y are taken separately and they are each, independently, hydrogen, dialkylphosphoryl having 2 to carbon atoms, alkyl having from 1 to 6 carbon atoms, alkenyl having from 2 to 6 carbon atoms or alkynyl having from 2 to 6 carbon atoms; or X and Y are taken together and they represent a hydrocarbon chain having 3, 4, or 5 carbon atoms, optionally containing up to 2 double bonds and optionally having 1 or 2 substituents selected from oxo, hydroxy and alkyl having from 1 to 6 carbon atoms; or Y is methoxy when X is ethyl; provided that when X and Y are taken together they are attached to adjacent carbon atoms; and provided that if either X or Y is hydrogen, then the other one must be alkenyl or alkynyl; and provided that when Y is methoxy and X is ethyl, then Y is at the 4-position and X is at the 5-position, Ar.sup.1 or Ar.sup.2 must each be phenyl, R.sup.1 is methyl and R.sup.2 is hydrogen.

    摘要翻译: PCT No.PCT / US93 / 09168 Sec。 371日期1995年04月20日 102(e)1995年4月20日PCT PCT 1993年9月30日PCT公布。 公开号WO94 / 08997 日期1994年4月28日可用于治疗炎症性疾病,中枢神经系统疾病和式I的其它病症及其药学上可接受的盐的化合物,其中Ar1和Ar2各自独立地为芳基或取代的芳基; R1是具有1至6个碳原子的烷基; R2是氢或具有1至6个碳原子的烷基; X和Y分开取代,它们各自独立地为氢,具有2-碳原子的二烷基磷酰基,具有1-6个碳原子的烷基,具有2-6个碳原子的链烯基或具有2-6个碳原子的炔基 ; 或X和Y一起并且它们表示具有3,4或5个碳原子的烃链,任选地含有至多2个双键并且任选地具有1或2个选自氧代,羟基和具有1至6个碳原子的烷基的取代基 原子 或当X为乙基时,Y为甲氧基; 条件是当X和Y一起取代时,它们连接到相邻的碳原子上; 并且条件是如果X或Y是氢,则另一个必须是烯基或炔基; 并且条件是当Y为甲氧基且X为乙基时,则Y为4-位,X为5-位,Ar1或Ar2各自为苯基,R1为甲基,R2为氢。

    Headstock of a polishing machine
    25.
    发明授权
    Headstock of a polishing machine 失效
    抛光机头架

    公开(公告)号:US6027401A

    公开(公告)日:2000-02-22

    申请号:US955701

    申请日:1997-10-23

    IPC分类号: B24B37/30 B24B41/04 B24B7/22

    CPC分类号: B24B37/30 B24B41/042

    摘要: The present invention provides a headstock of a polishing machine, having a simple structure and capable of tracing a pad surface. The headstock of the present invention is formed of a spindle, a holder plate, a spherical bearing, and a plate spring. The holder plate is connected to a lower end portion of the spindle via the spherical bearing and the plate spring. A workpiece is attached to the lower surface of the holder plate. The spherical bearing has a center of tilting movement on a rotation axis of the spindle. The holder plate has a balance plate. The center of gravity of the holder plate including the balance plate coincides with the center of tilting movement of the spherical bearing. The plate spring has an axisymmetric shape. More specifically, the plate spring has an opening portion at the center and a plurality of arm portions extending to the outer periphery in the diameter direction. The plate spring is connected to the lower end of the spindle by use of first fitting holes which are formed along the inner periphery, and the plate spring is also attached to the holder plate by use of second fitting holes which are formed in the distal end of the plate spring. The first and second fitting holes are respectively located on small- and large-diameter circles which are concentrically arranged around the rotation axis of the spindle.

    摘要翻译: 本发明提供一种抛光机的头架,其具有简单的结构并且能够跟踪垫表面。 本发明的主轴箱由主轴,保持板,球面轴承和板簧构成。 保持板通过球面轴承和板簧连接到主轴的下端部分。 工件附接到保持板的下表面。 球面轴承在主轴的旋转轴线上具有倾斜运动的中心。 支架板具有平衡板。 包括平衡板的保持板的重心与球面轴承的倾斜运动的中心重合。 板簧具有轴对称形状。 更具体地,板簧在中心具有开口部分,并且在直径方向上延伸到外周的多个臂部分。 板簧通过使用沿着内周形成的第一嵌合孔连接到主轴的下端,并且板簧也通过使用形成在远端的第二装配孔附接到保持板 的板簧。 第一和第二装配孔分别位于围绕主轴的旋转轴线同心布置的小直径和大直径的圆周上。

    Morphinan hydroxamic acid compounds
    26.
    发明授权
    Morphinan hydroxamic acid compounds 失效
    吗啡异羟肟酸化合物

    公开(公告)号:US5834478A

    公开(公告)日:1998-11-10

    申请号:US928953

    申请日:1997-09-12

    申请人: Fumitaka Ito

    发明人: Fumitaka Ito

    CPC分类号: C07D489/08 Y02P20/55

    摘要: This invention provides a compound of the following formula: ##STR1## and the pharmaceutically acceptable salts thereof, wherein R is hydrogen, C.sub.1 -C.sub.5 alkyl or an O-protecting group; B is a dircet bond, C.sub.1 -C.sub.5 alkylene or C.sub.2 -C.sub.5 alkenylene; R.sup.1 is C.sub.1 -C.sub.5 alkyl, C.sub.2 -C.sub.5 alkenyl or C.sub.3 -C.sub.7 cycloalkyl-C.sub.1 -C.sub.3 alkyl; R.sup.2 is hydroxy or C.sub.1 -C.sub.5 alkoxy; R.sup.3 is hydrogen, hydroxy or C.sub.1 -C.sub.5 alkoxy; and R.sup.4 is hydrogen, phenyl or heteroaryl selected from furyl, thienyl and pyrrolyl, the phenyl and heteroaryl being optionally substituted by one to five substitutents selected from halo, hydroxy, C.sub.1 -C.sub.3 allyl, C.sub.1 -C.sub.3 alkoxy and C.sub.2 -C.sub.5 alkenyl. These compounds and pharmaceutical compositions containing such compounds are useful as analgesic, antiinflammatory, diuretic, anesthetic or neuroprotective agents, or an agent for stroke or treatment of functional bowel diseases such as abdominal pain, for the treatment of a mammalian subject, especially a human subject.

    摘要翻译: 本发明提供了下式的化合物:其中R是氢,C 1 -C 5烷基或O-保护基; B是Dircet键,C1-C5亚烷基或C2-C5亚烯基; R 1是C 1 -C 5烷基,C 2 -C 5烯基或C 3 -C 7环烷基-C 1 -C 3烷基; R2是羟基或C1-C5烷氧基; R3是氢,羟基或C1-C5烷氧基; R4是氢,选自呋喃基,噻吩基和吡咯基的苯基或杂芳基,苯基和杂芳基任选被1至5个选自卤素,羟基,C 1 -C 3烯丙基,C 1 -C 3烷氧基和C 2 -C 5烯基的取代基取代。 含有这些化合物的这些化合物和药物组合物可用作止痛剂,抗炎药,利尿剂,麻醉剂或神经保护剂,或用于中风或治疗功能性肠病如腹痛的药剂,用于治疗哺乳动物受试者,特别是人类受试者 。

    Facsimile receiving method and facsimile apparatus carrying out the
method
    27.
    发明授权
    Facsimile receiving method and facsimile apparatus carrying out the method 失效
    传真接收方法和传真机实施方法

    公开(公告)号:US5377257A

    公开(公告)日:1994-12-27

    申请号:US972551

    申请日:1992-11-06

    IPC分类号: H04N1/327 H04M11/00

    摘要: A facsimile apparatus which carries out ringing of a telephone first for calling, and transmits a voice message informing of "absence" and "facsimile receivable" to a calling station when offhook is not detected during a predetermined period. The facsimile apparatus also transmits a called station identification signal CED after a silence interval of about 5 seconds. When the calling station onhooks a handset during the period of ringing of the telephone by judging that the called station is absent, a fee for a telephone call will not be charged. Furthermore, by setting the silence interval, the CED signal after the voice message is prevented from being heard by the calling station.

    摘要翻译: 在预定时间段期间未检测到摘机的情况下,首先进行电话振铃的传真装置,并且向主叫站发送通知“不存在”和“传真可接收”的语音消息。 传真机还在大约5秒的静音间隔之后发送被叫站识别信号CED。 当呼叫站在电话铃声期间挂起手机时,通过判断被叫站不存在,不接收电话费。 此外,通过设置静音间隔,防止语音消息之后的CED信号被主叫台听到。

    1,3,8-Triuazaspiro(4,5)decanone compounds as ORL1-receptor agonists
    30.
    发明授权
    1,3,8-Triuazaspiro(4,5)decanone compounds as ORL1-receptor agonists 失效
    1,3,8-三氮杂螺环(4,5)癸酮化合物作为ORL1受体激动剂

    公开(公告)号:US06465478B1

    公开(公告)日:2002-10-15

    申请号:US09426824

    申请日:1999-10-22

    IPC分类号: A61K31438

    CPC分类号: C07D471/10

    摘要: A compound of formula: R1 and R2 are independently C1-C4 alkyl; or R1 and R2, taken together with the carbon atom to which they are attached, form a mono-, bi-, tri- or spiro-cyclic group having 3 to 13 carbon atoms, wherein the cyclic group is optionally substituted by one to five substituents; A is (C1-C3)alkyl, phenyl, benzyl or the like; R is hydrogen, (C1-C3)alkyl, amino-(C1-C6)alkyl, heterocyclic-(C1-C3)alkyl wherein the heterocyclic is optionally substituted by amino, ((C1-C4)alkyl)-Z—(C1-C6)alkyl wherein Z is OC(═O) or the like; and X is (C1-C3)alkyl, phenyl or the like. These compounds are useful as ORL1-receptor agonists, and useful as analgesics or the like in mammalian subjects.

    摘要翻译: 式R 1和R 2的化合物独立地是C 1 -C 4烷基; 或R 1和R 2与它们所连接的碳原子一起形成具有3至13个碳原子的单 - ,双 - ,三 - 或螺 - 环基团,其中环状基团任选被一至五个 取代基; A是(C 1 -C 3)烷基,苯基,苄基等; R 1是氢,(C 1 -C 3)烷基,氨基 - (C 1 -C 6)烷基,杂环 - (C 1 -C 3)烷基,其中杂环任意被氨基,((C 1 -C 4)烷基) -C 6)烷基,其中Z为OC(= O)等; 和X是(C 1 -C 3)烷基,苯基等。 这些化合物可用作ORL1受体激动剂,并且可用作哺乳动物受试者中的止痛剂等。