公开(公告)号：US20220364154A1

公开(公告)日：2022-11-17

申请号：US17878491

申请日：2022-08-01

Applicant: Gen-Probe Incorporated

Inventor： David A. Buse ,  Norbert D. Hagen ,  David Opalsky

IPC: C12Q1/6806 ,  G01N35/04 ,  B01L3/00 ,  B01L7/00 ,  C12Q1/686

Abstract: A reagent pack changer includes a reagent pack input device, a reagent pack storage compartment, a reagent pack storage carousel disposed within the storage compartment, and a rotary distributor. The input device includes a reagent pack input carousel rotatable about an axis of rotation, with reagent pack stations for holding reagent packs disposed around the axis of rotation of the carousel. The reagent pack storage carousel is rotatable about an axis of rotation with reagent pack stations for holding reagent packs disposed around the axis of rotation. The rotary distributor is configured to move a reagent pack between the reagent pack input carousel and the reagent pack storage carousel.

公开(公告)号：US11434521B2

公开(公告)日：2022-09-06

申请号：US17668775

申请日：2022-02-10

Applicant: Gen-Probe Incorporated

Inventor： David A. Buse ,  David Howard Combs ,  Byron J. Knight ,  Norbert D. Hagen ,  David Opalsky ,  Jason F. Rhubottom ,  Keith Moravick ,  Tyler Moore ,  Anita Prasad ,  Bruce Richardson

IPC: C12Q1/6806 ,  G01N35/04 ,  B01L3/00 ,  B01L7/00 ,  C12Q1/686

Abstract: A method for performing a nucleic acid amplification assay employs a thermally-conductive receptacle holder with one or more receptacle wells, each conforming to an outer surface of a lower portion of a vial. A through-hole extends from an inner surface of each well to an outer surface of the holder. A thermal element is positioned proximal to the holder for altering a temperature of the holder. A signal detection module is configured to generate an excitation signal directed through the through-hole of the well and detect an optical emission from a fluid contained in the vial supported by the well. At least one well supports a capped vial containing a reagent for a nucleic acid amplification assay and including an opaque cap sealing an open end of the vial. The lower portion of the vial is contained within a well, and the cap is situated above a top surface of the holder.

公开(公告)号：US11345946B2

公开(公告)日：2022-05-31

申请号：US15934339

申请日：2018-03-23

Applicant: GEN-PROBE INCORPORATED

Inventor： David Opalsky ,  David Buse ,  James T. Tuggle ,  Alexander Navarro ,  Patrick Sheehan

IPC: B01L3/00 ,  C12Q1/6806 ,  G01F23/263 ,  G01N35/04 ,  G01N35/10 ,  C12Q1/686

Abstract: A fluid container holder includes a body having a receptacle configured to receive a container. The body has a conductive outer surface for connection to an electrical ground or voltage source, and the holder is not formed solely of an electrically conductive metal. A fluid container handling assembly includes a drawer having a holder supporting a fluid container, and a frame supporting the holder. The frame is movable between a first position providing access to the holder and a second position positioning the holder within the instrument. The assembly also includes a first lock securing the holder to the frame when the frame is at the first frame position and unlocking the holder from the frame when the frame is at the second frame position. The assembly also includes a holder transporter configured to move the holder between a first holder position and a second holder position within the instrument.

公开(公告)号：US11279967B2

公开(公告)日：2022-03-22

申请号：US17036730

申请日：2020-09-29

Applicant: Gen-Probe Incorporated

Inventor： David A. Buse ,  David Howard Combs ,  Byron J. Knight ,  Norbert D. Hagen ,  David Opalsky ,  Jason F. Rhubottom ,  Keith Moravick ,  Tyler Moore ,  Anita Prasad ,  Bruce Richardson

IPC: C12Q1/6806 ,  G01N35/04 ,  B01L3/00 ,  B01L7/00 ,  C12Q1/686

Abstract: A system for performing a nucleic acid amplification assay that includes a receptacle holder formed from a thermally conductive material and having a receptacle well for receiving a lower portion of a vial; a thermal element for cycling the temperature of the receptacle holder; a signal detection module in optical communication with the receptacle well; and a robotic pipettor. The receptacle holder supports a capped vial having a plastic, opaque cap in a snap-fit with a single plastic vial containing a nucleic acid amplification reagent. An upper portion of the cap includes a probe recess that is configured to be removably engaged by an end of a probe of the robotic pipettor. A lower portion of the vial is contained within the receptacle well, and the cap is situated above a top surface of the receptacle holder.

公开(公告)号：US11098343B2

公开(公告)日：2021-08-24

申请号：US16011229

申请日：2018-06-18

Applicant: GEN-PROBE INCORPORATED

Inventor： David A. Buse ,  David Opalsky ,  Jason F. Rhubottom ,  Norbert D. Hagen ,  Jennifer L. Tidd

IPC: C12Q1/6806 ,  B01L3/00 ,  B01L7/00 ,  C12Q1/686 ,  G01N35/04

Abstract: A processing module is configured to extend the capabilities of an analyzer configured to process substances within each of a plurality of receptacles. The module includes a container transport configured to transport a container from a location within the processing module to a location within the analyzer that is accessible to a substance transfer device of the analyzer. A receptacle distribution system is configured to receive a receptacle from the analyzer, transfer the receptacle into the processing module, and to move the receptacle between different locations within the analyzer. A substance transfer device of the module is configured to dispense substances into or remove substances from the receptacle within the processing module. A reagent card exchanger provides an input device for inserting reagent cards into and removing reagent cards from the module, stores reagent cards within the module, and transfers reagent cards to different location within the module.

公开(公告)号：US10969336B2

公开(公告)日：2021-04-06

申请号：US15176867

申请日：2016-06-08

Applicant: Gen-Probe Incorporated

Inventor： Norbert D. Hagen ,  David Opalsky ,  George T. Walker ,  Byron J. Knight

IPC: G01N21/64 ,  G01N21/27

Abstract: An optical signal detection module includes an optical measurement device (OMD) configured to detect an optical emission signal from an emission signal source placed in a signal-detecting position of the OMD. The optical signal detection module also includes a cover moveable between a closed position covering the signal-detecting position and an open position not covering the signal-detecting position. The cover includes an optical reference material that emits a reference emission detectable by the OMD. The cover is configured so that, when the cover is in the closed position, the inner surface is in the signal-detecting position of the OMD so that the OMD detects the reference emission. The optical signal detection module can also include a drive assembly coupled to the cover and configured to move the cover between the open position and the closed position. In some embodiments, the OMD can include a fluorometer.

公开(公告)号：US10961572B2

公开(公告)日：2021-03-30

申请号：US16434910

申请日：2019-06-07

Applicant: Gen-Probe Incorporated

Inventor： David Buse ,  David Howard Combs ,  Norbert D. Hagen ,  David Opalsky ,  Bruce Richardson ,  Anita Prasad ,  Keith Moravick ,  Tyler Moore

IPC: C12Q1/686 ,  B01L7/00 ,  G01N21/64 ,  B01L9/06

Abstract: A thermally conductive receptacle holder includes a plurality of wells that each receive a receptacle. A cross-brace is mounted to a support to exert a force onto an outer surface of a compressive housing such that the compressive housing exerts a force onto the receptacle holder. An optical fiber associated with each well provides optical communication between the receptacle well and an excitation signal source and/or an emission signal detector.

公开(公告)号：US20210017579A1

公开(公告)日：2021-01-21

申请号：US17036730

申请日：2020-09-29

Applicant: Gen-Probe Incorporated

Inventor： David A. Buse ,  David Howard Combs ,  Byron J. Knight ,  Norbert D. Hagen ,  David Opalsky ,  Jason F. Rhubottom ,  Keith Moravick ,  Tyler Moore ,  Anita Prasad ,  Bruce Richardson

IPC: C12Q1/6806 ,  G01N35/04 ,  B01L3/00 ,  B01L7/00 ,  C12Q1/686

Abstract: A system for performing a nucleic acid amplification assay comprises a thermally-conductive receptacle holder with one or more receptacle wells, each conforming to an outer surface of a lower portion of a vial. A through-hole extends from an inner surface of each well to an outer surface of the holder. A thermal element is positioned proximal to the holder for altering a temperature of the holder. A signal detection module is configured to generate an excitation signal directed through the through-hole of the well and detect an optical emission from a fluid contained in the vial supported by the well. At least one well supports a capped vial containing a reagent for a nucleic acid amplification assay and including an opaque cap sealing an open end of the vial. The lower portion of the vial is contained within a well, and the cap is situated above a top surface of the holder.

公开(公告)号：US10890720B2

公开(公告)日：2021-01-12

申请号：US16179609

申请日：2018-11-02

Applicant: GEN-PROBE INCORPORATED

Inventor： Norbert D. Hagen ,  David Opalsky

IPC: G02B6/36 ,  G02B6/06 ,  G02B6/08 ,  G01N21/25 ,  G01N21/64 ,  G02B6/42

Abstract: A method of measuring a time-varying signal emission, the method including subjecting the contents of a receptacle to a thermal cycling process. During the thermal cycling process, measuring a signal emission from the contents of the receptacle at regular time intervals and recording the measured signal emission and a time stamp at each time interval. Also during the thermal cycling process, determining a temperature of the thermal cycling process at regular time intervals and recording the determined temperature and a time stamp at each time interval. The measured signal emissions are synchronized with a specific temperature of the thermal cycling process by comparing the time stamps of the measured emission signals with the time stamps of the determined temperatures.

公开(公告)号：US10829810B2

公开(公告)日：2020-11-10

申请号：US15720467

申请日：2017-09-29

Applicant: GEN-PROBE INCORPORATED

Inventor： Byron J. Knight ,  David Opalsky

IPC: C12Q1/686 ,  C08J7/18 ,  C08J7/12 ,  G01N3/303 ,  C08J7/06 ,  B01L3/00

Abstract: The disclosure provides solid compositions such as lyophilisates adhered to surfaces such as plasma-treated surfaces and related methods, uses, kits, intermediates, starting materials, and downstream products.